Minor/Significance Unknown. Does it really work quicker? Monitor Closely (2)atorvastatin will increase the level or effect of paclitaxel by P-glycoprotein (MDR1) efflux transporter. Paclitaxel levels/toxicity may increase when coadministered with CYP2C8 inhibitors. marijuana will increase the level or effect of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Common side effects of paclitaxel may include: fever, chills, or other signs of infection; sores or white patches in or around your mouth; tenderness or irritation where the medicine was injected. Hepatic Impairment: Patients with hepatic impairment may be at increased risk of toxicity, particularly grade IIIIV myelosuppression (seeCLINICAL PHARMACOLOGYand PRECAUTIONS: Hepatic). The results from an in vitro study with human liver tissue indicate that valsartan is a substrate of the hepatic uptake transporter OATP1B1; coadministration with OATP1B1 inhibitors may increase valsartan systemic exposure. palifermin increases toxicity of paclitaxel by Other (see comment). For patients with AIDS-related Kaposis sarcoma, paclitaxel administered at a dose of 135 mg/m2 given intravenously over 3 hours every 3 weeks or at a dose of 100 mg/m2 given intravenously over 3 hours every 2 weeks is recommended (dose intensity 4550 mg/m2/week). Paclitaxel levels/efficacy may decrease when coadministered with CYP2C8 inducers, paclitaxel decreases levels of phenytoin by inhibition of GI absorption. Minor/Significance Unknown. Monitor Closely (1)bosutinib increases levels of paclitaxel by P-glycoprotein (MDR1) efflux transporter. amiodarone will increase the level or effect of paclitaxel by P-glycoprotein (MDR1) efflux transporter. clarithromycin will increase the level or effect of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)pazopanib increases levels of paclitaxel by decreasing metabolism. Monitor Closely (1)rifapentine will decrease the level or effect of paclitaxel by Other (see comment). Some drugs will absorb into your body through mucous membranes like your mouth. The clinical trial used 4 courses of doxorubicin and cyclophosphamide (see CLINICAL STUDIES: Breast Carcinoma). However, you have been prescribed this drug because your doctor has judged that the benefit to you is greater than the risk of side effects. Minor/Significance Unknown. The .gov means it's official. Use Caution/Monitor.erythromycin ethylsuccinate will increase the level or effect of paclitaxel by P-glycoprotein (MDR1) efflux transporter. The trek . anastrozole will increase the level or effect of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Tell your doctor right away of any unusual skin/injection site symptoms.This is not a complete list of possible side effects. Monitor or titrate P-gp substrate dose if coadministered. Either increases toxicity of the other by immunosuppressive effects; risk of infection. Gemfibrozil inhibits CYP2C8.gemfibrozil will increase the level or effect of paclitaxel by Other (see comment). Monitor Closely (2)nifedipine will increase the level or effect of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Immunosuppressives may diminish therapeutic effects of vaccines and increase risk of adverse effects (increased risk of infection). phenytoin will decrease the level or effect of paclitaxel by Other (see comment). Minor/Significance Unknown. Monitor Closely (1)ranolazine will increase the level or effect of paclitaxel by P-glycoprotein (MDR1) efflux transporter. By clicking send, you acknowledge that you have permission to email the recipient with this information. Use Caution/Monitor. paclitaxel increases toxicity of pitavastatin by Other (see comment). . Minor (1)eslicarbazepine acetate will decrease the level or effect of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Paclitaxel levels/toxicity may increase when coadministered with CYP2C8 inhibitors. commonly, these are "non-preferred" brand drugs or specialty Paclitaxel contains alcohol and may cause a drunken feeling when the medicine is injected into your vein. Minor (1)zafirlukast will increase the level or effect of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Caution when coadministering glecaprevir/pibrentasvir with OATP1B1/OATP1B3 inhibitors glecaprevir/pibrentasvir will increase the level or effect of paclitaxel by Other (see comment). Use Caution/Monitor. Use Caution/Monitor.rifampin will decrease the level or effect of paclitaxel by Other (see comment). Warnings Use in Cancer Paclitaxel is approved to be used alone or with other drugs to treat: AIDS-related Kaposi sarcoma. Use Caution/Monitor. lapatinib will increase the level or effect of paclitaxel by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Batch CBD Full-Spectrum Gummies. Avoid or Use Alternate Drug. Use Caution/Monitor. Use caution when switching patients from long-acting therapies with immune effects. Smoothie. Serious - Use Alternative (1)quinidine will increase the level or effect of paclitaxel by P-glycoprotein (MDR1) efflux transporter. cobicistat will increase the level or effect of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)isoniazid will increase the level or effect of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. provider for the most current information. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor for adverse reactions if coadministered with P-gp substrates where minimal concentration changes may lead to serious or life-threatening toxicities. Minor (1)acetazolamide will increase the level or effect of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. a. Paclitaxel administered intravenously over 3 hours at a dose of 175 mg/m2 followed by cisplatin at a dose of 75 mg/m2; or. It only takes a few minutes. Minor/Significance Unknown. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternative therapies. If unavoidable, reduce CYP3A substrate dose according to product labeling. Use Caution/Monitor. Use Caution/Monitor.ketoconazole will increase the level or effect of paclitaxel by P-glycoprotein (MDR1) efflux transporter. The above information is provided for general Minor/Significance Unknown. This drug is available at the lowest co-pay. Paclitaxel levels/toxicity may increase when coadministered with CYP2C8 inhibitors. Avoid taking selinexor with other medications that may cause dizziness or confusion. May increase risk of hypotension. Minor/Significance Unknown. Monitor Closely (1)sorafenib will increase the level or effect of paclitaxel by Other (see comment). Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Other (see comment). Use Caution/Monitor. Minor (1)rufinamide will decrease the level or effect of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. letermovir increases levels of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Comment: Combination may increase risk of myelosuppression. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor CYP3A substrates if coadministered. Use Caution/Monitor.erythromycin lactobionate will increase the level or effect of paclitaxel by P-glycoprotein (MDR1) efflux transporter. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Use Caution/Monitor. eliglustat increases levels of paclitaxel by P-glycoprotein (MDR1) efflux transporter. griseofulvin will decrease the level or effect of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. erdafitinib will increase the level or effect of paclitaxel by P-glycoprotein (MDR1) efflux transporter. Minor/Significance Unknown. Use Caution/Monitor. Stability: Unopened vials of Paclitaxel Injection, USP are stable until the date indicated on the package when stored between 20 to 25C (68 to 77F), in the original package. etravirine will decrease the level or effect of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)belatacept and paclitaxel both increase immunosuppressive effects; risk of infection. Use Caution/Monitor. If you or your partner becomes pregnant, talk to your doctor right away about the risks and benefits of this medication.It is unknown if this drug passes into breast milk. FDA label information for this drug is available at DailyMed. Stevens-Johnson syndrome, toxic epidermal necrolysis, and extravasation, The drug should be administered under the supervision of an experienced cancer chemotherapy physician in a facility equipped to diagnose and manage complications, The drug is contraindicated in patients with solid tumor who have baseline neutrophil counts <1500 cells/m and in patients with AIDS-related Kaposi sarcoma who have baseline neutrophil counts <1000 cells/m; perform frequent peripheral blood counts to monitor for occurrence of bone marrow suppression, primarily neutropenia, which may result in infection, Fatal anaphylaxis and severe hypersensitivity reactions characterized by dyspnea and hypotension requiring treatment, angioedema, and generalized urticaria have occurred in patients despite premedication, Pretreat all patients with corticosteroids, diphenhydramine, and H2 antagonists, Do not rechallenge patients who experience severe hypersensitivity reactions to the drug, Patients with solid tumors or patients with AIDS-related Kaposis sarcoma with baseline neutrophil counts of <1,500 cells/mm3, Documented hypersensitivity to drug or excipients, All patients should be pretreated with corticosteroids, diphenhydramine, and H2 antagonists; fatal reactions have occurred in patients despite premedication; patients who experience severe hypersensitivity reactions to paclitaxel should not be rechallenged with the drug, Bone marrow suppression (primarily neutropenia) is dose-dependent and is dose-limiting toxicity; should not be administered to patients with baseline neutrophil counts <1,500 cells/mm3 (<1,000 cells/mm3 for patients with KS); frequent monitoring of blood counts should be instituted during paclitaxel treatment; patients should not be re-treated with subsequent cycles of paclitaxel until neutrophils recover to a level >1,500 cells/mm3 (>1,000 cells/mm3 for patients with KS) and platelets recover to a level >100,000 cells/mm3, Severe conduction abnormalities have been documented in <1% of patients during paclitaxel therapy and in some cases requiring pacemaker placement; if patients develop significant conduction abnormalities during paclitaxel infusion, appropriate therapy should be administered and continuous cardiac monitoring should be performed during subsequent therapy with paclitaxel, Contact of the undiluted concentrate with plasticized polyvinyl chloride (PVC) equipment or devices used to prepare solutions for infusion is not recommended; in order to minimize patient exposure to the plasticizer DEHP [di-(2-ethylhexyl)phthalate], which may be leached from PVC infusion bags or sets, diluted paclitaxel solutions should preferably be stored in bottles (glass, polypropylene) or plastic bags (polypropylene, polyolefin) and administered through polyethylene-lined administration sets, Paclitaxel should be administered through an in-line filter with a microporous membrane not greater than 0.22 microns; use of filter devices such as IVEX-2R filters which incorporate short inlet and outlet PVC-coated tubing has not resulted in significant leaching of DEHP, May increase the risk of cardiac dysfunction if received in conjunction with trastuzumab or anthracyclines, Lactation: not known if excreted in breast milk, do not nurse. 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