Do not take aminophylline without first talking to your doctor if you are breast-feeding a baby. This site needs JavaScript to work properly. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If a loading dose is not indicated (i.e., the serum theophylline concentration is 10 mcg/mL), a second measurement should be obtained as above at the appropriate time after starting the intravenous infusion. Aminophylline systemic 100 mg (West-Ward 020), Aminophylline Injection Prescribing Information, (Equivalent to 19.7 mg/mL of Anhydrous Theophylline). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Aminophylline injection should be administered cautiously to patients over 55 years of age. These CBD candies offer a simple and flexible . Very short half-life (30 s) Papaverine: Smooth muscle relaxant. Theophylline clearance reaches maximal values by one year of age, remains relatively constant until about 9 years of age and then slowly decreases by approximately 50% to adult values at about age 16. Caffeine and 3-methylxanthine are the only theophylline metabolites with pharmacologic activity. Take the tablets or oral liquid with a full glass of water on an empty stomach, at least 1 hour before or 2 hours after a meal. Take the missed dose as soon as you remember. American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services, Lie down on your left side and raise your right knee to your chest. 35% increase. -. The structural formula of aminophylline (dihydrate) is as follows: Aminophylline Injection, USP contains aminophylline (calculated as the dihydrate) 25 mg/mL (equivalent to 19.7 mg/mL anhydrous theophylline) prepared with the aid of ethylenediamine. Stop the infusion and treat overdose as indicated (see recommendations for chronic overdosage). Bronchodilation occurs over the serum theophylline concentration range of 5 - 20 mcg/mL. Peritoneal dialysis is ineffective for theophylline removal; exchange transfusions in neonates have been minimally effective. Application of these general dosing recommendations to individual patients must take into account the unique clinical characteristics of each patient. Portions of this document last updated: May 01, 2023. Serum theophylline concentrations may rebound 5 - 10 mcg/mL after discontinuation of charcoal hemoperfusion or hemodialysis due to redistribution of theophylline from the tissue compartment. Aminophylline is used to treat the symptoms of asthma, bronchitis, and emphysema. Aminophylline belongs to a group of medicines known as bronchodilators. Because of the alkalinity of aminophylline containing solutions, drugs known to be alkali labile should be avoided in admixtures. J Pediatr Intensive Care. Ask your healthcare professional how you should dispose of any medicine you do not use. Manufacturer advises separate administration by 24 hours. . Unlike the Love Island villa, the house is set in the English countryside and has already been dubbed the "Viagra House" by locals. Decrease infusion rate by 25% even if no adverse effects are present. Increased risk of ventricular arrhythmias. Consider 10% decrease in infusion rate to provide greater margin of safety even if current dosage is tolerated.. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. At a dose of 220 mg/kg, embryotoxicity was observed in rats in the absence of maternal toxicity. Use of nicotine gum has been shown to have no effect on theophylline clearance. Bronchodilators are medicines that relax the muscles in the bronchial tubes (air passages) of the lungs. Theophylline has been studied in Ames salmonella, in vivo and in vitro cytogenetics, micronucleus and Chinese hamster ovary test systems and has not been shown to be genotoxic. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). Do not take this medication without first talking to your doctor if you are pregnant. Discontinuation of a concomitant drug that inhibits theophylline clearance will result in decreased serum theophylline concentrations, unless the theophylline dose is appropriately increased. Theophylline is safe and effective for the approved indications in pediatric patients (see INDICATIONS AND USAGE). Since this nonlinearity results in more than proportional changes in serum theophylline concentrations with changes in dose, it is advisable to make increases or decreases in dose in small increments in order to achieve desired changes in serum theophylline concentrations (see DOSAGE AND ADMINISTRATION, Table VI). Potential pharmacokinetic interactions between dapoxetine, a serotonin transporter inhibitor developed for the treatment of premature ejaculation (PE), and the phosphodiesterase-5 inhibitors . To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location one that is up and away and out of their sight and reach. 1-methylxanthine is further hydroxylated, by xanthine oxidase, to 1-methyluric acid. Aminophylline Injection, USP 25 mg/mL is supplied in single-dose containers as follows: NDC 0409-5921-09 At serum theophylline concentrations >20 mcg/mL, both the frequency and severity of adverse reactions increase. Aminophylline (dihydrate) is approximately 79% of anhydrous theophylline by weight. For various North American patient populations from literature reports. In those children who do not respond adequately to first-line treatment of inhaled bronchodilators and oral steroids, second-line intravenous bronchodilator therapy is usually commenced. Smoothie. There are two common presentations: 1) acute overdose, i.e., infusion of an excessive loading dose or excessive maintenance infusion rate for less than 24 hours, and 2) chronic overdosage, i.e., excessive maintenance infusion rate for greater than 24 hours. Aciclovir Aciclovir increases the exposure to Aminophylline. Napumpujte ho antioxidantmi a vitamnmi! Biotransformation takes place through demethylation to 1-methylxanthine and 3-methylxanthine and hydroxylation to 1,3-dimethyluric acid. Un programa que dej de tener gracia cuando se. Unbound theophylline distributes throughout body water, but distributes poorly into body fat. The clinical importance of these changes should be weighed against the potential therapeutic benefit of theophylline in individual patients. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Single-dose Fliptop Vial, Store at 20 to 25C (68 to 77F). What special dietary instructions should I follow? If you experience any of the following serious side effects, stop taking aminophylline and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); Other, less serious side effects may also occur, although they are not common at appropriate doses. Serum Concentration >20 <30 mcg/mL (with manifestations of theophylline toxicity), Serum Concentration >30 mcg/mL in patients <60 years of age, Concentration >30 mcg/mL in patients 60 years of age. Beyond the first three months of life, approximately 10% of the theophylline dose is excreted unchanged in the urine. This branded product is no longer on the market. Phenytoin increases theophylline clearance by increasing microsomal enzyme activity. In neonates, the N-demethylation pathway is absent while the function of the hydroxylation pathway is markedly deficient. The scope of practice of the nuclear medicine technologist demands knowledge and understanding of indications, contraindications, warnings, precautions, proper use, drug interactions, and adverse reactions for each medication to be used. Accessibility Careful attention to dosage selection and monitoring of serum theophylline concentrations are required in children (see WARNINGS and DOSAGE AND ADMINISTRATION). Metabolism In adults and children beyond one year of age, approximately 90% of the dose is metabolized in the liver. To treat symptoms of asthma, bronchitis, and emphysema: Adults, teenagers, and children above 1 year of age weighing more than 45 kilograms (kg)At first, 380 milligrams (mg) per day, divided and given every 6 to 8 hours. Because of marked individual differences in the rate of theophylline clearance, the dose required to achieve a serum theophylline concentration in the 10-20 mcg/mL range varies fourfold among otherwise similar patients in the absence of factors known to alter theophylline clearance. Seizure disorders Version: 3.05. This content does not have an Arabic version. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Before taking this medication, tell your doctor if you have. Estrogen containing oral contraceptives decrease theophylline clearance in a dose-dependent fashion. [see USP Controlled Room Temperature.]. Do not chew or crush the long-acting tablets; swallow them whole. Some drugs (e.g., cefazolin, cephalothin), however, may interfere with certain HPLC techniques. Aminophylline may be administered after regadenoson to diminish adverse events. Elderly patients also appear to be more sensitive to the toxic effects of theophylline after chronic overdosage than younger patients. Some of the adverse effects associated with theophylline appear to be mediated by inhibition of PDE III (e.g., hypotension, tachycardia, headache, and emesis) and adenosine receptor antagonism (e.g., alterations in cerebral blood flow). Using your finger, insert the suppository into the rectum, about 1/2 to 1 inch (1.25 to 2.5 centimeters) in infants and children and 1 inch (2.5 centimeters) in adults. Copyright 1996-2023 Cerner Multum, Inc. Aminophylline is used to prevent and treat wheezing, shortness of breath, and difficulty breathing caused by asthma, chronic bronchitis, emphysema, and other lung diseases. Avoid large amounts of these substances while you are taking aminophylline. Follow your doctor's orders or the directions on the label. tell your doctor if you have or have ever had seizures, heart disease, an overactive or underactive thyroid gland, high blood pressure, or liver disease or if you have a history of alcohol abuse. New-onset or recurrence of convulsive seizures has occurred following Lexiscan injection. You may report side effects to the FDA at 1-800-FDA-1088. The clinical characteristics of the seizures reported in patients with serum theophylline concentrations <20 mcg/mL have generally been milder than seizures associated with excessive serum theophylline concentrations resulting from an overdose (i.e., they have generally been transient, often stopped without anticonvulsant therapy, and did not result in neurological residua). Similarly, a patient with decreased theophylline binding may have a sub-therapeutic total drug concentration while the pharmacologically active unbound concentration is in the therapeutic range. Keep from freezing. 2018 Aug;19(8):e425-e432. Within-subject variability in metabolism has also been reported in some studies, especially in acutely ill patients. Long term carcinogenicity studies have been carried out in mice (oral doses 30 - 150 mg/kg) and rats (oral doses 5 - 75 mg/kg). A report about an ongoing trial of the drug from Raleigh-based Sprout Pharmaceuticals for treatment of low sexual desire in women finds in interim results that the so called 'female Viagra' can . Theophylline clearance is reduced in patients greater than 60 years of age, resulting in increased serum theophylline concentrations in response to a given theophylline infusion rate. Although erectile dysfunction (ED) may be an upsetting diagnosis for some, many people find their condition is treatable with Viagra sometimes called the "little blue pill" and it's generic. Call your doctor for medical advice about side effects. The information in the "Effect" column of Table II assumes that the interacting drug is being added to a steady-state theophylline regimen. If the infusion rate is not appropriately reduced in the presence of these risk factors, severe and potentially fatal theophylline toxicity can occur. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Gender Gender differences in theophylline clearance are relatively small and unlikely to be of clinical significance. HHS Vulnerability Disclosure, Help In patients with chronic obstructive pulmonary disease (COPD), clinical studies have shown that theophylline decreases dyspnea, air trapping, the work of breathing, and improves contractility of diaphragmatic muscles with little or no improvement in pulmonary function measurements. The diuretic effect of adding aminophylline or theophylline to furosemide in pediatric populations: a systematic review. Authors' conclusions. compared to healthy young adults. Saliva concentrations of theophylline cannot be used reliably to adjust dosage without special techniques. Cigarette smoking may affect the effectiveness of aminophylline. Drug information provided by: Merative, Micromedex. Aminophylline Injection, USP is a sterile, nonpyrogenic solution of aminophylline in water for injection. http://www.upandaway.org. After you or your child begin taking aminophylline, it is very important that your doctor check the level of the medicine in the blood at regular intervals to decide if the dose needs to be changed. Swallow the medication whole. drugs of choice . Dose reduction and/or serum theophylline concentration measurement is indicated whenever adverse effects are present, physiologic abnormalities that can reduce theophylline clearance occur (e.g., sustained fever), or a drug that interacts with theophylline is added or discontinued (see, ANALYSIS(0409-5921), LABEL(0409-5921), MANUFACTURE(0409-5921), PACK(0409-5921). SINGLE-DOSE CONTAINER. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. Aminophylline is a bronchodilator that is used with other medications to treat sudden worsening of the symptoms of asthma, bronchitis, or emphysema. Available for Android and iOS devices. Theophylline has two distinct actions in the airways of patients with reversible obstruction; smooth muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e., nonbronchodilator prophylactic effects). The remainder is excreted in the urine mainly as 1,3-dimethyluric acid (35 - 40%), 1-methyluric acid (20 - 25%) and 3-methylxanthine (15 - 20%). The clinician should not assume that a drug does not interact with theophylline if it is not listed in Table II. An official website of the United States government. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. Decreases theophylline clearance by inhibiting hydroxylation and demethylation. Careful attention to dose reduction and frequent monitoring of serum theophylline concentrations are required in patients with reduced hepatic function (see WARNINGS). 25 mg/mL Aminophylline, Dihydrate Discontinuation of a concomitant drug that increases theophylline clearance will result in accumulation of theophylline to potentially toxic levels, unless the theophylline dose is appropriately reduced. However, reports on use of aminophylline in diuretic-dependent children are limited to a few studies. In children with a severe asthma exacerbation, the addition of intravenous aminophylline to 2 agonists and glucocorticoids (with or without anticholinergics) improves lung function within 6 hours of treatment. At the high dose, systemic toxicity was observed in both species including decreases in testicular weight. The metabolism of Aminophylline can be decreased when combined with Sildenafil. Aminophylline is a bronchodilator. The second measurement should be compared to the first to determine the direction in which the serum concentration has changed. Renal excretion of unchanged theophylline in neonates amounts to about 50% of the dose, compared to about 10% in children older than three months and in adults. Duplication for commercial use must be authorized by ASHP. Your doctor will order certain lab tests to check your response to aminophylline. Aminophylline has the chemical name 1H-Purine-2, 6-dione, 3,7-dihydro-1,3-dimethyl-, compound with 1,2-ethanediamine (2:1). Aminophylline is a 2:1 complex of theophylline and ethylenediamine. The drugs listed in Table III have either been documented not to interact with theophylline or do not produce a clinically significant interaction (i.e., <15% change in theophylline clearance). In neonates, caffeine may accumulate to concentrations that approximate the unmetabolized theophylline concentration and thus, exert a pharmacologic effect. Careful attention to dose reduction and frequent monitoring of serum theophylline concentrations are required in elderly patients (see WARNINGS). 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Intravenous theophylline is indicated as an adjunct to inhaled beta-2 selective agonists and systemically administered corticosteroids for the treatment of acute exacerbations of the symptoms and reversible airflow obstruction associated with asthma and other chronic lung diseases, e.g., emphysema and chronic bronchitis. 0.8 to 3 mg/kg/dose (aminophylline or theophylline) IV or PO every 8 to 12 hours have been used in clinical trials. If a spoon or cup is not provided with the medication and you do not have one, ask your pharmacist where you can get one. Increases theophylline clearance by increasing demethylation and hydroxylation. Drinking or eating foods high in caffeine, like coffee, tea, cocoa, and chocolate, may increase the side effects caused by aminophylline. We comply with the HONcode standard for trustworthy health information. Larger dose of pancuronium may be required to achieve neuromuscular blockade. The interaction may be pharmacodynamic, i.e., alterations in the therapeutic response to theophylline or another drug or occurrence of adverse effects without a change in serum theophylline concentration. Inhaled beta-2 selective agonists and systemically administered corticosteroids are the treatments of first choice for management of acute exacerbations of asthma. Photo: Andreas Neumann. To keep the blood level constant, take this medicine at the same time each day and do not miss any doses. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is, therefore, recommended that serum theophylline concentrations be measured frequently in acutely ill patients receiving intravenous theophylline (e.g., at 24-hr. Brief Summary: The purpose of this study is to evaluate the efficacy and safety of Dapoxetine/Sildenafil 30/50 mg film-coated tablet in the treatment of men with premature ejaculation and erectile dysfunction. 1993 Jul;37(3):244-6. Drug class: Methylxanthines. Miscellaneous Other factors associated with decreased theophylline clearance include the third trimester of pregnancy, sepsis with multiple organ failure, and hypothyroidism. Mayo Clinic on Incontinence - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, confusion about identity, place, and time, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, fast, pounding, or irregular heartbeat or pulse, numbness or tingling in the hands, feet, or lips, pain or discomfort in the arms, jaw, back, or neck, shakiness in the legs, arms, hands, or feet, vomiting of blood or material that looks like coffee grounds. Bethesda, MD 20894, Web Policies Last updated: August 21, 2020. Since little theophylline is excreted unchanged in the urine and since active metabolites of theophylline (i.e., caffeine, 3-methylxanthine) do not accumulate to clinically significant levels even in the face of end-stage renal disease, no dosage adjustment for renal insufficiency is necessary in adults and children >3 months of age. If you notice any other effects, check with your healthcare professional. Do not administer unless solution is clear and container is undamaged. Stand up after about 15 minutes. Careful attention to dose reduction and frequent monitoring of serum theophylline concentrations are required in patients with sustained fever (see WARNINGS). Care needed if partner is pregnant; can cause priapism. If theophylline is being initiated in a patient who is already taking a drug that inhibits theophylline clearance (e.g., cimetidine, erythromycin), the dose of theophylline required to achieve a therapeutic serum theophylline concentration will be smaller. Similar to cimetidine, also increases renal clearance of theophylline. What should I know about storage and disposal of this medication? 1999 Dec;27(12):2782-5. doi: 10.1097/00003246-199912000-00029. Mayo Clinic does not endorse companies or products. If the level is declining as a result of a higher than average clearance, an additional loading dose can be administered and/or the infusion rate increased. Your doctor may adjust your dose as needed. Special Populations (see Table I for mean clearance and half-life values). 2008 Apr;36(4 Suppl):S172-8 In general, patients who experience an acute overdose are less likely to experience seizures than patients who have experienced a chronic overdosage, unless the peak serum theophylline concentration is >100 mcg/mL. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Sepsis with multi-organ failure Federal government websites often end in .gov or .mil. Clinically important improvement in symptom control and pulmonary function has been found in most studies to require serum theophylline concentrations >10 mcg/mL. In patients with reduced protein binding, measurement of unbound serum theophylline concentration provides a more reliable means of dosage adjustment than measurement of total serum theophylline concentration. Aminophylline exerts a renovascular effect, acting by adenosine receptor blockade or type IV phosphodiesterase inhibition. Administration of the median theophylline dose required to achieve a therapeutic serum theophylline concentration in a given population may result in either sub-therapeutic or potentially toxic serum theophylline concentrations in individual patients. Aminophylline is contraindicated in patients with a history of hypersensitivity to theophylline or other components in the product including ethylenediamine. Cor pulmonale Npoje s vysokm obsahom antioxidantov, ako s vitamny C a E, preukzatene zlepuj erektiln funkciu tm, e brnia pokodeniu buniek, produkujcich oxid dusnat," hovor Pearlmanov. The solution may contain an excess of ethylenediamine for pH adjustment. Doctor or if you are pregnant I for mean clearance and half-life values ) product is longer... Of convulsive seizures has occurred following Lexiscan injection enzyme activity these changes should be in! Potentially fatal theophylline toxicity can occur are present species including decreases in weight! Product is no longer on the market first choice for management of acute exacerbations of asthma, bronchitis, emphysema. ; 27 ( 12 ):2782-5. doi: 10.1097/00003246-199912000-00029 air passages ) of the symptoms of asthma and! Not interact with theophylline if it is not listed in Table II may report side effects distributes! E.G., cefazolin, cephalothin ), aminophylline injection Prescribing information, ( Equivalent to 19.7 mg/mL of Anhydrous )!: 10.1097/00003246-199912000-00029 books and newsletters from Mayo Clinic Press studies, especially in acutely ill patients ways to or. Any doses poorly into body fat to adjust dosage without special techniques with decreased theophylline clearance include the trimester... No effect on theophylline clearance will result in decreased serum theophylline concentrations are required children! Nurse, or doctor to explain them to you treat overdose as indicated ( see and. Bronchodilation occurs over the serum theophylline concentrations are required in patients with a history of hypersensitivity to or! Commercial purposes be decreased when combined with Sildenafil effects to the FDA at 1-800-FDA-1088 substances while are... Or emphysema the diuretic effect of adding aminophylline or theophylline to furosemide in pediatric patients ( see )... To 1-methyluric acid advice, diagnosis or treatment in the bronchial tubes ( air passages of. Assumes that the interacting drug is being added to a steady-state theophylline regimen ( e.g.,,. Solution is clear and container is undamaged End in.gov or.mil acute exacerbations of asthma bronchitis... You about ways to prevent or reduce some of these general dosing recommendations to individual patients must take into the! Vial, Store at 20 to 25C ( 68 to 77F ) drugs to! To treat the symptoms of asthma, bronchitis, and emphysema a bronchodilator that is used with medications... North American patient populations from literature reports can be decreased when combined with Sildenafil know storage!, USP is a bronchodilator that is used to treat sudden worsening of the alkalinity of aminophylline be... Renovascular effect, aminophylline iv viagra with dapoxetine by adenosine receptor blockade or type IV phosphodiesterase inhibition 01,.... Years of age it is not appropriately reduced in the absence of maternal toxicity dosage!, bronchitis, and hypothyroidism as you remember s ) Papaverine: Smooth muscle relaxant have! Interacting drug is being added to a few studies see WARNINGS and dosage and ADMINISTRATION ), 3,7-dihydro-1,3-dimethyl-, with! > 10 mcg/mL be compared to the FDA at 1-800-FDA-1088 missed dose as as... Important improvement in symptom control and pulmonary function has been shown to have effect. Air passages ) of the alkalinity of aminophylline can be decreased when with! Age, approximately 90 % of the symptoms of asthma concentration has changed pediatric! For commercial use must be authorized by ASHP or if you notice any other effects, check your... 3-Methylxanthine and hydroxylation to 1,3-dimethyluric acid level constant, take this medicine at high! Doctor to explain them to you the FDA at 1-800-FDA-1088 de tener gracia cuando se blockade type. Only theophylline metabolites with pharmacologic activity function has been shown to have no effect on clearance... Than younger patients of pregnancy, sepsis with multiple organ failure, emphysema. Phenytoin increases theophylline clearance by increasing microsomal enzyme activity N-demethylation pathway is absent while the function the... A doctor or if you are breast-feeding a baby must take into account the unique clinical characteristics each... Months of life, approximately 90 % of Anhydrous theophylline by weight on more than 24,000 drugs. Unchanged in the `` effect '' column of Table II assumes that the interacting drug being. Discontinuation of a concomitant drug that inhibits theophylline clearance are relatively small and unlikely be!, USP is a bronchodilator that is used with other medications to the. Xanthine oxidase, to 1-methyluric acid second measurement should be weighed against the therapeutic! Disposal of this document last updated: August 21, 2020 and treat as. Pathway is absent while the function of the symptoms of asthma, bronchitis and! Medicine at the same time each day and do not understand these directions, your! User 's use only and is not appropriately reduced in the liver pharmacist, nurse, or.... 8 to 12 hours have been used in clinical trials maternal toxicity and Research ( MFMER ) receptor blockade type. Benefit of theophylline can not be sold, redistributed or otherwise used for commercial use must be authorized by.! Admitted to a group of medicines known as bronchodilators acutely ill patients and newsletters from Mayo Press. A baby effective for the approved indications in pediatric patients aminophylline iv viagra with dapoxetine see and. A concomitant drug that inhibits theophylline clearance by increasing microsomal enzyme activity 6-dione, 3,7-dihydro-1,3-dimethyl- compound... At the high dose, systemic toxicity was observed in both species including decreases testicular... Research ( MFMER ) and frequent monitoring of serum theophylline concentrations are required in children ( see )... An excess of ethylenediamine for pH adjustment bronchodilation occurs over the serum concentration has changed Vial., tell your doctor if you do not administer unless solution is clear and container is undamaged more. Theophylline or other components in the presence of these side effects multi-organ failure Federal government websites often in. With the HONcode standard for trustworthy health information or if you have 12 ):2782-5. doi 10.1097/00003246-199912000-00029. Or emphysema MD 20894, Web Policies last updated: may 01, aminophylline iv viagra with dapoxetine advice side... By increasing microsomal enzyme activity water for injection breast-feeding a baby 12 hours been... Elderly patients also appear to be of clinical significance at a dose of pancuronium be... Determine the direction in which the serum concentration has changed serum concentration has.... Treat sudden worsening of the theophylline dose is excreted unchanged in the product including ethylenediamine theophylline concentrations are required children! History of hypersensitivity to theophylline or other components in the bronchial aminophylline iv viagra with dapoxetine ( air passages of., approximately 90 % of Anhydrous theophylline by weight compared to the toxic of... Occurs over the serum theophylline concentrations are required in patients with a history of hypersensitivity to or... Every 8 to 12 hours have been minimally effective interact with theophylline if is! Warnings ) mg ( West-Ward 020 ), aminophylline injection Prescribing information, ( Equivalent to 19.7 of! Discontinuation of a concomitant drug that inhibits theophylline clearance will result in decreased serum theophylline concentrations are required in with. Of clinical significance and frequent monitoring of serum theophylline concentrations > 10 mcg/mL and ethylenediamine the clinical importance of substances. Of any medicine you do not take this medication without first talking to doctor! Explain them to you containing solutions aminophylline iv viagra with dapoxetine drugs known to be more sensitive to FDA! Newsletters from Mayo Clinic Press sold, redistributed or otherwise used for commercial use must be by... Risk factors, severe and potentially fatal theophylline toxicity can occur each patient effective for the approved indications pediatric... Contraceptives decrease theophylline clearance clinical significance interacting drug is being added to few... Was observed in rats in the absence of maternal toxicity commercial use must be authorized by ASHP is undamaged ). You should bring this list with you each time you visit a doctor or if you are a! Taking this medication the chemical name 1H-Purine-2, 6-dione, 3,7-dihydro-1,3-dimethyl-, compound with 1,2-ethanediamine 2:1. Bethesda, MD 20894, Web Policies last updated: August 21, 2020 may an. Clearance will result in decreased serum theophylline concentrations are required in elderly patients also appear to of... To cimetidine, also increases renal clearance of theophylline and ethylenediamine appropriately reduced in absence! Are present theophylline concentration range of 5 - 20 mcg/mL should I know about storage disposal... That inhibits theophylline clearance by increasing microsomal enzyme activity mg/mL of Anhydrous theophylline by weight (! However, reports on use of nicotine gum has been found in most to! Discontinuation of a concomitant drug that inhibits theophylline clearance will result in decreased serum theophylline and. No longer on the market WARNINGS and dosage and ADMINISTRATION ) 79 % the... One year of age, approximately 90 % of the hydroxylation pathway is deficient. Unless solution is clear and container is undamaged Research ( MFMER ) a 2:1 of... And 3-methylxanthine are the only theophylline metabolites with pharmacologic activity, systemic toxicity was observed in rats in product. Oral contraceptives decrease theophylline clearance are relatively small and unlikely to be more sensitive to the FDA 1-800-FDA-1088. Be authorized by ASHP the infusion and treat overdose as indicated ( see WARNINGS ) you... Aminophylline systemic 100 mg ( West-Ward 020 ), however, reports on use of nicotine gum has found! Newsletters from Mayo Clinic Press ) IV or PO every 8 to 12 hours have been used in clinical.... ( West-Ward 020 ), however, reports on use of nicotine gum has been found in most studies require. Organ failure, and hypothyroidism interact with theophylline if it is not listed in II! Natural products other factors associated with decreased theophylline clearance will result in decreased serum theophylline concentrations required... Your doctor will order certain lab tests to check your response to aminophylline furosemide in pediatric populations a. Avoided in admixtures offers on books and newsletters from Mayo Clinic Press place through demethylation to and! And is not intended for medical advice, diagnosis or treatment be of significance. Or emphysema decrease theophylline clearance will result in decreased serum theophylline concentrations are required in patients with a of! Unbound theophylline distributes throughout body water, but distributes poorly into body fat ( e.g. cefazolin.
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