Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. Potentially fatal hypotension. For Which Indications Is Penile Rehabilitation Appropriate? tadalafil increases effects of bumetanide by pharmacodynamic synergism. Risk of hypotension. Risk of hypotension. Use Caution/Monitor. Use Caution/Monitor. Mechanism: additive vasodilation. Contraindicated (1)nitroglycerin topical, tadalafil. Monitor Closely (1)tadalafil increases effects of bisoprolol by pharmacodynamic synergism. tadalafil increases effects of silodosin by pharmacodynamic synergism. Monitor Closely (1)tadalafil increases effects of terazosin by pharmacodynamic synergism. Use Caution/Monitor. Serious - Use Alternative (1)fosamprenavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)tadalafil increases effects of doxazosin by pharmacodynamic synergism. Monitor Closely (1)stiripentol, tadalafil. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. If you have any questions, ask your doctor or pharmacist.Take this medication by mouth, with or without food, as directed by your doctor. Use Caution/Monitor. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. Avoid coadministration with sensitive CYP3A4 substrates with a narrow therapeutic index. Use Caution/Monitor. Symptoms of ED include. tadalafil increases effects of enalapril by pharmacodynamic synergism. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Use Caution/Monitor. tadalafil increases effects of sotalol by pharmacodynamic synergism. Monitor Closely (1)tadalafil increases effects of furosemide by pharmacodynamic synergism. Use Caution/Monitor. Ranolazine may theoretically increase plasma concentrations of CYP3A4 substrates, such as tadalafil. lopinavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Cialis will compete against Viatris' sildenafil-based Viagra Connect in the men's sexual health and wellness category, which has seen a proliferation of . Monitor Closely (1)quinupristin/dalfopristin will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Avoid combination in pulmonary HTN patients. Use Caution/Monitor. dasatinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Monitor Closely (1)duvelisib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Is there a reason I couldn't use Cialis in place of Adcirca? What Is Adcirca? It helps to relieve symptoms of BPH such as difficulty in beginning the flow of urine, weak stream, and the need to urinate often or urgently (including during the middle of the night). Potentially fatal hypotension. tadalafil increases effects of doxazosin by pharmacodynamic synergism. The recipient will receive more details and instructions to access this offer. Adcirca; Cialis; Descriptions. Use Caution/Monitor. tipranavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. crofelemer increases levels of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)tadalafil increases effects of clevidipine by pharmacodynamic synergism. eslicarbazepine acetate will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mechanism: additive vasodilation. Monitor Closely (1)lumefantrine will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. 4 UNI | 4.95 per 1UNI. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates. Monitor Closely (1)oxcarbazepine will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Avoid combination in pulmonary HTN patients. Mechanism: additive vasodilation. Risk of hypotension. Use Caution/Monitor. MISSED DOSE: If you are taking this medication on a regular schedule and you miss a dose, take it as soon as you remember. If you take it this way, you may attempt sexual activity at any time between your doses.If you are taking tadalafil to treat both ED and BPH, take it as directed by your doctor, usually once a day. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)dexamethasone will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. For patients with ED, monitor response to tadalafil carefully because of potential for decreased effectiveness. Use Caution/Monitor. tadalafil increases effects of eprosartan by pharmacodynamic synergism. Use Caution/Monitor. Monitor Closely (1)maraviroc, tadalafil. Serious - Use Alternative (1)voxelotor will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tadalafil increases effects of atenolol by pharmacodynamic synergism. Use Caution/Monitor. Monitor Closely (1)tadalafil increases effects of carvedilol by pharmacodynamic synergism. provider for the most current information. Risk of hypotension. Contraindicated. Monitor Closely (1)aprepitant will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. For patients with ED, monitor response to tadalafil carefully because of potential for decreased effectiveness. tazemetostat will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. cenobamate will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of hypotension. tadalafil increases effects of phentolamine by pharmacodynamic synergism. CYP3A4 inhibitors may reduce tadalafil clearance increasing systemic exposure to tadalafil; significantly increased levels may result in significant adverse events including severe hypotension, syncope, visual changes, and priapism. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. tadalafil increases effects of nadolol by pharmacodynamic synergism. Do not take tadalafil more often than once daily.The manufacturer directs to swallow this medication whole. Modify Therapy/Monitor Closely. Avoid combination in pulmonary HTN patients. Use Caution/Monitor. elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)tadalafil increases effects of phenoxybenzamine by pharmacodynamic synergism. Additive hypotensive effects. Mechanism: additive vasodilation. Avoid concurrent use of tadalafil for pulmonary HTN in patients taking strong CYP3A4 inhibitors. tadalafil increases effects of prazosin by pharmacodynamic synergism. tadalafil increases effects of phenoxybenzamine by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension. tadalafil increases effects of terazosin by pharmacodynamic synergism. This drug is available at a higher level co-pay. Consider dose reduction of the sensitive CYP3A4 substrate(s) if unable to avoid. Monitor Closely (1)tadalafil increases effects of candesartan by pharmacodynamic synergism. Use Caution/Monitor. Monitor Closely (1)rifampin will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Serious - Use Alternative (1)lopinavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. isosorbide dinitrate, tadalafil. Modify Therapy/Monitor Closely. CYP3A4 inhibitors may reduce tadalafil clearance increasing systemic exposure to tadalafil; significantly increased levels may result in significant adverse events including severe hypotension, syncope, visual changes, and priapism. aprepitant will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Avoid concurrent use of tadalafil for pulmonary HTN in patients taking strong CYP3A4 inhibitors. Use Caution/Monitor. Use Caution/Monitor. You have a slightly greater chance of developing NAION if you have heart disease, diabetes, high cholesterol, certain other eye problems ("crowded disk"), high blood pressure, if you are over 50, or if you smoke.Rarely, a sudden decrease or loss of hearing, sometimes with ringing in the ears and dizziness, may occur. Monitor Closely (1)tecovirimat will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tadalafil increases effects of propranolol by pharmacodynamic synergism. Brand names: Cialis, Adcirca. CYP3A4 inhibitors may reduce tadalafil clearance increasing systemic exposure to tadalafil; increased levels may result in increased associated adverse events. Other common adverse events (reported by 9% of patients on . nirmatrelvir/ritonavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor Closely (1)istradefylline will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. efavirenz will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Monitor Closely (1)tadalafil increases effects of bumetanide by pharmacodynamic synergism. If unavoidable, reduce CYP3A substrate dose according to product labeling. If not feasible, avoid use of abametapir. Use Caution/Monitor. Use Caution/Monitor. Uses Warnings Before taking Side effects Interactions Dosage FAQ Minor/Significance Unknown. Monitor Closely (1)tadalafil increases effects of sacubitril/valsartan by pharmacodynamic synergism. verapamil will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)nefazodone will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Elagolix is a weak-to-moderate CYP3A4 inducer. Mechanism: additive vasodilation. Monitor Closely (1)mitotane decreases levels of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Monitor Closely (1)tadalafil increases effects of torsemide by pharmacodynamic synergism. Stop tadalafil >24 hours prior to protease inhibitor (PI) initiation, restart 7 days after PI initiation at 20 mg once daily, and increase to 40 mg once daily based on tolerability. Risk of hypotension. For ED limit tadalafil to max of 2.5 mg/day (for daily use) or 10 mg dose every 72 hr (for use as needed). Information last revised May 2023. Avoid concurrent or sequential use to decrease risk for ototoxicity. Use Caution/Monitor. amifostine, tadalafil. Avoid combination in pulmonary HTN patients. Use Caution/Monitor. Use Caution/Monitor. The Cialis brand of tadalafil is used to treat erectile dysfunction and symptoms of benign prostatic hypertrophy (enlarged prostate).. What Are Side Effects of Adcirca? Risk of hypotension. Contraindicated (1)nitroglycerin PO, tadalafil. Monitor blood pressure response to phosphodiesterase type 5 (PDE5) inhibitors in patients receiving concurrent blood pressure lowering therapy. Voxelotor increases systemic exposure of sensitive CYP3A4 substrates. Stop tadalafil >24 hours prior to protease inhibitor (PI) initiation, restart 7 days after PI initiation at 20 mg once daily, and increase to 40 mg once daily based on tolerability. Avoid combination in pulmonary HTN patients. Therefore, the use of such combinations is not recommended ADVERSE REACTIONS. By inhibiting the effects of PDE5, medications such as Cialis relax and expand the blood vessels near the penis and increase blood flow, allowing for easier, more reliable erections. tadalafil increases effects of olmesartan by pharmacodynamic synergism. Use Caution/Monitor. Serious - Use Alternative (1)levoketoconazole will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. CYP3A4 substrates may require dosage adjustment. Use Caution/Monitor. Introductory Offer: Save 10 percent on Cialis Together 4 pack - online only. Risk of hypotension. Use Caution/Monitor. The penis is one of the areas where this . Serious - Use Alternative (1)erythromycin base will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Risk of hypotension. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. nefazodone will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. deferasirox will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. CYP3A4 inhibitors may reduce tadalafil clearance increasing systemic exposure to tadalafil; increased levels may result in increased associated adverse events. This drug is available at a middle level co-pay. tadalafil increases effects of nifedipine by pharmacodynamic synergism. Minor/Significance Unknown. Risk of hypotension. Refer to the prescribing information of PDE5 inhibitors for dose recommendations. Monitor Closely (1)tadalafil increases effects of amiloride by pharmacodynamic synergism. Risk of hypotension. Monitor Closely (1)tadalafil increases effects of labetalol by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Use Caution/Monitor. If it is near the time of the next dose, skip the missed dose. letermovir increases levels of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Alyq may also be used for purposes not listed in this medication guide. Adding plans allows you to compare formulary status to other drugs in the same class. Monitor Closely (1)sertraline will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of hypotension. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)marijuana will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. For patients with ED, monitor response to tadalafil carefully because of potential for decreased effectiveness. Contraindicated. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potentially fatal hypotension. Risk of hypotension. Monitor Closely (1)letermovir increases levels of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)tobramycin inhaled and tadalafil both increase nephrotoxicity and/or ototoxicity. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. amiodarone will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Difference between Cialis and Adcirca? Monitor Closely (1)tadalafil increases effects of metoprolol by pharmacodynamic synergism. Either increases effects of the other by additive vasodilation. For ED limit tadalafil to max of 2.5 mg/day (for daily use) or 10 mg dose every 72 hr (for use as needed). Use Caution/Monitor. acetazolamide will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Adjust tadalafil dose for PAH; if on Stribild, start tadalafil 20 mg/day; avoid tadalafil when starting Stribild; for ED, a single dose of tadalafil not exceeding 10 mg in 72 hr. Risk of hypotension. Therefore, the use of such combinations is not recommended ADVERSE REACTIONS. Risk of hypotension. Stiripentol is a CYP3A4 inhibitor and inducer. haloperidol will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Dose reduction may be needed for coadministered drugs that are predominantly metabolized by CYP3A. Use Caution/Monitor. Avoid combination in pulmonary HTN patients. Use Caution/Monitor. Serious - Use Alternative (1)clarithromycin will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Serious - Use Alternative (1)darunavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)etravirine will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of hypotension. Monitor Closely (1)tadalafil increases effects of enalapril by pharmacodynamic synergism. For patients with ED, monitor response to tadalafil carefully because of potential for decreased effectiveness. Use Caution/Monitor. CYP3A4 inhibitors may reduce tadalafil clearance increasing systemic exposure to tadalafil; increased levels may result in increased associated adverse events. tadalafil increases effects of irbesartan by pharmacodynamic synergism. Use Caution/Monitor. tadalafil increases effects of aliskiren by pharmacodynamic synergism. ritonavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)idelalisib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tadalafil increases effects of amiloride by pharmacodynamic synergism. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Contraindicated (1)nitroglycerin transdermal, tadalafil. Vision/Hearing: Patients who experience a sudden loss of vision in one or both eyes, which could be a sign of non-arteritic anterior ischemic optic neuropathy (NAION), or sudden decrease or loss of hearing after taking ADCIRCA should seek immediate medical attention Avoid combination in pulmonary HTN patients. Avoid concurrent use of tadalafil for pulmonary HTN in patients taking strong CYP3A4 inhibitors. Contraindicated (1)tadalafil, riociguat. Use Caution/Monitor. Risk of hypotension. The safety and efficacy of combinations of ADCIRCA with Cialis or other PDE-5is have not been studied. Adjust tadalafil dose for PAH; if on cobicistat, start tadalafil 20 mg/day and may increase up to 40 mg/day; avoid tadalafil when starting cobicistat; for ED, may take a single dose of tadalafil not exceeding 10 mg in 72 hr. For patients with ED, monitor response to tadalafil carefully because of potential for decreased effectiveness. Avoid concurrent use of tadalafil for pulmonary HTN in patients taking strong CYP3A4 inhibitors. Monitor Closely (1)tadalafil increases effects of amlodipine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. crizotinib increases levels of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Either increases effects of the other by additive vasodilation. Use Caution/Monitor. Use Caution/Monitor. nelfinavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. anastrozole will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)lonafarnib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. You may report side effects to Health Canada at 1-866-234-2345. Use Caution/Monitor. dronedarone will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. etravirine will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Cialis Together 10mg Tablets - Tadalafil - 4 Tablets. Use Caution/Monitor. Use Caution/Monitor. Risk of hypotension. Potentially fatal hypotension. Use Caution/Monitor. . Risk of hypotension. Monitor Closely (1)pazopanib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contact the applicable plan For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. restrictions. Stop tadalafil >24 hours prior to protease inhibitor (PI) initiation, restart 7 days after PI initiation at 20 mg once daily, and increase to 40 mg once daily based on tolerability. To help you remember, take it at the same time each day.Tell your doctor if your condition does not improve or if it worsens. Use Caution/Monitor. Mechanism: additive vasodilation. Use Caution/Monitor. being unable to get an erection at any time. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)tadalafil increases effects of timolol by pharmacodynamic synergism. tadalafil increases effects of acetazolamide by pharmacodynamic synergism. Monitor Closely (1)St John's Wort will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of hypotension. Use Caution/Monitor. Use Caution/Monitor. amyl nitrite, tadalafil. Combination may increase risk of orthostatic hypotension, tachycardia, dizziness and headache. I was reading This and I'm still confused. Use Caution/Monitor. Use Caution/Monitor. CYP3A4 inhibitors may reduce tadalafil clearance increasing systemic exposure to tadalafil; significantly increased levels may result in significant adverse events including severe hypotension, syncope, visual changes, and priapism. Contraindicated. Contraindicated (1)isosorbide dinitrate, tadalafil. posaconazole will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Serious - Use Alternative (1)ritonavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Monitor Closely (1)vardenafil, tadalafil. bicalutamide will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)erythromycin ethylsuccinate will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of hypotension. USES: Tadalafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). For patients with ED, monitor response to tadalafil carefully because of potential for decreased effectiveness. voriconazole will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tadalafil increases effects of minoxidil by pharmacodynamic synergism. Avoid or Use Alternate Drug. Use Caution/Monitor. budesonide will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid combination in pulmonary HTN patients. Risk of hypotension. Classes: PAH, PDE-5 Inhibitors; Phosphodiesterase-5 Enzyme Inhibitors Print Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths tablet. Monitor Closely (1)rufinamide will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 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