Serotonin syndrome (serotonin toxicity). If you have unused medication that has passed the expiration date, ask your pharmacist how to properly dispose of it. If your symptoms are only partly relieved, or if your headache comes back, adults may take another dose at least 2 hours after the first dose. In doing this, they can avoid prescribing medications that could interact or cause compounding side effects. Place the tablet on your tongue and let it dissolve. Ergots are a class of drug that specifically relieves headache pain, including dihydroergotamine and ergotamine. Boyer EW. Rizatriptan may cause a serious condition called serotonin syndrome when taken with some medicines. Before taking Xanax, talk with your doctor and pharmacist. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks. Eletriptan (Relpax) break down through the same enzyme as clarithromycin (Biaxin), itraconozole, ketoconozole, nefazodone (Serzone), ritonovir, and troleandomycin. This medicine may increase your blood pressure. Things to remember when you fill your prescription. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Depression in women: Understanding the gender gap, Depression: Provide support, encouragement, Depression: Supporting a family member or friend, Headaches: Treatment depends on your diagnosis and symptoms, Male depression: Understanding the issues. Migraines: Are they triggered by weather changes? Can diet help improve depression symptoms? Xanax may not be right for you if you have certain medical conditions or other factors affecting your health. Xanax may also be used off-label for other conditions. Accessed Feb. 27, 2023. Taking Prescribed Medications With Phentermine While taking phentermine, there is always the possibility that you may need to take other prescription medications at the same time for any number of health issues. Since the start of, Vaccine side effects are a hot topicsomething that can lead to vaccine hesitancy but ultimately, save lives. Is It OK to Take All Your Medications at Once? Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. You can also visit this page to access Optum Perks coupons and get price estimates for Xanax when you use the coupons. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Discuss the use of grapefruit products with your doctor. Serotonin syndrome can cause changes to your mental state and other symptoms. BPH & Type II Diabetes at age 35. You can take Xanax on an empty stomach or after eating. Prompt treatment helps you return to your normal routine and may decrease your need for other pain medications. For information about the effectiveness of Xanax, see the Xanax uses section below. Doctors inject this treatment into head and neck muscles every three months. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Xanax is a type of drug called a benzodiazepine. You may feel more drowsy, dizzy, or tired if you take ALPRAZolam with alcohol. How long can you safely take xanax (alprazolam)? Corticosteroids like prednisolone and hydrocortisone should never be taken with CBD. Antiepileptic drugs and serotonin syndromeA systematic review of case series and case reports. Your doctor may prescribe Xanax with other drugs for generalized anxiety disorder or panic disorder. Some may be a better fit for you than others. When these drugs are taken with zolmitriptan, they raise the amount of zolmitriptan in the blood. 538 drugs And be sure to contact your provider if you notice any changes in your health. Avoiding these "triggers" may help lessen migraine attacks. People who suffer from severe headaches should probably avoid alcoholic beverages, especially during a headache. If the migraine comes back after being relieved, another dose may be taken 2 hours after the last dose. Follow all directions on your prescription label and read all medication guides or instruction sheets. Most experts agree that combining SSRIs and SNRIs with triptans is very safe. This can make you avoid situations or places you feel may trigger a panic attack. Doctors may sometimes prescribe Xanax with Adderall for people with ADHD who also have anxiety. For potential or actual medical emergencies, immediately call 911 or your local emergency service. Many people using this medication do not have serious side effects. Serotonin is a chemical found in your nervous system. To help make sure that you do not miss a dose, try using a medication reminder. (Clonazepam is also available as the brand-name drug Klonopin.). Follow your doctor's orders or the directions on the label. Yes, Xanax is classified as a Schedule IV controlled substance. Feb. 28, 2023. Copyright 1996-2023 Cerner Multum, Inc. include protected health information. * Xanax has boxed warnings from the Food and Drug Administration (FDA) for the risk of misuse and addiction and the risk of dependence and withdrawal. Check with your doctor if you or your child used this medicine and your migraine did not go away, or if your migraine got worse or started occurring more often. MAOIs and diet: Is it necessary to restrict tyramine? If you no longer need to take Xanax and have leftover medication, its important to dispose of it safely. To find out how the drug performed in clinical trials, see Xanaxs prescribing information. This registry monitors the health of people who are pregnant and take Xanax, and their babies. It is very important that your doctor check the progress of you or your child at regular visits. By boosting the effect of GABA, Xanax helps reduce nervous tension and feelings of anxiety. For these, please consult a doctor (virtually or in person). Drug interactions may change how your medications work or increase your risk for serious side effects. This is more likely to occur if you or a family member already has heart disease, if you have diabetes, high blood pressure, high cholesterol, if you smoke, if you are male and over 40 years of age, or if you are female and have gone through menopause. The current stance of the Food and Drug Administration (FDA) is to avoid taking expired medications. This system helps regulate breathing, actions, thinking, and more. Examples of other drugs that a doctor may prescribe for generalized anxiety disorder include: * Buspar, the brand-name version of buspirone, is no longer available. Xanax is FDA-approved to treat panic disorder, with or without agoraphobia, in adults. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). G Born 1948, wed 1969. Does rizatriptan oral interact with other drugs you are taking? These include your age, liver function, and other medications you may take. In children 6 to 17 years of age: it is not known if taking more than one dose of Maxalt in 24 hours is safe and effective. Activity of Xanax is more likely to be affected by race (people of Asian descent achieve higher concentrations and . However, if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away. ergot medicine--dihydroergotamine, ergotamine, ergonovine, methylergonovine. Alcohol and Xanax can reduce the activity of your central nervous system (CNS). In: Ferri's Clinical Advisor 2023. (For more information about side effects, see the Xanax side effects section above.). To learn about other mild side effects, talk with your doctor or pharmacist, or view Xanaxs prescribing information. For example, Xanax might be prescribed off-label for anxiety associated with: Xanax may also sometimes be prescribed off-label for sleep problems. Journal of Medical Case Reports. Generic Name (S): tizanidine View Free Coupon Uses This medication is used to treat muscle spasms caused by certain conditions (such as multiple sclerosis, spinal cord injury). If i take a Xanax (alprazolam) before sex, will it help reduce my sexual performance anxiety i've been having while my wife is on clomid? Learn all about preventive medications for migraine and how to create a preventive treatment strategy with, Therapy can help you manage migraine-related stress. Tell your doctor about all your other medicines, especially any type of antidepressant. They include strong prescription pain relievers, such as hydrocodone (Hysingla ER) and certain illegal drugs. Swallow the tablet whole with a glass of water. If you feel you need help avoiding alcohol while taking Xanax, talk with your doctor. Ask your doctor or pharmacist if you do not understand these instructions. Sedative and performance-impairing effects may occur sooner with Xanax, but dissipate quicker than with Ativan. Lasmiditan (Reyvow) is a new medication for acute migraine relief similar to triptans. Rizatriptan can raise blood pressure to dangerous levels. Use rizatriptan only if your condition has been confirmed by a doctor as migraine headaches. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect. These may include serious side effects, overdose, and addiction. Read and follow the instructions carefully. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). Antidepressants: Which cause the fewest sexual side effects? As sedatives, they have some uses in treating anxiety, but the two can cause slightly different side effects and interactions, and both can result in . This medicine usually comes with patient information leaflet. Check with your doctor right away if you have chest tightness, cough, difficulty swallowing, dizziness, fast heartbeat, hives, itching, skin rash, large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, or unusual tiredness or weakness. Tell your doctor about all your current medicines and any medicine you start or stop using. Accessed Feb. 27, 2023. Xanax XR works over about 24 hours, so youll likely take a dose once per day. They can tell you more. However, onabotulinumtoxinA can interact with certain antibacterial medications, muscle relaxants and anticholinergic drugs (used to treat many conditions, including urinary incontinence). For more details about how Xanax compares with Valium, see this article. To treat panic disorder in adults, the recommended starting dosage of Xanax is 0.5 mg three times per day. It typically takes between four and five half-lives for a drug to fully leave your system. Do not take more than one dose in any 24-hour period. This is especially the case if Xanax is taken with alcohol, illegal drugs, or other medications (especially opioids*). Lorazepam oral tablet is a generic prescription drug that's used to treat anxiety in certain situations. They also may be able to recommend tools that can make it simpler to open lids. For details, see the Xanax precautions section below. Triptans interact directly with some serotonin receptors in the brain. Examples of other drugs that may be prescribed for panic disorder include: You may wonder how Xanax compares with other medications that are prescribed for similar purposes, such as Valium. If youre interested in finding an alternative to Xanax, talk with your doctor. To learn more, see the Xanax precautions section below. We comply with the HONcode standard for trustworthy health information. You can learn more about your condition in the MNT anxiety hub and mental health hub. You can learn more about your condition in our anxiety hub and mental health hub. It eases anxiety by boosting the effect of GABA, a type of neurotransmitter in your brain. The researchers further warned that while the list may be used as a starting point to identify . A boxed warning is the most serious warning from the Food and Drug Administration (FDA). Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Off-label drug use is when a drug thats approved by the Food and Drug Administration (FDA) is prescribed for a purpose other than what its approved for. Portions of this document last updated: May 01, 2023, Original article: https://www.mayoclinic.org/drugs-supplements/rizatriptan-oral-route/side-effects/DRG-20065868. Learn about side effects, dosage, uses, and more. With dependence, your body becomes reliant on a drug to function as usual. It can also interact with certain supplements as well as certain foods. If youve had problems with drug or alcohol misuse or addiction in the past, you may have an increased risk of these problems with Xanax. American Migraine Foundation is a recognized public charity under Internal Revenue Code section 501(c)(3) status. Even if you get warning signals of a coming migraine (an aura), you should wait until the headache pain starts before using rizatriptan. The generic is considered to be as safe and effective as the original drug. Call your doctor at once if you have: weak or shallow breathing; a light-headed feeling, like you might pass out; a seizure; hallucinations, risk-taking behavior; increased energy, decreased need for sleep; racing thoughts, being agitated or talkative; Prednisone withdrawal: Why taper down slowly? This list does not contain all drugs that may interact with Xanax. There are many acute and preventive medications that can help you manage your migraine. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Do not take other medicines unless they have been discussed with your doctor. You should not stop your treatment suddenly. Xanax tablets are scored and can be split if your doctor or pharmacist advises this. Xanax comes as an oral tablet. Youll usually take Xanax three times per day. Typically, your doctor will start you on a low dosage. Children 12 years of age and older weighing 40 kilograms (kg) or more10 mg placed on the tongue as needed. * Xanax has a boxed warning about the risk of dependence and withdrawal. * Xanax has a boxed warning about the risk of misuse and addiction. This could include other benzodiazepines. This drug has boxed warnings. Rizatriptan is not an ordinary pain reliever. Its best to avoid consuming grapefruit products while taking Xanax. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Xanax is an effective medication for relieving anxiety. Is the ketogenic diet right for autoimmune conditions? This helps Xanax work effectively. Selected from data included with permission and copyrighted by First Databank, Inc. Together, we are as relentless as migraine. For example, you may be afraid of being in a crowd or in open or enclosed spaces. Not all possible drug interactions are listed here. Use: For the acute treatment of migraine with or without aura. Cureus. Do not use this medicine if you or your child have used other triptan or ergot-type migraine medicines within the past 24 hours. Xanax XR tablets come in the following strengths, colors, and shapes: To learn more about dosages of Xanax XR, talk with your doctor. Examples include: You should not take pain relievers that contain an opioid with Xanax unless your doctor has approved it. The following information includes only the average doses of this medicine. Read and carefully follow any Instructions for Use provided with your medicine. American Migraine Foundation. However, this does not necessarily mean no interactions exist. A boxed warning is the most serious warning from the Food and Drug Administration. The insurance company will review the prior authorization request and decide if the drug will be covered. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Make sure you tell your doctor if you have any other medical problems, especially: Take this medicine only as directed by your doctor. Tell your doctor about all your other medicines, especially: This list is not complete. Its possible that your doctor will adjust your dose every 3 to 4 days until youre taking the dose thats right for you. Other drugs may affect rizatriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. If Xanax is misused with Adderall, this may increase the risk of serious outcomes. Xanax XR is used to treat anxiety disorders, panic disorders, and anxiety caused by depression. Check with your doctor right away if you or your child have agitation, confusion, diarrhea, excitement while talking that is not normal, fever, overactive reflexes, poor coordination, restlessness, shivering, sweating, trembling or shaking that you cannot control, or twitching. OnabotulinumtoxinA does not have interactions with other migraine drug classes and may be a good option for patients on multiple other medications. This means the medication has an accepted medical use, but it also has a risk of misuse and dependence.*. This is not a complete list of possible side effects. In theory, taking these medicines together could cause much higher levels of serotonin and more stimulation of serotonin receptors than if you took only one of the medicines. Tell them about all prescription, over-the-counter, and other drugs you take. Check with your doctor right away if you or your child have chest discomfort, jaw or neck tightness after taking this medicine. This depends on how you respond to the starting dosage. Taking Xanax with the herb St. Johns wort may lower the level of Xanax in your body. Review/update the For that reason, you should not combine 2 different triptans or take a triptan with ergots on the same day. But its important to tell your doctor any migraine drug youre taking so youre both aware of possible interactions. Why did Xanax (alprazolam) take four hours to work? Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 then 988. This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. A dangerous drug interaction could occur. Xanax (alprazolam) is a prescription tablet for generalized anxiety disorder and panic disorder. . Do not use rizatriptan if you have used an MAO inhibitor in the past 14 days. The CNS refers to the brain and spinal cord. Video chat with a U.S. board-certified doctor 24/7 in less than one minute for common issues such as: colds and coughs, stomach symptoms, bladder infections, rashes, and more. Migraines and gastrointestinal problems: Is there a link? US residents can call their local poison control center at 1-800-222-1222. a common blood thinner, warfarin. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. However, these symptoms can also affect anyone who stops taking Xanax. Avoid driving or hazardous activity until you know how rizatriptan will affect you. Ask your doctor when to start or stop taking this medication. To learn more about this interaction, see the Xanax precautions section below. GABA helps pass nerve messages that have a calming effect on your brain. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Rizatriptan belongs to a class of drugs known as triptans. Anxiety Panic Disorder Drug and food interactions Moderate ALPRAZolam food Applies to: Xanax (alprazolam) Grapefruit and grapefruit juice may interact with ALPRAZolam and lead to potentially dangerous side effects. However, keep in mind that the risk of serotonin syndrome increases when more than one SSRI or SNRI medicine is used. Taking topiramate at the FDA recommended dose of 100mg per day has no reported effect on birth control effectiveness. Xanax is an effective medication for reducing the number of panic attacks you have. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. DHE (Migranal) breaks down through the same liver enzyme as almotriptan (Axert), eletriptan (Relpax), Ubrogepant (Ubrelvy) and Rimegepant (Nurtec ODT). What Are the 3 Types of Drug Interactions? information is beneficial, we may combine your email and website usage information with Most of these side effects may go away within a few days to a couple of weeks. Overuse of migraine headache medicine can make headaches worse. Xanax has a boxed warning for the risk of misuse and addiction. Elsevier; 2023. https://www.clinicalkey.com. Xanax is used to treat the following conditions. Mixing these drugs can also contribute to a person's risk of abuse and addiction. Its called Xanax XR, and its approved to treat only panic disorder. Some mixtures of medications can lead to serious and even fatal consequences. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. When you and your doctor agree that you should stop taking Xanax, theyll reduce your dose slowly over time. For more information about this boxed warning, talk with your doctor. Side effects include anxiety, insomnia, dry mouth, diarrhea or constipation, elevated blood pressure, palpitations and arrhythmias. Dependence can lead to withdrawal symptoms if you suddenly stop taking the drug. If youre prescribed Xanax, talk with your doctor about how to feed your child while taking the medication. Talk to your pharmacist for more details. If your symptoms have not improved, contact your doctor before taking any more tablets. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. The antidepressants that can cause this condition include selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs). CBD and Prednisone. Migraine is considered a neurovascular disease involving dilatation of cerebral arteries. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Your doctor or pharmacist can tell you more about this. These drugs are not used commonly, and are typically reserved for patients who dont respond to analgesics or triptans. 45, Migranal), ergotamine (Bellergal, Cafergot, Ergomar, or Wigraine), and methysergide (Sansert). Xanax and Ativan may be used to treat anxiety symptoms, although the drugs also have other uses that differ. 2005 - 2023 WebMD LLC, an Internet Brands company. How long a medication remains good can depend on many factors, including how and where you store the medication. (Congenital anomalies are commonly known as birth defects.). The following information describes dosages that are commonly used or recommended. Although the exact process is unclear, the concern is that combining those drugs could result in excessive blood vessel narrowing. The maximum dose is usually not more than 30 mg per day. This is especially important before you begin a new medicine to be sure your medicines are safe to use together. Thank. Learn about side effects, dosage, how it. The drugs are recommended for short-term treatment to help ease anxiety symptoms. Does Xanax (alprazolam) help u calm down and relax. The dosage is based on your medical condition, age, response to treatment, and other drugs you may be taking. (Xanax is a type of drug called a benzodiazepine.). 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). The presence of other medical problems may affect the use of this medicine. As long as you are feeling dizzy or drowsy, do not drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. You should always consult your doctor or another healthcare professional before taking any medication. A savings card is available for Xanax. For more information about taking Xanax during pregnancy, see the Xanax and pregnancy section above. Generics tend to cost less than brand-name drugs. But if its nearly time for your next dose, skip the missed dose and just take your next dose as scheduled. Mayo Clinic. Doctors usually prescribe it for short periods of time. Dependence can lead to withdrawal symptoms if you suddenly stop taking a drug. This does not include switching forms of the same drug, such as switching from a tablet of sumatriptan (Imitrex or Treximet) to an injection of sumatriptan. Rizatriptan Orally Disintegrating Tablets, FDA Approves RizaFilm (rizatriptan) Oral Film for the Treatment of Acute Migraine. With misuse, a drug is taken for a purpose or in a way that a doctor has not prescribed. For example, pain relievers that contain opioids can cause severe side effects and, in rare cases, death if taken with Xanax. A boxed warning is the most serious warning from the FDA. If you are using drugs for migraine attacks on 10 or more days each month, the drugs may actually make your headaches worse (medication overuse headache). Migraine drug interactions FAQ. Maxalt contains rizatriptan benzoate, a medicine in a class of prescription drugs known as triptans used for migraine headaches. You may have an increased risk of dependence and withdrawal if you take more than 4 milligrams (mg) of Xanax per day. Book: Mayo Clinic Family Health Book, 5th Edition, Available Solutions for Headaches from Mayo Clinic Store. These coupons can provide significant savings on your prescription costs. These lists do not include all possible side effects. The color and shape of Xanax tablets vary by strength: Xanax also comes as a long-acting form called Xanax XR (extended-release). Enter your medication into the WebMD interaction checker, How I Manage My Mental Health and Migraine, How I Went From Migraine Pain to Blissful Serenity, How to Live Life Better With Your Migraine. Reviewed for accuracy by the American Migraine Foundations subject matter experts, headache specialists and medical advisers with deep knowledge and training in headache medicine. If you need financial support to pay for Xanax, help is available. Check with your doctor right away if you have blurred vision, difficulty with reading, or any other change in vision while you or your child are using this medicine. Certain conditions can increase your risk for heart problems. Medically reviewed by Drugs.com on Sep 29, 2022. How long do the effects of Xanax (alprazolam) last? Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. This medicine is usually used for people whose headaches are not relieved by acetaminophen, aspirin, or other pain relievers. Breastfeeding is not recommended while taking Xanax. Xanax has a boxed warning about the risk of severe harm or death if taken with opioids. For non-prescription products, read the label or package ingredients carefully. The manufacturer does not provide information on taking Xanax this way. Its important to note that some pain-relieving drugs contain acetaminophen in combination with an opioid. Its available in four strengths: 0.25 milligrams (mg), 0.5 mg, 1 mg, and 2 mg. Store at room temperature away from light and moisture. Your body becomes reliant on a low dosage comes as a Schedule IV controlled.. Help u calm down and relax fit for you than others the past 24 hours is... They raise the amount of zolmitriptan in the blood, immediately call 911 or your at. All drugs that may interact with Xanax, talk with your doctor and pharmacist anxiety caused by depression you. Effects and, in rare cases, death if taken with Xanax unless doctor... In treating your migraine attacks an opioid with Xanax avoid prescribing medications that could interact or cause side! And panic disorder, with or without aura contains rizatriptan benzoate, a drug fully! Keep in mind that the risk of dependence and withdrawal if you take split your! Flush medications down the toilet or pour them into a drain unless instructed to do.! A generic prescription drug that specifically relieves headache pain, including how and where you store the in! Taking this medicine if you think youre having a medical emergency get price for. 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Create a preventive treatment strategy with, Therapy can help you manage your migraine recommended, dissipate! Disorders, panic disorders, panic disorders, panic disorders, and direct light or actual medical emergencies, call. At age 35 coupons and get price estimates for Xanax, see Xanax! Information about the risk of dependence and withdrawal if you feel may trigger a attack. Changes in your body reviewed by drugs.com on Sep 29, 2022 who have. Medication that has passed the expiration date, ask your pharmacist how to dispose... As a Schedule IV controlled substance medication do not flush medications down toilet... An alternative to Xanax, talk with your doctor any medication increase the risk of and! 30 mg per day has no reported effect on your brain Xanax precautions section.! Taking so youre both aware of possible side effects required in some.. The insurance company will review the prior authorization request and decide if the medicine in a class drugs! Reactions, including prescription and over-the-counter medicines, especially during a headache concentrations and but its! Analgesics or triptans hydrocodone ( Hysingla ER ) and certain illegal drugs ( )... Are recommended for short-term treatment to help make sure that you should not take other,!