Follow all directions on your prescription label. If serotonin syndrome is suspected, serotonergic agents should be discontinued and appropriate medical treatment instituted. Educate patients about the risks and symptoms of respiratory depression and sedation. The severity of this interaction may be increased when additional CNS depressants are given. Limit the use of opioid pain medication with metaxalone to only patients for whom alternative treatment options are inadequate. Avoid concomitant use if possible and monitor for serotonin syndrome if use is necessary. Limit the use of opioid pain medication with metaxalone to only patients for whom alternative treatment options are inadequate. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. Concomitant use of metaxalone and opioid agonists increases the risk for serotonin syndrome. Concomitant use of metaxalone and opioid agonists increases the risk for serotonin syndrome. Therefore, caution should be exercised with patients who take Chlordiazepoxide; Clidinium: (Moderate) Concomitant use of skeletal muscle relaxants with benzodiazepines can result in additive CNS depression. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location one that is up and away and out of their sight and reach. metaxalone + butorphanol use alternative or monitor resp. Taking metaxalone with food may enhance general CNS depression; elderly patients may be especially susceptible to this CNS effect. Concomitant use of metaxalone and opioid agonists increases the risk for serotonin syndrome. Limit the use of pentazocine with metaxalone to only patients for whom alternative treatment options are inadequate. The severity of this interaction may be increased when additional CNS depressants are given. Acetaminophen; Caffeine; Dihydrocodeine: (Major) Concomitant use of opioid agonists with metaxalone may cause respiratory depression, profound sedation, and death. Educate patients about the risks and symptoms of respiratory depression and sedation. Oxycodone: (Major) Concomitant use of opioid agonists with metaxalone may cause respiratory depression, profound sedation, and death. Monitor for excessive sedation, somnolence, and serotonin syndrome. Educate patients about the risks and symptoms of respiratory depression and sedation. Consider prescribing naloxone for the emergency treatment of opioid overdose. Monitor patients who take barbiturates with another CNS depressant for symptoms of excess sedation. Concomitant use of pentazocine and metaxalone increases the risk for serotonin syndrome. Uses Warnings Before taking Side effects Dosage Interactions Be careful if you drive or do anything that requires you to be awake and alert. Methadone: (Major) Concomitant use of opioid agonists with metaxalone may cause respiratory depression, profound sedation, and death. Educate patients about the risks and symptoms of respiratory depression and sedation. Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.Towers Administrators LLC (operating as 'SingleCare Administrators') is the authorized prescription discount plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. Tell your doctor if you are pregnant or plan to become pregnant. Benzodiazepines: (Moderate) Concomitant use of skeletal muscle relaxants with benzodiazepines can result in additive CNS depression. Your doctor will check your progress and the effects of this medicine at regular visits. Limit the use of opioid pain medication with metaxalone to only patients for whom alternative treatment options are inadequate. If concurrent use is necessary, reduce initial dosage and titrate to clinical response; use the lowest effective doses and minimum treatment durations. Educate patients about the risks and symptoms of excessive CNS depression. Lasmiditan: (Moderate) Monitor for excessive sedation, somnolence, and serotonin syndrome during coadministration of lasmiditan and metaxalone. It does not act Limit the use of opioid pain medication with metaxalone to only patients for whom alternative treatment options are inadequate. Visit the FDA MedWatch website or call 1-800-FDA-1088. Limit the use of opioid pain medication with metaxalone to only patients for whom alternative treatment options are inadequate. Monitor patients who take barbiturates with another CNS depressant for symptoms of excess sedation. Aspirin, ASA; Butalbital; Caffeine: (Moderate) Concomitant use of skeletal muscle relaxants with barbiturates can result in additive CNS depression. Limit the use of opioid pain medication with metaxalone to only patients for whom alternative treatment options are inadequate. Cyproheptadine: (Moderate) Concomitant administration of metaxalone with other CNS depressants can potentiate the sedative effects of either agent. Concomitant use of metaxalone and opioid agonists increases the risk for serotonin syndrome. Limit the use of opioid pain medication with metaxalone to only patients for whom alternative treatment options are inadequate. Concomitant use of metaxalone and opioid agonists increases the risk for serotonin syndrome. Azelastine; Fluticasone: (Moderate) Monitor for excessive sedation and somnolence during coadministration of azelastine and skeletal muscle relaxants. metaxalone is co-administered with drugs that may affect the serotonergic neurotransmitter The severity of this interaction may be increased when additional CNS depressants are given. Amitriptyline: (Moderate) Coadministration of tricyclic antidepressants (TCAs) with metaxalone may result in additive CNS-depressant effects, such as sedation, and may increase the risk for serotonin syndrome. What side effects can this medication cause? Consult the IV methylene blue product label for management. Concomitant use of butorphanol and metaxalone increases the risk for serotonin syndrome. Metaxalone is a skeletal muscle relaxant. Avoid prescribing opioid cough medication in patients taking metaxalone. Depending on the specific agent (e.g., cyclobenzaprine, and orphenadrine), additive anticholinergic effects may also be seen. Relaxes muscles and relieves pain caused by muscle injuries, sprains, and strains. Do not take more or less of it or take it more often than prescribed by your doctor. Skelaxin; Descriptions. Excretion is via the urine as unidentified metabolites. Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate: (Moderate) Concomitant use of IV methylene blue and metaxalone may increase the risk for serotonin syndrome. Norco and Tramadol treat pain but they work in different ways. Educate patients about the risks and symptoms of respiratory depression and sedation. What should I know about STORAGE and DISPOSAL of this medication? If concurrent use is necessary, reduce initial dosage and titrate to clinical response; use the lowest effective doses and minimum treatment durations. A reduction in the dose of these medications may be considered to minimize additive sedative effects, if they occur. Get emergency medical help if you have signs of an allergic reaction to Skelaxin: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Tell any doctor or dentist who treats you that you are using this medicine. Concomitant use may increase the risk for these adverse reactions. In the absence of such information, Limit the use of opioid pain medication with metaxalone to only patients for whom alternative treatment options are inadequate. by the FDA in 1962. Do not take extra medicine to make up the missed dose. Educate patients about the risks and symptoms of respiratory depression and sedation. Consider prescribing naloxone for the emergency treatment of opioid overdose. With hypnotic medications, the risk of next-day psychomotor impairment is increased during co-administration of other CNS depressants, which may decrease the ability to perform tasks requiring full mental alertness such as driving. Skelaxin pregnancy and breastfeeding warnings. Metaxalone may affect the results tests that checks for sugar in the urine of patients with diabetes. and irritable bowel syndrome. Use caution in patients with renal impairment, or varying severities of hepatic disease. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. Consider prescribing naloxone for the emergency treatment of opioid overdose. <= 12 years: Safety and efficacy have not been established. Take the missed dose as soon as you remember it. Consider prescribing naloxone for the emergency treatment of opioid overdose. Triazolam: (Moderate) Concomitant use of skeletal muscle relaxants with benzodiazepines can result in additive CNS depression. Monitor patients who take benzodiazepines with another CNS depressant for symptoms of excess sedation. You should not breast-feed while using this medicine. All rights reserved. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Educate patients about the risks and symptoms of respiratory depression and sedation. SKELAXIN should be used with caution in patients with hepatic and/or renal Granisetron: (Moderate) Concomitant use of metaxalone and serotonin-receptor antagonists (5HT-3 receptor antagonists) may increase the risk for serotonin syndrome. Concomitant use of buprenorphine and metaxalone increases the risk for serotonin syndrome. Erectile dysfunction (ED) is often a symptom . Medically reviewed by John P. Cunha, DO, FACOEP; Board Certified Emergency Medicine. The most common side effects with metaxalone are: Other important, but less common, side effects include: Metaxalone usually is taken at a dose of 800 mg, three or four Prescribers should re-assess patients for drowsiness or sleepiness regularly throughout treatment, especially since events may occur well after the start of treatment. How quickly can acute migraines be treated. Phenobarbital: (Moderate) Concomitant use of skeletal muscle relaxants with barbiturates can result in additive CNS depression. Metaxalone (Skelaxin) is a muscle relaxer used to treat muscle pain and discomfort that is not chronic or long-lasting. Older adults should not usually take metaxalone because it is not as safe or effective as other medications that can be used to treat the same condition. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Monitor patients who take benzodiazepines with another CNS depressant for symptoms of excess sedation. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Post marketing experience has not demonstrated evidence of impaired fertility or harm to the fetus, but the possibility of infrequent or subtle damage to the fetus cannot be excluded. Estazolam: (Moderate) Concomitant use of skeletal muscle relaxants with benzodiazepines can result in additive CNS depression. Buprenorphine; Naloxone: (Major) Concomitant use of buprenorphine with metaxalone may cause respiratory depression, profound sedation, and death. Concomitant use of opioid overdose either agent pain medicine, narcotic pain medicine, and death ; the. Cns depression should I know about STORAGE and DISPOSAL of this interaction may be especially susceptible to this effect... The specific agent ( e.g., cyclobenzaprine, and strains doctor if you are or... Barbiturates can result in additive CNS depression ; elderly patients may be increased when additional depressants. 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