Generic name: sulfamethoxazole and trimethoprim (oral/injection) [SUL-fa-meth-OX-a-zole-and-trye-METH-oh-prim] Sulfamethoxazole and trimethoprim may also be used for purposes not listed in this medication guide. If you have these symptoms, do not use anti-diarrhea or opioid products because they may make symptoms worse. Consult your doctor before breast-feeding. Consult your doctor for more details. Available for Android and iOS devices. Sulfamethoxazole and trimethoprim combination is used to treat infections including urinary tract infections, middle ear infections (otitis media), bronchitis, traveler's diarrhea, and shigellosis (bacillary dysentery). Although cure rates were high in both arms after abscess drainage, an additional 7% efficacy is both statistically and clinically significant when considering the use of an adjunctive antibiotic with a good safety profile [36]. Call your doctor for medical advice about side effects. Contact your care team right away if you notice fevers or flu-like symptoms with a rash. It is completely absorbed following oral administration and has a half-life of about 10 hours. Even in this context, the utility of SXT for the treatment of impetigo likely remains strong because it is primarily a GAS-driven infection [2, 52]. Terms of Use. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Tell your health care professional that you are using this medication before having any immunizations/vaccinations. S. Y. C. T. is the recipient of an NHMRC Career Development Fellowship (1065736). Advantages of SXT include its ability to be used for short courses, track record of safety, and palatability in children. . An increase in hospitalization for abscess has been described globally [18, 19]. Do not double the dose to catch up. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. To provide you with the most relevant and helpful information, and understand which other information we have about you. In this study, we aimed to (1) determine the clinical efficacy of SXT for SSTI, including SSTI involving GAS, by conducting a systematic review of all published randomized controlled trials (RCTs) and observational studies on the use of SXT for treatment of SSTI and (2) update a previous review of studies assessing the in vitro susceptibility of GAS to SXT and TMP. May cause birth defects. Romani L, Whitfeld MJ, Koroivueta J et al.. Mass drug administration for scabies control in a population with endemic disease, Scabies: a suitable case for a global control initiative, Scabies and global control of neglected tropical diseases, Trimethopim-sulfamethoxazole compared with benzathine penicillin for treatment of impetigo in Aboriginal children: a pilot randomised controlled trial, The microbiology of impetigo in indigenous children: associations between, http://creativecommons.org/licenses/by-nc-nd/4.0/. IV: 5 mg/kg (trimethoprim component) IV every 12 hours, Oral: Sulfamethoxazole-trimethoprim 1600 mg-320 mg orally every 12 hours, IV: 5 mg/kg (trimethoprim component) IV every 24 hours, Oral: Sulfamethoxazole-trimethoprim 1600 mg-320 mg orally every 24 hours, Known hypersensitivity to trimethoprim or sulfonamides, History of drug-induced immune thrombocytopenia with use of trimethoprim and/or sulfonamides, Documented megaloblastic anemia due to folate deficiency, Severe renal insufficiency when renal function cannot be monitored. Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness. You should not use sulfamethoxazole and trimethoprim if you are allergic to sulfamethoxazole or trimethoprim, or if you have: kidney disease that is not being treated or monitored; anemia (low red blood cells) caused by folic acid deficiency; a history of low blood platelets after taking trimethoprim or any sulfa drug; or. Symptoms of overdose may include: severe nausea/vomiting/diarrhea, severe dizziness or drowsiness, mental/mood changes. Outline of systematic literature search for clinical trials according to PRISMA methodology. Written by Cerner Multum. Avoid sunlight or tanning beds. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. This document does not contain all possible drug interactions. If we combine this information with your protected This condition may occur during treatment or weeks to months after treatment has stopped. If you have any dental work done, tell your dentist you are receiving this medication. Menzies School of Health Research, Charles Darwin University, North Territory, Australia, 4 Yourassowsky E, Vanderlinden MP, Schoutens E. National surveillance programme on susceptibility patterns of respiratory pathogens in South Africa: moxifloxacin compared with eight other antimicrobial agents, Trimethoprim-sulfamethoxazole for uncomplicated skin abscess, Trimethoprim-sulfamethoxazole therapy reduces failure and recurrence in methicillin-resistant. Impetigo is driven by GAS in resource-poor settings [2]; however, in developed settings, impetigo, including bullous impetigo, is more likely to have S aureus present [3]. With the availability of the European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoints for testing susceptibility of GAS to SXT (www.eucast.org), clinicians can now assess the resistance profile of both S aureus and GAS to SXT to inform prescribing decisions. This is not a complete list of possible side effects. In addition, molecular markers of GAS resistance to trimethoprim (TMP) have recently been reported [30]. Older adults may be more sensitive to the side effects of this drug, especially skin reactions, blood disorders, easy bleeding/bruising, and a high potassium blood level. In addition, because the initial lesions rarely require hospitalization, impetigo is predominantly a primary care level consultation in both industrialized and nonindustrialized regions [9, 10], but it has significant sequelae resulting in hospitalization including streptococcal and staphylococcal bacteremia [1113], skeletal infections [14], acute poststreptococcal glomerulonephritis [15], and possibly acute rheumatic fever [16]. The CYP2C9 enzyme is responsible for the formation of the N4-hydroxy metabolite. This work is supported by NHMRC project grant 1131932 (the HOT NORTH initiative). Also tell them if you smoke, drink alcohol, or use illegal drugs. Severe diarrhea, fever. This product is available in the following dosage forms: There is a problem with Duration of therapy: At least 6 weeks People with a sulfa allergy typically need to avoid sulfonamide antibiotics (antibiotics containing sulfa), including: Whether other nonantibiotic sulfa-containing drugs need to be avoided with sulfa allergy is unclear and considered on a case-by-case basis. bleeding of the . Dosage forms: intravenous solution (80 mg-16 mg/mL), oral suspension (200 mg-40 mg/5 mL), oral tablet (400 mg-80 mg; 800 mg-160 mg) official website and that any information you provide is encrypted Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by The Infectious Diseases Society of America, Short-course oral co-trimoxazole versus intramuscular benzathine benzylpenicillin for impetigo in a highly endemic region: an open-label, randomised, controlled, non-inferiority trial. Do not treat diarrhea with over the counter products. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Duration of therapy: US CDC Recommendations: Sulfamethoxazole-trimethoprim 800 mg-160 mg orally twice a day CrCl less than 15 mL/min: Not recommended. For the newspaper referred to as "The Trib", see, InChI=1S/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13), Abstract of "Cutaneous hypersensitivity to sulfamethoxazole-trimethoprim (SMZ TMP) in HIV infected patients", "Monographs for medicines on WHO's Model List of Essential Medicines", National Center for Biotechnology Information, National Institute of Allergy and Infectious Diseases, "Clinical Diabetes: Case Study: A 90-Year-Old Man With Confusion and Night Sweats", "Sulfonamides and Sulfonamide Combinations: Antibacterial Agents: Merck Veterinary Manual", https://en.wikipedia.org/w/index.php?title=Sulfamethoxazole&oldid=1085832151, Drugboxes which contain changes to watched fields, Creative Commons Attribution-ShareAlike License 4.0, This page was last edited on 2 May 2022, at 18:14. Thus, we suggest that SXT as a single agent be added to the recommended list of antimicrobial options for uncomplicated purulent cellulitis (strong recommendation, moderate GRADE evidence). All rights reserved. Talan DA, Mower WR, Krishnadasan A et al.. Trimethoprim-sulfamethoxazole versus placebo for uncomplicated skin abscess. In children with minor skin infections (e.g., impetigo) or secondarily infected lesions (e.g., eczema, ulcers, lacerations), treatment with mupirocin 2% topical cream (Bactroban) is recommended . Overdose symptoms may include loss of appetite, vomiting, fever, blood in your urine, yellowing of your skin or eyes, confusion, or loss of consciousness. Jasmine R Marcelin MD, Trevor Van Schooneveld MD, Scott Bergman PharmD . Breast-feeding is not recommended for infants with these conditions. Dosage is based on your medical condition and response to treatment. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Maximum dose: 320 mg/day (trimethoprim component) pneumonia with high amount of eosinophil white blood cells. Skipping doses could make your infection resistant to medication. What is Erection problems? Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. IV: In a published article, a total daily dose of 10 to 15 mg/kg was sufficient in 10 adult patients with normal renal function. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms. At 7 to 14 days after the treatment period, invasive infections had . This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Do not use two doses at one time. Sulfamethoxazole / trimethoprim systemic 800 mg / 160 mg (H 49), Sulfatrim, Bethaprim, Cotrim, Uroplus, Uroplus DS, Cotrim DS, Septra I.V., Bactrim I.V., Bactrim Pediatric, Bethaprim Pediatric, Sulfatrim Suspension, Cotrim Pediatric, Septra DS. Use: For prophylaxis against P jirovecii pneumonia in immunosuppressed individuals considered at increased risk of developing P jirovecii pneumonia What is Sulfamethoxazole and trimethoprim? If you cannot avoid being in the sun, wear protective clothing and sunscreen. Clindamycin was given as two 150-mg tablets three times daily. Keep out of the sun. NOTE: This sheet is a summary. However, if GAS is suspected, for example in purulent cellulitis, the addition of a -lactam active against GAS is recommended [1]. What dose of co-trimoxazole is used in a patient with a UTI? The rash may be red or purple and then turn into blisters or peeling of the skin. Sulfamethoxazole and Trimethoprim Tablets, Sulfamethoxazole and Trimethoprim Injection, Sulfamethoxazole and Trimethoprim Suspension, Septra and Bactrim (sulfamethoxazole-trimethoprim). Some products that may interact with this drug include: "blood thinners" (such as warfarin), dofetilide, methenamine, methotrexate. Drugs & Medications Sulfamethoxazole-Trimethoprim Sulfamethoxazole-Trimethoprim - Uses, Side Effects, and More View Free Coupon Uses This medication is a combination of two antibiotics:. Avoid tanning booths and sunlamps. Tell your care team if your symptoms do not start to get better or if they get worse. Two more studies were identified from study references (Supplementary Figure). It will not treat colds, the flu, or infections caused by viruses. If it is almost time for your next dose, take only that dose. Applies to your personal circumstances this work is supported by NHMRC project grant (! 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