There was no fever, chills, fatigue, anorexia, weakness, nausea, abdominal pain, dark-colored urine, jaundice, pruritus, lymphadenopathy, or rash. HHS Vulnerability Disclosure, Help We did not test hepatitis E virus in this patient; however, the patient had not recently traveled to any regions in Africa, Asia, or Central America where the virus is well known. It is well prescribed and oral administration has a high bioavailability. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. In some cases, surgery may be necessary. Drug-induced liver injury (DILI) is very common and has been reported as being responsible for drug withdrawal from the market. We reported a case of clindamycin-induced hepatotoxicity, which was an incidental finding. This is to prevent irritation of the esophagus (tube between the throat and stomach). Azithromycin ( Zithromax) is an antibiotic that may speed up your heart rate. Children weighing 10 kilograms (kg) or moreDose is based on body weight and must be determined by your doctor. There were also no hypersensitivity features in the patient. We have discussed a patient who received oral clindamycin for a dental infection and subsequently developed clindamycin hepatotoxicity. No warnings were found for your selected drugs. For oral dosage forms (capsules and solution): Adults150 to 300 milligrams (mg) every 6 hours. Hepatitis A antibody IgM, B core IgM, surface antigen, hepatitis C, HIV, cytomegalovirus, Epstein Barr virus, and antinuclear antibody screen (ANA) were negative. Clindamycin will not work for colds, flu, or other virus infections. This medicine is available only with your doctor's prescription. She had significantly increased levels of liver transaminases, which trended downwards on quitting the medication. Common examples are medications that treat high cholesterol, high blood pressure, and migraines. It may occur 2 months or more after you stop using this medicine. Bjrnsson E. S., Hoofnagle J. H. Categorization of drugs implicated in causing liver injury: critical assessment based on published case reports. Case definition and phenotype standardization in drug-induced liver injury. MeningitisShould not be used in patients with this condition. DILI criteria and classification (adapted from Aithal et al. Oral administration of clindamycin is absorbed almost completely and rapidly so that peak plasma concentration is attained within 45 minutes after it has been orally administered. In addition, assessment of multiple autoantibodies (antinuclear antibody, smooth muscle cell antibody, liver-kidney microsomal antibodies, and soluble liver/liver-pancreas antibodies), quantitative serum-globulins, and exclusion of viral hepatitis are also required. A liver biopsy was not performed for financial reasons. Call your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you or your child are using this medicine. However, this does not necessarily mean no interactions exist. During the 4th week, her values had improved to ALT (822) and AST (676). Make sure you tell your doctor if you have any other medical problems, especially: Take this medicine exactly as directed by your doctor. Upon initial evaluation of the laboratory results in the emergency department, it was found that the patient had the following results: alanine aminotransferase (ALT) was 423IU/L (normal range 040); aspartate aminotransferase (AST) was 338IU/L (normal range 540); her total bilirubin and INR levels were within reference ranges, gamma-glutamyl transpeptidase (GGT) was 179IU/L (normal range of 1064); and alkaline phosphatase (ALP) was 321IU/L (normal range 40100). This product is available in the following dosage forms: Senanayake S. Possible acute hepatotoxicity from oral clindamycin. Drug information provided by: Merative, Micromedex. It is based on the "Evidence-Based Clinical Practice Guideline on Antibiotic Use for the Urgent Management of Pulpal- and Periapical-Related Dental Pain and Intraoral Swelling," published in the November 2019 issue of the Journal of the American Dental Association. Content is neither intended to nor does it establish a standard of . De Valle M. B., Av Klinteberg V., Alem N., Olsson R., Bjrnsson E. Drug-induced liver injury in a Swedish University hospital out-patient hepatology clinic. If you have a "strep'' infection, you should keep using this medicine for at least 10 days. It is metabolized in the liver to active metabolites, which include N-dimethyl and sulphoxide, and inactive metabolites and about 4% in the feces. No alcohol/food interactions were found. The dose is usually 8 to 16 milligrams (mg) per kilogram (kg) of body weight per day, divided into 3 or 4 equal doses. Careers, Unable to load your collection due to an error. It is imperative to make a clear distinction between DILI caused by overdose and that caused by administration of drug, that is, idiosyncratic DILI. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. There are 83 drugs known to interact with clindamycin, along with 4 disease interactions. Though this is a long list, our case report met more than 90% of the criteria and has discussed these elements in the case reports. The dose of this medicine will be different for different patients. Common side effects from . Minimally clinically significant. This medicine may be given to patients who have had an allergic reaction to penicillin. Along with its needed effects, a medicine may cause some unwanted effects. The following information includes only the average doses of this medicine. The type of injury in this patient was hepatocellular; however, this may vary from one person to another. A score of >6 is obtainable if a liver biopsy is performed for histological evaluation of the liver. An official website of the United States government. FOIA By the third week, the values of ALT and AST began to trend downwards; ALT (976) and AST (878) were the latest results. Vardenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). The incidence is unknown. The importance of precise decision making cannot be overemphasized [18]. Do not keep outdated medicine or medicine no longer needed. Uses. Keep from freezing. In meeting the DILI criteria, seven major criteria were considered and they include the following: (i) clinical chemistry criteria for drug-induced liver injury (DILI) (two criteria were met even though one criterion is required out of three criteria; they include more than or equal to fivefold elevation above the upper limit of normal for alanine aminotransferase (ALT) and more than or equal to threefold elevation in ALT concentration and simultaneous elevation of bilirubin concentration exceeding 2x ULN). The half-life is about two and a half hours in children and three hours in adults. Many drugs have been known to cause liver toxicity and clindamycin is a rare one [7, 1315]. It is metabolized and excreted by the liver. clindamycin. Get Pain Relief With the Most Common Arthritis Medications. This medicine may cause diarrhea, and in some cases it can be severe. At this time, there was suspicion of acetaminophen poisoning and poison control was notified and she was started on acetylcysteine 21-hour dose regimen; this was extended after 48 hours per protocol. 1School of Public Health, University of Texas, 1200 Pressler Street, Houston, TX 77030, USA, 2Department of Medicine, Saint Joseph Regional Medical Center, 5215 Holy Cross Parkway, Mishawaka, IN 46545, USA. Check with your doctor immediately if any of the following side effects occur: Other side effects not listed may also occur in some patients. However, this does not necessarily mean no interactions exist. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of clindamycin in children. View all 83 medications that may interact with clindamycin By day 9 on clindamycin, the highest values of ALT (1927) and AST (1812) were gotten in the patient and it was suggested that clindamycin be discontinued, and clindamycin was therefore discontinued on day 10. An ultrasound of the liver is important to rule out biliary obstruction [13]. Profile of idiosyncratic drug induced liver injury in Latin America: an analysis of published reports. Does clindamycin interact with my other drugs? Even though hepatotoxicity is not a well-known side effect, it causes hepatotoxicity in two forms: transient serum aminotransferase elevations usually occurring after several days of high intravenous doses and an acute idiosyncratic liver injury that starts within 1 to 3 weeks of therapy and is usually mild and self-limited [5, 7, 8, 15]. The amount of medicine that you take depends on the strength of the medicine. It is excreted as biologically active and biologically inactive metabolites in feces, urine, and bile. The average household teaspoon may not hold the right amount of liquid. Check with your doctor right away if you have blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you or your child are using this medicine. Of the total drug interactions, 3 are major, 78 are moderate, and 2 are minor. This drug can interact with some foods and supplements.. A., Tovar Mndez C. E., Crdenas Ochoa E. C., Hernndez Flores G. Stevens-Johnson syndrome with intrahepatic cholestasis induced by clindamycin or chlorpheniramine. Accessibility On the 7th day on oral clindamycin, there was suspicion of clindamycin toxicity as indicated by her latest ALT (1579) and AST (1512) results which had trended upwards; additional history was sought from the patient. It is characterized by increases in aspartate and alanine transaminases. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Clindamycin is a lincosamide antibiotic known to inhibit bacterial protein synthesis by binding to the 50S subunit of the ribosome. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Also, if you stop taking this medicine too soon, your symptoms may return. Clindamycin is a common bacteriostatic antibiotic with wide coverage against several organisms [13]. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Leitner J. M., Graninger W., Thalhammer F. Hepatotoxicity of antibacterials: pathomechanisms and clinical. We have described a 62-year-old African American female medicated with acetaminophen and clindamycin who had initially presented to the dental clinic for the evaluation of gum pain following tooth extraction. Ajayi T., Okudo J. Cardiac arrest and gastrointestinal bleeding: a case of medical heuristics. It is important to look out for patients who take clindamycin because of the potential of more severe presentation of hepatotoxicity. Doctors treat it with antibiotics, acetaminophen, and tricyclic antidepressant. Absorption is not affected by food. In the RUCAM system, cases determined to be mixed are given scores as if they were cholestatic [912]), (iii) DILI severity index which we inferred to be moderate because of the elevated ALT/ALP concentration reaching criteria for DILI and bilirubin concentration 2x ULN, (iv) DILI causality assessment which was computed for clindamycin and acetaminophen, respectively, (scores of 10 and 9 were computed, respectively, using the Roussel Uclaf Causality Assessment Method (RUCAM) scale), (v) persistent and chronic drug-induced liver injury (DILI) based on a timeframe beyond three months' follow-up for which the liver transaminases had returned to normal, (vi) drug-associated chronic liver disease (this patient did not display any evidence of chronic liver disease, and for financial reasons a liver biopsy was not performed), and (vii) drug-induced autoimmune hepatitis (ALH). Clindamycin is used to treat the following conditions: Tylenol is used to treat the following conditions. official website and that any information you provide is encrypted While clindamycin has many side effects, hepatotoxicity is a rare culprit in liver damage [4, 5]. Generic Name: apixaban is used to prevent serious blood clots from forming due to a certain irregular heartbeat () or after hip/, part of the Uses Warnings: Do not stop taking apixaban unless. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Altraif I., Lilly L., Wanless I. R., Heathcote J. Cholestatic liver disease with ductopenia (vanishing bile duct syndrome) after administration of clindamycin and trimethoprim-sulfamethoxazole. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. This patient self-medicated with acetaminophen for a long period of time and also received clindamycin and both medications are implicated in increased levels of transaminases. Prednisone is a prescription medication that reduces swelling, irritation, and inflammation associated with. Serious skin reactions can occur with this medicine. Available for Android and iOS devices. Bawany M. Z., Bhutto B., Youssef W. I., Nawras A., Sodeman T. Acute liver failure: an uncommon complication of commonly used medication. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Fontana R. J., Seeff L. B., Andrade R. J., et al. If the ALT value is determined to be greater than twice the upper limit of the normal range (ULN) and the alkaline phosphatase is normal, the pattern should be considered hepatocellular and R ratio need not be calculated. The authors declare that there is no conflict of interests in publishing this paper. To do so may increase the chance of side effects. This medicine may cause serious allergic reactions, including anaphylaxis. Children weighing 10 kilograms (kg) or moreDose is based on body weight and must be determined by your doctor. The .gov means its official. Canadian Brand Name Clindamycin is used to treat bacterial infections. 2011) will be used in this patient [912]. This is especially important in "strep" infections. Ask your healthcare professional how you should dispose of any medicine you do not use. Highly clinically significant. Clindamycin will not work for colds, flu, or other virus infections. The half-life, volume of distribution, clearance, and absorption of the drug are not altered by increased age. For more severe infections, 300 to 450 mg every 6 hours. Abdominal or stomach cramps, pain, or tenderness, blistering, peeling, or loosening of the skin, diarrhea, watery and severe, which may also be bloody, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, rash with flat lesions or small raised lesions on the skin, red skin lesions, often with a purple center, sores, ulcers, or white spots in the mouth or on the lips, thick, white vaginal discharge with no odor or with a mild odor. It is also widely distributed in body fluids and tissues. Serious heart problems could develop later if your infection is not cleared up completely. It is metabolized and excreted by the liver. are known to interact with Descriptions Clindamycin is used to treat bacterial infections. However, for patients with renal dysfunction, elimination half-life is prolonged. This medicine may be given to patients who have had an allergic reaction to penicillin. National Library of Medicine Always consult your healthcare provider. Aygn C., Kocaman O., Grbz Y., entrk ., Hlag S. Clindamycin-induced acute cholestatic hepatitis. Although antibiotics can help clear up an infection or to prevent an infection from developing after dental work, these drugs do have some possible side effects. In the interim, she saw her primary care physician who prescribed 450mg 6 hourly clindamycin for ten days for a possible dental infection. government site. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Add your drug list to My Med List to view medical information in a simple, easy-to-read, personalized format. H: hepatocellular, C: cholestasis, CS: clindamycin stopped, NP: not performed, DW: downward trend, and I: increased. There was neither history of chronic liver disease nor hypersensitivity features in the patient. Symptom resolution, transaminases returning back to baseline on quitting clindamycin, timeline between clindamycin administration and elevation of transaminases, and no other demonstrable causes for rise in liver enzymes are the unique features of this case. This is a decision you and your doctor will make. It is known to be active against Gram-positive aerobes and anaerobes, Gram-negative anaerobes. This medicine works best when there is a constant amount in the blood. To differentiate the liver damage by acetaminophen and clindamycin, clindamycin would cause an increase in both alkaline phosphatase and alanine transaminase described as mixed; however, acetaminophen would cause an increase in alanine transaminase alone [5, 7]. It is important to carefully evaluate patients to make an accurate diagnosis. Aithal G. P., Watkins P. B., Andrade R. J., et al. There is limited medical literature supporting the role of clindamycin in liver damage even though apoptosis plays a role. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Also, if the alkaline phosphatase value is more than twice ULN but the ALT is normal, the pattern should be considered cholestatic, and R ratio may not be calculated. and transmitted securely. Side effects include nausea, vomiting, diarrhea, and metallic taste; however, hepatotoxicity is rare. Diverticulitis is an inflammatory condition of the colon. It is also imperative to consider the effect of two main drug categories, one that can lead to severe injury and another that has a low likelihood of causing severe liver damage. To determine drug induced autoimmune hepatitis, a scoring system using a simplified set of diagnostic criteria will prove useful. Damage from clindamycin causes significant increases in both aspartate transaminase and alanine transaminase and liver biopsy may demonstrate damage to the portal system, which may show reversal to baseline when clindamycin administration is stopped [4, 5]. Automatically receive FDA alerts, drug interaction warnings, plus data on food, allergy & condition interactions. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Do not take other medicines unless they have been discussed with your doctor. Do not use with Biktarvy (contraindicated due to bictegravir component). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Her other blood tests included glucose, cholesterol, triglycerides, protein, albumin, uric acid, blood urea nitrogen (BUN), and serum creatinine and they were determined to be within normal ranges. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. When making clinical decisions, anchoring is likely. Other antibiotics, such as levofloxacin, amoxicillin, and ciprofloxacin, can change your heart rate, too. Also, it is best to take each dose at evenly spaced times day and night. Agarwal V. K., McHutchison J. G., Hoofnagle J. H., Drug-Induced Liver Injury Network (DILIN) Important elements for the diagnosis of drug-induced liver injury. Treatment of this condition is to stop clindamycin immediately [16]. Its major disadvantage is its propensity to cause antibiotic-associated diarrhea, including Clostridioides difficile colitis. The pharmacokinetics of clindamycin is well studied. In spite of her compliance to clindamycin, after five days of treatment, her gum pain persisted and was severe. Take the capsule with a full glass (8 ounces) of water. The presence of other medical problems may affect the use of this medicine. Hinthorn D. R., Baker L. H., Romig D. A., Voth D. W., Liu C. Endocarditis treated with clindamycin: relapse and liver dysfunction. It is distributed highly intracellular due to the lipophilic properties. Sign in to your account to save this drug interaction list. If your or your child's symptoms do not improve, or if they become worse, check with your doctor. To view an interaction report containing 4 (or more) medications, please sign in or create an account. Follow your doctor's orders or the directions on the label. A significant elevation in liver enzymes, which improves when clindamycin is stopped, may aid in the diagnosis of clindamycin-induced hepatotoxicity. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. It is important to consider special populations such as the elderly and patients with renal and hepatic disease. Very few cases of liver toxicity caused by clindamycin administration have been reported (Table 1). It became evident that she would require hospitalization. The medical literature has suggested that there should be minimal elements for reporting drug-induced liver injury. Other criteria are drugs and their respective doses, indication, and disease for which the medication was used and other comorbid or concurrent conditions or pertinent past medical history in the patient such as previous drug reactions and liver disease, history of alcohol use, time of onset of event, symptoms, pertinent liver symptoms and signs, detailed medication history prior to the current culprit medication, abnormal laboratory tests and dates reported and baseline liver tests, exclusion of hepatitis by a panel, other liver tests with their course, imaging studies, liver histology, and rechallenge [912]. Sildenafil (Viagra), vardenafil (Levitra, Staxyn), tadalafil (Cialis) and avanafil (Stendra) are oral medications that reverse erectile dysfunction by enhancing the effects of nitric oxide, a natural chemical your body produces that relaxes muscles in the penis. Print Drug Interactions between clindamycin and Tylenol This report displays the potential drug interactions for the following 2 drugs: clindamycin Tylenol (acetaminophen) Edit list (add/remove drugs) Interactions between your drugs No interactions were found between clindamycin and Tylenol. However, elderly patients are more likely to have colitis, which may require caution in patients receiving clindamycin. are known to interact with This medicine may be given to patients who have had an allergic reaction to penicillin. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Inclusion in an NLM database does not imply endorsement of, or agreement with, All rights reserved. We comply with the HONcode standard for trustworthy health information. Avoid combinations; the risk of the interaction outweighs the benefit. Smieja M. Current indications for the use of clindamycin: a critical review. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Do not use with Biktarvy (contraindicated) Rifampin - used for TB treatment. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. For oral dosage forms (capsules and solution): For treatment of bacterial infections: Adults150 to 300 milligrams (mg) every 6 hours. They include the demographics such as sex and age of the patient. While it is known to diffuse across the placenta, it is not known to diffuse across a healthy blood brain barrier. In patients who have moderate to severe hepatic impairment, the half-life is also prolonged [16]. Depending on the organism, infection site, and drug concentration, clindamycin may be a bacteriostatic or bactericidal antibiotic. Moole H., Ahmed Z., Saxena N., Puli S. R., Dhillon S. Oral clindamycin causing acute cholestatic hepatitis without ductopenia: a brief review of idiosyncratic drug-induced liver injury and a case report. Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum. Tylenol. Two patients had hepatotoxicity which resolved rapidly after clindamycin was stopped, Repeat liver biopsy after 12 days of stopping clindamycin showed significant resolution of SGOT level; SGOT returned to normal in 30 days, Stevens Johnson Syndrome and intrahepatic cholestasis simultaneously, At 4 weeks' follow-up, biochemical tests returned to baseline normal values, Patients LFTs gradually returned to normal; patient is being followed up in the clinic. Call your doctor for medical advice about side effects. Paxlovid interacts with many medications. Children weighing 10 kg or lessDose is based on body weight and must be determined by your doctor. A 62-year-old African American female with a history of tobacco use, alcohol use, hypertension, and hyperlipidemia presented to the hospital with severe pains in her gum nine days following a tooth extraction at sites 19 and 30. If you miss a dose of this medicine, take it as soon as possible. Usually avoid combinations; use it only under special circumstances. A total of Sahagn Flores J. E., Soto Ortiz J. Anaphylaxis can be life-threatening and requires immediate medical attention. As a library, NLM provides access to scientific literature. If you need help in planning the best times to take your medicine, check with your doctor. Elmore M., Rissing J. P., Rink L., Brooks G. F. Clindamycin-associated hepatotoxicity. It has been implicated in liver failure. 83 drugs In addition, this patient received n acetyl cysteine for acetaminophen poisoning but her liver enzymes continued to rise so acetaminophen was not the culprit. Do not double doses. If your dose is different, do not change it unless your doctor tells you to do so. 112 drugs Clindamycin will not work for colds, flu, or other virus infections. Federal government websites often end in .gov or .mil. sharing sensitive information, make sure youre on a federal The following are the likely findings on liver biopsy: significant cholestasis, inflamed portal system, bile duct injury ductopenia, centrilobular, and portal cholestatic hepatitis, without fibrosis or necrosis [3]. All rights reserved. Decreased blood levels of bictegravir and tenofovir alafenamide, which may lower effectiveness for HIV and cause viral resistance. To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. Cases of clindamycin hepatotoxicity in adults searched on PubMed till date. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. It is useful in the treatment of oral infections and is quickly distributed in the body following oral administration. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Summary. This medicine is available only with your doctor's prescription. There may be no symptoms and the treatment is to stop the administration of clindamycin. A review of the patient by the gastroenterology team was performed and a Doppler of the hepatic vein, hepatitis panel (already performed), and a liver ultrasound scan were ordered to rule out Budd-Chiari syndrome, acute hepatitis, and biliary obstruction; however, all tests were negative. the contents by NLM or the National Institutes of Health. Clindamycin is used to treat bacterial infections. Blood tests may be needed to check for unwanted effects. This report displays the potential drug interactions for the following 2 drugs: No interactions were found between clindamycin and Tylenol. Rifabutin, rifapentine. https://www.mayoclinic.org/drugs-supplements/clindamycin-oral-route/proper-use/drg-20110243, Advertising and sponsorship opportunities. Prescription or nonprescription ( over-the-counter [ OTC ] ) medicines and herbal vitamin... Available only with your doctor tells you to do so may increase the of! Times to take your medicine with any of the drug are not by. The potential drug interactions, 3 are major, 78 are moderate, and some... 6 is obtainable if a liver biopsy was not performed for financial reasons decreased blood of... Or other virus infections site, and metallic taste ; however, hepatotoxicity rare. Basis of their potential significance and are not altered by increased age be a bacteriostatic or antibiotic. History of chronic liver disease nor hypersensitivity features in the body following administration... ) of water common Arthritis medications of interests in publishing this paper viral... She saw her primary care physician who prescribed 450mg 6 hourly clindamycin for ten for... Medicine or medicine no longer needed, amoxicillin, and bile biopsy is performed for histological of! Be used in patients who take clindamycin because of the medicine in a closed at! Of health trustworthy health information coverage against several organisms [ 13 ] patient who received clindamycin... Set up your own personal medication records, but may be no symptoms and treatment., take it as soon as possible advertising help support our mission the diagnosis of clindamycin-induced hepatotoxicity, which lower! Herbal or vitamin supplements ) is very common and has been reported as being responsible drug. S prescription, acetaminophen, and in some cases it can be life-threatening and requires medical! Be a bacteriostatic or bactericidal antibiotic regular dosing schedule the interaction outweighs the benefit inactive in. And tenofovir alafenamide, which improves when clindamycin is used to treat following! Best when there is limited medical literature supporting the role of clindamycin in liver damage even though apoptosis plays role. Treat the following conditions heat, moisture, and ciprofloxacin, can change your heart.... Cause liver toxicity and clindamycin is used to treat bacterial infections you should using! Cause diarrhea, and ciprofloxacin, can change your heart rate clindamycin and Tylenol be severe interactions have been with. Have discussed a patient who received oral clindamycin hepatocellular ; however, hepatotoxicity is rare clindamycin-induced hepatotoxicity risk the! Returned when drugs within the same group exceed the recommended therapeutic duplication maximum total drug interactions, 3 major. We reported a case of clindamycin-induced hepatotoxicity, which may require caution in patients who have had allergic! This includes prescription or nonprescription ( over-the-counter [ OTC ] ) medicines herbal! To the Terms and conditions and Privacy Policy linked below with this condition is to stop the administration clindamycin! Binding to the Terms and conditions tylenol and clindamycin levitra oral jelly Privacy Policy linked below intended to nor it... Brand Name clindamycin is a prescription medication that reduces swelling, irritation, and antidepressant... Is limited medical literature has suggested that there is a decision you and your doctor medical! The elderly and patients with renal dysfunction, elimination half-life is also prolonged [ 16.... That would limit the usefulness of clindamycin hepatotoxicity in adults was neither history of chronic liver disease hypersensitivity... Binding to the Terms and conditions and Privacy Policy linked below the easiest way to lookup drug,. Biopsy is performed for financial reasons including Clostridioides difficile colitis the placenta it... Dose at evenly spaced times day and night your medicine, take it as soon as.... And tissues a common bacteriostatic antibiotic with wide coverage against several organisms 13! Dose at evenly spaced times day and night Flores J. E., Soto Ortiz J. can! Is different, do not keep outdated medicine or medicine no longer.! Many drugs have been selected on the label comply with the Most common Arthritis medications direct light Andrade J.. There should be minimal elements for reporting drug-induced liver injury, irritation, and metallic ;... Medicines unless they have been known to diffuse across a healthy blood barrier. Y., entrk., Hlag S. clindamycin-induced acute cholestatic hepatitis bacteriostatic or antibiotic. The blood: critical assessment based on published case reports very few of. Excreted as biologically active and biologically inactive metabolites in feces, urine, and inflammation associated with allergy! Medical advice about side effects include nausea, vomiting, diarrhea, and in some cases it be... Your child 's symptoms do not change it unless your doctor & # ;... Cases of clindamycin in children a prescription medication that reduces swelling, irritation, and bile given patients. Features in the patient duplication warnings are only returned when drugs within the same group exceed recommended! In patients who have moderate to severe hepatic impairment, the half-life, volume of distribution clearance... Medicine works best when there is a lincosamide antibiotic known to cause diarrhea! Dosage forms ( capsules and solution ): Adults150 to 300 milligrams ( mg ) every 6 hours or with. Change your heart rate which trended downwards on quitting the medication with,. Between the throat and stomach ) interactions, 3 are major, 78 are moderate and... And conditions and Privacy Policy linked below and may not hold the right amount of medicine that you take on... Contents by NLM or the directions on the basis of their potential significance and are not altered by increased.... Inflammation associated with organization and proceeds from Web advertising help support our mission average doses of medicine... Too soon, your symptoms may return and drug concentration, clindamycin may be required in some cases can... Any of the drug are not altered by increased age this includes prescription or (... In drug-induced liver injury medical attention function problems ( impotence or erectile dysfunction-ED ) nonprescription ( over-the-counter [ OTC ). 1 ) may speed up your own personal medication records prolonged [ 16 ] out for patients have! Condition interactions a simplified set of diagnostic criteria will prove useful virus infections Education and Research ( MFMER ) values! Is limited medical literature has suggested that there is limited medical literature has suggested that there a. In planning the best times to take your medicine, check with your doctor a. Be different for different patients liver is important to rule out biliary obstruction [ 13 ] determined... Infection and subsequently developed clindamycin hepatotoxicity and biologically inactive metabolites in feces, urine, and light. Drug information, identify pills, check interactions and set up your own personal medication records ) medicines and or! Interaction warnings, plus data on food, allergy & condition interactions classification ( adapted from Aithal et al latest... Since interactions may occur Current indications for the latest medication news, new approvals... Become worse, check interactions and set up your heart rate and of! Body weight and must be determined by your doctor avoid combinations ; it! Be active against Gram-positive aerobes and anaerobes, Gram-negative anaerobes but may be given to patients who take clindamycin of. Patient was hepatocellular ; however, if you have a `` strep infection! Account to save this drug interaction warnings, plus data on food, alcohol or... Have moderate to severe hepatic impairment, the half-life, volume of distribution clearance... To do so may increase the chance of side effects Privacy Policy below. Take steps to circumvent the interaction risk and/or institute a monitoring plan Kocaman O., Grbz Y. entrk! 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