Cancer Research 2012;72:20282035. It is usually taken once a day on certain days of a regular monthly cycle. To induce optimum secretory transformation of an endometrium that has been adequately primed with endogenous or exogenous estrogen, 10 mg daily for 10 days. ), Management of pain associated with endometriosis. The recommended regimen . Most of these side effects are not common. Your provider may have you take a pregnancy test before getting the shot. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Unlike the Depo-Provera shot that you may receive in your providers office, this version doesnt need to go into your muscular tissue. Fluid retention may occur. Copyright 2023, Selected Revisions August 1, 2005. Bone loss is greater with increasing duration of therapy; may not be reversible. Studies in animals have shown that progestogens, including this drug, may have an adverse effect on the developing fetus, including teratogenicity and fetotoxicity. MedroxyPROGESTERone Acetate (medroxyPROGESTERone)." It contains a type of progesterone hormone Depo-Provera shots provide protection against pregnancy for up to 14 weeks though you typically need to receive one shot every 12 weeks. Management of GnRH-dependent (central) forms of precocious puberty [off-label]; however, GnRH analogs generally are preferred. Youre immediately protected after receiving the first Depo-Provera shot if you get it during your menstrual period. Provera (medroxyprogesterone)." What other information should I know before choosing Depo-Provera CI? Depo-Provera CI and certain other medicines may affect each other, causing serious side effects. allergic reactions. Call your doctor if you have any unusual problems while taking this medication. Effect of Depo-Medroxyprogesterone Acetate on Breast Cancer Risk among Women 20 to 44 years of Age. PROVERA is not for pregnant women. Patients should be instructed to call if they experience symptoms of potential complications, including heavy bleeding, no bleeding following misoprostol use, pain not relieved by analgesics, purulent vaginal discharge, or fever or feeling ill more than 24 hours after using misoprostol. This injectable type of birth control has a few differences from other forms of birth control. Depo-Provera (depot medroxyprogesterone acetate) is an injectable birth control method for women. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation and COVID-19 information. It is not known if your risk of developing osteoporosis is greater if you are a teenager or young adult when you start to use Depo-Provera CI (see ". blood clots in your arms, legs, lungs, and eyes. Your chance of getting pregnant depends on how well you follow the directions for taking your Depo-Provera CI. are allergic to medroxyprogesterone acetate or any of the other ingredients in Depo-Provera CI. 150 mg every 3 months. Medroxyprogesterone intramuscular (into a muscle) injection and medroxyprogesterone subcutaneous (under the skin) injection are used to prevent pregnancy. Littleton, MA: Publishing Sciences Group, Inc. (1977): 297, Gray RH, Pardthaisong T "In utero exposure to steroid contraceptives and survival during infancy" Am J Epidemiol 134 (1991): 804-11, Pardthaisong T, Gray RH "In utero exposure to steroid contraceptives and outcome of pregnancy" Am J Epidemiol 134 (1991): 795-803, Resseguie LJ, Hick JF, Bruen JA, Noller KL, O'Fallon WM, Kurland LT "Congenital malformations among offspring exposed in utero to progestins, Olmsted County, Minnesota, 1936-1974." Greenstone LLC (2022): "Product Information. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking medroxyprogesterone. Known or suspected malignancy of the breast. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Recommendations about the use of hormonal contraceptive methods (including depot medroxyprogesterone acetate) . When improvement is noted and disease has stabilized (within weeks or months), maintain response with as little as 400 mg/month. Write a review. The Depo-Provera shot works by impacting ovulation the part of the reproductive cycle when an egg is released from a womans ovary and thickening your cervical mucus, which prevents sperm from successfully getting to the egg. Depo-Provera Contraceptive: IM: 150 mg every 3 months (every 13 weeks) Depo-subQ Provera 104: SubQ: 104 mg every 3 months (every 12 to 14 weeks) . Effect of long-term therapy on pituitary, ovarian, adrenal, hepatic, or uterine function not determined. Medroxyprogesterone Acetate use while Breastfeeding, Heinonen O, Shapiro S; Kaufman DW ed., Slone D "Birth Defects and Drugs in Pregnancy." Save 2.20. Both the 1 mL vial and the 1 mL prefilled syringe of Depo-Provera CI should be vigorously shaken just before Prefilled syringes are available packaged with 22-gauge 1 1/2 inch Terumo SurGuard Needles. It is also important information to carry with you in case of emergencies. Especially tell your healthcare provider if you take: Know the medicines you take. PROVERA . Remember, you can also become pregnant if you miss a dose of the birth control shot or if its late. When switching from other contraceptive methods, initiate depo-subQ provera 104 in a manner that ensures continuous contraceptive coverage based on the mechanism of action of both methods. Effectiveness between 64 and 77 days' gestation increases with the addition of a second dose of misoprostol, 800 mcg four hours after the first dose. There may be an increased risk of minor birth defects in children whose mothers take PROVERA during the first 4 months of pregnancy. When used in fixed combination with conjugated estrogens or estradiol cypionate, consider the cautions, precautions, and contraindications associated with estrogens. About two-thirds of the women who used Depo-Provera CI in the clinical trials reported a weight gain of about 5 pounds during the first year of use. (medroxyprogesterone acetate injectable suspension, for intramuscular use), (medroxyprogesterone acetate injectable suspension). Take medroxyprogesterone exactly as directed. The most effective regimen for medication management of early pregnancy loss is mifepristone, 200 mg orally, followed 24 to 48 hours later by misoprostol, 800 mcg vaginally; when available, the combination should be recommended over misoprostol alone. 510 mg daily for 510 days beginning on the assumed or calculated 16th or 21st day of the menstrual cycle. When switching from other contraceptive methods, initiate Lunelle in a manner that ensures continuous contraceptive coverage based on the mechanism of action of both methods (e.g., patients switching from oral contraceptives should be given an initial injection within 7 days after taking the last hormonally active tablet). However, in a study of teenage girls who used Depo-Provera CI for more than 2 years, their hip bones did not completely recover by 5 years after they stopped using Depo-Provera CI. Last updated on Mar 28, 2023. It is not known if medroxyprogesterone increases the risk of breast cancer in humans. The box on the bottom of the chart shows the chance of getting pregnant for women who do not use birth control and are trying to get pregnant. You need to regularly visit your healthcare providers office for injections. See the end of this leaflet for a complete list of ingredients in Depo-Provera CI. If you get your shot more than 15 weeks after getting your last shot, wait to have sex or . Do not take more or less of it or take it more often than prescribed by your doctor. It undergoes rigorous internal medical review and is updated regularly to reflect new information. Possible loss of BMD with parenteral medroxyprogesterone; loss of BMD is of particular concern during adolescence. Instead, the best way to dispose of your medication is through a medicine take-back program. Consider other therapies in women with existing risk factors for osteoporosis, since use of medroxyprogesterone may pose additional risk. Distributed into milk. Medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone acetate, and what is almost always being referred to when the term is used is MPA and not medroxyprogesterone. The most effective regimens for medication management of early pregnancy loss and medication abortion include 200 mg of oral mifepristone (a progesterone receptor antagonist) followed by 800 mcg of misoprostol (a prostaglandin E1analogue) administered buccally or vaginally. Available for Android and iOS devices. When used IM or sub-Q as a contraceptive or sub-Q for the management of endometriosis, possible increased rate of bone loss, especially during initial years of therapy. Adjunctive therapy and palliative treatment of inoperable, recurrent, and metastatic endometrial carcinoma. sharp chest pain, coughing up blood, or sudden shortness of breath (indicating a possible clot in the lung), sudden severe headache or vomiting, dizziness or fainting, problems with your eyesight or speech, weakness, or numbness in an arm or leg (indicating a possible stroke), severe pain or swelling in the calf (indicating a possible clot in the leg), sudden blindness, partial or complete (indicating a possible clot in the blood vessels of the eye), severe pain or tenderness in the lower abdominal area, persistent pain, pus, or bleeding at the injection site, swelling of the face, mouth, tongue or neck, irregular vaginal bleeding, such as lighter or heavier menstrual bleeding, or continued spotting. Contraceptive effect is prolonged. Continue to take medroxyprogesterone according to your monthly schedule even if you feel well. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Counsel patients about the possible increased risk of breast cancer in women who use Depo-Provera CI. Exercise particular care in women with a strong family history of breast cancer or those who have breast nodules. This product's labeling may have been updated. It regulates menstrual periods by helping to balance the levels of progesterone in the body. Peak plasma concentrations attained approximately 1 week following sub-Q injection. Clinicians should inform patients that gastrointestinal symptoms such as nausea, vomiting, and diarrhea are common with misoprostol use. Your bones may not recover completely when you stop using Depo-Provera CI. At the end of the 3 months, you will need to return to your healthcare provider for your next injection in order to continue your protection against pregnancy, during the first 5 days of a normal menstrual period, or. Read this Patient Information carefully before you decide if Depo-Provera CI is right for you. Sometimes the doses of other medicines may need to be changed while you are taking Depo-Provera CI. VA class: HS800 The product information provided by this site is intended only for health care professionals, patients, consumers and caregivers in the United States. Depo-Provera can cause you to experience a number of side effects, including: You should talk to your healthcare provider about any possible side effects of Depo-Provera. II. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This medication strong family history of breast cancer in humans changed while you are taking medroxyprogesterone medical. Menstrual periods by helping to balance the levels of progesterone in the body particular concern during adolescence of progesterone the... Dental surgery, including dental surgery, tell the doctor or dentist you. 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