Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Use Caution/Monitor. atazanavir and lamivudine both increase risk of immune reconstitution syndrome. Use alternatives if available. 2023 May 29. Use Caution/Monitor. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. The hepatitis B virus can mutate while you are taking Epivir-HBV and may become resistant to treatment. ritonavir and lamivudine both increase risk of immune reconstitution syndrome. Talk to your pharmacist for more details. Hepatitis B virus (HBV) antiviral Resistance-Associated Mutations (RAMs) in human immunodeficiency virus (HIV) coinfected patients undergoing highly active antiretroviral therapy (HAART) are complex and incompletely understood. Lamivudine doesnt cure infection with HIV or HBV. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Monitor Closely (1)indinavir and lamivudine both increase risk of immune reconstitution syndrome. peginterferon alfa 2b, lamivudine. 2008 Jan-Mar;71(1):30-2. Most Alcohol or marijuana (cannabis) can make you more dizzy. The Epivir brand contains a higher dose of lamivudine than Epivir-HBV brand. Theyll do a virus count to measure the number of copies of the HIV or HBV virus in your body. Michelle Nguyen, PharmD Last reviewed on: December 12, 2020 What is lamivudine (Epivir)? Use Caution/Monitor. Individual plans may vary In the same way, if you have HIV infection, dont use lamivudine prescribed to treat HBV infection. Epivir is for treating HIV and Epivir-HBV is for treating hepatitis B. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. What we learned, loved, and are leaving with from, primary alcohol, oxacycle, monothioacetal (, Human Immunodeficiency Virus (HIV) Infections, Human Immunodeficiency Virus Type 1 (HIV-1) Infection, J05AR27 Lamivudine, tenofovir disoproxil and dolutegravir, J05AR Antivirals for treatment of HIV infections, combinations, J05AR11 Lamivudine, tenofovir disoproxil and efavirenz, J05AR07 Stavudine, lamivudine and nevirapine, J05AR13 Lamivudine, abacavir and dolutegravir, J05AR12 Lamivudine and tenofovir disoproxil, J05AR24 Lamivudine, tenofovir disoproxil and doravirine, J05AR04 Zidovudine, lamivudine and abacavir, J05AR05 Zidovudine, lamivudine and nevirapine, J05AF Nucleoside and nucleotide reverse transcriptase inhibitors, Antivirals used in combination for the treatment of HIV infections, Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor, Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor, Nucleic Acids, Nucleotides, and Nucleosides, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors, Nucleoside Reverse Transcriptase Inhibitors, Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), Ethanolamine-phosphate cytidylyltransferase, 5'(3')-deoxyribonucleotidase, cytosolic type, Multidrug resistance-associated protein 1, ATP-binding cassette sub-family G member 2, Multidrug resistance-associated protein 4, Canalicular multispecific organic anion transporter 2, Canalicular multispecific organic anion transporter 1. 2001 Mar;33(3):751-7. Long-term use of zidovudine can cause muscle weakness, or loss of muscle tissue . This information should not be interpreted without the help of a healthcare provider. Abemaciclib may decrease the excretion rate of Lamivudine which could result in a higher serum level. Do not skip any doses. Monitor Closely (1)lamivudine increases levels of erdafitinib by decreasing renal clearance. What Are the Trends in the Aging Population With HIV? Increased risk of liver decompensation. Lamivudine oral tablet is available as the brand-name drugs Epivir and Epivir-HBV. Monitor Closely (1)fosamprenavir and lamivudine both increase risk of immune reconstitution syndrome. [, Errasti-Murugarren E, Pastor-Anglada M: Drug transporter pharmacogenetics in nucleoside-based therapies. Our datasets provide approved product information including: Access drug product information from over 10 global regions. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. MeSH Acetylsalicylic acid may decrease the excretion rate of Lamivudine which could result in a higher serum level. Avoid or Use Alternate Drug. lamivudine will increase the level or effect of cabozantinib by Other (see comment). Acemetacin may decrease the excretion rate of Lamivudine which could result in a higher serum level. Antiviral Res. Before taking lamivudine, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. When phosphorylated, lamivudine can form active metabolites that compete for incorporation into viral DNA. The impact of the M184V substitution in HIV-1 reverse transcriptase on treatment response. There are 42 drugs known to interact with Consult your doctor for more details. Lamivudine is an antiviral medicine that prevents human immunodeficiency virus ( HIV) or hepatitis B virus from multiplying in your body. Clinical monitoring while you take this drug may include: Many insurance companies require a prior authorization for this drug. Avoid or Use Alternate Drug. lamivudine and nevirapine both increase risk of immune reconstitution syndrome. As your immune system gets stronger, it can begin to fight off infections you already had, possibly causing disease symptoms to come back. Drug interactions may change how your medications work or increase your risk for serious side effects. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Liquid preparations of lamivudine-HBV contain sugar (sucrose). Use Caution/Monitor. This information is not individual medical advice and does not substitute for the advice of your health care professional. This survey is being conducted by the WebMD marketing sciences department. tafenoquine will increase the level or effect of lamivudine by Other (see comment). If you believe you are experiencing an interaction, contact a healthcare provider immediately. This biotransformation is catalyzed by sulfotransferases. Other (see comment). Remember to use it at the same time each day. 2006 Aug;50(8):2686-94. There are 3 disease interactions with lamivudine which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. By clicking send, you acknowledge that you have permission to email the recipient with this information. Combination will result in therapeutic duplication. nose or throat infection--stuffy nose, sneezing, sore throat, cough. Lamivudine should be used during pregnancy only if the potential benefit outweighs potential risk to the pregnancy. Generic name: lamivudine [la-MIV-ue-deen] Compare formulary status to other drugs in the same class. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. This medication is a nucleoside reverse transcriptase inhibitor (NRTI) that works by slowing the growth of the virus, thereby decreasing liver damage caused by the virus. Many people using this medication do not have serious side effects. Cialis will compete against Viatris' sildenafil-based Viagra Connect in the men's sexual health and wellness category, which has seen a proliferation of . [, Wang X, Furukawa T, Nitanda T, Okamoto M, Sugimoto Y, Akiyama S, Baba M: Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors. Modify Therapy/Monitor Closely. Increased risk of liver decompensation. Get medical help right away if you have any serious symptoms, including: unexplained weight loss, severe tiredness, muscle aches/weakness that doesn't go away, headaches that are severe or don't go away, joint pain, numbness/tingling of the hands/feet/arms/legs, vision changes, signs of infection (such as fever, chills, swollen lymph nodes, trouble breathing, cough, non-healing skin sores), signs of an overactive thyroid (such as irritability, nervousness, heat intolerance, fast/pounding/irregular heartbeat, bulging eyes, unusual growth in the neck/thyroid known as a goiter), signs of a certain nerve problem known as Guillain-Barre syndrome (such as unsteadiness, loss of coordination, trouble swallowing/speaking/chewing, trouble moving your eyes). The use of the eHealthMe site and its content is at your own risk. For people with hepatitis C: If you have HIV infection and hepatitis C virus (HCV) infection and take interferon and ribavirin for HCV infection, you could experience liver damage. [, Choi MK, Song IS: Genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. For people with pancreatitis: People who have had pancreatitis in the past may be at greater risk for developing the condition again when taking this drug. Does lamivudine oral interact with other drugs you are taking? In order to replicate and spread in your body, HIV and HBV need to use an enzyme called reverse transcriptase. This includes prescription and over-the-counter medications. NOTES: Do not share this medication with others.Lab and/or medical tests (such as kidney function, liver tests, viral load, T-cell counts) should be done while you are taking this medication. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug are: orlistat, sorbitol.Emtricitabine is similar to lamivudine and should not be taken with this medication. PMC Coadministration of emtricitabine containing products and lamivudine containing products should be avoided. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV) to disrupt viral DNA synthesis. Available for Android and iOS devices. Medically reviewed by Drugs.com on Jun 27, 2022. Careers. These could be a sign that youre experiencing immune reconstitution syndrome. It helps to decrease the amount of HIV in your body so your immune system can work better. The above information is provided for general This could result in dangerous side effects. eHealthMe is studying from 874 Dovato users for its . This document does not contain all possible drug interactions. Talk to your doctor if you are using marijuana (cannabis). If you have hepatitis B infection along with HIV, your hepatitis symptoms may get worse or become very serious if you stop taking lamivudine. Your doctor may decrease your dosage so that the drug doesnt build up in your body. Talk with your doctor before stopping this medication. Do not share this medication with others. Worsening of your condition, decreased response to medication, or development of drug-resistant types of the virus may occur during or after treatment. Each time you get a refill of this medication, be sure you have received the correct brand to treat your condition. Use Caution/Monitor. Lamivudine, in combination with abacavir, and either efavirenz, raltegravir, boosted atazanavir, or boosted darunavir, is not recommended in patients with pretreatment HIV RNA 100,000 copies/mL (HHS [adult] 2019). Use Caution/Monitor.Minor (1)lamivudine increases effects of zidovudine by pharmacodynamic synergism. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Use Caution/Monitor. Your doctor will perform liver function tests for several months after you stop lamivudine. Different brands of this medication have different storage needs. Today, hes one of only five people whove been effectively cured of HIV thanks to a breakthrough. Select a condition to view a list of medication options. Provides a summary of interactions with vitamins, herbs, and food Consult your doctor or pharmacist for more information. Either increases toxicity of the other by pharmacodynamic synergism. Bethesda, MD 20894, Web Policies In children, the dosage is also based on weight.It is very important to continue taking this medication (and other HIV medications) exactly as prescribed by your doctor. -, Quercia R, Perno CF, Koteff J, Moore K, McCoig C, St Clair M, Kuritzkes D. Twenty-Five Years of Lamivudine: Current and Future Use for the Treatment of HIV-1 Infection. Combination will result in therapeutic duplication. In: StatPearls [Internet]. [, De Clercq E: Emerging anti-HIV drugs. Some HBV infections can become resistant to lamivudine treatment. Tell your doctor if you have new or worsening hepatitis symptoms. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. HIV is the virus that can cause acquired immunodeficiency syndrome (AIDS). For instance, some can interfere with how well a drug works, while others can cause increased side effects. Use Caution/Monitor. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Use Caution/Monitor. This is the most serious warning from the Food and Drug Administration (FDA). The elimination half-life is 5-7 hours. You may report side effects to FDA at 1-800-FDA-1088. elivaldogene autotemcel, lamivudine. Tell your doctor right away if you develop symptoms of worsening liver problems. Via DNA incorporation, lamivudine metabolites competitively inhibit the activity of the HIV reverse transcriptase enzyme and act as a chain terminator of DNA synthesis. Store at room temperature away from moisture and heat. Consult your doctor or pharmacist for more details. Call 911 if your symptoms feel life-threatening or if you think youre having a medical emergency. [, FDA Approved Drug Products: Triumeq/Triumeq PD (abacavir, dolutegravir, and lamivudine) for oral administration [, Murfreesboro Pharmaceutical Nursing Supply, van Leeuwen R, Lange JM, Hussey EK, Donn KH, Hall ST, Harker AJ, Jonker P, Danner SA: The safety and pharmacokinetics of a reverse transcriptase inhibitor, 3TC, in patients with HIV infection: a phase I study. Call your doctor at once if you have: severe pain in your upper stomach spreading to your back, nausea, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). Either increases toxicity of the other by pharmacodynamic synergism. Approved . ublituximab decreases effects of lamivudine by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug. nucleoside reverse transcriptase inhibitors (NRTIs), Lamivudine may interact with other medications, Centers for Disease Control and Prevention, Important considerations for taking lamivudine, accessdata.fda.gov/drugsatfda_docs/label/2018/020564s038,020596s037lbl.pdf, accessdata.fda.gov/drugsatfda_docs/label/2018/021003s020lbl.pdf, dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2d31d849-0882-4a71-b889-e57036e6fabe, dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ac824c7e-9c9f-487b-ad2f-d50eaef5cbda. Emtricitabine is similar to lamivudine and should not be taken with this medication. You should not take lamivudine if you are allergic to it. Lamivudine is a medication used in the management and treatment of HIV-1 and hepatitis B. Dovato has active ingredients of dolutegravir sodium; lamivudine. Use Caution/Monitor. Common interactions include chronic kidney disease among males. Drugs & Vitamins Drugs A-Z Generic Drugs A-Z Drugs by Classification Drugs Comparison (Drug Vs. HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start taking lamivudine and each time you get a refill. Introductory Offer: Save 10 percent on Cialis Together 4 pack - online only. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Avoid or Use Alternate Drug. Before taking lamivudine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Lamivudine-HBV contains a lower dose of the drug lamivudine, which is used to treat HIV infection as well as hepatitis B. You could also have symptoms if your immune system becomes overactive. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Dont use lamivudine thats prescribed to treat HIV. USES: This drug is used with other HIV medications to help control HIV infection. Do not share personal items (such as needles/syringes, toothbrushes, and razors) that may have contacted blood or other body fluids. Roussos A, Koilakou S, Kalafatas I, Kalantzis C, Apostolou N, Grivas E, Raptis N, Mantzaris G. Lamivudine treatment for acute severe hepatitis B: report of a case and review of the literature. Lamivudine was rapidly absorbed after oral administration in HIV-infected patients. If any of these effects last or get worse, tell your doctor or pharmacist promptly. HIV counseling and testing should be offered to all patients both before and during treatment with lamivudine-HBV. Use Caution/Monitor. It helps to decrease the amount of HIV in your body so your immune system can work better. The risk or severity of adverse effects can be increased when Acyclovir is combined with Lamivudine. Because breast milk can transmit HIV, do not breast-feed. This drug may make you dizzy or drowsy. Enter other medications to view a detailed report. Applies only to oral form of both agents. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Other drugs that . Talk with your doctor before stopping this medication. Use Caution/Monitor. Lamivudine and zidovudine combination is used in the treatment of human immunodeficiency virus (HIV) infection. Due to the lack of a 3'-OH group, incorporated nucleoside analogues prevent the formation of a 5' to 3' phosphodiester linkage that is essential for DNA chain elongation. emtricitabine/tenofovir disoproxil fumarate (, emtricitabine/tenofovir alafenamide fumarate (Descovy), efavirenz/emtricitabine/tenofovir disoproxil fumarate (Atripla), rilpivirine/emtricitabine /tenofovir disoproxil fumarate (Complera), rilpivirine/emtricitabine/tenofovir alafenamide fumarate (Odefsey), emtricitabine/tenofovir disoproxil fumarate/elvitegravir/cobicistat (, emtricitabine/tenofovir alafenamide fumarate/elvitegravir/cobicistat (, the type and severity of the condition youre using lamivudine to treat. Different brands of this drug have different amounts of drug. J Acquir Immune Defic Syndr. Properly discard this product when it is expired or no longer needed. occasional blood tests for liver function and. Treasure Island (FL): StatPearls Publishing; 2023 Jan. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and trunk). 2010 Jan;6(1):105-14. Epivir is not a cure for HIV or AIDS. 2010 Jun;11(6):809-41. doi: 10.2217/pgs.10.70. 2005 Dec;272(24):6287-96. The tablets can occasionally be in temperatures between 59F and 86F (15C and 30C). Use Caution/Monitor. It is very important to continue taking this medication (and other HIV medications) exactly as prescribed by your doctor. FOIA commonly, these are "preferred" (on formulary) brand drugs. Cialis Together 10mg Tablets - Tadalafil - 4 Tablets. Do not increase your dose, take this drug more often than prescribed, or stop taking it (or other HIV medicines) even for a short time unless directed to do so by your doctor. These drugs are often used to treat similar conditions. Aceclofenac may decrease the excretion rate of Lamivudine which could result in a higher serum level. 2005 - 2023 WebMD LLC, an Internet Brands company. Otherwise, call a poison control center right away. isavuconazonium sulfate will increase the level or effect of lamivudine by Other (see comment). Different individuals may respond to medication in different ways. Use all HIV medications as directed and read all medication guides you receive. Below is a list of medications that can interact with lamivudine. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. There are many drugs and combinations that can treat HIV and HBV infection. Cialis has active ingredients of tadalafil. Lamivudine, also known as 3TC, (brand name Epivir) is a drug used as part of antiretroviral therapy (ART). Use Caution/Monitor. 2023 Feb 11. They are similar drugs and taking them together can increase the dangerous side effects of emtricitabine. Applies only to oral form of both agents. Tell your doctor about all your current medicines and any medicine you start or stop using. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. For people with reduced kidney function: If you have kidney disease or reduced kidney function, your kidneys may not process lamivudine from your body quickly enough. View the formulary and any restrictions for each plan. Selected from data included with permission and copyrighted by First Databank, Inc. Helps you get and maintain an erection when you need it. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. Do not switch brands of this medication without first checking with your doctor. A black box warning is the most serious warning from the Food and Drug Administration (FDA). Increased risk of hematologic toxicity. If you notice other effects not listed above, contact your doctor or pharmacist. The phase IV clinical study analyzes what interactions people who take Cialis and Dovato have. Nat Rev Drug Discov. Minor/Significance Unknown. [, Wada S, Tsuda M, Sekine T, Cha SH, Kimura M, Kanai Y, Endou H: Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs. Consult your doctor or pharmacist for more details. All rights reserved. Use Caution/Monitor. Minimally clinically significant. Monitor Closely (1)trimethoprim increases effects of lamivudine by basic (cationic) drug competition for renal tubular clearance. Properly discard this product when it is expired or no longer needed. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Use Caution/Monitor. Symptoms of pancreatitis may include stomach bloating, pain, nausea, vomiting, and tenderness when touching the stomach. Avoid or Use Alternate Drug. You may need frequent liver function tests for several months. (2018). Mild symptoms of lactic acidosis may worsen over time, and this condition can be fatal. HIV Med. Copyright(c) 2023 First Databank, Inc. US residents can call their local poison control center at 1-800-222-1222. If you have HBV and take lamivudine but then stop taking it, your HBV infection could become much more severe. This document does not contain all possible drug interactions. Although HPV and HIV can both be sexually transmitted, these infections have different symptoms and management plans. Learn how HIV is transmitted. Keep all medical and lab appointments. Many people using this medication do not have serious side effects. -, Kumar PN, Patel P. Lamivudine for the treatment of HIV. We comply with the HONcode standard for trustworthy health information. Comment: Elvitegravir/cobicistat/emtricitabine/tenofovir is a complete regimen for HIV and should not be administered with other antiretrovirals. Monitor Closely (1)interferon alfa 2b, lamivudine. It is often used in erection problems. The phase IV clinical study analyzes what interactions people who take Cialis and Abacavir; lamivudine have. Personalize this study to your gender and age. If you have HIV infection (with or without hepatitis B infection), you should be taking the higher-strength dosage. Lamivudine is 86% orally bioavailable and protein binding is low (<36%). 1959 Aug;234(8):1998-2000. Do not take lamivudine and zidovudine if you have ever had an allergic reaction to any medicine that contains lamivudine or zidovudine.. Zidovudine can weaken your immune system and cause signs of infection (fever, mouth sores, skin sores, flu symptoms, pale skin).Your blood will need to be tested often. Always ask your health care professional for complete information about this product and your specific health needs. 2005 Jul;107(1):1-30. It is created by eHealthMe based on reports the from the FDA, and is updated regularly. Minor/Significance Unknown. Keep all medications away from children and pets. Tell your doctor if you are pregnant before using this medication. Use Caution/Monitor. commonly, these are generic drugs. A pharmacokinetic interaction is unlikely as lamivudine and adefovir are eliminated by different renal transporters and coadministration of adefovir dipivoxil (10 mg) and lamivudine (100 mg) did not alter the pharmacokinetic profile of either drug. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvZXBpdmlyLWhidi1sYW1pdnVkaW5lLTM0MjYyMQ==, View explanations for tiers and We comply with the HONcode standard for trustworthy health information. National Library of Medicine Antimicrob Agents Chemother. Stop taking it immediately and go to an emergency room or call 911. This drug has a boxed warning. Monitor Closely (1)valganciclovir, lamivudine. If you miss a dose, take it as soon as you remember. [, Minuesa G, Volk C, Molina-Arcas M, Gorboulev V, Erkizia I, Arndt P, Clotet B, Pastor-Anglada M, Koepsell H, Martinez-Picado J: Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3. Dovato has active ingredients of dolutegravir sodium; lamivudine. A product that may interact with this drug is: sorbitol. Lamivudine is used to treat two different viral infections: HIV and hepatitis B (HBV). Breastfeeding: Human immunodeficiency virus (HIV). [, KENNEDY EP, BORKENHAGEN LF, SMITH SW: Possible metabolic functions of deoxycytidine diphosphate choline and deoxycytidine diphosphate ethanolamine. Minor/Significance Unknown. Headache, dizziness, nausea, diarrhea, or trouble sleeping may occur. The lamivudine dosage your doctor prescribes will depend on several factors. Do not start, stop, or change the dosage of any medicines without your doctor's approval. If coadministration cannot be avoided, monitor for substrate-related toxicities and consider dosage reduction if needed based on product labeling of the coadministered drug. Treasure Island (FL): StatPearls Publishing; 2023 Jan. [, Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. saquinavir and lamivudine both increase risk of immune reconstitution syndrome. Write a review. Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as depression), stomach/back pain with nausea (pancreatitis), easy bleeding/bruising, signs of anemia (unusual tiredness, rapid heartbeat, pale/bluish skin). Your doctor will monitor your HBV levels using blood tests, and may recommend a different treatment if your HBV levels remain high. A very serious allergic reaction to this drug is rare. Use Caution/Monitor. Version: 13.01. The peak serum lamivudine concentration (Cmax) was 1.5 0.5 mcg/mL when an oral dose of 2 mg/kg twice a day was given to HIV-1 patients. Biopharm Drug Dispos. Talk with your doctor about safe ways to prevent HIV transmission during sex. HIV treatment: 150 mg twice daily or 300 mg once daily. Check the product package for instructions on how to store your brand, or ask your pharmacist. Discuss the risks and benefits with your doctor.Lamivudine passes into breast milk. The absence of an interaction does not necessarily mean no interactions exist. It inserts itself into the virus's DNA by pretending to be a DNA building block, but actually stops the DNA-making process. Metabolic functions of deoxycytidine diphosphate choline and deoxycytidine diphosphate ethanolamine zidovudine combination is used to treat similar.! Multiplying in your body based on reports the from the Food and drug (. Alcohol or marijuana ( cannabis ) administered with other antiretrovirals Epivir-HBV and may become resistant to treatment medications as and... To ensure the information displayed on this website is protected by copyright, copyright 1994-2023 by LLC... Of drug Cialis Together 10mg Tablets - Tadalafil - 4 Tablets system becomes overactive from... Preferred '' ( on formulary ) brand drugs absorbed after oral Administration HIV-infected. Medication have different amounts of drug drug interactions may change how your medications work or increase risk... ) infection ) that may have contacted blood or other body fluids lamivudine-HBV contain sugar ( ). May interact with other HIV medications to help control HIV infection, dont lamivudine... Incorporation into viral DNA virus ( HIV ) or hepatitis B by other ( comment! About side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch information on more than 24,000 prescription,! Different treatment if your immune system can work better run phase IV trials... Latest medication news, new drug approvals, alerts and updates use an enzyme called reverse on! Read all medication guides you receive immune reconstitution syndrome be a sign that youre experiencing reconstitution. Call your doctor if you miss a dose, take steps to circumvent the interaction and/or... Above information is provided for general this could result in a higher serum level or.... Online only box warning is the most serious warning from the FDA and. Variants of organic cation transporter 1 ( OCT1 ) and OCT2 significantly reduce lamivudine.! 1-800-Fda-1088 or at www.fda.gov/medwatch.In Canada - call your doctor will monitor your HBV infection could become much more severe taking. Always ask your pharmacist tubular clearance care professional for complete information about this product when it is created by based. You believe you are experiencing an interaction does not necessarily mean no interactions exist and benefits with doctor.Lamivudine... Condition can be fatal oral tablet is available as the brand-name drugs Epivir and Epivir-HBV is treating. Reaction to this drug is rare different ways interfere with how well a drug used as of! Be fatal as passing out or trouble sleeping may occur during or after treatment may... Clicking send, you acknowledge that you have received the correct brand to treat infection. The latest medication news, new drug approvals, alerts and updates infections can become resistant to treatment. Lamivudine if you have any other allergies Closely ( 1 ) lamivudine increases of... Guides you receive tenderness when touching the stomach of lamivudine by other ( see comment ) similar conditions level! Immune reconstitution syndrome reduce lamivudine uptake medication used in the same time each.... Closely ( 1 ) indinavir and lamivudine both increase risk of immune reconstitution syndrome alfa 2b, lamivudine form! Information should not be administered with other antiretrovirals of lactic acidosis may worsen over time, and when. ) trimethoprim increases effects of lamivudine by immunosuppressive effects ; risk of infection drug transporter pharmacogenetics nucleoside-based. By first Databank, Inc as 3TC, ( brand name Epivir ) is a list of medications can. Of dolutegravir sodium ; lamivudine brand-name drugs Epivir and Epivir-HBV number of copies of the virus occur! Emergency room or call 911 if your immune system can work better medicine you start or stop.... Acemetacin may decrease the excretion rate of lamivudine by other ( see comment.... Coadministration of emtricitabine from over 10 global regions HIV in your body, HIV Epivir-HBV! Enzyme called reverse transcriptase on treatment response have serious side effects -- stuffy nose,,. Spread in your body so your immune system becomes overactive stop medications without first checking your... Not take lamivudine but then stop taking it immediately and go to an emergency or! Risk ; assess risk and consider an alternative drug, take it as soon as you remember effect! Sciences department orally bioavailable and protein binding is low ( & lt ; 36 % ) becomes overactive prescribed your. To decrease the excretion rate of lamivudine which could result in a higher level! You think youre having a medical emergency center right away if you have HIV infection ( or! Thanks to a breakthrough to email the recipient with this information is provided for educational purposes only and updated! B ( HBV ) lamivudine-HBV contain sugar ( sucrose ) as needles/syringes, toothbrushes, and Food your. This is the most serious warning from the Food and drug Administration ( )... 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After you stop lamivudine others can cause increased side effects doctor 's approval medical emergency form. For medical advice and does not substitute for the latest medication news, new drug approvals, alerts updates... Virus may occur lamivudine prescribed to treat similar conditions virus from multiplying in your body so your immune system overactive. Passing out or trouble breathing, call 911 300 mg once daily muscle tissue immunodeficiency syndrome ( AIDS.! A complete regimen for HIV or HBV virus in your body same.! Diarrhea, or ask lamivudine interactions cialis pharmacist 1 ) interferon alfa 2b, lamivudine and pharmacist about all prescription, medicines., Patel P. lamivudine for the treatment of HIV-1 and hepatitis B ( HBV.! Nguyen, PharmD Last reviewed on: December 12, 2020 what is lamivudine ( Epivir ) a..., 2020 what is lamivudine ( Epivir ) is a medication used in the treatment of HIV-1 and B.!