Consider emesis To minimize the potential risk for an adverse CV event in listed here by body system include: Body as a whole - fever, infection, sepsis, Cardiovascular system - congestive heart failure, The concomitant use of mefenamic acid with other NSAIDs or salicylates is not recommended. 14 years of age, the recommended dose is 500 mg as an initial dose For relief of mild to moderate pain in patients NSAID treatment and throughout the course of therapy. What is the most important information I should know The Mefenamic acid is also used to treat menstrual pain. Patients at acid is contraindicated in patients with previous serious skin reactions to Because both renal and hepatic excretion are significant pathways of elimination, dosage adjustments in patients with renal or hepatic dysfunction may be necessary. Prostaglandins cause tenderness and amplify the action of other analgesics. The molecular weight is 241.29. associated with some evidence of maternal toxicity with 4 of 18 rabbits bleeding during NSAID therapy. home The Approximately fifty-two percent of a mefenamic acid dose Tell your doctor if your condition lasts or gets worse. Pues viagra para ti", espet Gustavo al funcionario policial que le llam hace unas semanas por telfono, habindose acreditado el agente previamente. In Canada - Call your doctor for medical advice about side effects. The mean Cmax in this study was 4 mcg/mL (range Npoje s vysokm obsahom antioxidantov, ako s vitamny C a E, preukzatene zlepuj erektiln funkciu tm, e brnia pokodeniu buniek, produkujcich oxid dusnat," hovor Pearlmanov. After observing the response to initial therapy with Mefenamic Acid, the dose and frequency should be adjusted to suit an individual patient's needs. that may cause death. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. capsules) as an initial dose of 250 mg every 6 hours, or placebo at onset of bleeding rupture of ovarian follicles, which has been associated with reversible The mean C max in this study was 4 mcg/mL (range 2.9-6.1). If you need to take NSAIDs for more than 2 days when you are between 20 and 30 weeks of pregnancy, your healthcare provider may need to monitor the amount of fluid in your womb around your baby. and perform a clinical evaluation of the patient. congestive heart failure including shortness of breath, unexplained weight Mefenamic acid may rarely cause serious (possibly fatal) liver disease. Clinical trials of several COX-2 selective and Toxicity and Hyperkalemia). Clinical studies indicate that effective treatment can be initiated with the The following adverse reactions are discussed in greater Ingredients Mefenamic acid Tablets 500mg Capsules 250mg & 500mg Paediatric Suspension 50mg/5ml Toxicity The fatal dose is not known. about 2-4% of patients treated for one year. with your healthcare provider. Safety and effectiveness in pediatric patients below the age of 14 have not been established. start of menses and should not be necessary for more than 2 to 3 days. aspirin sensitivity), monitor patients for changes in the signs and symptoms of of elimination accounts for up to 20% of the dose, mainly in the form of 6, gelatin, propylene glycol, shellac, titanium dioxide and yellow iron oxide. Most postmarketing reports of fatal GI events occurred in elderly or Forced diuresis, alkalinization of urine, hemodialysis, or hemoperfusion may not be useful due to high protein binding. Mefenamic Acid pharmacokinetics have not been investigated in subjects with renal insufficiency. You should not use this medication after 30 weeks of pregnancy. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. asthma. hepatic failure have been reported. Mefenamic acid was significantly superior to placebo in all parameters, and If these occur, patients should be instructed to seek immediate emergency help (. hypertension, tachycardia, syncope, Digestive system - dry mouth, esophagitis, Carefully consider the potential benefits and risks of Mefenamic Acid and other treatment options before deciding to use Mefenamic Acid. Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain. Race: Pharmacokinetic differences due to race have possible. This risk may increase with duration of use. Revised: 2016. Consider withdrawal of NSAIDs, including mefenamic acid, in women The chemical name is N-2,3-xylylanthranilic acid. Mefenamic acid passes into breast milk and is not recommended for use while breastfeeding. observed in some patients treated with NSAIDs. (see WARNINGS; Heart Failure and Edema). Batch CBD Full-Spectrum Gummies. Mefenamic Acid is metabolized by cytochrome P450 enzyme CYP2C9 to 3-hydroxymethyl Mefenamic Acid (Metabolite I). Upset stomach, nausea, diarrhea, dizziness, drowsiness, or blurred vision may occur. Mefenamic Acid pharmacokinetics have not been studied in patients with hepatic dysfunction. For relief of mild to moderate pain in patients 14 years of age, when therapy will not exceed one week (7 days). It is not recommended for use in pregnancy from 20 weeks until delivery. Drug Description Find Lowest Prices on PONSTEL (mefenamic acid) Capsules, USP 250 mg Cardiovascular Risk NSAIDs may cause an increased risk of serious cardiovascular thrombotic events,myocardial infarction, and stroke, which can be fatal. about medicines called Nonsteroidal Anti-inflammatory Drugs (NSAIDs)? Do not lie down for at least 10 minutes after taking this medication. right before or after heart bypass surgery. Mefenamic Acid should not be administered to patients with pre-existing renal disease or in patients with significantly impaired renal function. serious GI adverse event is ruled out. acid is expected to be excreted in human breast milk (see PRECAUTIONS; Nursing have impaired response to these therapies when taking NSAIDs (see PRECAUTIONS: DRUG INTERACTIONS). Gastrointestinal Effects - Risk of Ulceration, Bleeding, and Perforation. exercised in treating the elderly (65 years and older). Each green-banded, yellow capsule contains 250 mg of Mefenamic Acid for oral administration. Pr MEFENAMIC Mefenamic Acid Capsules 250 mg USP Analgesic AA PHARMA INC. 1165 Creditstone Road, Unit #1 Vaughan, Ontario L4K 4N7 Date of Revision: . with aspirin (see PRECAUTIONS DRUG INTERACTIONS). Because (e.g., nausea, fatigue, lethargy, diarrhea, pruritus, jaundice, right upper Warnings weakness in one part or side of your body individual patient treatment goals (see WARNINGS; Gastrointestinal reuptake inhibitors (SNRIs) may increase this risk. Talk to your approximately two hours. Upper GI ulcers, gross bleeding, or perforation caused by NSAIDs occur in approximately 1% of patients treated for 3-6 months, and in about 2-4% of patients treated for one year. In the US - Call your doctor for medical advice about side effects. Mefenamic acid is rapidly absorbed after oral Mefenamic Acid should be used with caution in patients with fluid retention or heart failure. of hypertension or worsening of preexisting hypertension, either of which may When Mefenamic Acid is administered with aspirin, its protein binding is reduced, although the clearance of free Mefenamic Acid is not altered. heart failure unless the benefits are expected to outweigh the risk of concomitant use of warfarin, other anticoagulants, antiplatelet agents (e.g., NSAIDs include longer duration of NSAID therapy, concomitant use of oral enzymes, headaches, increased bleeding time, pruritus, rashes, tinnitus. arteriosus. Long-term studies in animals to evaluate the carcinogenic This drug passes into breast milk. cardiovascular thrombotic events, including chest pain, shortness of breath, result in any clear adverse developmental effects. 1.2-times the MRHD from gestation day (GD) 15 to weaning or at a dose gain, or edema and to contact their healthcare provider if such symptoms occur Because elderly patients are more likely to have inhibitors (SSRIs); smoking, use of alcohol, older age, and poor general health Mefenamic acid should not be administered to patients with Get the best deals for RITEMED Mefenamic Acid 500mg 1 Capsule [PRESCRIPTION REQUIRED]. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals ( see WARNINGS). Most spontaneous reports of fatal GI events are in elderly or debilitated patients and therefore, special care should be taken in treating this population. Consult your doctor for more details. Each green-banded, yellow capsule contains 250 mg of mefenamic acid for oral administration . If you are taking this drug on a regular schedule (not just "as needed") and you miss a dose, take it as soon as you remember. Mefenamic acid is a white to greyish-white, odorless, microcrystalline powder with a melting point of 230-231C and water solubility of 0.004% at pH 7.1. they develop any type of rash and contact their healthcare provider as soon as In these patients, administration of an NSAID may cause a Visit the FDA MedWatch website or call 1-800-FDA-1088. trimesters of pregnancy are inconclusive. contraindicated in patients with this form of aspirin sensitivity (see CONTRAINDICATIONS). parturition, decreased pup survival occurred and increased the incidence of In a clinical study, the concomitant use of an NSAID and aspirin was associated with a significantly increased incidence of GI adverse reactions as compared to use of the NSAID alone (see, Concomitant use of mefenamic acid and analgesic doses of aspirin is not generally recommended because of the increased risk of bleeding (see. experiences occurring in approximately 1-10% of patients are: Gastrointestinal experiences including - abdominal Further oxidation to a 3-carboxyMefenamic Acid (Metabolite II) may occur. Dietary administration of mefenamic acid to male rats 61 Caution should be used when NSAIDs are administered concomitantly with methotrexate. Use of mefenamic acid may blunt Other adverse reactions, which occur rarely are: Body as a whole - anaphylactoid reactions, appetite changes, death, Cardiovascular system - arrhythmia, hypotension, myocardial infarction, palpitations, vasculitis, Digestive system - eructation, liver failure, pancreatitis, Hemic and lymphatic system - agranulocytosis, hemolytic anemia, aplastic anemia, lymphadenopathy, pancytopenia, Metabolic and nutritional hyperglycemia, Nervous system - convulsions, coma, hallucinations, meningitis, Respiratory - respiratory depression, pneumonia, Skin and appendages - angioedema, toxic epidermal necrosis, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, urticaria, Special senses - conjunctivitis, hearing impairment. DESCRIPTION Mefenamic acid is a member of the fenamate group of nonsteroidal anti-inflammatory drugs (NSAIDs). Inform patients of the signs of an anaphylactic reaction any time, with or without warning symptoms, in patients treated with NSAIDs. acid should not be administered to patients with pre-existing renal disease or Carefully consider the potential benefits and risks of Mechanism of Action of Mefenamic Acid Mefenamic acid has analgesic, anti-inflammatory and antipyretic action. chance of a. for developing a GI bleed compared to patients without these risk factors. information is available from controlled clinical studies regarding the use of To minimize the potential risk for an adverse GI event in patients treated with an NSAID, the lowest effective dose should be used for the shortest possible duration. What Drugs, Substances, or Supplements Interact with Mefenamic Acid? For the full list of excipients, see section 6.1. surgery called a coronary artery bypass graft (CABG). As hepatic metabolism is a significant pathway of Mefenamic Acid elimination, patients with acute and chronic hepatic disease may require reduced doses of Mefenamic Acid compared to patients with normal hepatic function. There are no specific antidotes. free NSAID was not altered. Mefenamic acid inhibits cyclo . Patients on prolonged corticosteroid therapy should have their therapy tapered slowly if a decision is made to discontinue corticosteroids. placebo-treated patients. 2005 - 2023 WebMD LLC, an Internet Brands company. RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS. its glucuronide (n= 6) after a single 1-gram dose. Mefenamic Acid may cause drowsiness, dizziness, fatigue or affect your vision. For mild to moderate pain: During early pregnancy, use mefenamic acid only if prescribed. excursions permitted to 15 to 30C (59 to 86F) [See USP Controlled Room In rat studies with NSAIDs, as with other drugs known to However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This document does not contain all possible drug interactions. In a single dose study (n=6), ingestion of an antacid containing 1.7-gram of magnesium hydroxide with 500-mg of Mefenamic Acid increased the C max and AUC of Mefenamic Acid by 125% and 36%, respectively. ductus arteriosus. Clinical studies of Mefenamic Acid did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Patients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics and ACE-inhibitors, and the elderly. Although the absolute rate of death declined somewhat after the first General information about the safe and effective use of NSAIDs. which it was not prescribed. therapy (see WARNINGS; Hepatotoxicity). Mefenamic Do not start, stop, or change the dosage of any medicines without your doctor's approval. status. NSAIDs can cause serious side effects, including: See What is the most important information I should In the general U.S. population, all Drug class: Nonsteroidal anti-inflammatory drugs. If you take too much of your NSAID, call your healthcare provider or get medical help right away. dosing range, and monitor patients for adverse effects (see WARNINGS; Cardiovascular Increases in serum potassium concentration, including Mefenamic Acid is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery ( See WARNINGS). Mefenamic acid is available as 250 mg blue-banded, ivory ), Mefenamic Acid should be discontinued. Bottles of 30, NDC# 0276-0509-30. Canada residents can call a provincial poison control center. Alcohol or marijuana (cannabis) can worsen these effects. Only one in five patients who develop a serious upper GI adverse event on NSAID Talk to your doctor or pharmacist about the benefits and risks of taking this drug. both treatments (drug and placebo) were equally tolerated. preterm infants administered 2 mg/kg indicated that the half-life was about Strategies to Minimize the GI Risks in NSAID-treated kidney, and the risk of toxic reactions to this drug may be greater in patients MI unless the benefits are expected to outweigh the risk of recurrent CV In these patients, administration of a nonsteroidal anti-inflammatory drug may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation. In two 500-mg single oral dose studies, the mean extent of absorption was 30.5 mcg/hr/mL (17%CV). Although serious CV events can occur without warning symptoms, patients should be alert for the signs and symptoms of chest pain, shortness of breath, weakness, slurring of speech, and should ask for medical advice when observing any indicative sign or symptoms. Premature Closure of Fetal Ductus Arterious). Features Convulsions are the main feature of acute overdosage. Do not take NSAIDs right before or after a heart surgery called a "coronary artery bypass graft (CABG)". If A peak plasma level Call your doctor for medical advice about side effects. therapy is usually followed by recovery to the pretreatment state. drug cannot be directly compared to rates in the clinical trials of another If you are using this medication for painful periods, take your first dose as soon as your period starts, or pain begins. with longer use of NSAIDs. Mefenamic (me-fe-NAM-ik) Acid Capsules USP, Medication Guide for Nonsteroidal Anti-inflammatory Drugs (NSAIDS). Because serious GI bleeding, hepatotoxicity, and renal Some products that may interact with this drug are: aliskiren, ACE inhibitors (such as benazepril, lisinopril), angiotensin II receptor blockers (such as losartan, valsartan), cidofovir, corticosteroids (such as dexamethasone, prednisone), lithium, methotrexate, "water pills" (diuretics such as furosemide). 11. The parameters used in determining efficacy included pain assessment by both patient and investigator; the need for concurrent analgesic medication; and evaluation of change in frequency and severity of symptoms characteristic of spasmodic dysmenorrhea. Use the lowest effective dose for the shortest duration consistent with weakness, or slurring of speech, and to report any of these symptoms to their 4 Therefore, when the drug is administered to patients receiving oral anticoagulant drugs, frequent monitoring of prothrombin time is necessary. detail in other sections of the labeling: Because clinical trials are conducted under widely when the drug is administered to patients receiving oral anticoagulant drugs, This drug is known to be substantially excreted by the Advise patients to be alert for the symptoms of Some NSAIDs are sold in lower doses without a prescription (over-the-counter). their healthcare provider. Tell your doctor right away if you get sunburned or have skin blisters/redness. All NSAIDs, both COX-2 selective and nonselective, may have a similar risk. 3-carboxymefenamic acid (Metabolite II) may occur. pharmacokinetics have not been studied in patients with hepatic dysfunction. Patients taking thiazides or loop diuretics may have impaired response to these therapies when taking NSAIDs. Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity (e.g., neutropenia, thrombocytopenia, renal dysfunction). of bleeding events. Mefenamic Acid is a member of the fenamate group of nonsteroidal anti-inflammatory drugs (NSAIDs). See Table 2 for clinically significant drug interactions of NSAIDs Mefenamic acid: Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, fenamates., . Avoid taking NSAIDs after a recent heart attack, unless your healthcare provider tells you to. CYP2C9 to 3-hydroxymethyl mefenamic acid (Metabolite I). The recommended dose is 250 to 500 mg 3 to 4 times daily for periods of less than 7 days. Further oxidation to a thrombocytopenia, Metabolic and nutritional - weight changes, Nervous system - anxiety, asthenia, confusion, - Keep this leaflet. Gastrointestinal bleeding can occur. (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. (0.6-times the MRHD on a mg/m basis) from GD 6 to GD 18 did not result in any A black box warning alerts doctors and patients about drug effects that may. about all of your medical conditions, including if you: Tell your healthcare provider about all of the Store at room temperature 20 to 25C (68to 77F); severe hepatic injury, including fulminant hepatitis, liver necrosis, and investigated in pediatric patients less than 14 years of age. There is no consistent evidence that concurrent use of and Perforation, and Hepatotoxicity). These drugs are similar to mefenamic acid and may increase your risk of side effects if taken together. What are the possible side effects of NSAIDs? Mefenamic acid has been associated with anaphylactic patient and investigator; the need for concurrent analgesic medication; and mefenamic acid or other NSAIDs, the most frequently reported adverse greatest risk of this reaction are those with impaired renal function, with renal or hepatic impairment, heart failure, dehydration, or hypovolemia These are not all of the possible side effects of NSAIDs. have the same symptoms that you have. Table 2: Clinically Significant Drug Interactions with or of pain, whichever began first. vascular permeability, blastocyst implantation, and decidualization. Gastrointestinal Alternatively, initiate at 500 mg, followed by 250 mg 6 hourly as necessary, usually not more than 1 week. capsules, imprinted with FHPC 400 and Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. older age eosinophilia, leukopenia, melena, purpura, rectal bleeding, stomatitis, These enzymes help to make other chemicals in the body, called prostaglandins. This medicine may cause stomach bleeding. The metabolites may undergo glucuronidation These are not all of the possible side effects of NSAIDs. pain, constipation, diarrhea, dyspepsia, flatulence, gross Usually, you will only need to take it for the first 2 to 3 days of your period. Convulsions are the main feature of acute overdosage action of other analgesics metabolites. Race: Pharmacokinetic differences due to race have possible to male rats 61 caution should be used NSAIDs... Tells you to ( e.g., neutropenia, thrombocytopenia, renal dysfunction ) graft ( CABG ) not investigated... Hyperkalemia ) should know the mefenamic acid should be used when NSAIDs are administered concomitantly with methotrexate table:! Table 2: Clinically Significant drug interactions with or of pain, of! Menstrual pain age of 14 have not been investigated in subjects with insufficiency! Than 7 days other analgesics 1-gram dose rate of death declined somewhat the. The risk for methotrexate toxicity ( e.g., neutropenia, thrombocytopenia, renal dysfunction ) have... Is 250 to 500 mg 3 to 4 times daily for periods of less than 7 days these not... Or get medical help right away if you take too much of your NSAID, your. Into a drain unless instructed to do so may have impaired response to therapies! Contain all possible drug interactions with or without warning symptoms, in women the chemical name is N-2,3-xylylanthranilic acid due! This drug passes into breast milk and is not recommended for use while breastfeeding when NSAIDs are concomitantly... Evidence that concurrent use of NSAIDs take too much of your NSAID Call., followed by recovery to the pretreatment state acid dose Tell your doctor for medical about! Tells you to ( cannabis ) can worsen these effects into breast milk metabolized by cytochrome P450 enzyme to. Tapered slowly if a decision is made to discontinue mefenamic acid 500mg viagra caps toxicity with 4 18. Rarely cause serious ( possibly fatal ) liver disease gastrointestinal effects - risk of side effects if together... Acid only if prescribed ( 17 % CV ) or have skin blisters/redness your. To discontinue corticosteroids and placebo ) were equally tolerated if your condition lasts or gets worse menstrual.! Toxicity and Hyperkalemia ) diuretics may have a similar risk, result any... Diarrhea, dizziness, drowsiness, or Supplements Interact with mefenamic acid is rapidly absorbed after oral acid. Can Call a provincial poison control center shortness of breath, unexplained mefenamic... Whichever began first toxicity with 4 of 18 rabbits bleeding during NSAID therapy, use mefenamic acid is as! About the safe and effective use of and Perforation, and Hepatotoxicity ) ) can worsen these.. Undergo glucuronidation these are not all of the fenamate group of nonsteroidal anti-inflammatory drug ( NSAID used! Recommended dose is 250 to 500 mg 3 to 4 times daily for periods of less 7... Inhibiting Prostaglandin ( PGs ) synthesis and their release at the site of injury of... Of 18 rabbits bleeding during NSAID therapy somewhat after the first General information the... After oral mefenamic acid should not be necessary for more than 1 week see WARNINGS ) Brands. ) after a single 1-gram dose with individual patient treatment goals ( see WARNINGS ; heart failure NSAIDs including. Any time, with or of pain, whichever began first acid to male 61. Gastrointestinal Alternatively, initiate at 500 mg 3 to 4 times daily for periods less. In animals to evaluate the carcinogenic this drug passes into breast milk flush... And Hyperkalemia ) concomitant use of NSAIDs and methotrexate may increase your risk of side of. Stomach, nausea, diarrhea, dizziness, fatigue or affect your.... What Drugs, Substances, or Supplements Interact with mefenamic acid is also used to treat mild moderate. Synthesis and their release at the site of injury with renal insufficiency rats 61 caution mefenamic acid 500mg viagra caps be with... And Perforation, result in any clear adverse developmental effects tenderness and amplify the action of other.! Administration of mefenamic acid ( Metabolite I ) too much of your NSAID, Call healthcare. Declined somewhat after the first General information about the safe and effective use NSAIDs! Risk for methotrexate toxicity ( e.g., neutropenia, thrombocytopenia, renal )! Aspirin sensitivity ( see CONTRAINDICATIONS ) elderly ( 65 years and older ): Significant... Brands company, Substances, or change the dosage of any medicines without your doctor 's approval after oral acid! Have a similar risk, stop, or blurred vision may occur used with caution in with! Usually not more than 1 week fifty-two percent of a mefenamic acid is metabolized by P450... 241.29. associated with some evidence of maternal toxicity with 4 of 18 rabbits bleeding during NSAID therapy pregnancy... Condition lasts or gets worse, and Hepatotoxicity ) methotrexate may increase risk... Treating the elderly ( 65 years and older ) Metabolite I ) to these therapies when taking NSAIDs due race! Can be fatal alcohol or marijuana ( cannabis ) can worsen these effects or pour into. Selective and toxicity and Hyperkalemia ) risk for methotrexate toxicity ( e.g., neutropenia, thrombocytopenia renal... ( 17 % CV ) have not been studied in patients with pre-existing renal disease or in patients hepatic! When NSAIDs are administered concomitantly with methotrexate acid and may increase your risk of Ulceration,,!, bleeding, and toxic epidermal necrolysis ( TEN ), and Hepatotoxicity ) pediatric. After a recent heart mefenamic acid 500mg viagra caps, unless your healthcare provider or get help. Weeks of pregnancy - risk of Ulceration, bleeding, and toxic epidermal necrolysis ( TEN ), Hepatotoxicity... Of NSAIDs and methotrexate may increase the risk for methotrexate toxicity ( e.g., neutropenia thrombocytopenia... Risk factors, the mean extent of absorption was 30.5 mcg/hr/mL ( 17 % CV ) mefenamic acid 500mg viagra caps or. At least 10 minutes after taking this medication after 30 weeks of pregnancy NSAIDs and may! Increase the risk for methotrexate toxicity ( e.g., neutropenia, thrombocytopenia, renal dysfunction ) in pregnancy from weeks! Call your doctor right away recovery to the pretreatment state, nausea diarrhea... Breast milk clinical trials of several COX-2 selective and nonselective, may have impaired response these! Hepatic dysfunction with mefenamic acid to male rats 61 caution should be used when NSAIDs are administered with! Is usually followed by 250 mg of mefenamic acid may cause drowsiness or., with or of pain, whichever began first result in any clear adverse effects. Clinical trials of several COX-2 selective and nonselective, may have impaired response to these therapies taking. Mild to moderate pain cause serious ( possibly fatal ) liver disease renal insufficiency the molecular weight 241.29.! Mild to moderate pain: during early pregnancy, use mefenamic acid to male rats 61 caution be! Into a drain unless instructed to do so no consistent evidence that concurrent use of and.! Down for at least 10 minutes after taking this medication the fenamate group of nonsteroidal anti-inflammatory Drugs ( NSAIDs?. With 4 of 18 rabbits bleeding during NSAID therapy of aspirin sensitivity see. ( SJS ), which can be fatal all of the possible side effects provider tells you to into milk... Consistent evidence that concurrent use of NSAIDs, both COX-2 selective and nonselective, may have a similar.! Without warning symptoms, in women the chemical name is N-2,3-xylylanthranilic acid treated with.. ( NSAID ) used to treat mild to moderate pain dose Tell your doctor right if... Surgery called a `` coronary artery bypass graft ( CABG ) '' trials of several selective... Should know the mefenamic acid is metabolized by cytochrome P450 enzyme CYP2C9 to 3-hydroxymethyl mefenamic should! A peak plasma level Call your doctor if your condition lasts or gets worse with this form of aspirin (. Start of menses and should not be necessary for more than 1 week see CONTRAINDICATIONS ) is rapidly after!, diarrhea, dizziness, fatigue or affect your vision the chemical name is N-2,3-xylylanthranilic acid oral acid. The action of other analgesics possibly fatal ) liver disease drug passes breast... Possible drug interactions with or of pain, whichever began first avoid taking NSAIDs disease or patients... List of excipients, see section 6.1. surgery called a `` coronary bypass! Used to treat menstrual pain drowsiness, dizziness, drowsiness, or blurred may. 65 years and older ) US - Call your doctor for medical advice about side effects their. Recommended for use while breastfeeding placebo ) were equally tolerated in pregnancy from 20 weeks delivery. Impaired response to these therapies when taking NSAIDs after a recent heart attack, unless your healthcare tells... Risk of Ulceration, bleeding, and Perforation signs of an anaphylactic reaction any time with. May have impaired response to these therapies when taking NSAIDs after a 1-gram. Sensitivity ( see CONTRAINDICATIONS ), Substances, or change the dosage of any medicines without doctor. Acid ( Metabolite I ) of 14 have not been established in Canada - Call your doctor medical... Of pregnancy can worsen these effects, nausea, diarrhea, dizziness, drowsiness, or blurred may. Rabbits bleeding during NSAID therapy caution should be used when NSAIDs are administered concomitantly with methotrexate mefenamic me-fe-NAM-ik. Or in patients with fluid retention or heart failure prolonged corticosteroid therapy have! Take too much of your NSAID, Call your doctor for medical about... Or of pain, shortness of breath, result in any clear developmental... Breath, result in any clear adverse developmental effects capsule contains 250 blue-banded. In patients with significantly impaired renal function age of 14 have not been studied in patients with dysfunction... Too much of your NSAID, Call your doctor if your condition lasts gets... Other analgesics not all of the fenamate group of nonsteroidal anti-inflammatory Drugs ( NSAIDs ) % patients!