Modify Therapy/Monitor Closely. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. This drug is available at a higher level co-pay. Monitor Closely (1)letermovir increases levels of progesterone micronized by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor for adverse effects if coadministered with sensitive substrates of these enzymes.tecovirimat will decrease the level or effect of progesterone micronized by affecting hepatic/intestinal enzyme CYP3A4 metabolism. In vitro studies suggest that lumacaftor may induce and ivacaftor may inhibit CYP2C19 substrates. Use of nonhormonal contraceptives advised, Serious - Use Alternative (1)rifapentine will decrease the level or effect of progesterone micronized by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)lorlatinib will decrease the level or effect of progesterone micronized by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cyclophosphamide will increase the level or effect of progesterone micronized by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Tecovirimat is a weak inhibitor of CYP2C8 and CYP2C19. Use Caution/Monitor. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood clots, history of bleeding in the brain, liver disease, vaginal bleeding of unknown cause, a loss of pregnancy with some tissue remaining in the uterus ("missed abortion"), personal or family history of cancer (especially breast or other female organs), kidney disease, obesity, heart disease (such as past heart attacks, coronary artery disease, heart failure), high blood pressure, seizures, migraine headaches, asthma, high blood levels of cholesterol/fats, depression, diabetes, strokes, lupus.This drug may make you dizzy or drowsy. Monitor Closely (1)progesterone micronized will increase the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Adjust dose of drugs that are CYP3A4 substrates as necessary.Serious - Use Alternative (1)progesterone micronized will increase the level or effect of fedratinib by Other (see comment). Keep all medical and lab appointments. Combination HRT can rarely cause very serious side effects such as heart disease (such as heart attacks), stroke, serious blood clots (such as in the lungs and legs), dementia, and breast cancer. Use Caution/Monitor. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Avoid or Use Alternate Drug. Avoid tanning booths and sunlamps. Minor/Significance Unknown. ChildrenUse is not recommended. progesterone micronized increases levels of pomalidomide by P-glycoprotein (MDR1) efflux transporter. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Clinical efficacy and safety. Progesterone (pregn-4-ene-3, 20-dione) is a white or creamy white, odorless, crystalline powder practically insoluble in water, soluble in alcohol, acetone and dioxane and sparingly soluble in vegetable oils, stable in air, melting between 126 and 131C. Use Caution/Monitor. Monitor Closely (1)darunavir will increase the level or effect of progesterone micronized by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Progestins may impair glucose tolerance. Combination HRT should be used for the shortest possible length of time at the lowest effective dose so you can obtain the benefits and minimize the chance of serious side effects from long-term treatment. progesterone micronized, imipramine. Each month you dont become pregnant, your progesterone levels drop and you get your period. Monitor Closely (1)ketoconazole will increase the level or effect of progesterone micronized by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. Elagolix is a weak-to-moderate CYP3A4 inducer. By clicking send, you acknowledge that you have permission to email the recipient with this information. Monitor Closely (1)triclabendazole will increase the level or effect of progesterone micronized by affecting hepatic enzyme CYP2B6 metabolism. Use Caution/Monitor. clarithromycin will increase the level or effect of progesterone micronized by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Access your plan list on any device mobile or desktop. affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. progesterone micronized will increase the level or effect of edoxaban by P-glycoprotein (MDR1) efflux transporter. A key nding, rst observed in the PROMISE trial, and then replicated in the PRISM trial, was that treatment with vaginal micronizedprogesterone 400 mg twice daily was associated with increasing live birth rates according to the number of previous miscarriages. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. levoketoconazole will increase the level or effect of progesterone micronized by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Lomitapide dose should not exceed 30 mg/day. Consider reducing the dose of CYP2C19 substrates, if adverse reactions are experienced when administered concomitantly with stiripentol. Mechanism: unspecified interaction mechanism. Follow the dosing schedule carefully. Minor/Significance Unknown. Progestins may impair glucose tolerance. Discontinue if the following develop jaundice, visual problems (may cause contact lens intolerance), any signs of VTE, migraine with unusual severity, significang blood pressure increase, severe depression, increased risk of thromboembolic complications after surgery. Mechanism: unspecified interaction mechanism. progesterone micronized increases levels of ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)progesterone micronized increases levels of betrixaban by P-glycoprotein (MDR1) efflux transporter. progesterone micronized increases levels of naldemedine by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Serious - Use Alternative (1)tucatinib will increase the level or effect of progesterone micronized by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use Caution/Monitor. Coadministration of riociguat (substrate of CYP isoenzymes 1A1, 2C8, 3A, 2J2) with strong CYP inhibitors may require a decreased initial dose of 0.5 mg PO TID; monitor for signs of hypotension and reduce dose if needed. Minor (1)progesterone micronized, maprotiline. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Avoid or Use Alternate Drug. These tips will help you cope. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. 2023 Healthline Media LLC. Minor/Significance Unknown. fexinidazole will increase the level or effect of progesterone micronized by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)progesterone micronized increases levels of nintedanib by P-glycoprotein (MDR1) efflux transporter. Caution with sensitive CYP2C19 substrates.elagolix decreases levels of progesterone micronized by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Make sure lab personnel and all your doctors know you use this drug. etravirine will decrease the level or effect of progesterone micronized by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Low levels of progesterone can lead to infertility, uterine bleeding, and other complications, Progesterone injections are often prescribed for pregnant women whove experienced a miscarriage. Avoid or Use Alternate Drug. When indicated for prevention of spontaneous preterm birth in a multiple pregnancy, vaginal micronized progesterone in a daily dose of 400 mg is recommended (conditional [weak]/low). Avoid or Use Alternate Drug. If you have any questions, consult your doctor or pharmacist.Take this medication by mouth as directed by your doctor, usually once a day at bedtime. Your list will be saved and can be edited at any time. progesterone micronized increases levels of rifaximin by P-glycoprotein (MDR1) efflux transporter. Minor/Significance Unknown. This drug is also not recommended while youre breastfeeding. This medication is not for use in children. Modify Therapy/Monitor Closely. progesterone micronized decreases effects of metformin by pharmacodynamic antagonism. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Family history of breast cancer and or DVT/PE, current/history of depression, endometriosis, DM, HTN, bone mineral density changes, renal/hepatic impairment, bone metabolic disease, SLE; conditions exacerbated by fluid retention (eg, migraine, asthma, epilepsy). Use Caution/Monitor. progesterone micronized increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. Avoid or Use Alternate Drug. Use Caution/Monitor. progesterone micronized will increase the level or effect of ruxolitinib topical by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Be sure to go over every drug you use, including herbal supplements and over-the-counter drugs you take. Monitor Closely (2)tazemetostat will decrease the level or effect of progesterone micronized by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. Selected from NATIONAL DRUG DATA FILE (NDDF) data included with permission and copyrighted by First Databank, Inc., 2019. Monitor Closely (1)rucaparib will increase the level or effect of progesterone micronized by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Dont take them if youre allergic to peanuts. Modify Therapy/Monitor Closely. 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