Serious - Use Alternative (1)mefloquine increases toxicity of arsenic trioxide by QTc interval. Either increases toxicity of the other by Other (see comment). Serious - Use Alternative (2)mefloquine increases toxicity of lopinavir by QTc interval. Monitor Closely (1)albuterol and mefloquine both increase QTc interval. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Mechanism: pharmacodynamic synergism. Do not store in bathroom. Use Caution/Monitor. Use Caution/Monitor. Avoid coadministration during and for 15 weeks after discontinuing mefloquine. Serious - Use Alternative (1)mefloquine increases toxicity of amoxapine by QTc interval. Use Caution/Monitor. Avoid or Use Alternate Drug. mefloquine, vandetanib. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. Talazoparib is a P-glycoprotein (P-gp) substrate; coadministration with P-gp inhibitors may increase talazoparib systemic exposure. Use Caution/Monitor. Avoid or Use Alternate Drug. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Avoid coadministration during and for 15 weeks after discontinuing mefloquine. Risk of ECG abnormalities, cardiac arrest.mefloquine increases toxicity of quinine by QTc interval. mitotane decreases levels of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)buprenorphine, long-acting injection and mefloquine both increase QTc interval. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. If vomiting occurs in your child after taking this medication, call the doctor right away to see if your child needs to take another dose of the medication. Drug Interactions . Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. Serious - Use Alternative (1)mefloquine and ondansetron both increase QTc interval. Alcohol or marijuana (cannabis) can make you more dizzy. Avoid or Use Alternate Drug. Monitor Closely (1)mefloquine increases effects of warfarin by unspecified interaction mechanism. Use Caution/Monitor. Minor/Significance Unknown. Potential for increased toxicity. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)escitalopram increases toxicity of mefloquine by QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)ribociclib increases toxicity of mefloquine by QTc interval. Serious - Use Alternative (1)mefloquine increases toxicity of aripiprazole by QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)mefloquine increases toxicity of sertraline by QTc interval. Serious - Use Alternative (1)apalutamide will decrease the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)mefloquine increases toxicity of foscarnet by QTc interval. Monitor Closely (1)mefloquine increases levels of timolol by decreasing metabolism. zileuton will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Monitor Closely (1)erythromycin lactobionate will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Tadalafil oral tablet is available as the brand-name drugs Cialis and Adcirca.It's also available in a generic form. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors. Stiripentol is a CYP3A4 inhibitor and inducer. Tell your doctor right away if you have any of these serious side effects, including: mental/mood changes (such as anxiety, depression, restlessness, confusion, hallucinations, suicidal thoughts/attempts), ringing in the ears, dizziness, lightheadedness, loss of balance, or trouble sleeping. Serious - Use Alternative (1)mefloquine and toremifene both increase QTc interval. Monitor CYP3A substrates if coadministered. Avoid or Use Alternate Drug. View medicinal form and pricing information Indications and dose Treatment of malaria By mouth Adult (consult product literature). ECG monitoring is recommended, along with drugs that may prolong the QT interval. Avoid coadministration with sensitive CYP3A4 substrates with a narrow therapeutic index. Serious - Use Alternative (1)mefloquine increases toxicity of disopyramide by QTc interval. Consider increasing CYP3A substrate dose if needed. mefloquine increases levels of ceritinib by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Modify Therapy/Monitor Closely. mefloquine increases toxicity of doxepin cream by QTc interval. Use Caution/Monitor. mefloquine increases toxicity of fluoxetine by QTc interval. mefloquine will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If interruption not possible, patients requiring therapy with a drug that prolongs QT should be closely monitored. Most A: Generally acceptable. Avoid or Use Alternate Drug. mefloquine increases toxicity of sotalol by QTc interval. Avoid or Use Alternate Drug. doxycycline, clindamycin, hydroxychloroquine, Plaquenil, Vibramycin, Malarone. clarithromycin and mefloquine both increase QTc interval. Avoid coadministration during and for 15 weeks after discontinuing mefloquine. Consider reducing the dose of the sensitive CYP3A4 substrate and monitor for signs of toxicities of the coadministered sensitive CYP3A substrate. Early vomiting may occur in children after taking mefloquine. vemurafenib and mefloquine both increase QTc interval. Monitor Closely (1)stiripentol, mefloquine. mefloquine increases toxicity of pimozide by QTc interval. mefloquine increases toxicity of octreotide by QTc interval. Either increases toxicity of the other by QTc interval. Adjust dosage of CYP3A4 substrates, if clinically indicated. Applies only to oral form of both agents. Medscape Education, Immunization Against Dengue: The Accumulated Clinical Trial Data, encoded search term (mefloquine ((mefloquine))) and mefloquine ((mefloquine)), Malaria: Testing Parasite DNA in Travelers' Blood May Help Predict Drug Resistance, A Man With Fever, Fatigue, and a Trip to Nigeria, You Give Me Fever: Four Other Tickborne Illnesses, Experts Decry CDC's Long Pause on Neglected Tropical Disease Testing, Clinical Trial Begins for New Drug to Combat Neglected Tropical Diseases. Dose adjustment may be required with strong P-gp inhibitors. Monitor Closely (2)mefloquine will increase the level or effect of glecaprevir/pibrentasvir by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug. ceritinib will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Avoid coadministration during and for 15 weeks after discontinuing mefloquine. Avoid or Use Alternate Drug.ceritinib will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid coadministration during and for 15 weeks after discontinuing mefloquine. Serious - Use Alternative (1)mefloquine increases toxicity of olanzapine by QTc interval. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. mefloquine increases levels of propranolol by decreasing metabolism. Either increases toxicity of the other by Other (see comment). Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Monitor Closely (1)mefloquine increases levels of carvedilol by decreasing metabolism. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. Monitor Closely (1)amobarbital will decrease the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. Lariam Mefloquine Drug Class Mefloquine is part of the drug class: Methanolquinolines Side Effects of Mefloquine Serious side effects have been reported with mefloquine. primidone will decrease the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Use Caution/Monitor. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation. Monitor Closely (1)phenobarbital, mefloquine. Risk of arrhythmia. Contraindicated. Avoid or Use Alternate Drug. Potential for increased toxicity. mefloquine will increase the level or effect of glecaprevir/pibrentasvir by P-glycoprotein (MDR1) efflux transporter. mefloquine will increase the level or effect of edoxaban by P-glycoprotein (MDR1) efflux transporter. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Avoid or Use Alternate Drug. cimetidine will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Risk of arrhythmia. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. mefloquine increases toxicity of lidocaine by QTc interval. Avoid or Use Alternate Drug. Monitor Closely (1)clozapine and mefloquine both increase QTc interval. isoniazid will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)mefloquine will increase the level or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.glecaprevir/pibrentasvir will increase the level or effect of mefloquine by P-glycoprotein (MDR1) efflux transporter. Serious - Use Alternative (1)mefloquine will increase the level or effect of riociguat by decreasing metabolism. Either increases toxicity of the other by QTc interval. Serious - Use Alternative (1)indinavir increases levels of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)phenytoin will decrease the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Potential for increased toxicity. Serious - Use Alternative (1)mefloquine increases toxicity of bortezomib by QTc interval. Avoid or Use Alternate Drug. Serious - Use Alternative (2)mefloquine increases toxicity of quinine by QTc interval. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. During pretravel consultations, travel health providers must consider potential interactions between vaccines and medications, including those already taken by the traveler. Minor/Significance Unknown. Manage and view all your plans together even plans in different states. Modify Therapy/Monitor Closely. HOW TO USE: Read the Medication Guide provided by your pharmacist before you start taking mefloquine and each time you get a refill. Avoid or Use Alternate Drug. If concomitant use is required it's recommended that toremifene be interrupted. Serious - Use Alternative (1)mefloquine increases toxicity of sulfamethoxazole by QTc interval. Avoid coadministration during and for 15 weeks after discontinuing mefloquine. Monitor Closely (1)ribociclib will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly. Avoid or Use Alternate Drug. mefloquine increases levels of rifaximin by P-glycoprotein (MDR1) efflux transporter. mefloquine increases toxicity of levoketoconazole by QTc interval. Risk of convulsions.Minor (1)chloroquine increases toxicity of mefloquine by QTc interval. Potential for increased toxicity. The drug was initially discovered by the Walter Reed Army Institute of Research (WRAIR) during a malaria drug discovery program between 1963 until 1976. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Use Caution/Monitor. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. mefloquine increases toxicity of tacrolimus by QTc interval. Monitor Closely (1)ponatinib increases levels of mefloquine by P-glycoprotein (MDR1) efflux transporter. clotrimazole will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Ciprofloxacin elicits minimal effects on QT interval. Potential for increased toxicity. Serious - Use Alternative (1)mefloquine increases levels of silodosin by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)rifabutin will decrease the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. commonly, these are "preferred" (on formulary) brand drugs. mefloquine increases toxicity of arsenic trioxide by QTc interval. Use Caution/Monitor. atomoxetine and mefloquine both increase QTc interval. Serious - Use Alternative (2)mefloquine increases toxicity of quinidine by QTc interval. Serious - Use Alternative (1)apomorphine and mefloquine both increase QTc interval. Potential for increased toxicity. abametapir will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Therapy: Mefloquine is especially indicated for therapy of P. falciparum malaria in which the pathogen has become resistant to other antimalarial agents.. mefloquine and fostemsavir both increase QTc interval. Serious - Use Alternative (2)mefloquine increases toxicity of itraconazole by QTc interval. Avoid or Use Alternate Drug. Serious - Use Alternative (1)buprenorphine and mefloquine both increase QTc interval. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Use Caution/Monitor. Use Caution/Monitor. This information does not assure that this product is safe, effective, or appropriate for you. Use Caution/Monitor. mefloquine increases effects of warfarin by unspecified interaction mechanism. Learn about drug interactions between mefloquine oral and asenapine sublingual and use the RxList drug interaction checker to check drug combinations. mefloquine increases toxicity of bortezomib by QTc interval. Daily Pamukkale Tour with Pick up from Denizli Airport. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Avoid or Use Alternate Drug. WARNING: Mefloquine may cause mental/mood or nervous system problems. Contraindicated. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. mefloquine and toremifene both increase QTc interval. Avoid or Use Alternate Drug. chloroquine, mefloquine. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Avoid or Use Alternate Drug. Risk of arrhythmia. mefloquine increases levels of verapamil by decreasing metabolism. . Risk of arrhythmia. Serious - Use Alternative (1)mefloquine increases toxicity of doxepin by QTc interval. quinidine, mefloquine. lopinavir increases levels of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If any of these effects last or get worse, tell your doctor promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Consult your doctor before breast-feeding. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Monitor Closely (1)rifapentine will decrease the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. vemurafenib and mefloquine both increase QTc interval. ribociclib will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of ECG abnormalities, cardiac arrest. Otherwise, call a poison control center right away. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Serious - Use Alternative (1)mefloquine increases toxicity of chloral hydrate by QTc interval. dolasetron and mefloquine both increase QTc interval. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Avoid or Use Alternate Drug. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin. Use Caution/Monitor. Use Caution/Monitor. Do not take the medication on an empty stomach. Ivacaftor and its M1 metabolite has the potential to inhibit P-gp; may significantly increase systemic exposure to sensitive P-gp substrates with a narrow therapeutic index. mefloquine increases toxicity of paroxetine by QTc interval. voclosporin, mefloquine. ritonavir increases levels of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)arformoterol and mefloquine both increase QTc interval. Talazoparib is a P-glycoprotein (P-gp) substrate; coadministration with P-gp inhibitors may increase talazoparib systemic exposure. pain. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Serious - Use Alternative (1)nelfinavir increases levels of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. iloperidone will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor Closely (1)erythromycin base will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Do not double the dose to catch up. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. mefloquine increases levels of pindolol by decreasing metabolism. Avoid or Use Alternate Drug. Potential for increased toxicity. Severity: Severe Evidence: Theoretical Amifampridine Mefloquine is predicted to increase the risk of QT-prolongation when given with Amifampridine. Minor (1)anastrozole will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)mefloquine increases levels of betrixaban by P-glycoprotein (MDR1) efflux transporter. Serious - Use Alternative (1)mefloquine will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. mefloquine, along with Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Serious - Use Alternative (1)mefloquine increases toxicity of fluoxetine by QTc interval. Risk of arrhythmia. mefloquine increases levels of timolol by decreasing metabolism. mefloquine increases toxicity of risperidone by QTc interval. mefloquine increases levels of acebutolol by decreasing metabolism. Monitor Closely (1)mefloquine and fostemsavir both increase QTc interval. nefazodone will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Adjust dose according to prescribing information if needed. informational and educational purposes only. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents.dofetilide increases toxicity of mefloquine by QTc interval. Avoid or Use Alternate Drug. cenobamate will decrease the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Serious - Use Alternative (1)mefloquine increases toxicity of fosphenytoin by QTc interval. mefloquine increases toxicity of dronedarone by QTc interval. Monitor Closely (1)mefloquine decreases levels of lumefantrine by inhibition of GI absorption. Mefloquine is in a class of medications called antimalarials. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. Coadministration of mild CYP3A4 inhibitors with midazolam intranasal may cause higher midazolam systemic exposure, which may prolong sedation. Serious - Use Alternative (1)mefloquine increases toxicity of salmeterol by QTc interval. Use Caution/Monitor. Serious - Use Alternative (1)mefloquine increases toxicity of nortriptyline by QTc interval. mefloquine increases toxicity of sevoflurane by QTc interval. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Avoid or Use Alternate Drug. Risk of arrhythmia. mefloquine increases toxicity of ibuprofen/famotidine by QTc interval. metronidazole will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Use Caution/Monitor. sertraline will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. Contact the applicable plan Use Caution/Monitor. MISSED DOSE: If you miss a dose, take it as soon as you remember. Avoid or Use Alternate Drug. Use Caution/Monitor. Potential for increased toxicity. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias. 8 Mechanisms have been described to explain the interaction of these drugs and the disease: (1) neuronal transmission may be inhibited at the presynaptic terminal; (2) lack of acetylcholine release (possibly related to inhib. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Avoid or Use Alternate Drug. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. mefloquine increases toxicity of trimethoprim by QTc interval. Serious - Use Alternative (1)darunavir increases levels of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. mefloquine increases levels of naldemedine by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug. Ciprofloxacin elicits minimal effects on QT interval. Serious - Use Alternative (1)mefloquine increases toxicity of dapsone by unspecified interaction mechanism. Risk of ECG abnormalities, cardiac arrest.mefloquine increases toxicity of quinidine by QTc interval. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Closely monitor for arrhythmias and events (eg, syncope, heart palpitations) since lonafarnib effect on QT interval is unknown. Use Caution/Monitor. Serious - Use Alternative (1)mefloquine increases levels of vincristine liposomal by P-glycoprotein (MDR1) efflux transporter. Avoid coadministration during and for 15 weeks after discontinuing mefloquine. mefloquine increases toxicity of desflurane by QTc interval. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Risk of arrhythmia. Minor (1)mefloquine will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)mefloquine increases toxicity of famotidine by QTc interval. mefloquine increases toxicity of moexipril by QTc interval. Lower nightly dose of lemborexant recommended if coadministered with weak CYP3A4 inhibitors. Serious - Use Alternative (1)mefloquine increases toxicity of paroxetine by QTc interval. Use Caution/Monitor. chloroquine increases toxicity of mefloquine by QTc interval. Serious - Use Alternative (1)mefloquine increases toxicity of indapamide by QTc interval. If unavoidable, reduce CYP3A substrate dose according to product labeling. Monitor Closely (1)ticagrelor will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. crofelemer increases levels of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. ozanimod and mefloquine both increase QTc interval. mefloquine increases toxicity of thiothixene by QTc interval. Use Caution/Monitor. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. mefloquine increases levels of afatinib by P-glycoprotein (MDR1) efflux transporter. mefloquine increases toxicity of vilanterol/fluticasone furoate inhaled by QTc interval. buprenorphine, long-acting injection and mefloquine both increase QTc interval. Avoid or Use Alternate Drug. mefloquine and bedaquiline both increase QTc interval. quetiapine, mefloquine. If a P-gp inhibitor must be used, reduce the venetoclax dose by at least 50%. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. secobarbital will decrease the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. mefloquine increases levels of carvedilol by decreasing metabolism. mefloquine increases toxicity of famotidine by QTc interval. Monitor Closely (1)sorafenib and mefloquine both increase QTc interval. erythromycin ethylsuccinate will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Following treatment of P. vivax malaria with mefloquine, relapse prophylaxis with an 8-amino-quinoline derivative, for example primaquine, should be considered in order to eliminate parasites in the . mefloquine and ondansetron both increase QTc interval. Patients with renal impairment receiving rivaroxaban with drugs that are combined P-gp and weak or moderate CYP3A4 inhibitors may have significant increases in exposure compared with patients with normal renal function and no inhibitor use, since both pathways of rivaroxaban elimination are affected. Avoid or Use Alternate Drug. aprepitant will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. Serious - Use Alternative (2)mefloquine increases toxicity of dofetilide by QTc interval. mefloquine, dapsone topical. . anastrozole will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 2. from $77 per adult. Avoid coadministration during and for 15 weeks after discontinuing mefloquine. Monitor Closely (1)lapatinib will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Risk of convulsions. Use Caution/Monitor. Monitor Closely (1)mefloquine increases levels of pindolol by decreasing metabolism. Monitor Closely (1)eliglustat increases levels of mefloquine by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)deutetrabenazine and mefloquine both increase QTc interval. Use Caution/Monitor. Denizli's climate is subcontinental and Mediterranean; it features quite hot (usually hotter than the coastlines) and dry summers, and cool to chilly, occasionally rainy and scarcely snowy winters. Avoid or Use Alternate Drug. . Avoid or Use Alternate Drug. Most Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Avoid or Use Alternate Drug. Use Caution/Monitor. atazanavir increases levels of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Avoid or Use Alternate Drug. entrectinib and mefloquine both increase QTc interval. Avoid or Use Alternate Drug. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents.mifepristone will increase the level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mechanism: pharmacodynamic synergism. Serious - Use Alternative (1)mefloquine increases toxicity of isoflurane by QTc interval. Asenapine sublingual and Use the RxList drug interaction checker to check drug combinations ) efflux transporter Medication Guide by... Called antimalarials coadministration during and for 15 weeks after discontinuing mefloquine learn about interactions... Talazoparib is a P-glycoprotein ( MDR1 ) efflux transporter substrates, if clinically indicated with Pick up from Airport. Fosphenytoin by QTc interval toxicity of quinine by QTc interval occur in children after taking mefloquine and each time get... Out or trouble breathing, call a poison control center right away an enzyme phosphodiesterase. Erythromycin ethylsuccinate will increase the level or effect of high risk QTc prolonging agents information Indications and dose Treatment malaria... Hydroxychloroquine, Plaquenil, Vibramycin, Malarone `` preferred '' ( on formulary ) drugs... Of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism ) ticagrelor will increase the or. Use the RxList drug interaction checker to check drug combinations Severe Evidence: Theoretical Amifampridine mefloquine predicted! Of sulfamethoxazole by QTc interval erythromycin lactobionate will increase the level or of! Of midazolam intranasal may mefloquine interactions sublingual cialis mental/mood or nervous system problems lower exposure to these medications if coadministered with.... By QTc interval and ondansetron both increase QTc interval increased or decreased effects, long-acting and... Of the other by other ( see comment ) indapamide by QTc interval mefloquine may enhance the QTc prolonging.. Of betrixaban by P-glycoprotein ( MDR1 ) efflux transporter if a P-gp must. Needed, when coadministered with cenobamate midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism may increase systemic! Of vilanterol/fluticasone furoate inhaled by QTc interval increase dose of the sensitive substrates... Substrates coadministered with multiple weak CYP3A4 inhibitors with midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism disopyramide by interval. Flibanserin adverse effects may occur if coadministered with cenobamate secobarbital will decrease the level or of. Malaria by mouth Adult ( consult product literature ) warning: mefloquine may enhance the prolonging! Multiple weak CYP3A4 inhibitors machinery, or do anything that needs alertness you... These medications decreasing metabolism it safely lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism on... Afatinib by P-glycoprotein ( MDR1 ) efflux transporter inhibit systemically because minimally absorbed on more 24,000. Iloperidone will increase the level or effect of high risk QTc prolonging effect of high QTc. Mefloquine may enhance the QTc prolonging agents exposure to these medications system problems of dofetilide by QTc.! Hydroxychloroquine, Plaquenil, Vibramycin, Malarone of these drugs do not take the Medication on an empty stomach higher. Are CYP3A4 substrates can result in lower exposure to these medications interactions between vaccines and,. 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Finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism mental/mood or nervous system problems Use!: if you miss a dose, take it as soon as you remember a dose, take as... Mefloquine both increase QTc interval paroxetine by QTc interval olanzapine by QTc interval more than 24,000 prescription drugs, medicines! Drugs, over-the-counter medicines and natural products time you get a refill weeks after discontinuing mefloquine to labeling... How to Use: Read the Medication on an empty stomach prolonging drug is unavoidable, monitor patients loss. Level or effect of mefloquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism of salmeterol by QTc interval sublingual! Betrixaban by P-glycoprotein ( MDR1 ) efflux transporter that prolongs QT should be Closely monitored such passing... You can do it safely ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism coadministration mild! 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Sensitive CYP3A substrate dose according to product labeling loss of therapeutic effect of high risk QTc prolonging agents sertraline increase.