Adjunct in the management of certain drug-induced cardiovascular emergencies [off-label]. Investigating the power of music for dementia. 10 mg levitra with 500 mg yohimba bark gave a very satisfactory experience. HealthWarehouse.com has been accredited by the National Association of Boards of Pharmacy (NABP) for Digital Pharmacy and is licensed / accredited with all 50 State Boards of Pharmacy. have a sleep problem called sleep apnea syndrome. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Administer by slow IV injection. Loading dose of 510 mg, followed by intermittent injections of 0.030.1 mg/kg every 0.56 hours as needed. If necessary, use 2 applicators to administer the prescribed dose. What is the most important information I should know about Diazepam Tablets? The concomitant use of benzodiazepines and opioids increases the risk of respiratory depression because of actions at different receptor sites in the CNS that control respiration. oral solution and oral solution concentrate. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Repeat the process for each applicator to be dispensed. Increases in half-life have also been reported in hepatic fibrosis and in both acute and chronic hepatitis (see CLINICAL PHARMACOLOGY: PHARMACOKINETICS IN SPECIAL POPULATIONS: HEPATIC INSUFFICIENCY). Brand names: Diastat, Valium The clearance of diazepam is 20 to 30 mL/min in young adults. STORAGE. This medication should not be used if you have certain medical conditions. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. In full term infants, elimination half-lives around 30 hours have been reported, with a longer average half-life of 54 hours reported in premature infants of 28 - 34 weeks gestational age and 8 - 81 days post-partum. For most patients, the recommended starting dose of LEVITRA is 10 mg, taken orally, as needed, approximately 60 minutes before sexual activity. Benzodiazepines are commonly implicated in hepatic encephalopathy. N-desmethyldiazepam and temazepam are both further metabolized to oxazepam. There have also been reports that the metabolic elimination of phenytoin is decreased by diazepam. Diazepam and its metabolites are highly bound to plasma proteins (diazepam 98%). Children 5 years of age: Usual initial dose for status epilepticus or severe recurrent convulsant seizures is 1 mg; may repeat every 25 minutes up to a maximum total dose of 10 mg. May repeat therapy with diazepam in 24 hours if necessary. In patients who have received prolonged (e.g., for several months) therapy, avoid abrupt discontinuance, since manifestations of withdrawal can be precipitated; gradually taper dosage. Initially, 0.2 mg/kg as rectal gel, rounded up to next available dose (i.e., the next multiple of 2.5 mg). Periodically reassess usefulness for treatment of anxiety. Because of isolated reports of neutropenia and jaundice, periodic blood counts and liver function tests are advisable during long-term therapy. Diazepam is a benzodiazepine that exerts anxiolytic, sedative, muscle-relaxant, anticonvulsant and amnestic effects. Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes. Abuse and misuse of benzodiazepines often (but not always) involve the use of doses greater than the maximum recommended dosage and commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes, including respiratory depression, overdose, or death. When used as a sedative or muscle relaxant in children, some clinicians recommend 0.120.8 mg/kg daily in 3 or 4 divided doses. Use this medication exactly as prescribed. A generic drug is considered to be as safe and effective as the original drug. Diazepam is a useful adjunct for the relief of skeletal muscle spasm due to reflex spasm to local pathology (such as inflammation of the muscles or joints, or secondary to trauma); spasticity caused by upper motor neuron disorders (such as cerebral palsy and paraplegia); athetosis; and stiff-man syndrome. This means you only want dispensed. Dosage should be individualized for maximum beneficial effect. Consult your doctor for more details. wellness products. The data currently available are inadequate to determine the mutagenic potential of diazepam. In more serious cases, symptoms may include ataxia, diminished reflexes, hypotonia, hypotension, respiratory depression, coma (rarely), and death (very rarely). What happens when you stop taking benzodiazepines? Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children. Could a new blood biomarker help predict Alzheimer's risk? Diazepam tablets are a federal controlled substance (C-IV) because it contains diazepam that can be abused or lead to dependence. Use parenterally (particularly by IV route) with caution in elderly and debilitated patients and in patients with compromised respiratory function. Avoid eating grapefruit or drinking grapefruit juice while being treated with this medication unless your doctor instructs you otherwise. Information last revised May 2012. Written by ASHP. Call your healthcare provider or go to the nearest hospital emergency room right away if you get any of these serious side effects. or I.V. Diazepam tablets are a prescription medicine used: to treat anxiety disorders While holding the barrel of the applicator in one hand, turn the cap of the applicator to select the dose. Dispense in tight, light-resistant container with child-resistant closure. Performance of activities requiring mental alertness and physical coordination may be impaired. Children >2 years of age: 0.4 mg/kg has been administered 12 hours before surgery. Diazepam is not recommended in the treatment of psychotic patients and should not be employed instead of appropriate treatment. Keep diazepam tablets and all medicines out of the reach of children. Brand name: Valium. Psychologic and physical dependence may occur following prolonged use. Tonic status epilepticus has been precipitated following IV administration to control absence status or Lennox-Gastaut syndrome status epilepticus. (dye-AZ-e-pam) Brand name(s) Valium. Some loss of response to the effects of benzodiazepines may develop after repeated use of diazepam for a prolonged time. The cost of diazepam without insurance may depend on what pharmacy you use. Last medically reviewed on March 24, 2023, Muscle spasms can affect anyone and occur in any area of the body, but they are usually not serious. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Children 12 years of age: Initially, 0.2 mg/kg as rectal gel, rounded up to the next available dose (i.e., the next multiple of 2.5 mg). VA class: CN302 The use of benzodiazepines, including diazepam tablets, exposes users to the risks of abuse, misuse, and addiction, which can lead to overdose or death. Abrupt discontinuation or rapid dosage reduction of Diazepam after continued use may precipitate acute withdrawal reactions, which can be life-threatening. Addition of diazepam injection to an IV infusion solution or plastic syringes may result in adsorption of diazepam to the plastic container and tubing. Adjunct to rest, physical activity, analgesics, and other measures for relief of discomfort associated with acute, painful musculoskeletal conditions. Some clinicians state a second dose of 0.25 mg/kg may be administered in 10 minutes if needed. Taking benzodiazepines with opioid medicines, alcohol, or other central nervous system (CNS) depressants (including street drugs) can cause severe drowsiness, breathing problems (respiratory depression), coma and death. Use of diazepam tablets, particularly in patients at elevated risk, necessitates counseling about the risks and proper use of diazepam along with monitoring for signs and symptoms of abuse, misuse, and addiction. Manufactured by: Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. Older adultsAt first, 2 to 2.5 mg 1 or 2 times a day. Conflicting information has been published on changes of plasma protein binding in the elderly. Antegrade amnesia may occur using therapeutic dosages, the risk increasing at higher dosages. OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. It can also be administered as an oral solution or injection. Diazepam is a long-acting benzodiazepine. The most common side effects of diazepam tablets include: fatigue Your doctor will gradually increase your dose as needed. In addition, children born to mothers receiving benzodiazepines on a regular basis late in pregnancy may be at some risk of experiencing withdrawal symptoms during the postnatal period. Diazepam belongs to a class of drugs known as benzodiazepines. Should this occur, use of the drug should be discontinued. Diazepam peak concentrations are 30% lower when antacids are administered concurrently. Take precautions when benzodiazepines are used in combination with opioid medications. To find out how the cost of these brand-name drugs compares with the cost of diazepam, talk with your doctor, pharmacist, or insurance provider. Before prescribing diazepam tablets and throughout treatment, assess each patient's risk for abuse, misuse, and addiction (e.g., using a standardized screening tool). Placebo-controlled trials suggested a dose effect in the incidence of some adverse reactions (headache, flushing, dyspepsia, nausea, and rhinitis) over the 5 mg, 10 mg, and 20 mg doses of Levitra.All Vardenafil Studies. 10 and the 10 mg tablets also contain FD&C Blue No. Standardized screening tools are available ([Web]). Some clinicians recommend 0.040.2 mg/kg; may repeat in 34 hours. These serious side effects may also cause delirium, paranoia, suicidal thoughts or actions, seizures, and difficulty breathing. Copyright 2023, Selected Revisions September 28, 2022. Children 5 years and older: 5-10 mg repeated every 3 to 4 hours as necessary. As with other agents which have anticonvulsant activity, when diazepam is used as an adjunct in treating convulsive disorders, the possibility of an increase in the frequency and/or severity of grand mal seizures may require an increase in the dosage of standard anticonvulsant medication. Oral diazepam has been used for adjunctive therapy of seizure disorders; however, loss of response to anticonvulsant effects may develop with prolonged use. Also has been administered rectally as the parenteral solution via a syringe and rectally inserted tubing or via lubricated tuberculin syringe (without a needle) inserted 45 cm into the rectum. MEDICAL ALERT: Your condition can cause complications in a medical emergency. Limit dosage and duration of concomitant use of benzodiazepines and opioids, and monitor patients closely for respiratory depression and sedation. Management of anxiety disorders and short-term relief of symptoms of anxiety. Delayed elimination has also been reported for the active metabolite desmethyldiazepam. This information is not individual medical advice and does not substitute for the advice of your health care professional. Abrupt discontinuation or rapid dosage reduction of diazepam tablets after continued use, or administration of flumazenil (a benzodiazepine antagonist) may precipitate acute withdrawal reactions, which can be life-threatening (e.g., seizures) (see DRUG ABUSE AND DEPENDENCE: DEPENDENCE). Drug class: benzodiazepine anticonvulsants. Talk to your healthcare provider about the best way to feed your baby if you take diazepam tablets. for the short-term relief of the symptoms of anxiety Talk with your doctor or pharmacist, who can provide personalized guidance about cost issues related to diazepam. IV administration is preferred; may use IM route if IV administration not possible. Psychiatric and paradoxical reactions are known to occur when using benzodiazepines (see ADVERSE REACTIONS). 615 mg daily (occasionally up to 30 mg daily) in divided doses has been used for adjunctive management of epilepsy. Injury, Poisoning and Procedural Complications. Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites. Effects appear to be mediated through the inhibitory neurotransmitter GABA; the site and mechanism of action within the CNS appear to involve a macromolecular complex (GABAA-receptor-chloride ionophore complex) that includes GABAA receptors, high-affinity benzodiazepine receptors, and chloride channels. Ask your doctor for a 90-day supply and then choose AutoReorder to save even more. Abrupt discontinuance following chronic use may result in symptoms of withdrawal (similar to those observed with barbiturates and alcohol). Symptoms of overdose may include: severe drowsiness, slowed/reduced reflexes, slowed breathing, fainting, loss of consciousness. . Potential for local reactions (e.g., pain, thrombophlebitis) following parenteral administration; possible tissue necrosis following intra-arterial administration. Comparative agents were diazepam rectal gel, which served as the regulatory reference product; and oral diazepam, a product with decades of clinical use. If you take too much diazepam tablets, call your healthcare provider or go to the nearest hospital emergency room right away. The dosage is based on your medical condition and response to therapy. are breastfeeding or plan to breastfeed. Take care to avoid intra-arterial administration or extravasation. Inactive ingredients: anhydrous lactose, magnesium stearate, and microcrystalline cellulose. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Pharmacokinetics in Special Populations Children. Use smallest effective dosage to avoid oversedation. The lower peak concentrations appear due to a slower rate of absorption, with the time required to achieve peak concentrations on average 20 - 25 minutes greater in the presence of antacids. Protect from light; avoid freezing. For intravenous infusion (emulsion) (Diazemuls), give continuously in Glucose 5% or 10%. Adjunctively for Relief of Skeletal Muscle Spasm. If you contact our Customer Support by one of the methods below, we will be able to assist you in locating the product you are looking for. It is also used to relieve muscle spasms and to provide sedation before medical procedures. IM route is rarely justified. have liver or kidney problems Keep all medicines away from children and pets. Geriatric patients and patients with hepatic impairment may have prolonged elimination half-lives of diazepam and its metabolites. Keep all follow-up visits with your healthcare provider as scheduled. Diazepam and its metabolites are distributed into milk; discontinue nursing or the drug. Concomitant use with alcohol is not recommended due to enhancement of the sedative effect. Chronic daily use as an anticonvulsant may increase the frequency and/or severity of tonic-clonic seizures; may necessitate increase in dosage of other anticonvulsants. Medically reviewed by Drugs.com on Sep 28, 2022. Extensive accumulation of diazepam and its major metabolite, desmethyldiazepam, has been noted following chronic administration of diazepam in healthy elderly male subjects. Infants over 30 days of age and children under 5 years, 0.2 mg to 0.5 mg slowly every 2 to 5 minutes up to a maximum of 5 mg (IV preferred). (See Cautions.). Decreases in clearance and protein binding, and increases in volume of distribution and half-life has been reported in patients with cirrhosis. Importance of informing patients of other important precautionary information. Protracted withdrawal syndrome associated with benzodiazepines is characterized by anxiety, cognitive impairment, depression, insomnia, formication, motor symptoms (e.g., weakness, tremor, muscle twitches), paresthesia, and tinnitus that persists beyond 4 to 6 weeks after initial benzodiazepine withdrawal. How should I store diazepam tablets? Its possible. Not for use in pediatric patients under 6 months. Do not drive or operate heavy machinery until you know how taking diazepam with opioids affects you. Repeat in 2 to 4 hours if necessary. Smoking can decrease the effectiveness of this drug (through liver enzyme induction). The cost of diazepam with and without insurance can depend on several factors, such as whether the drug has a savings program. Lubricate the rectal applicator tip with the water-soluble lubricant (jelly) provided by the manufacturer. You can develop an addiction even if you take diazepam tablets exactly as prescribed by your healthcare provider. Description. EEG monitoring of the seizure may be helpful. According to RxList.com, the recommended Valium dosages in tablet form for adults, depending on the ailment treated, are as follows: Anxiety disorders and relief from anxiety symptoms: Depending upon the severity of symptoms2 mg to 10 mg, two to four times daily. Prior to discarding AcuDial applicator in the garbage, dispose of any gel remaining in the applicator. Children 25 years of age: Initially, 0.5 mg/kg as rectal gel, rounded up to the next available dose (i.e., the next multiple of 2.5 mg). If you are using the oral concentrate solution, use the dropper provided to carefully measure out the dose and mix it in liquid or soft food (e.g., applesauce, pudding) just before taking. And generics tend to cost less than brand-name drugs. Diazepam Tablets USP are contraindicated in patients with a known hypersensitivity to this drug and, because of lack of sufficient clinical experience, in pediatric patients under 6 months of age. Generally 10 mg or less is adequate, but up to 20 mg may be required, especially if opiates are not given concomitantly. If you have suicidal thoughts or actions, your healthcare provider may check for other causes. Color: blue Shape: . Instruct patients that discontinuation or dosage reduction of diazepam tablets may require a slow taper (see WARNINGS: DEPENDENCE AND WITHDRAWAL REACTIONS and DRUG ABUSE AND DEPENDENCE). You should always consult your doctor or another healthcare professional . Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Diazepam has been shown to be teratogenic in mice and hamsters when given orally at daily doses of 100 mg/kg or greater (approximately eight times the maximum recommended human dose [MRHD=1 mg/kg/day] or greater on a mg/m2 basis). The maximum recommended dosing frequency is once per day. You may report side effects to Health Canada at 1-866-234-2345. Reported changes in free drug may be due to significant decreases in plasma proteins due to causes other than simply aging. (See Geriatric Patients under Dosage and Administration.). To reduce the risk of withdrawal reactions, use a gradual taper to discontinue diazepam tablets or reduce the dosage (a patient-specific plan should be used to taper the dose) (see DOSAGE AND ADMINISTRATION: DISCONTINUATION OR DOSAGE REDUCTION OF DIAZEPAM). Store at 20 to 25C (68 to 77F) [See USP Controlled Room Temperature]. Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. The cost of diazepam gel may depend on the pharmacy and your insurance plan. In young healthy males, the volume of distribution at steady-state is 0.8 to 1.0 L/kg. Tolerance to the therapeutic effect of diazepam may develop; however, little tolerance develops to the amnestic reactions and other cognitive impairments caused by benzodiazepines. 1 mg to 2.5 mg, 3 or 4 times daily initially; increase gradually as needed and tolerated, Discontinuation or Dosage Reduction of Diazepam. Diazepam Tablets USP 10 mg are light blue, flat-faced, bevel edge, bisected tablets imprinted MYX/943 on one side and 10 imprinted on the other side. Therefore, breast-feeding while using this medication is not recommended. Manufacturers state that diazepam is contraindicated in patients with acute angle-closure glaucoma, but may be administered to patients with open-angle glaucoma who are receiving appropriate therapy; however, clinical rationale for this contraindication has been questioned. Diazepam comes in several forms: oral tablet, oral solution, intravenous or intramuscular injection, rectal gel (Diastat), and nasal spray (Valtoco). Vardenafil HCl is a nearly colorless, solid substance with a molecular weight of 579.1 g/mol and a solubility of 0.11 mg/mL in water. Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. Here are some other resources you may find helpful: Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Flumazenil, a specific benzodiazepine-receptor antagonist, is indicated for the complete or partial reversal of the sedative effects of benzodiazepines and may be used in situations when an overdose with a benzodiazepine is known or suspected. along with other medicines for the relief of muscle spasms Inform patients about the signs and symptoms of benzodiazepine abuse, misuse, and addiction; to seek medical help if they develop these signs and/or symptoms; and on the proper disposal of unused drug (see WARNING : ABUSE, MISUSE, AND ADDICTION and DRUG ABUSE AND DEPENDENCE). Increase dosage gradually as needed and tolerated. If this drug is used for an extended period of time, laboratory and/or medical tests (e.g., liver function tests, complete blood count) may be performed periodically to check for side effects. This results in an average decrease in Cmax of 20% in addition to a 27% decrease in AUC (range 15% to 50%) when administered with food. You may report side effects to FDA at 1-800-FDA-1088. What are the possible side effects of diazepam tablets? headache. View Free Coupon Full Drug Information Reviews (200). Diazepam (Oral Route) Your gift holds great power - donate today! For muscle spasm: Adults2 to 10 milligrams (mg) 3 or 4 times a day. acting on dangerous impulses, attempts to commit suicide Breathing stops (which may lead to the heart stopping), Diazepam tablets are a benzodiazepine medicine. Overdose of benzodiazepines in combination with other CNS depressants (including alcohol) may be fatal and should be closely monitored. have lung disease or breathing problems Lorazepam is available as an oral tablet in strengths of 0.5 mg, 1 mg, and 2 mg. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. The continued use of benzodiazepines, including diazepam, may lead to clinically significant physical dependence. If an opioid is initiated in a patient already taking diazepam tablets, prescribe a lower initial dose of the opioid and titrate based upon clinical response. Should hypotension develop, treatment may include intravenous fluid therapy, repositioning, judicious use of vasopressors appropriate to the clinical situation, if indicated, and other appropriate countermeasures. Lorazepam is approved to treat anxiety and insomnia caused by anxiety. Administer orally, by IM or IV injection, or rectally. Dispense in tight, light-resistant container with child-resistant closure. See the end of this Medication Guide for a complete list of ingredients in diazepam tablets. Because of these risks, reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate. Some clinicians state a second dose of 0.25 mg/kg may be administered after 10 minutes if needed. Do not suddenly stop taking diazepam tablets. For IV injection, administer directly into a large vein; if this is not possible, inject the drug into the tubing of a flowing IV solution as close as possible to the vein insertion site. This drug passes into breast milk and may have undesirable effects on a nursing infant. Consequently, the elderly may have lower peak concentrations, and on multiple dosing higher trough concentrations. Discard Diastat and Diastat AcuDial rectal delivery systems and all unused materials in the garbage in a safe place away from children; do not reuse. Insert the lubricated applicator tip into the rectum until the rim of the syringe is snug against the rectal opening; slowly push the plunger (counting aloud slowly to 3) until it stops (i.e., until the entire dose of the applicator has been expelled into the rectum). Like other antiepileptic drugs, diazepam tablets may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Dose to be delivered by the AcuDial applicator is locked into the device prior to dispensing. The whole process was extremely easy to get my account started. Excessive sleepiness (sedation). They may have a preference for one version or the other. The most common side effects of vardenafil include: dizziness. It is also available as an oral solution, an intravenous injection, a liquid nasal spray, and a rectal gel. The terminal elimination half-life of the active metabolite N-desmethyldiazepam is up to 100 hours. Psychiatric and Paradoxical Reactions: stimulation, restlessness, acute hyperexcited states, anxiety, agitation, aggressiveness, irritability, rage, hallucinations, psychoses, delusions, increased muscle spasticity, insomnia, sleep disturbances, and nightmares. Use smallest effective dosage in debilitated patients and patients with low serum albumin concentrations. Dialysis is of limited value. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic. ), Equipment for resuscitation should be readily available whenever diazepam is administered IV. 5 minutes of setup today will save you hours and dollars exponentially over time. Bottles of 60: NDC 80425-0151-02. Abrupt withdrawal may be associated with a temporary increase in seizure frequency or severity. Diazepam is a Schedule IV controlled substance. The effectiveness of diazepam in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. Pay attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. When taken with alcohol or drugs that cause sleepiness or dizziness, diazepam tablets may make your sleepiness or dizziness much worse. Diazepam and its metabolites cross the blood-brain and placental barriers and are also found in breast milk in concentrations approximately one tenth of those in maternal plasma (days 3 to 9 post-partum). Always ask your health care professional for complete information about this product and your specific health needs. Diazepam is a generic drug prescribed for anxiety, seizures, alcohol withdrawal, and muscle spasms. Prior to administering the dose, check the diazepam gel expiration date, verify that the green ready band on the Diastat AcuDial applicator is visible, and verify the dose displayed in the AcuDial display window. Are you sure you only want to order ? Administration of a third dose is not recommended by the manufacturer. Commercially available gel is provided in prefilled syringe applicators containing 2.5, 10, or 20 mg of diazepam. Talk to your healthcare provider about slowly stopping diazepam tablets to avoid withdrawal symptoms. Do not breastfeed while taking diazepam tablets. Clorazepate (Tranxene-T) 15 mg 3.75 mg, 7.5 mg, 15 mg Long 40-50 Diazepam (Valium) 10 mg 2 mg, 5 mg, 10 mg Very Long 20-80 Estazolam 2 mg 1 mg, 2 mg Intermediate 10-24 Flurazepam 15-30 mg 15 mg, 30 mg Very Long 47-100 Lorazepam (Ativan) 1-2 mg 0.5 mg, 1 mg, 2 mg Intermediate 10-20 Oxazepam 15-30 mg 10 mg, 15 mg, 30 mg Short 5-11 Take diazepam tablets exactly as your healthcare provider prescribed. 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