The recipient will receive more details and instructions to access this offer. Serious - Use Alternative (1)leuprolide and entrectinib both increase QTc interval. Contraindicated. QTc prolongation reported with higher than recommended doses of fostemsavir. Monitor Closely (1)leuprolide increases toxicity of erythromycin stearate by QTc interval. Use Caution/Monitor. leuprolide increases toxicity of pazopanib by QTc interval. Use Caution/Monitor. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Increases risk of torsades de pointes. Contraindicated. Increases risk of torsades de pointes. Leuprolide Acetate (Lupron, Lupron Depot, Eligard, Prostap, Viadur), for women, is a hormone therapy used in the treatment of ovarian cancer and breast cancer. leuprolide decreases effects of metformin by pharmacodynamic antagonism. Use Caution/Monitor. amisulpride and leuprolide both increase QTc interval. Monitor Closely (1)sertraline and leuprolide both increase QTc interval. leuprolide increases toxicity of droperidol by QTc interval. Monitor Closely (1)leuprolide increases toxicity of sorafenib by QTc interval. Increases risk of torsades de pointes. Increases risk of torsades de pointes. Monitor Closely (1)lithium and leuprolide both increase QTc interval. Monitor Closely (1)leuprolide increases toxicity of sunitinib by QTc interval. Use Caution/Monitor. Monitor Closely (1)leuprolide and lenvatinib both increase QTc interval. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval. Use Caution/Monitor. Use Caution/Monitor. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Vhody smoothies zvisia od toho, o do nich dte. Use Caution/Monitor. Use Caution/Monitor. What Is Eligard? Increases risk of torsades de pointes. Increases risk of torsades de pointes. Use Caution/Monitor. Compare formulary status to other drugs in the same class. Respiratory System-Interstitial lung disease, Cardiovascular system: Hypotension, myocardial infarction, pulmonary embolism, Respiratory, thoracic and mediastinal disorder: Interstitial lung disease, Hepatobiliary disorder: Serious drug-induced liver injury, Hemic and lymphatic system: Decreased WBC, Central/peripheral nervous system: Convulsion, peripheral neuropathy, spinal fracture/paralysis, Musculoskeletal system: Tenosynovitis-like symptoms, During early phase of therapy, gonadotropins and sex steroids rise above baseline because of the initial stimulatory effect of the drug; therefore, an increase in clinical signs and symptoms of puberty including vaginal bleeding may be observed during the first weeks of therapy or after subsequent doses, Psychiatric adverse events or emotional lability, including crying, irritability, impatience, anger, and aggression, reported; many, but not all, patients had a history of psychiatric illness or other comorbidities with an increased risk of depression, Postmarketing reports of convulsions reported, including patients with or without a history of seizures, epilepsy, cerebrovascular disorders, central nervous system anomalies, and patients on concomitant medications associated with convulsions such as bupropion and SSRIs, Pseudotumor cerebri (idiopathic intracranial hypertension) reported in pediatric patients receiving GnRH agonists, including leuprolide acetate; monitor patients for signs and symptoms of pseudotumor cerebri, including headache, papilledema, blurred vision, diplopia, loss of vision, pain behind the eye or pain with eye movement, tinnitus, dizziness, and nausea, Spinal cord compression reported; observe patients closely for weakness and paresthesias in first few weeks of therapy; observe patients with metastatic vertebral lesions closely, Tumor flare resulting from transient increases in testosterone, leading to bone pain, hematuria, bladder outlet obstruction, and neuropathy in prostate cancer patients reported during first few weeks of therapy, Closely observe patients for urinary tract obstruction and hematuria in first few weeks of therapy, Orchiectomy or luteinizing hormone agonists recommended as initial treatment for androgen deprivation in patients with advanced androgen sensitive prostate cancer, Decrease in bone density reported when drug used for >6 months; use caution if there are additional risk factors for bone loss, including corticosteroid therapy or chronic alcohol use, Worsening of endometriosis or uterine leiomyomata symptoms with therapy reported initially, Rare cases of pituitary apoplexy, frequently secondary to pituitary adenoma reported (onset 1hr to usually <2 weeks): may present as sudden headache, vomiting, visual or mental status changes and cardiovascular collapse (rare), requiring immediate medical attention, Worsening of glycemic control reported in men receiving GnRH agonists; monitor blood glucose and/or glycosylated hemoglobin (HbA1c) periodically in patients receiving a GnRH agonist and manage with current practice for treatment of hyperglycemia or diabetes, Prostate cancer symptoms may worsen during initial treatment period, Androgen deprivation therapy may prolong the QT/QTc interval; consider whether benefits of androgen deprivation outweighs potential risks in patients with congenital long QT syndrome, congestive heart failure, frequent electrolyte abnormalities, and patients taking drugs known to prolong the QT interval; correct electrolyte abnormalities and monitor ECG and electrolytes periodically, Men receiving GnRH agonists for prostate cancer have slightly increased risk of diabetes, heart attack, stroke, and sudden death, In women, duration of treatment with GnRH agonists not to exceed 1 year, except in treatment of breast cancer. Get medical help right away if any of these very serious side effects occur: symptoms of a heart attack (such as chest/jaw/left arm pain, shortness of breath, unusual sweating), signs of a stroke (such as weakness on one side of the body, trouble speaking, sudden vision changes, confusion), fast/irregular heartbeat, severe dizziness, fainting.Get medical help right away if any of these very serious side effects occur: seizures.Children using leuprolide may be at risk for increased pressure around the brain (intracranial hypertension). Use Caution/Monitor. Increases risk of torsades de pointes. commonly, these are "preferred" (on formulary) brand drugs. Avoid or Use Alternate Drug. Use Caution/Monitor. More About Leuprolide Acetate Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug. Endometriosis 3.75 mg IM monthly for up to 6 months or 11.25 mg IM every 3 months for 2 doses (6 months total) Recommended duration of treatment is 6 months; may treat again for additional 6. Avoid or Use Alternate Drug. Use Caution/Monitor. However, you should see an improvement in symptoms usually within 1 to 2 months. Access your plan list on any device mobile or desktop. When given regularly to men, leuprolide decreases testosterone levels. New Trials in Urologic Cancers: Could Your Patient Benefit? aripiprazole and leuprolide both increase QTc interval. sertraline and leuprolide both increase QTc interval. Contraindicated. SIDE EFFECTS: Mild burning/pain/bruising at the injection site, hot flashes (flushing), increased sweating, night sweats, tiredness, headache, upset stomach, breast changes, acne, joint/muscle aches, trouble sleeping, reduced sexual interest, vaginal discomfort/dryness, vaginal bleeding, swelling of the ankles/feet, increased urination at night, or dizziness may occur. being able to get an erection sometimes, but not every time you want to have sex. Manage and view all your plans together even plans in different states. Queens of the Stone Age will bring Phantogram, Viagra Boys, the Armed, and Savages' Jehnny Beth along for the ride on their fall North American tour, which will begin Aug. 3 in Sterling Heights . Contraindicated. Use Caution/Monitor. Leuprolide is a luteinizing hormone releasing hormone (LHRH) agonist. Use Caution/Monitor. Use Caution/Monitor. Canada residents can call a provincial poison control center. By clicking send, you acknowledge that you have permission to email the recipient with this information. leuprolide increases toxicity of pentamidine by QTc interval. Increases risk of torsades de pointes. Contraindicated (1)leuprolide increases toxicity of escitalopram by QTc interval. It is given in women who need 3 months of hormonal suppression. leuprolide increases toxicity of arsenic trioxide by QTc interval. Use Caution/Monitor. leuprolide increases toxicity of escitalopram by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes. This drug is available at a higher level co-pay. Contraindicated. Synthetic luteinizing hormone-releasing hormone (LHRH) analogs (also called LHRH agonists) available in the United States include leuprolide acetate . Increases risk of torsades de pointes. Monitor Closely (1)leuprolide increases toxicity of haloperidol by QTc interval. Always ask your health care professional for complete information about this product and your specific health needs. osilodrostat and leuprolide both increase QTc interval. leuprolide and lenvatinib both increase QTc interval. Monitor Closely (1)mirtazapine and leuprolide both increase QTc interval. Serious - Use Alternative (1)buprenorphine transdermal and leuprolide both increase QTc interval. Increases risk of torsades de pointes. Increases risk of torsades de pointes. Monitor Closely (1)dichlorphenamide and leuprolide both decrease serum potassium. vorinostat and leuprolide both increase QTc interval. Increases risk of torsades de pointes. leuprolide increases toxicity of ibutilide by QTc interval. leuprolide increases toxicity of degarelix by QTc interval. donepezil and leuprolide both increase QTc interval. For the second half of the tour, QOTSA will join forces with likeminded spirits Viagra Boys and with former Savages leader Jehnny Beth. Monitor Closely (1)leuprolide and fostemsavir both increase QTc interval. Serious - Use Alternative (1)olanzapine and leuprolide both increase QTc interval. Monitor Closely (1)valbenazine and leuprolide both increase QTc interval. female: Clitoral engorgement Ecchymosis Face oedema Lip disorder Lip swelling Localised oedema Nausea Oedema genital Pain in jaw Circumoral oedema male: Bladder disorder Drug effect decreased Drug maladministration Emphysema Haemorrhage Hypertension Increases risk of torsades de pointes. If unable to avoid concomitant use, obtain ECGs and electrolytes before and after initiation of any drug known to prolong QTc, and periodically monitor as clinically indicated during treatment. Increases risk of torsades de pointes. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Rarely in men, shrinking of the testicles, breast tenderness/swelling, and reduced sexual interest/ability may also occur as a result of lowered testosterone levels. leuprolide increases toxicity of ofloxacin by QTc interval. The effect of ADT on the performance of gallium Ga 68 PSMA-11 is unknown. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Avoid or Use Alternate Drug. Increases risk of torsades de pointes. Talk with the doctor. Contraindicated. leuprolide increases toxicity of ciprofloxacin by QTc interval. Use Caution/Monitor. Contraindicated (1)leuprolide increases toxicity of disopyramide by QTc interval. Use Caution/Monitor. This document does not contain all possible drug interactions. Monitor Closely (1)leuprolide increases toxicity of osimertinib by QTc interval. Contraindicated. Women have contacted NWHN, stating that Lupron has had adverse effects on their health and daily life. Alcohol or marijuana (cannabis) can make you more dizzy. Increases risk of torsades de pointes. Avoid or Use Alternate Drug. Increases risk of torsades de pointes. Increases risk of torsades de pointes. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Monitor Closely (1)leuprolide decreases effects of dengue vaccine by immunosuppressive effects; risk of infection. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation). Use Caution/Monitor. Increases risk of torsades de pointes. Increases risk of torsades de pointes. May cause fetal harm when administered to pregnant females, Based on animal data and mechanism of action, fetal harm may occur, Insufficient data available to assess the risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes, Exclude pregnancy in females of reproductive potential prior to initiation, No data available on presence of leuprolide acetate in either animal or human milk, effects on breastfed infants, or effects on milk production, Developmental and health benefits of breastfeeding should be considered along with the mothers clinical need for therapy and any potential adverse effects on the breastfed infant therapy or from underlying maternal conditions. Monitor for ECG changes if therapy is initiated in patients with drugs known to prolong QT interval.Serious - Use Alternative (1)oxaliplatin and leuprolide both increase QTc interval. Increases risk of torsades de pointes. leuprolide increases toxicity of lopinavir by QTc interval. Panobinostat prescribing information states use with drugs known to prolong QTc is not recommended. Use Caution/Monitor. Increases risk of torsades de pointes. Contraindicated. Leuprolide overstimulates the body's own production of certain hormones, which causes that production to shut down temporarily. leuprolide increases toxicity of chloroquine by QTc interval. Increases risk of torsades de pointes. olanzapine and leuprolide both increase QTc interval. Monitor Closely (1)leuprolide increases toxicity of ondansetron by QTc interval. leuprolide increases toxicity of citalopram by QTc interval. Increases risk of torsades de pointes. Your list will be saved and can be edited at any time. 22.5-mg injection every 3 months for . leuprolide increases toxicity of sorafenib by QTc interval. Contraindicated. Lenvatinib prescribing information recommends monitoring ECG closely when coadministered with QT prolonging drugs. Serious - Use Alternative (1)buprenorphine and leuprolide both increase QTc interval. Contraindicated (1)leuprolide increases toxicity of paliperidone by QTc interval. Monitor Closely (1)leuprolide and alfuzosin both increase QTc interval. Increases risk of torsades de pointes. Use Caution/Monitor. Avoid or Use Alternate Drug. Uses: Lupron typically is used to reduce the risk of early-stage, hormone-receptor-positive breast cancer coming back in premenopausal women after surgery and other treatments. Use Caution/Monitor. leuprolide increases toxicity of crizotinib by QTc interval. Increases risk of torsades de pointes. This drug is available at the lowest co-pay. Modify Therapy/Monitor Closely. Uses Before taking Warnings Side effects Overdose Dosage FAQ Uses of Lupron Depot: It is used to treat endometriosis . Monitor Closely (1)itraconazole and leuprolide both increase QTc interval. 2. buprenorphine, long-acting injection and leuprolide both increase QTc interval. Increases risk of torsades de pointes. asenapine transdermal and leuprolide both increase QTc interval. leuprolide increases toxicity of sotalol by QTc interval. LHRH agonists stop the production of luteinizing hormone by the pituitary gland. Serious - Use Alternative (1)amisulpride and leuprolide both increase QTc interval. Uses. Avoid or Use Alternate Drug. Additional information: Once you stop receiving Lupron, the ovaries . Minor (1)maitake increases effects of leuprolide by pharmacodynamic synergism. Contraindicated. leuprolide increases toxicity of amiodarone by QTc interval. Graham Head, 66, who kidnapped and tried to rape two women, was caught after one victim remembered three digits of his car registration. Monitor Closely (1)aripiprazole and leuprolide both increase QTc interval. Most Increases risk of torsades de pointes. Contraindicated (1)leuprolide increases toxicity of dronedarone by QTc interval. Many people using this medication do not have serious side effects.Tell your doctor right away if any of these serious side effects occur: new/worsening bone pain (in adults), easily broken bones (in adults), increased thirst/urination (in adults), mental/mood changes (such as depression, thoughts of suicide, mood swings, aggression).In adults, this medication may rarely cause heart problems and stroke. Increases risk of torsades de pointes. Contraindicated. Agonist analogue of luteinizing hormone-releasing hormone (LHRH), When administered continuously, decreases LH and FSH levels by acting as potent inhibitor of gonadotropin secretion; decrease in LH and FSH levels followed by suppression of ovarian and testicular steroidogenesis; testosterone levels reduced to below castrated levels in males, Metabolized to smaller inactive peptides, a pentapeptide (metabolite I), tripeptides (metabolites II and III), and a dipeptide (metabolite IV); these fragments may be further catabolized. Last updated on Feb 14, 2023. leuprolide increases toxicity of lumefantrine by QTc interval. Minor (1)leuprolide decreases levels of taurine by unspecified interaction mechanism. Use Caution/Monitor. leuprolide increases toxicity of toremifene by QTc interval. being unable to get an erection at any time. Serious - Use Alternative (1)sevoflurane and leuprolide both increase QTc interval. ECG monitoring is recommended if coadministered. Monitor Closely (1)leuprolide increases toxicity of formoterol by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. To help you remember, use it at the same time each day.During the first few weeks of treatment, your hormone levels will actually go up before they go down. Use Caution/Monitor. Avoid or Use Alternate Drug. Stasia Obremskey is Managing Director and founding team member at RH Capital.She believes the world is a better place when you educate women and give them the tools to manage . Avoid or Use Alternate Drug. PRECAUTIONS: Before using leuprolide, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as histrelin, triptorelin); or of any other allergies. Monitor Closely (1)leuprolide increases toxicity of bedaquiline by QTc interval. DESCRIPTION Synthetic nonpeptide analog of gonadotropin-releasing hormone (GnRH) Used for endometriosis, precocious puberty, prostate cancer, and uterine fibroids May cause an increase in symptoms during the first weeks of therapy; monitor patients closely COMMON BRAND NAMES Increases risk of torsades de pointes. Immunosuppressive therapies (eg, irradiation, antimetabolites, alkylating agents, cytotoxic drugs, corticosteroids [greater than physiologic doses]) may reduce immune response to dengue vaccine. Use Caution/Monitor. Monitor Closely (1)leuprolide decreases effects of metformin by pharmacodynamic antagonism. Contraindicated. Increases risk of torsades de pointes. Increases risk of torsades de pointes. It's effective for four to five hours or more if you have mild to moderate erectile dysfunction. Avoid or Use Alternate Drug. Increases risk of torsades de pointes. Serious - Use Alternative (1)leuprolide and pitolisant both increase QTc interval. Leuprolide reduces the amount of testosterone in men or estrogen in women. Use Caution/Monitor. Increases risk of torsades de pointes. Contraindicated. Treatment of precocious puberty GnRH agonist preparations available to us, we typically use the three-month preparation of leuprolide depot ( Lupron Depot PED [three month]) at a starting dose of 11.25 mg. Use Caution/Monitor. Contraindicated (1)leuprolide increases toxicity of mifepristone by QTc interval. Modify Therapy/Monitor Closely. Contraindicated. Monitor Closely (1)leuprolide increases toxicity of lapatinib by QTc interval. Increases risk of torsades de pointes. Use Caution/Monitor. buprenorphine transdermal and leuprolide both increase QTc interval. Contraindicated. Consult your doctor before breast-feeding. Use Caution/Monitor. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir. Increases risk of torsades de pointes. Contraindicated. Increases risk of torsades de pointes. Increases risk of torsades de pointes. Can women take it? leuprolide increases toxicity of thioridazine by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes. leuprolide increases toxicity of clozapine by QTc interval. Increases risk of torsades de pointes. Avoid or Use Alternate Drug. Monitor Closely (1)leuprolide increases toxicity of ezogabine by QTc interval. If puberty is not adequately suppressed Side effects of androgen deprivation therapy Monitor Closely (1)leuprolide increases toxicity of degarelix by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes. pain or difficulty passing urine spinal cord metastasis stroke tobacco smoker an unusual or allergic reaction to leuprolide, benzyl alcohol, other medicines, foods, dyes, or preservatives pregnant or trying to get pregnant breast-feeding How should I use this medication? Monitor Closely (1)leuprolide increases toxicity of azithromycin by QTc interval. Monitor Closely (1)siponimod and leuprolide both increase immunosuppressive effects; risk of infection. and formulary information changes. mirtazapine and leuprolide both increase QTc interval. Use Caution/Monitor. Share cases and questions with Physicians on Medscape consult. Use Caution/Monitor. Increases risk of torsades de pointes. Monitor Closely (1)dasatinib and leuprolide both increase QTc interval. leuprolide increases toxicity of ranolazine by QTc interval. Increases risk of torsades de pointes. Use Caution/Monitor. Most types of prostate cancer need the hormone testosterone to grow and spread. Use Caution/Monitor. The first look at the 'middle aged Love Island' set has been released, which has already been nicknamed the 'Viagra House' by locals after single parents searched for love Serious - Use Alternative (1)lefamulin and leuprolide both increase QTc interval. Increases risk of torsades de pointes. Contraindicated. 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