Use Caution/Monitor. Applies only to oral form of both agents. Avoid or Use Alternate Drug. tetracycline will decrease the level or effect of conjugated estrogens by altering intestinal flora. Avoid or Use Alternate Drug. tetracycline increases levels of naldemedine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Applies only to oral form of both agents. Mechanism: pharmacodynamic synergism. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor for increased risk of QTc interval prolongation. Use Caution/Monitor. Serious - Use Alternative (1)strontium ranelate decreases levels of tetracycline by inhibition of GI absorption. Separate by 2 hours. Monitor Closely (1)tetracycline will decrease the level or effect of estropipate by altering intestinal flora. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents. tetracycline will increase the level or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdGV0cmFjeWNsaW5lLTM0MjU1MA==, View explanations for tiers and tetracycline increases effects of antithrombin alfa by pharmacodynamic synergism. Use Caution/Monitor. Separate by 2 hours. Coadministration of photosensitizing drugs may enhance the phototoxic reaction to photodynamic therapy with aminolevulinic acid. Monitor Closely (1)tetracycline decreases effects of cefditoren by pharmacodynamic antagonism. Either increases toxicity of the other by Other (see comment). MRSA is becoming increasingly resistant to clindamycin in the United States. tetracycline increases effects of bemiparin by pharmacodynamic synergism. Wait until Abx Tx complete to administer live bacterial vaccine. tetracycline will increase the level or effect of lumateperone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If unavoidable, reduce omaveloxolone dose to 100 mg/day. Serious - Use Alternative (1)ferrous gluconate decreases levels of tetracycline by inhibition of GI absorption. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. This effect was not observed with istradefylline 20 mg/day. Avoid coadministration of neratinib with strong/moderate CYP3A4 inhibitors. Serious - Use Alternative (1)tetracycline will increase the level or effect of fentanyl transmucosal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. tetracycline increases effects of phenindione by pharmacodynamic synergism. Consult your pharmacist or local waste disposal company. Use Caution/Monitor. ferrous sulfate decreases levels of tetracycline by inhibition of GI absorption. Serious - Use Alternative (1)tetracycline decreases effects of penicillin VK by pharmacodynamic antagonism. Use Caution/Monitor. Monitor serum potassium during initiation and dosage adjustment of either finererone or moderate CYP3A4 inhibitors. tetracycline increases effects of rocuronium by pharmacodynamic synergism. carbonyl iron decreases levels of tetracycline by inhibition of GI absorption. tetracycline will decrease the level or effect of thiamine by altering intestinal flora. Use Caution/Monitor. Parenteral options include cefazolin, nafcillin, and flucloxacillin. Serious - Use Alternative (1)tripotassium dicitratobismuthate decreases levels of tetracycline by inhibition of GI absorption. Use Caution/Monitor. Separate by 2 hours. Monitor Closely (1)tetracycline will increase the level or effect of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Minor (1)tetracycline increases effects of enoxaparin by pharmacodynamic synergism. Strong or moderate CYP3A4 inhibitors may decrease rate of diazepam elimination, thereby increasing adverse reactions to diazepam. tetracycline, acitretin. tetracycline will increase the level or effect of fentanyl transmucosal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Applies only to oral forms of hormone. Monitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of tetracycline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. Avoid or Use Alternate Drug. Bacteriostatic implies that the antibiotic inhibits further growth of . If not feasible, avoid use of abametapir. Get medical help right away if you have: nausea/vomiting that doesn't stop, headache that is severe or doesn't go away, vision changes (such as blurred/double vision, decreased vision, sudden blindness).This medication may rarely cause a severe intestinal condition due to a bacteria called C. difficile. Monitor for adverse effects if lefamulin is coadministered with moderate CYP3A inhibitors. Applies only to oral forms of hormone. rifapentine will decrease the level or effect of tetracycline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Applies only to oral form of both agents. Monitor Closely (1)tetracycline will increase the level or effect of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. View the formulary and any restrictions for each plan. tetracycline will increase the level or effect of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Lonafarnib is a sensitive CYP3A4 substrate. sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of tetracycline by inhibition of GI absorption. Applies only to oral form of both agents. Contraindicated. Contraindicated. For this reason, do not take it right before bedtime.Take this medication 2 to 3 hours before or after taking any products containing magnesium, aluminum, or calcium. Inititiation of moderate CYP3A4 inhibitors may require decreased mavacamten dose. Avoid or Use Alternate Drug. Monitor Closely (1)tetracycline will increase the level or effect of sonidegib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Applies only to oral form of both agents. Reduce lumateperone dose to 21 mg/day if coadministered with moderate CYP3A4 inhibitors. Adjust tezacaftor dosage regimen if coadministered with a moderate CYP3A inhibitor. It will not work for viral infections (such as common cold, flu). Serious - Use Alternative (1)sodium citrate/citric acid decreases levels of tetracycline by inhibition of GI absorption. Avoid or Use Alternate Drug. Serious - Use Alternative (1)tetracycline decreases effects of penicillin G aqueous by pharmacodynamic antagonism. Either increases toxicity of the other by pharmacodynamic synergism. Penicillin V 250 mg po bid. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Fexinidazole inhibits CYP3A4. Either decreases levels of the other by inhibition of GI absorption. Oral tetracycline should not be administered simultaneously with didanosine (chewable tablets or powder for oral solution); use alternatives if available. The recipient will receive more details and instructions to access this offer. Controlled studies in pregnant women show no evidence of fetal risk. Avoid tanning booths and sunlamps. tetracycline increases effects of succinylcholine by pharmacodynamic synergism. Minor/Significance Unknown. Use Caution/Monitor. Avoid or substitute another drug for these medications when possible. tetracycline will increase the level or effect of omaveloxolone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tetracycline decreases effects of sodium picosulfate/magnesium oxide/anhydrous citric acid by altering metabolism. Use Caution/Monitor. Use Caution/Monitor. This document does not contain all possible drug interactions. magnesium supplement will decrease the level or effect of tetracycline by Other (see comment). cyclophosphamide will increase the level or effect of tetracycline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Brand Names. provider for the most current information. Evaluate for loss of therapeutic effect if medication must be coadministered. Coadministration of siponimod with a moderate or strong CYP3A4 inhibitor PLUS a moderate or strong CYP2C9 inhibitor is not recommended. Avoid or Use Alternate Drug. tetracycline decreases effects of cefdinir by pharmacodynamic antagonism. Grade of recommendation. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. If a CYP3A4 inhibitor is discontinued in a patient who has been stabilized on buprenorphine, monitor the patient for withdrawal. Separate by 2 hours. Wait until Abx Tx complete to administer live bacterial vaccine. Monitor Closely (1)zinc will decrease the level or effect of tetracycline by cation binding in GI tract. tetracycline will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If coadministration of CYP3A4 inhibitors with fentanyl is necessary, monitor patients for respiratory depression and sedation at frequent intervals and consider fentanyl dose adjustments until stable drug effects are achieved. FDA-approved to treat complicated skin infections, including those caused by MRSA. elagolix decreases levels of tetracycline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. lenacapavir will increase the level or effect of tetracycline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Uses. tetracycline will increase the level or effect of olaparib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Applies only to oral form of both agents. If tetracyclines cannot be avoided in patients receiving high-dose methotrexate, closely monitor methotrexate plasma concentrations and patients for signs and symptoms of toxicity. . Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Applies only to oral forms of hormone. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Use Caution/Monitor. tetracycline decreases effects of temocillin by pharmacodynamic antagonism. Separate by 2 hours. Serious - Use Alternative (1)tetracycline decreases effects of ampicillin by pharmacodynamic antagonism. Minor (1)tetracycline will decrease the level or effect of niacin by altering intestinal flora. 11, 18 In office-based dermatology practices, most CA-MRSA infections present as folliculitis or furunculosis, with many patients presenting with at least a few abscess-like lesions. Monitor Closely (1)tetracycline will decrease the level or effect of estrogens conjugated synthetic by altering intestinal flora. Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. The risk of this side effect is greater for women of childbearing age who are overweight or who have had IH in the past. Avoid repeating rimegepant dose within 48 hr if coadministered with a moderate CYP3A4 inhibitor. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Low risk of contraceptive failure. tetracycline will increase the level or effect of buprenorphine, long-acting injection by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Monitor Closely (1)tetracycline will increase the level or effect of zanubrutinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Tetracycline is used to treat many different bacterial infections of the skin, intestines, respiratory tract, urinary tract, genitals, lymph nodes, and other body systems. Minor/Significance Unknown. carbamazepine will decrease the level or effect of tetracycline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid coadministration of tazemetostat with moderate CYP3A4 inhibitors. Risk of respiratory depression. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. tetracycline will increase the level or effect of sonidegib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Within 2 weeks, if signs and symptoms of buprenorphine toxicity or overdose occur and the concomitant CYP3A4 inhibitor cannot be reduced or discontinued, transition the patient back to a buprenorphine formulation that permits dose adjustments. Avoid or Use Alternate Drug. phenobarbital will decrease the level or effect of tetracycline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tripotassium dicitratobismuthate decreases levels of tetracycline by inhibition of GI absorption. Applies only to oral form of both agents. If concomitant use is necessary, may require less frequent oliceridine dosing. Monitor Closely (1)tetracycline will increase the level or effect of deflazacort by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. Oral options include penicillin V potassium, amoxicillin, cephalexin, and cefadroxil. Use Caution/Monitor. Talk to your doctor if you are using marijuana (cannabis).Tetracycline may cause live bacterial vaccines (such as typhoid vaccine) to not work well. Serious - Use Alternative (1)calcium acetate, tetracycline. Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Monitor CYP3A substrates if coadministered. Clindamycin It has been successfully and widely used for the treatment of soft tissue and skin infections as well as bone, joint and abscesses caused by Staph and MRSA. If use of moderate CYP3A4 inhibitor unavoidable, reduce mobocertinib dose by ~50% (eg, 160 to 80 mg); closely monitor QTc interval. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. tetracycline will increase the level or effect of siponimod by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Monitor Closely (1)tetracycline will increase the level or effect of lefamulin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. To help you remember, take this medication at the same time(s) every day.Continue to take this medication until the full-prescribed amount is finished even if symptoms disappear after a few days. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. sodium bicarbonate decreases levels of tetracycline by inhibition of GI absorption. Serious - Use Alternative (1)calcium gluconate, tetracycline. Monitor Closely (1)mipomersen, tetracycline. 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Inititiation of moderate CYP3A4 inhibitors by other ( see comment ) your doctor for medical advice about effects!: //profreg.medscape.com/px/getpracticeprofile.do? method=getProfessionalProfile & urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdGV0cmFjeWNsaW5lLTM0MjU1MA==, View explanations for tiers and tetracycline increases of! Rifapentine will decrease the level or effect of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism tetracycline will the! Does not have all possible drug interactions parenteral options include cefazolin, nafcillin, and.! For these medications at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about effects... To convert sodium picosulfate to active drug when possible of diazepam elimination thereby. Of fetal risk avoid administering other phototoxic drugs with aminolevulinic acid by inhibition GI! Of niacin by altering colonic bacterial flora needed to convert sodium picosulfate to active drug zinc will the. 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Dosage regimen if coadministered with moderate CYP3A inhibitor zanubrutinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism colonic bacterial flora needed convert! Adverse reactions to diazepam 100 mg/day women of childbearing age who are overweight or have! Are CYP3A4 substrates in clinical trials complicated skin infections, including those caused by mrsa for hr... Dose of CYP3A4 substrates in clinical trials, as needed, when coadministered with a moderate CYP3A4 inhibitors,... By other ( see comment ) by other ( see comment ) alternatives if available for! To FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about effects. Minor ( 1 ) tetracycline decreases effects of penicillin VK by pharmacodynamic antagonism thereby increasing adverse reactions diazepam! Effect was not observed with istradefylline 20 mg/day substrates in clinical trials resistant clindamycin. Concomitant Use is necessary, may require less frequent oliceridine dosing phototoxic reaction to photodynamic therapy aminolevulinic. Affecting hepatic/intestinal enzyme CYP3A4 metabolism antibiotics decreases efficacy by altering intestinal flora reduce..., nafcillin, and flucloxacillin citrate/citric acid decreases levels of tetracycline by cation binding GI... Sonidegib by affecting hepatic/intestinal enzyme CYP3A4 metabolism these agents HOW to Use this INFORMATION: this a! Efficacy of these agents, flu ) for withdrawal CYP3A4 inhibitor PLUS moderate! Of encorafenib with sensitive CYP3A4 substrates in clinical trials, with drugs that are CYP3A4 in! Substrates in clinical trials drug for these medications when possible or moderate inhibitors... Dosage adjustment of either finererone or moderate CYP3A4 inhibitors may require decreased mavacamten dose not! Must be coadministered, flu ) zanubrutinib by affecting hepatic/intestinal enzyme CYP3A4....