Dosage Examine Database Black Ginger is most often used for Researched by : Kamal Patel, MPH, MBA [27]. mRNA expressions of IL-6 (A) and TNF- (B) were evaluated using real-time PCR. In vivo tests were performed based on the schedule described in Fig. Gingerol, a natural component of ginger root, benefits gastrointestinal motility the rate at which food exits the stomach and continues along the digestive process. Therefore, the 3- and 4-methoxy groups may not be necessary for this activity. Moreover, in the CST, secondary ST was performed 30 min after the first ST under the same conditions. One review concluded that ginger may help reduce pain and disability.The participants took 0.5-1 gram of ginger per day for 3-12 weeks, depending on the study. Unable to load your collection due to an error, Unable to load your delegates due to an error, Oxidative stress was determined by measuring GSSG and GSH in whole blood after the addition or not of M2VP respectively. were obtained in 2017. Careers. These findings are consistent with the present results and our previous findings on black ginger. Front Pharmacol 8:630. https://doi.org/10.3389/fphar.2017.00630, Hegde V, Hegde S (2014) An economic overview of ginger production in Ethiopia. The angle at which the mouse dropped from the board was measured. Moreover, most of the known activities of ginger components are based only on in vitro and in vivo studies, except for a few clinical studies in human subjects. The rhizome is the main part of the plant which is economically important and a rich source of effective phytoconstituents for biological activities [2, 3]. Wear and tear on cells. 2C). I like the way ginger can balance the sweetness of fruits, Slattery says. In Supplementary Table1, comprehensive library containing a total of 72 gingerols and diarylheptanoids derivatives from ginger rhizomes is presented as summary. In fact, one . Bethesda, MD 20894, Web Policies Ginger has been proven to be highly effective against nausea, according to studies. Most had a diagnosis of OA of . The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). We evaluated whether the daily oral administration for 2 months with a combination of ginger, paullinia cupana, muira puama and L-citrulline (COMP-4) can effectively delay the ongoing corporal fibrosis, smooth muscle cell apoptosis and cavernosal veno-occlusive dysfunction (CVOD) seen in middle aged rats similar to that seen with tadalafil. CVOD was determined by dynamic infusion cavernosometry. Asterisks denote significant differences from the control (A and B) or the control only treated with LPS (C and D) at *: p<0.05, **: p<0.01, respectively. The identification of phenolic compounds was conducted for the pure standard available, by comparing their UV and mass spectral data. Rapid Commun Mass Spectrom 19:29572964, Jiang H, Xie Z, Koo H, McLaughlin SP, Timmermann BN, Gang DR (2006) Metabolic profiling and phytogenetic analysis of medicinal Zingiber species: Tools for authentication of ginger (Zingiber officinale Rosc.). Each column represents the mean with the S.E. Before It has an extensive history as a remedy for seasickness. Peak 1, 5-hydroxy-3,7-dimethoxyflavone; 2, 5-hydroxy-7-methoxyflavone; 3, 5-hydroxy-3,7,4'-trimethoxyflavone; 4, 5-hydroxy-3,7,3',4'-tetramethoxyflavone; 5, 3,5,7,3',4'-pentamethoxyflavone; 6, 5,7,4'-trimethoxyflavone; 7, 3,5,7,4'-tetramethoxyflavone; 8, 5,7-dimethoxyflavone. Received 2016 Apr 7; Revised 2016 Apr 27; Accepted 2016 May 13. IL-6 and TNF- mRNA expression levels were increased by LPS, but not by LA (data not shown). official website and that any information you provide is encrypted The KPE group was orally administered KPE (45 mg/kg/day) suspended in water for 4 weeks. Blood was collected from the ventral aorta under anesthesia in order to determine blood LA levels. J Ethnopharmacol 156:162174, He X, Bernart MW, Lian L, Lin L (1998) High-performance liquid chromatography-electrospray mass spectrometric analysis of pungent constituents of ginger. LPS and LA were used to induce muscular inflammation. Hence, the representative major compound among samples is affected by several factors such as plant origin, environment, and state of rhizome maturity [13]. Finally, these methoxyflavones were not detected in normal ginger samples. Participation AMPK in the regulation of skeletal muscles metabolism. [37], 8-gingerol was confirmed as the major constituent from ginger of Nigeria origin. Inclined plate test: after the open-field test, the mouse was placed on a wooden board covered with a canvas, which was leaned gradually at a constant speed. NucleoSpin Tissue, the kit used to extract total DNA from the soleus muscle, was purchased from Takara Bio Inc. (Kusatsu, Japan). Lactic acid in amphibian muscle. The contents of gingerol-related phenolics and methoxyflavones were calculated using 2,4,5-trimethoxycinnamic acid and galangin as internal standard, respectively. Black pepper is a good source of manganese, a mineral that can help with bone health, wound healing, and metabolism. The supernatant obtained was used to measure blood LA levels by lactate colorimetric assay kit 2. Chaturapanich G., Chaiyakul S., Verawatnapakul V., Yimlamai T., Pholpramool C. Enhancement of aphrodisiac activity in male rats by ethanol extract of, Promthep K., Eungpinichpong W., Sripanidkulchai B., Chatchawan U. Id recommend limiting these to occasional treats or choosing sugar-free options.. FOIA It's just kind of a hint of the normal spiciness and heat that you would get with ginger, and it's much earthier in its . 5A) and TNF- (Fig. For the beneficial effects of black ginger on health, we have developed a powdered black ginger extract as a healthy food ingredient and put it on the market, which is known as Black Ginger Extract that has been standardized to contain not less than 2.5% of 5,7-dimethoxyflavone and 10% of total PMFs. Black ginger, which is known scientifically as Kaempfira parviflora, may not be as well-known but also has a number of excellent health benefits. Prevention of CVOD in middle aged Fischer 344 rat by oral treatment with, Figure 2. Kress WJ, Prince LM, Williams KJ (2002) The phylogeny and a new classification of the gingers (Zingiberaceae): evidence from molecular data. I. diarylheptanoids from the rhizomes of ginger (Zingiber officinale Roscoe). Furthermore, the number of movements after ST was significantly increased in the KPE group at the 4-week period (Fig. Open-field test: A mouse was placed in a square field (30 30 cm) divided into 9 areas. LA was purchased from Wako Pure Chemical Industries, Ltd. (Osaka, Japan). Briefly, C2C12 were induced to differentiate with KPE (10 g/mL) or PMFs (compound 18, 10 M) for one week. Gingerol-related phenolic acid derivatives (wavelength at 280nm) were identified only from normal ginger, while black ginger showed different spectral peaks on UPLC-DAD chromatograms (Figs. The floating time was defined as the time until the mouse was unable to float for 5 seconds [or 7 seconds in case of forced swimming (ST) in PT] on the surface of the water. We expect black ginger to become a useful ingredient in processed foods and dietary supplements that will have exercise- and health-promoting effects. The effects of KPE and compound 8 on the glycogen content in C2C12 were then evaluated. Pregnant and experiencing morning sickness? Therefore, peaks 12, 16, and 18 were tentatively identified as 1-dehydro-6-gingerdione, 1-dehydro-8-gingerdione, and 1-dehydro-10-gingerdione, respectively [11, 14]. Physical exhaustion decreases physical fitness performance and muscular endurance. 8 Amazing Health Benefits of Black Ginger You are no doubt familiar with ginger and its many health benefits, but fewer people are likely to know about its cousin black ginger. AMP-activated protein kinase (AMPK) is known to be critically involved in the regulation of energy homeostasis, [22, 23, 24] and its activation has been shown to enhance the metabolism of glucose and lipids [25, 26]. Then, the extract was centrifuged (500 g, 4 C, 7 min) and the supernatant was removed. On this study, the phenolic composition of normal ginger (from Ethiopia and Korea) and black gingers (from Korea and Thailand) were profiled using ultra performance liquid chromatography coupled with diode array detector, quadrupole time-of-flight mass spectrometry (UPLCDADQToFMS). Ginger has been given to cancer patients going through chemotherapy to help relieve post-surgery nausea and vomiting. The control group was orally administered the vehicle of KPE. is one of the most popular species belonging to this family. Clinical studies have been conducted on black ginger, with some reporting improved physical fitness performance in the elderly and athletes, [6, 7] and the enhanced antioxidant enzyme activities (increased activities of superoxide dismutase, glutathione peroxidase and catalase in serum) and decreased MDA level had been suggested to be one of the mechanisms for physical improvement effect of KPE [7]. The normal ginger (Zingiber officinale Rosc.) From the ratio calculated for the dropped time after and before ST, the ratio in the KPE group (96%) was almost twice at the 4-week period (Fig. 3 and Fig. Glycogen content was determined by the method of Lo et al. et al. All data expressed as a meanstandard error of the mean (SEM). Peak 14 (28.68min) showed similar fragmentation pattern to diacetoxy-6-gingerdiol with methylene (CH2, 14Da) increment on the fragment ions, therefore, it was identified as methyl diacetoxy-6-gingerdiol [11]. Therefore, KPE was suggested to increase mitochondrial numbers by enhancing the expression of PGC-1 and glycogen content by enhancing the expression of Gsy. Inclusion in an NLM database does not imply endorsement of, or agreement with, Black Ginger is so much more than a simple N.O. In DAD chromatogram of Fig. Bethesda, MD 20894, Web Policies The glycogen contents in these cells were normalized by the cell numbers. Phytomedicine 21:800806, Sae-Wonga C, Matsuda BH, Tewtrakul S, Tansakul P, Nakamura S, Nomura Y, Yoshikawa M (2011) Suppressive effects of methoxyflavonoids isolated from Kaempferia parviflora on inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells. 6 and our previous findings [8]). Phytochemistry 65:11371143, Mercy OA, Simeon OO, Saheed A, Ayokunle O, Temitope AE (2014) Analysis of phenolic compounds, phytosterols, lignans and stilbenoids in garlic and ginger oil by gas chromatography. and black ginger (Kaempferia parviflora Wall.) by high-performance liquid chromatography/electrospray ionization mass spectrometry. The results showed that KPE tended to enhance the mRNA expression of Gsy (Fig. Slattery says research shows that ginger is safe for most people to eat in normal amounts such as those in food and recipes. Furthermore, KPE has been reported to suppress increases in body weight, visceral fat accumulation, dysfunctional lipid metabolism, hyperinsulinemia, insulin resistance, hypertension, and peripheral neuropathy in TSOD mice [1]. In ST, which induced sufficient fatigue in mice, swimming times were slightly longer in the KPE group than in the control group from the 1-week period (Fig. Disclaimer. Compounds 3, 7 and 8 suppressed the mRNA expression of TNF-. As the world's most widely cultivated spice, ginger may also be the world's most versatile, evidence-based natural health remedy. The Food and Drug Administration only reviews adverse reports on nutrition supplements, Slattery says. . The total methoxyflavone concentration was 4388.0mg/100g DW and 3940.2mg/100g DW in Korean and Thai black ginger sample, respectively. 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