National Library of Medicine Coadministration of empagliflozin with diuretics results in increased urine volume and frequency of voids, which might enhance the potential for volume depletion. Effect of interaction is not clear, use caution. Keep this medication in the container it came in, and keep it tightly closed. In my own practice, I use hydralazine and nitrate combination for the Black patients with HFREF who remain symptomatic despite triple therapy with ACEi, betablockers, and mineralocorticoid inhibitors, provided that their systolic BP was >120mmHg. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)levalbuterol and hydrochlorothiazide both decrease serum potassium. Lomitapide dose should not exceed 30 mg/day. Minor/Significance Unknown. Either increases toxicity of the other by pharmacodynamic synergism. Hydralazine is used with or without other medications to treat high blood pressure. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts . Disclaimer. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Use Caution/Monitor. Effect of interaction is not clear, use caution. diazoxide, hydralazine. Use Caution/Monitor. Minor (1)hydrochlorothiazide decreases effects of acarbose by pharmacodynamic antagonism. ethacrynic acid and hydrochlorothiazide both decrease serum potassium. Use Caution/Monitor. Minor (1)hydrochlorothiazide will increase the level or effect of memantine by basic (cationic) drug competition for renal tubular clearance. mso-font-charset:78; Use Caution/Monitor. c) In the Ames reversion test all three drugs behaved as direct-acting mutagens of low potency, whose activity was not influenced by rat liver nor by mouse liver or lung S-9 fractions. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. indomethacin increases and hydrochlorothiazide decreases serum potassium. Potential additive hypercalcemia. mso-style-qformat:yes; mso-paper-source:0;} Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment. hydralazine, fenfluramine. ketorolac decreases effects of hydralazine by pharmacodynamic antagonism. Increased myelosuppressive effects. Mechanism: pharmacodynamic synergism. These observational studies showed low use of the combination even in the population from whom the evidence for its effectiveness was obtained, and with much lower effectiveness than that demonstrated in the randomized controlled trials, probably due to low adherence rate. mso-fareast-font-family:" "; Modify Therapy/Monitor Closely. tolvaptan increases and hydrochlorothiazide decreases serum potassium. hydrochlorothiazide decreases levels of magnesium sulfate by increasing renal clearance. flurbiprofen decreases effects of hydralazine by pharmacodynamic antagonism. font-family:Cambria; Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Use Caution/Monitor. Risk of alkalosis, hypercalcemia. hydralazine increases effects of atenolol by pharmacodynamic synergism. hydralazine increases effects of labetalol by pharmacodynamic synergism. Toxicity. Pexidartinib can cause hepatotoxicity. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose. Effect of interaction is not clear, use caution. hydralazine increases effects of sotalol by pharmacodynamic synergism. Minor (1)hydrochlorothiazide decreases effects of miglitol by pharmacodynamic antagonism. Hydralazine belongs to a group of drugs called peripheral vasodilator. Sympathomimetics can antagonize the activity of some antihypertensive agents. Minor/Significance Unknown. hydrochlorothiazide will increase the level or effect of memantine by basic (cationic) drug competition for renal tubular clearance. Adult Pediatric Patient Graphics Showing results for hydralazine Drugs used for the treatment of hypertensive emergencies sympathetic stimulation. carvedilol increases and hydrochlorothiazide decreases serum potassium. Sympathomimetics can antagonize the activity of some antihypertensive agents.ephedrine and hydrochlorothiazide both decrease serum potassium. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Minor (1)hydrochlorothiazide decreases effects of tolbutamide by pharmacodynamic antagonism. Use Caution/Monitor.Minor (1)chlorthalidone will increase the level or effect of hydrochlorothiazide by acidic (anionic) drug competition for renal tubular clearance. Additive photosensitizing effects. Minor/Significance Unknown. Use Caution/Monitor. hydrochlorothiazide will increase the level or effect of willow bark by acidic (anionic) drug competition for renal tubular clearance. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of hydrochlorothiazide by Other (see comment). etodolac decreases effects of hydralazine by pharmacodynamic antagonism. Minor/Significance Unknown. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. line-height:115%; hydralazine will increase the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. -->. Monitor Closely (2)ketorolac intranasal decreases effects of hydralazine by pharmacodynamic antagonism. 55).9. Minor/Significance Unknown. Effect of interaction is not clear, use caution. If coadministration of lonafarnib (a sensitive CYP3A substrate) with weak CYP3A inhibitors is unavoidable, reduce to, or continue lonafarnib at starting dose. Fentanyl may also lead to acute urinary retention by causing bladder sphincter spasm (particularly in men with enlarged prostates). Have your child avoid tasks or actions that call for alertness until you see how this drug affects your child. Use Caution/Monitor.Minor (1)pirbuterol, hydrochlorothiazide. Risk of hypertension. Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period. Use Caution/Monitor. Minor/Significance Unknown. Minor (1)hydrochlorothiazide increases levels of calcium acetate by decreasing renal clearance. Minor/Significance Unknown. Minor/Significance Unknown. Use Caution/Monitor. Minor/Significance Unknown. On the basis of the patients in the Get With The Guidelines Heart Failure (GWTGHF) registry, Khazanie et al.13 noted that amongst those older than 65years with HFREF, 22.7% were Black and 18.2% had estimated Glomerular Filtration Rate (eGFR)<30mL/min/1.73m2, the latter being a contraindication for the use of ACEi or ARB. Electrocardiographic changes and/or hypokalemia associated with non?potassium-sparing diuretics may worsen with concomitant beta-agonists, particularly if recommended dose is exceeded. valsartan increases and hydrochlorothiazide decreases serum potassium. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)hydrochlorothiazide decreases effects of exenatide injectable suspension by pharmacodynamic antagonism. Mechanism: pharmacodynamic synergism. mso-hansi-font-family:Cambria; Effect of interaction is not clear, use caution. hydralazine, phendimetrazine. Modify Therapy/Monitor Closely. hydrochlorothiazide decreases effects of tolazamide by pharmacodynamic antagonism. Minor/Significance Unknown. hydralazine, dexfenfluramine. Sympathomimetics can antagonize the activity of some antihypertensive agents. Monitor Closely (1)choline magnesium trisalicylate decreases effects of hydralazine by pharmacodynamic antagonism. Monitor Closely (2)aldesleukin increases effects of hydrochlorothiazide by pharmacodynamic synergism. Minor/Significance Unknown. You will need to talk about the benefits and risks to your child and the baby. Erectile dysfunction (ED) is often a symptom . Minor (1)prednisolone, hydrochlorothiazide. Careers, Unable to load your collection due to an error. Franciosa JA, Limas CJ, Guiha NH, Rodriguera E, Cohn JN. Mechanism: pharmacodynamic antagonism. Risk of hypotension. Effect of interaction is not clear, use caution. Survival in Black patients and White patients in the VHeFT II trial (from Carson et al.6). hydrochlorothiazide will increase the level or effect of mesalamine by acidic (anionic) drug competition for renal tubular clearance. mso-fareast-language:JA;} Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Have blood work checked if your child is on this drug for a long time. MeSH Mechanism: pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. hydrochlorothiazide decreases levels of trientine by increasing renal clearance. Mechanism: pharmacodynamic antagonism. Mechanism: pharmacodynamic synergism. Careers. NSAIDs decrease prostaglandin synthesis. Thiazide diuretics can decrease insulin sensitivity thereby leading to glucose intolerance and hyperglycemia. Use Caution/Monitor. Monitor Closely (1)cyclosporine increases toxicity of hydrochlorothiazide by unspecified interaction mechanism. Avoid or Use Alternate Drug. Use Caution/Monitor. Most Use Caution/Monitor.hydralazine increases effects of atenolol by pharmacodynamic synergism. hydralazine, ephedrine. Avoid or Use Alternate Drug. Comment: Diuretics may cause hyperglycemia and glycosuria in patients with diabetes mellitus, possibly by diuretic-induced hpokalemia. Use Caution/Monitor. Serious - Use Alternative (1)hydrochlorothiazide increases toxicity of cyclophosphamide by decreasing renal clearance. NSAIDs decrease prostaglandin synthesis. Use Caution/Monitor.lornoxicam decreases effects of hydralazine by pharmacodynamic antagonism. Both drugs lower blood pressure. Additive hypotensive effects. Applies only to oral form of both agents. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)dicloxacillin, hydrochlorothiazide. a) In mice, a single ip administration of the LD50 of the three drugs caused a small but statistically significant increase over controls in DNA elution rate, ie, a modest amount of DNA fragmentation, in three of the four organs (liver, lung, kidney, and spleen) tested, DNA damage being absent in lung for hydralazine and endralazine and in liver for dihydralazine. Minor (1)cortisone, hydrochlorothiazide. Use Caution/Monitor. Thiazide dosage >50 mg/day may increase blood glucose. It is not known if hydralazine crosses into human milk. Use Caution/Monitor. irbesartan increases and hydrochlorothiazide decreases serum potassium. Monitor Closely (2)acemetacin decreases effects of hydralazine by pharmacodynamic antagonism. Use Caution/Monitor. hydralazine increases effects of penbutolol by pharmacodynamic synergism. Risk of hypokalemia, especially with strong glucocorticoid activity. Comment: Increased risk of cardiac toxicity due to K+ depletion. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. However, the mortality rate was reduced in the group that received hydralazine and isosorbide dinitrate compared to the group on placebo. div.WordSection1 Comment: Theoretically, shepherd's purse may interfere with BP control.shepherd's purse, hydrochlorothiazide. Comment: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. Check with your pharmacist if you have questions about the best way to throw out drugs. Enhanced hypotensive effects; increased risk of nephrotoxicity. Minor/Significance Unknown. mycophenolate. Would you like email updates of new search results? Use Caution/Monitor.hydralazine, norepinephrine. Common side effects include dizziness, headache, tachycardia, orthostatic hypotension, flushing, nausea and gastrointestinal upset. Monitor Closely (1)hydrochlorothiazide will increase the level or effect of procainamide by basic (cationic) drug competition for renal tubular clearance. Monitor Closely (1)hydralazine, phenylephrine PO. Either increases toxicity of the other by pharmacodynamic synergism. Mechanism: pharmacodynamic synergism. Additive hypokalemic effects. Use Caution/Monitor. It may be given to your child for other reasons. Use Caution/Monitor. Comment: Potential for increased risk of hypotension with concurrent use. Monitor serum potassium during initiation and dosage adjustment of either finererone or weak CYP3A4 inhibitors. hydrochlorothiazide will increase the level or effect of acemetacin by acidic (anionic) drug competition for renal tubular clearance. mefenamic acid increases and hydrochlorothiazide decreases serum potassium. Applies only to oral form of both agents. Minor (1)hydrochlorothiazide will increase the level or effect of ganciclovir by acidic (anionic) drug competition for renal tubular clearance. hydralazine, bretylium. Minor/Significance Unknown. mso-font-pitch:variable; Monitor Closely (1)pirbuterol and hydrochlorothiazide both decrease serum potassium. hydralazine increases levels of ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of hypokalemia, especially with strong glucocorticoid activity. cornsilk increases effects of hydralazine by pharmacodynamic synergism. May increase the hypokalemic effects of thiazide diuretics. Careers. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)terbutaline and hydrochlorothiazide both decrease serum potassium. Minor/Significance Unknown. Each drug may increase the photosensitizing effect of the other. Risk of alkalosis, hypercalcemia. From diagnosis to treatment, our experts provide the care and support you need, when you need it. Effect of interaction is not clear, use caution. APO-HydrALAZINE; Apresoline; JAMP-HydrALAZINE; MINT-HydrALAZINE. hydrochlorothiazide will increase the level or effect of quinine by basic (cationic) drug competition for renal tubular clearance. Use Caution/Monitor. Possible enhanced electrolyte loss. Monitor Closely (1)hydralazine increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. FOIA Increased myelosuppression. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)hydrochlorothiazide increases toxicity of lily of the valley by Other (see comment). The baby competition for renal tubular clearance with enlarged prostates ) trientine by increasing renal clearance for 24 hr perioperative... Due to K+ depletion emergencies sympathetic stimulation hydralazine belongs to a group of drugs called vasodilator. Perioperative period: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone use Alternative 1. 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