Systematic literature searches were carried out and the available information on various plants traditionally used for cardiovascular disorders was collected via electronic search (using Pubmed, SciFinder, Scopus, Scirus, ScienceDirect, Google Scholar and Web of Science) and a library search for articles published in peer-reviewed journals and also locally available books. Before Two groups were observed between one and three months therapy with T.arjuna at a dose of 500mg twice a day and showed significant decreases in IMR, improvement in E/A ratio and considerable reduction in angina frequency. Nearly 24 species of Terminalia have been reported from various parts of India, some selected species are T. arjuna, Terminalia bellirica, Terminalia bialata, Terminalia catappa, Terminalia elliptica, Terminalia porphyrocarpa, Terminalia mantaly etc. The preliminary phytochemical analysis of existing compounds in T.arjuna was carried out according to various standard protocols as mentioned by Harbone54 in Table2. In rural areas bark powder of arjuna is used for snake bite and scor pion sting. View abstract. Taking Terminalia bellirica or Terminalia chebula along with diabetes medications might cause blood sugar to drop too low. Row L.R., Murty P.S., SubbaRao G.S.R., Sastry C.S.P., Rao K.V.J. Terminalia chebula has most often been used by adults in doses of 200 mg by mouth 2-3 times daily for up to 3 months. Gauthaman etal79 studied that oral administration of T.arjuna for 12 weeks in rabbits caused augmentation of myocardial antioxidants; superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) along with induction of heat shock protein72 (HSP72). Wight and Arn. Pieroni A. Constituents of Terminalia arjuna (Combretaceae). 2009;20(3):183-1190. It is commonly known as Arjuna, Indradru, Partha and Veeravriksha20 which is belongs to Combretaceae family comprising of nearly 200 species distributed around the world. Eighteen healthy male smokers (age 28.169.45 years) and an equal number of age-matched, non-smoker controls participated in the study. WebTerminalia chebula and Terminalia arjuna were widely used in traditional medicine for the treatment of memory impairment, inflammatory disorders and as an anti-aging agent. General Health The body breaks down chlorzoxazone to get rid of it. The present review encompases morphological features, distribution, a few traditional and ethnomedicinal formulations and uses, scientific studies on phytochemical Scientific investigations of T.arjuna extensively reported and discussed through various preclinical and clinical studies (Table3, Table4). WebOverview Terminalia is a tree. Objective: To enhance the dissolution rate and oral bioavailability of Terminalia arjuna bark extract by formulating its nanosuspension. Indian Materia Medica. Varghese A, Savai J, Pandita N, Gaud RS. Peer review under responsibility of The Center for Food and Biomolecules, National Taiwan University. A significant increase was observed at pH, NP-SH, GSH, enzymic antioxidants, protein bound carbohydrate complexes, adherent mucus content, nucleic acids with a significant decrease in volume of gastric juice, free and total acidity, pepsin concentration, acid output, LPO levels and MPO activities in DIC+TA rats compared to DIC rats. The alcoholic extract of the stem bark of T.arjuna (ALTA) has shown potent antioxidant activity with EC50 in DPPH assay, superoxide radical scavenging activity and lipid peroxidation assay. Evaluation of the cultural significance of wild food botanicals traditionally consumed in Northwestern Tuscany, Italy. A traditional Ayurvedic botanical for cardiac failure has been shown to be effective in controlled clinical studies. T.arjuna has been used in the dose between 1 to 2g per day in different clinical studies and found that this is an optimum dose in the patients particularly CAD. Arjuna contains triterpenoids, flavonoids, and glycosides, known to interact with the angiotensin converting enzyme-2 (ACE2), which plays a crucial role not only in the SARS-CoV2 infection but also in the post-COVID-19 complications. Methods: Nanoprecipitation approach was used for the formulation of nanosuspension using polysorbate-80 as a stabilizer. An observational study was conducted to find out the effects of T.arjuna in patients with dilated cardiomyopathy (DCMP) of idiopathic and ischemic cause. A significant decrease was observed in both SBP and DBP (P<0.001) in both the groups. Three groups as standard therapy (ST, Group 1), T.arjuna therapy (TA, Group 2) and standard therapy with T.arjuna (ST+TA, Group 3) were formed. Dwivedi S, Jauhari R. Beneficial effects of Terminalia arjuna in coronary artery disease. Stickel F., Schuppan D. Herbal medicine in the treatment of liver diseases. View abstract. Terminalia chebula might decrease how quickly the body breaks down omeprazole. Terminalia arjuna, Terminalia bellirica, and Terminalia chebula are three species used in medicine, especially Ayurvedic medicine. Biol Pharm Bull 1997;20:1017-9. Information from this source is evidence-based and objective, and without commercial influence. Singh etal68 investigated the effects of butanolic fraction of T.arjuna bark on Doxorubicin (Dox) induced cardiotoxicity using invivo study with male Wistar rats and they found that T.arjuna bark has protective effects against Dox-induced cardiotoxicity and may have potential as a cardioprotective agent. Gastroprotective effect of, Bhawani G., Kumar A., Murthy K.S.N., Kumari N., Ganapati Swami Ch. View abstract. WebTerminalia arjuna Wight and Arn., commonly known as Arjuna, is one such traditional plant, belonging to the family of Combretaceae. Arjuna is an evergreen tree belonging to the genus Terminalia along with medicinal marvels like harad ( Terminalia chebula) and baheda ( Terminalia bellerica ). The cancer cell growth inhibitory. The structure of this new compound was established as olean-1,3,22-triol-12-en-28-oic acid-3-d-glucopyranoside. View abstract. Yadava R.N., Rathore K. Anew cardenolide from the seeds of. After 8 weeks of STZ administration, rats showed a decline in left ventricular pressure (LVP), maximal rate of rise and fall in LVP (LV [dP/dt] max and LV [dP/dt] min), cardiac contractility index (LV [dP/dt] max/LVP), and a rise in LV end-diastolic pressure. WebVardenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). There were no reports in the regards of hematological, hepatic, metabolic and renal toxicity after more than two years of its administration.83 Recently Bhawani etal82 reported that there was no significant variation in the body and organ weights between the control and the treated group of 93 patients with dilated cardiomyopathy (DCMP) of idiopathic and ischemic cause was observed after 28 days of treatment under the treatment of T.arjuna capsules (500mg at 8h). Shridhar Dwivedi . T.arjuna exerts beneficial effect on LV functions, myocardial remodeling, and autonomic control in chronic heart failure possibly through maintaining endogenous antioxidant enzyme activities, inhibiting lipid peroxidation and cytokine levels. Preliminary tests for phytochemical analysis of the Terminalia arjuna (Roxb.) A similar reduction in diastolic score and mitral regurgitation (P<0.01 and P<0.0001) was observed in groups 1 and 3. Terminalia arjuna Benefits, How To Use, Research, Side Effects Can you imagine an herb which is antioxidant, reduces cholesterol, reduces BP and useful in Chaudhari M., Mengi S. Evaluation of phytoconstituents of. High-performance liquid chromatographic fingerprint for quality control of, Kokkiripati P.K., Kamsala R.V., Bashyam L. Stem-bark of, Kandil F.E., Nassar M.I. WebObjective: To enhance the dissolution rate and oral bioavailability of Terminalia arjuna bark extract by formulating its nanosuspension. J Assoc Physicians India. Pharmacological studies on Terminalia arjuna (Roxb.) WebSymptoms of ED include. Green synthesis of gold nanoparticles from leaf extract of, Yallappa S., Manjanna J., Sindhe M.A., Satyanarayan N.D., Pramod S.N., Nagaraja K. Microwave assisted rapid synthesis and biological evaluation of stable copper nanoparticles using, Edison T.J.I., Sethuraman M.G. Efficacy of, Rao B.C.S., Singh R.H., Tripathi K. Effect of, Khalil S. National Board of Examination; New Delhi, India: 2005. and transmitted securely. Parmar H.S., Panda S., Jatwa R., Kar A. Cardio-protective role of, Journal of Traditional and Complementary Medicine, Olean-3, 22-diol-12-en-28 -D-glucopyranosie-oic acid, (+)-catechin, (+)-gallocatechin and ()-epigallocatechin, Gallic acid, ellagic acid and its derivatives such as 3-O-methyl-ellagic acid 4-O--, Calcium, magnesium, aluminum, zinc, copper, silica, 2,19-Dihydroxy-3Oxo-Olean-12-En28-Olic acid 28-O--, Arjunic acid, Arjunone, Arachidic stearate, Cerasidin, Ellagic acid, Fridelin, Gallic acid, Hentriacontane, Methyl oleaolate, Myristyl oleate, -Sitisterol, Luteolin, 14,16-dianhydrogitoxigenin 3--, Antioxidant, antiinflammatory, and immunomodulatory, CYP3A4, CYP2D6 and CYP2C9 enzymes in human liver microsomes, Human polymorphonuclear (PMN) cells and hypochlorous acid from human neutrophils, Arjungenin is the most active compound than others and had moderate inhibitory effect on the process of respiratory oxyburst and its IC, Male Wistar albino rats (110140g) (67 weeks old), Chromic administration of butanolic fraction of alcoholic extract of, Wistar rats (200250g) and Swiss albino mice (1822g), Anticarcinogenic and antimutagenic potential, Aqueous extracts from 75g/ml to 200g/ml for lymphocyte culture for, Used human lymphocyte culture and bone marrow cells of albino mice (810 weeks old and weight ranges between 25-35g), Antioxidant, anti-inflammatory and immunomodulatory, Cell cultures of human monocytic (THP-1) and human aortic endothelial cells (HEACs), TAAE and TAWE inhibited the lipid peroxidation and attenuated H, Male albino Wistar rats (120150g body weight) were subjected to oxidative stress associated with, Two doses (500 and 750mg/kg in 2% carboxy methyl cellulose (CMC)), 6 days per week for 12 weeks. Tannins are known to enhance the synthesis of nitric oxide and relax vascular segments pre-contracted with norepinephrine. Acetaminophen is a commonly used analgesic and antipyretic agent, which causes liver and kidney damage when it is taken in high doses. View abstract. Antineoplastic agents 338. Bharani etal85 conducted a study on the efficacy of T.arjuna in chronic stable angina. Kakadia N, Kanaki N. Anti-osteoporotic effect of Terminalia arjuna (Roxb.) Triterpenoids from two Terminalia species. Structure of important flavonoids isolated from Terminalia arjuna. 2001;49:231-235. Wight and Arn. The aqueous extract contains flavon-3-ols, such as (+)-catechin, (+)-gallocatechin and ()-epigallocatechin; gallic acid, ellagic acid and its derivatives such as 3-O-methyl ellagic acid 4-O--d-xylopyranoside and 3-O-methyl ellagic acid 3-O-rhamnoside (Fig. WebSymptoms of ED include. 2002;54(2):170-175. Many useful phytoconstituents have been isolated from T. arjuna. WebThe bark decoction of Terminalia Arjuna is used for washing wounds and skin ulcers. Twelve patients with severe refractory congestive heart failure (class IV NYHA) received an extract (500 mg every 8 hours) from the bark of Terminalia arjuna or placebo for 2 weeks. : an ethnomedicinal plant against pathogens causing ear infection. View abstract. WebTerminalia arjuna. RP-LC determinationof oleane derivatives in, Anjaneyulu A.S.R., Prasad A.V.R. Alam etal39 were isolated two more glycosides namely Termiarjunoside I (olean-1,3,9,22-tetraol-12-en-28-oicacid-3-d-glucopyranoside) and Termiarjunoside II (Olean-3,5, 25-triol-12-en-23,28-dioicacid-3-d-glucophyranoside) from the ethanolic extract ofTA bark. Sharma P.C., Yelne M.B., Dennis T.J. CCRAS (The Central Council for Research in Ayurvedic Sciences); New Delhi: 2005. FOIA CSIR; New Delhi: 1993. Methanol extract from bark of T.arjuna exhibited medicinal as well as physiological activities. 3. 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