This drug is available at a middle level co-pay. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Copyright(c) 2023 First Databank, Inc. Pyrazinamide will not treat a viral infection such as the flu or a common cold. Also, pyrazinamide may cause laboratory test interference. Continue to take this medication (and other TB medications) until the full prescribed amount is finished, even if symptoms disappear. Pyrazinoic acid is hydroxylated to the main excretory product, 5-hydroxypyrazinoic acid. Reviewed By Dr. Ashish Ranjan MD (Pharmacology), MBBS Last updated 26 Aug 2022 | 10:13 PM (UTC) We provide you with authentic, trustworthy and revelant information Want to know more Available Medicine for Pyrazinamide Pyzina Lupin Ltd 48 to 105 4 variant (s) P Zide Cadila Pharmaceuticals Ltd 45 to 96 4 variant (s) Tuberculosis must be treated over a long period of time (up to 6 months or longer). Do not double the dose to catch up.If you are taking this drug on a weekly schedule and miss a dose, take it as soon as you remember if it is on the same day. Copyright: Merative US L.P. 1973, 2023. Discontinue riluzole if clinical signs of liver dysfunction are present. [30005], Optimal pyrazinamide dosing for obesity is not established. [61094] The FDA-approved dose is 15 to 30 mg/kg/dose PO once daily or 50 to 75 mg/kg/dose PO twice weekly. These drugs are often used together for the treatment of active tuberculosis (TB) infection, and patients should also be assessed for additional risk factors for hepatotoxicity, such as other hepatotoxic drugs, alcohol use, and underlying hepatic disease. All rights reserved. (Moderate) Careful monitoring of hepatic function is recommended with the concurrent use of rifampin and pyrazinamide, PZA. Patients with concomitant HIV infection may require longer courses of therapy. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Our datasets provide approved product information including: Access drug product information from over 10 global regions. However, if it is almost time for the next dose, skip the missed dose and take only your regularly scheduled dose. You are being redirected to Mark the days on the calendar when you need to take the medication. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. If you notice other effects not listed above, contact your doctor or pharmacist. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever that doesn't go away, new or worsening lymph node swelling, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Either increases toxicity of the other by Other (see comment). US-based MDs, DOs, NPs and PAs in full-time patient practice can register for free on PDR.net. The usual dose is 15 to 30 milligrams (mg) of pyrazinamide per kilogram (kg) (6.8 to 13.6 mg per pound) of body weight once a day; or 50 to 70 mg per kg (22.7 to 31.8 mg per pound) two times a week or three times a week, depending on the schedule your doctor chooses for you. A case reported demonstrated a decrease in cyclosporine plasma levels after pyrazinamide was added onto a renal transplant patient's therapy. [, Zimhony O, Vilcheze C, Arai M, Welch JT, Jacobs WR Jr: Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli. SIDE EFFECTS: Nausea, vomiting, loss of appetite, or mild muscle/joint pain may occur. Monitor for evidence of hepatotoxicity if coadministration is necessary. Follow your doctor's instructions about any restrictions on food, beverages, or activity. Allopurinol: (Minor) Because pyrazinamide, PZA can increase serum uric acid levels and precipitate gouty attacks, the dosages of antigout agents, including allopurinol, may need to be adjusted. This is not a complete list of possible side effects. Do not take a double dose to make up for a missed one. Pyrazinamide has the . However, some people take the medicine only 2 times per week. Pyrazinamide is given in combination with other medications and should not be used alone. Take with or without food. Either increases toxicity of the other by pharmacodynamic synergism. Pyrazinamide was not carcinogenic in rats or male mice and no conclusion was possible for female mice due to insufficient numbers of surviving control mice. Pexidartinib can cause hepatotoxicity. Pyrazinamide frequently will be an important component of such therapy. Pyrazinamide should be used with caution in patients with a history of diabetes mellitus, as management may be more difficult. This medicine can cause unusual results with certain medical tests. Baseline liver function studies [especially ALT (SGPT), AST (SGOT) determinations] and uric acid levels should be determined prior to therapy. Pyrazinamide is an antibiotic that fights bacteria. Mark the days on the calendar when you need to take the medication.Continue to take this medication (and other TB medications) until the full prescribed amount is finished, even if symptoms disappear. Do not take more or less of it or take it more often than prescribed by your doctor. provider for the most current information. Compare formulary status to other drugs in the same class. Description Clinical Pharmacology Indications and Usage Contraindications Warnings Precautions Patient Counseling Information Adverse Reactions/Side Effects Overdosage Dosage and Administration How Supplied/Storage and Handling References Pyrazinamide Description Pyrazinamide, the pyrazine analogue of nicotinamide, is an antituberculous agent. Antituberculosis agent; useful when resistance to isoniazid or rifampin has been confirmed; used in combination with other agents. Pyrazinamide also inhibits the tubular secretion of uric acid.M. Pyrazinamide is generally recommended as part of the initial 2-month intensive phase as first-line therapy. If you become pregnant while taking pyrazinamide, call your doctor. A: Generally acceptable. Dosage is based on your age, weight, medical condition, and response to treatment. Keep this medication in the container it came in, tightly closed, and out of reach of children. These drugs are often used together for the treatment of active tuberculosis (TB) infection, and patients should also be assessed for additional risk factors for hepatotoxicity, such as other hepatotoxic drugs, alcohol use, and underlying hepatic disease. Directly observed therapy (DOT) is recommended for all children, adolescents, and adults living with HIV and any regimen consisting of intermittent therapy. Information is also available online at https://www.poisonhelp.org/help. Do not start, stop, or change the dosage of any medicines without your doctor's approval.This medication may interfere with certain laboratory tests (including urine ketone tests), possibly causing false test results. Gout (see PRECAUTIONS). Drug created at June 13, 2005 13:24 / Updated at June 08, 2023 10:19, Structured drug data for data science & ML, Clinical intelligence tool for your software, Search for drug interactions with our API, Get drug allergy and cross sensitivities info. During pregnancy, this medication should be used only when clearly needed. 4 UNI | 4.95 per 1UNI. Starke JR. Multidrug therapy for tuberculosis in children. It is a white crystalline powder, stable at room temperature, and sparingly soluble in water. Tell your doctor right away if you have any serious side effects, including: symptoms of liver disease (such as nausea/vomiting that doesn't stop, unusual tiredness/ weakness, severe stomach /. If you are taking this medication daily, take it at the same time each day. **In persons older than 60 yrs of age the daily dose of streptomycin should be limited to 10 mg/kg with a maximal dose of 750 mg. Pyrazinamide Tablets, USP 500 mg are round, white, scored tablets, debossed "N" above the score and "484" below the score. National Cancer Institute Carcinogenesis Technical Report Series No. Latent TB Infection. Either increases toxicity of the other by pharmacodynamic synergism. Pyrazinamide has been found in small amounts in breast milk. In vitro and in vivo, the drug is active only at a slightly acid pH. You should confirm the information on the PDR.net site through independent sources and seek other professional guidance in all treatment and diagnosis decisions. Each drug has the potential to cause hepatotoxicity, and hepatotoxicity risk may be increased with concomitant use. [61094] The FDA-approved dose is 15 to 30 mg/kg/dose (lean body weight) PO once daily (Max: 3 g/day) or 50 to 75 mg/kg/dose (lean body weight) PO twice weekly. Use Caution/Monitor. Each drug has the potential to cause hepatotoxicity, and hepatotoxicity risk may be increased with concomitant use. The amount of medicine that you take depends on the strength of the medicine. (The current recommendation of the CDC for drug-susceptible disease is to use a six-month regimen for initial treatment of active tuberculosis, consisting of isoniazid, rifampin and Pyrazinamide given for 2 months, followed by isoniazid and rifampin for 4 months. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. This survey is being conducted by the WebMD marketing sciences department. GI disturbances including nausea, vomiting and anorexia have also been reported. to a friend, relative, colleague or yourself. Generic name: pyrazinamide [peer-a-ZIN-a-mide] If you are taking this medication daily, take it at the same time each day. Any adverse event leading to hospitalization or death should be reported to local or state health departments as well as the FDA MedWatch program. Copyright 1996-2023 Cerner Multum, Inc. Oleh karena itu, minumlah pirazinamid secara teratur. Stopping the medication too early or skipping doses may allow the bacteria to continue to grow, which may result in a return of the infection and cause the infection to be more difficult to treat (resistant).Tell your doctor if your condition lasts or gets worse. This drug is available at the lowest co-pay. These drugs may be used together for the treatment of active tuberculosis (TB) infection, and patients should also be assessed for additional risk factors for hepatotoxicity, such as other hepatotoxic drugs, alcohol use, and underlying hepatic disease. Store at room temperature away from light and moisture. [61094], 1 g PO once daily or 5 days/week, or alternatively, 1.5 g PO 3 days/week or 2 g PO twice weekly. It has no other indicated medical uses. The FDA-approved dose is 15 to 30 mg/kg/dose (lean body weight) PO once daily (Max: 3 g/day) or 50 to 75 mg/kg/dose (lean body weight) PO twice weekly. Any adverse event leading to hospitalization or death should be reported to local or state health departments as well as the FDA MedWatch program. TB can be an opportunistic infection (OI) of HIV. *Doses based on weight should be adjusted as weight changes. Rifampin belongs to the class of medicines called antibiotics and works to kill or prevent the growth of bacteria. 4-month daily regimen of rifampin (RIF) (4R) 3-month daily regimen of isoniazid (INH) and RIF (3HR) 6- or 9-month daily regimen of INH (6H or 9H) , with pyridoxine (vitamin B6) supplementation. Pyrazinamide diffuses into active M. tuberculosis that express pyrazinamidase enzyme that converts pyrazinamide to the active form pyrazinoic acid. 40 mg/kg/dose PO once daily has been used off-label. These drugs are often used together for the treatment of active tuberculosis (TB) infection, and patients should also be assessed for additional risk factors for hepatotoxicity, such as other hepatotoxic drugs, alcohol use, and underlying hepatic disease. Otherwise, call a poison control center right away. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Make sure laboratory personnel and all your doctors know you use this drug. Acyclovir may decrease the excretion rate of Pyrazinamide which could result in a higher serum level. For the treatment of drug-susceptible tuberculosis infection in persons without HIV as part of traditional combination therapy. This content does not have an English version. tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially allopurinol (Zyloprim), colchicine and/or probenecid (Col-Probenecid, Benemid), ethionamide (Trecator-SC), and vitamins. Do not double the dose to catch up. Follow patients with preexisting liver disease or those at increased risk for drug-related hepatitis (e.g., alcoholism) closely. [30005]Adult patients [34362] [61094] [65465]CrCl 30 mL/minute or more: No dosage adjustment needed.CrCl less than 30 mL/minute: 25 to 40 mg/kg/dose PO 3 days/week. Pexidartinib can cause hepatotoxicity. Discuss the risks and benefits with your doctor before breast-feeding. Comment: Both drugs have potential to increase hepatic enzymes; monitor LFTs. Common side effects may include: joint . Indications for: Pyrazinamide Susceptible pulmonary tuberculosis. Those patients with preexisting liver disease or those at increased risk for drug related hepatitis (e.g., alcohol abusers) should be followed closely. If it is near the time of the next dose, skip the missed dose. All rights reserved. Separate multiple email address with a comma. What should I know about storage and disposal of this medication? US residents can call their local poison control center at 1-800-222-1222. Store at 20 to 25C (68 to 77F) [See USP Controlled Room Temperature]. Pyrazinamide, the pyrazine analogue of nicotinamide, is an antituberculous agent. For intermittent supervised 2-mth treatment: <50 kg: 2 g 3 times weekly; 50 kg: 2.5 g 3 times weekly. Hepatotoxicity appears to be dose related, and may appear at any time during therapy. Copyright, 2023. Plasma concentrations generally range from 30 to 50 mcg/mL with doses of 20 to 25 mg/kg. [34362] [61094] The FDA-approved dose is 15 to 30 mg/kg/dose PO once daily or 50 to 75 mg/kg/dose PO twice weekly. Store it at room temperature and away from excess heat and moisture (not in the bathroom). [53484], 2 g PO once daily. Pyrazinamide is generally recommended as part of the initial 2-month intensive phase as first-line therapy. Plasma concentrations generally range from . Avoid or Use Alternate Drug. Pyrazinamide has been used extensively in high-burden countries for many years. Applies only to oral form of both agents. Do not use this medicine in larger or smaller amounts or for longer than recommended. Lab and/or medical tests (such as sputum test, kidney/liver function, uric acid levels, complete blood count) should be done while you are taking this medication. Pyrazinamide is available in generic form. How should this medicine be used? Pediatric patients [32569]40 mg/kg/dose PO 3 days/week. Enter your medication into the WebMD interaction checker, Surviving Respiratory Syncytial Virus (RSV). informational and educational purposes only. Continuous renal replacement therapy (CRRT)NOTE: Various CRRT modalities include continuous venovenous hemofiltration (CVVH), continuous venovenous hemodialysis (CVVHD), continuous venovenous hemodiafiltration (CVVHDF), continuous venovenous high-flux hemodialysis (CVVHFD), continuous arteriovenous hemofiltration (CAVH), continuous arteriovenous hemodialysis (CAVHD), and continuous arteriovenous hemodiafiltration (CAVHDF). , weight, medical condition, and out of reach of children muscle/joint pain may occur near time... 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Obesity is not established Careful monitoring of hepatic function is recommended with the concurrent use rifampin!: //www.poisonhelp.org/help is 15 to 30 mg/kg/dose PO once daily has been confirmed ; used in combination with agents... A drain unless instructed to do so your medication into the WebMD interaction,. Tubular secretion of uric acid.M the calendar when you need to take the medicine local! Laboratory personnel and all your doctors know you use this drug a poison control center right away not the!