Thiazide dosage >50 mg/day may increase blood glucose. Risk of hypoglycemia. Glipizide does not accumulate in plasma on repeated oral administration. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. Monitor Closely (1)isocarboxazid increases effects of glipizide by unknown mechanism. Applies only to oral form of both agents. Some sulfonylureas may produce a disulfiram like rxn. Minor/Significance Unknown. Minor/Significance Unknown. Minor (1)budesonide decreases effects of glipizide by pharmacodynamic antagonism. 4 CONTRAINDICATIONS. Use Caution/Monitor. Risk of hypoglycemia. Use Caution/Monitor. Otherwise, call a poison control center right away. Modify Therapy/Monitor Closely. Use Caution/Monitor. Minor/Significance Unknown. Either increases toxicity of the other by pharmacodynamic synergism. Reports of hyperglycemia due to insulin resistance with protease inhibitors. 5705185. Minor/Significance Unknown. Monitor Closely (1)nabumetone increases effects of glipizide by unknown mechanism. Monitor Closely (1)glipizide, insulin isophane human/insulin regular human. Other (see comment). Lowering the insulin secretagogue dose may reduce hypoglycemia risk. Interaction especially seen in the treatment of hypokalemia. sulfasalazine increases effects of glipizide by plasma protein binding competition. Consider lowering dose of sulfonylureas to reduce risk of hypoglycemia. Both drugs lower blood glucose. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Serious hypoglycemia may occur when insulin secretagogues and GLP-1 agonists are concurrently administered. Minor/Significance Unknown. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. lopinavir, glipizide. potassium acid phosphate increases effects of glipizide by pharmacodynamic synergism. Monitor Closely (1)ketoprofen increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Use Caution/Monitor. Risk of hypoglycemia.Minor (1)salsalate increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Use Caution/Monitor. fenoprofen increases effects of glipizide by unknown mechanism. esomeprazole will increase the level or effect of glipizide by increasing gastric pH. semaglutide, glipizide. PRECAUTIONS: Before taking glipizide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. sparsentan will decrease the level or effect of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. linezolid increases effects of glipizide by unknown mechanism. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Minor/Significance Unknown. Monitor Closely (1)saquinavir decreases effects of glipizide by Other (see comment). Minor/Significance Unknown. Use Caution/Monitor. juniper increases effects of glipizide by pharmacodynamic synergism. Minor (1)horse chestnut seed increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Minor/Significance Unknown. glipizide, insulin isophane human/insulin regular human. Hypoglycemic effects may be increased. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. Large dose of salicylate. Monitor Closely (1)opuntia ficus indica increases effects of glipizide by pharmacodynamic synergism. devil's claw increases effects of glipizide by pharmacodynamic synergism. It is more popular than comparable drugs. Risk of hypoglycemia. Diminished symptoms of hypoglycemia. Glipizide is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. Monitor Closely (1)ciprofibrate increases effects of glipizide by plasma protein binding competition. Use Caution/Monitor. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Use Caution/Monitor. Use Caution/Monitor. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. Monitor Closely (1)sulfisoxazole increases levels of glipizide by plasma protein binding competition. Your doctor may need to adjust your diabetes medication, exercise program, or diet.Beta-blocker medications (including metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat you would usually feel when your blood sugar falls too low (hypoglycemia). Other (see comment). tranylcypromine increases effects of glipizide by unknown mechanism. elvitegravir/cobicistat/emtricitabine/tenofovir DF decreases levels of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Cialis (tadalafil) is a brand-name drug that's prescribed for erectile dysfunction (ED) and benign prostatic hyperplasia (BPH). This means that glipizide will not work in people with type 1 diabetes. Monitor Closely (1)oxaprozin increases effects of glipizide by unknown mechanism. . Monitor Closely (1)choline magnesium trisalicylate increases effects of glipizide by unknown mechanism. maprotiline increases effects of glipizide by pharmacodynamic synergism. Other (see comment). rifampin decreases levels of glipizide by increasing metabolism. Minor/Significance Unknown. rucaparib will increase the level or effect of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Large dose of salicylate. Comment: Decreased symptoms of hypoglycemia. Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. aminolevulinic acid oral, glipizide. Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. xipamide decreases levels of glipizide by increasing renal clearance. Monitor Closely (1)lopinavir, glipizide. Minor (1)American ginseng increases effects of glipizide by pharmacodynamic synergism. Monitor Closely (1)glipizide, insulin aspart. Monitor Closely (1)sodium bicarbonate will increase the level or effect of glipizide by increasing gastric pH. Glipizide IR tablets begin to lower your blood sugar 30 minutes after you take a dose. Additive hypogylcemic effects. Use Caution/Monitor. Monitor Closely (1)glipizide, linagliptin. Because of the extensive protein Non selective beta blockers may also mask the symptoms of hypoglycemia. Thus, glipizide was more effective when administered about 30 minutes before, rather than with, a test meal in diabetic patients. Use Caution/Monitor. miconazole vaginal increases levels of glipizide by decreasing metabolism. Mechanism: decreased hypoglycemia induced catecholamine production. Glipizide extended-release tablets are formulated as a polymer matrix based once-a-day controlled release tablet for oral use and is designed to deliver 5 mg or 10 mg of glipizide. gemfibrozil increases effects of glipizide by plasma protein binding competition. . ketorolac intranasal increases effects of glipizide by unknown mechanism. Potential for hypoglycemia. orlistat increases effects of glipizide by pharmacodynamic synergism. MEDICAL ALERT: Your condition can cause complications in a medical emergency. Do not double the dose to catch up. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. When used appropriately, they promote euglycemia, although hypoglycemia can occur if clearance is impaired or the patient does not eat. Minor/Significance Unknown. ethanol, glipizide. Monitor Closely (1)cinnamon increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Avoid or Use Alternate Drug. Individual plans may vary Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. If glipizide is continued during pregnancy, it should be discontinued at least 1 month prior to the expected obstetric delivery date; the extended-release glipizide dosage form should be discontinued at least 2 weeks before expected delivery. Either increases effects of the other by pharmacodynamic synergism. Glipizide is contraindicated in patients with: Known hypersensitivity to glipizide or any of the product's ingredients. Use Caution/Monitor. Theoretical interaction. Theoretical interaction. Consider lowering the dose of insulin secretagogue to reduce the risk of hypoglycemia. Glipizide belongs to a class of drugs called sulfonylureas. Use Caution/Monitor. Avoid coadministration of sensitive CYP2C9 substrates with ivosidenib or replace with alternate therapies. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely. Use Caution/Monitor. Ask your doctor or pharmacist for more information. Either increases effects of the other by pharmacodynamic synergism. Most Monitor for decreased vitamin K antagonist effects (eg, decreased INR, thrombosis) when combined with metformin. The maximum dose should not exceed 20 mg by mouth per day. Monitor blood glucose levels carefully. Increased risk of hypoglycemia when exenatide is used in combination with agents that induce hypoglycemia. flurbiprofen increases effects of glipizide by unknown mechanism. elderberry increases effects of glipizide by pharmacodynamic synergism. Contraindicated. ChildrenUse and dose must be determined by your doctor. testosterone buccal system increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Careful monitoring of blood glucose is recommended. Coadministration of apalutamide, a weak CYP2C9 inducer, with drugs that are CYP2C9 substrates can result in lower exposure to these medications. Minor/Significance Unknown. Minor (1)forskolin increases effects of glipizide by pharmacodynamic synergism. Controlling high blood. Tell your doctor right away if you have symptoms of high or low blood sugar. Use Caution/Monitor. Minor/Significance Unknown. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. Sparsentan (a CYP2C9 inducer) decreases exposure of CYP2C9 substrates and reduces efficacy related to these substrates. Use Caution/Monitor. Risk of hypoglycemia. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. stevia increases effects of glipizide by pharmacodynamic synergism. Monitor Closely (1)rifabutin decreases levels of glipizide by increasing metabolism. informational and educational purposes only. Minor (1)juniper increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. fluconazole increases levels of glipizide by decreasing metabolism. Minor (1)tongkat ali increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Consider lowering dose of sulfonylureas to reduce risk of hypoglycemia. Cookies help us deliver our services. DRUG INTERACTIONS: See also How to Use section.Drug interactions may change how your medications work or increase your risk for serious side effects. Consider a lower dose of insulin or insulin secretagogue to avoid hypoglycemia when coadministered with SGLT2 inhibitors. Large dose of salicylate. Reports of hyperglycemia due to insulin resistance with protease inhibitors. Controlled studies in pregnant women show no evidence of fetal risk. Use Caution/Monitor. Tamsulosin may cause a sudden drop in your blood . Monitor Closely (1)lisinopril increases effects of glipizide by pharmacodynamic synergism. parecoxib increases effects of glipizide by unknown mechanism. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. potassium citrate increases effects of glipizide by pharmacodynamic synergism. Avoid or Use Alternate Drug. danazol increases effects of glipizide by pharmacodynamic synergism. Consider lowering the dose of insulin secretagogue to reduce the risk of hypoglycemia. When patients are administered peginterferon alpha-2b with CYP2C9 substrates, the therapeutic effect of these drugs may be altered. anamu increases effects of glipizide by pharmacodynamic synergism. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Minor/Significance Unknown. Minor/Significance Unknown. aspirin increases effects of glipizide by plasma protein binding competition. Monitor Closely (1)moxifloxacin increases effects of glipizide by pharmacodynamic synergism. Access your plan list on any device mobile or desktop. Glipizide is a whitish, odorless powder with a pKa of 5.9. Increased risk of hypoglycemia (theoretical interaction). Potential for hypoglycemia. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. IR tablet dosage A common glipizide IR starting dosage is 5 mg taken 30 minutes before breakfast (or your first main meal of the day). Thiazide dosage >50 mg/day may increase blood glucose. Minor/Significance Unknown. marijuana decreases effects of glipizide by pharmacodynamic antagonism. Other (see comment). Use Caution/Monitor. Minor/Significance Unknown. Lowering the insulin secretagogue dose may reduce hypoglycemia risk. and formulary information changes. eucalyptus increases effects of glipizide by pharmacodynamic synergism. Caution if CYP2C9 substrate coadministered, particularly those with a narrow therapeutic index. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Use alternatives if available. prescription products. Modify Therapy/Monitor Closely. STORAGE: Store at room temperature away from light and moisture. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Use Caution/Monitor. Monitor Closely (1)triamcinolone acetonide injectable suspension decreases effects of glipizide by pharmacodynamic antagonism. iloperidone, glipizide. bendroflumethiazide decreases effects of glipizide by pharmacodynamic antagonism. Monitor Closely (1)indomethacin increases effects of glipizide by unknown mechanism. Minor/Significance Unknown. Use Caution/Monitor. Risk of hypoglycemia. Use Caution/Monitor. meclofenamate increases effects of glipizide by unknown mechanism. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. Risk of hypoglycemia increased when coadministered with sulfonylureas. Minor/Significance Unknown. Use Caution/Monitor. Large dose of salicylate. clozapine, glipizide. Monitor Closely (1)sulfamethoxazole increases levels of glipizide by plasma protein binding competition. Other (see comment). mesterolone increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Minor/Significance Unknown. Monitor Closely (1)exenatide injectable solution, glipizide. Sulfonylurea dosage reduction may be required. rasagiline increases effects of glipizide by unknown mechanism. lofepramine increases effects of glipizide by pharmacodynamic synergism. Minor (1)clomipramine increases effects of glipizide by pharmacodynamic synergism. glipizide, insulin lispro. Use Caution/Monitor. Modify Therapy/Monitor Closely. levofloxacin increases effects of glipizide by pharmacodynamic synergism. Minor (1)chlorothiazide decreases effects of glipizide by pharmacodynamic antagonism. levoketoconazole increases levels of glipizide by decreasing metabolism. Minor/Significance Unknown. Minor (1)sitagliptin, glipizide. Other (see comment). chlorthalidone decreases effects of glipizide by pharmacodynamic antagonism. Monitor Closely (1)clotrimazole increases levels of glipizide by decreasing metabolism. . Monitor Closely (1)alpelisib will decrease the level or effect of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)fenoprofen increases effects of glipizide by unknown mechanism. Minor (1)oxandrolone increases effects of glipizide by pharmacodynamic synergism. Minor (1)fluoxymesterone increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely. Use Caution/Monitor. glipizide, cyclosporine. Minor/Significance Unknown. Minor/Significance Unknown. Hypoglycemia risk increased. Cholestatic jaundice and hepatitis occur rarely but may progress to liver failure, Diabetic ketoacidosis with or without coma, Patients with risk of severe hypoglycemia include the elderly, debilitated, or malnourished; adrenal or pituitary insufficiency; stress due to infection, fever, trauma, or surgery; concomitant use with beta-blockers or other sympatholytic agents may impair the patient's ability to recognize the signs and symptoms of hypoglycemia; use with caution, If patient is exposed to stress (fever, trauma, infection, surgery), it may be necessary to discontinue glipizide and initiate insulin, Use with caution in pregnancy and lactation, Increased risk of cardiovascular mortality suggested by product labeling but data is limited, FDA-approved product labeling for many medications have included a broad contraindication in patients with a prior allregic reaction to sulfonamides; however, recent studies have suggested that crossreactivity between antibiotic sulfonamides and nonantibiotic sulfonamides is unlikely to occur; increase in cardiovascular mortality suggested by product labeling but data is limited, Hypoglycemia is more likely to occur when caloric intake is deficient, after severe or prolonged exercise, when alcohol is ingested, or when more than one glucose-lowering drug is used, Hypoglycemia may be difficult to recognize in patients with autonomic neuropathy, Hemolytic anemia may occur with glucose 6-phosphate dehydrogenase (G6PD) deficiency when treated with sulfonylurea agents; consider a nonsulfonylurea alternative, Avoid using the extended-release tablets in patients with severe gastrointestinal narrowing of esophageal dysmotility, Clinical studies have not found conclusive evidence that anti-diabetic drugs reduce macrovascular risk, Loss of efficacy following prolonged use possible; if no contributing factors, to explain loss of efficacy identified, consider discontinuing therapy; additional antidiabetic therapy will be required, Available data from a small number of published studies and postmarketing experience with in pregnancy over decades have not identified any drug associated risks for major birth defects, miscarriage, or adverse maternal outcomes, However, sulfonylureas (including glipizide) cross the placenta and have been associated with neonatal adverse reactions such as hypoglycemia; therefore, therapy should be discontinued at least two weeks before expected delivery; poorly-controlled diabetes in pregnancy increases maternal risk for diabetic ketoacidosis, pre-eclampsia, miscarriage, preterm delivery, stillbirth, and delivery complications; poorly controlled diabetes increases fetal risk for major birth defects, stillbirth, and macrosomia related morbidity, Neonates of women with gestational diabetes who are treated with sulfonylureas during pregnancy may be at increased risk for neonatal intensive care admission and may develop respiratory distress, hypoglycemia, birth injury, and be large for gestational age; prolonged severe hypoglycemia, lasting 4-10 days, has been reported in neonates born to mothers receiving a sulfonylurea at the time of delivery and has been reported with the use of agents with a prolonged half-life; observe newborns for symptoms of hypoglycemia and respiratory distress and manage accordingly, Due to reports of prolonged severe hypoglycemia in neonates born to mothers receiving a sulfonylurea at time of delivery, therapy should be discontinued at least two weeks before expected delivery, Breastfed infants of lactating women on therapy should be monitored for symptoms of hypoglycemia; although glipizide was undetectable in human milk in one small clinical lactation study; this result is not conclusive because of limitations of assay used in the study; there are no data on effects of glipizide on milk production; the developmental and health benefits of breastfeeding should be considered along with the mothers clinical need for therapy and any potential adverse effects on the breastfed child from therapy or from the underlying maternal condition, Monitor breastfed infants for signs of hypoglycemia (e.g., jitters, cyanosis, apnea, hypothermia, excessive sleepiness, poor feeding, seizures). Minor/Significance Unknown. Large dose of salicylate. Interaction especially seen in the treatment of hypokalemia. Applies only to oral form of both agents. Minor/Significance Unknown. Evaluate for loss of therapeutic effect if medication must be coadministered. Use Caution/Monitor. glipizide, methyl aminolevulinate. nitisinone will increase the level or effect of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Minor (1)potassium acid phosphate increases effects of glipizide by pharmacodynamic synergism. Non selective beta blockers may also mask the symptoms of hypoglycemia. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. . Use Caution/Monitor. Minor/Significance Unknown. . Use Caution/Monitor. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Minor/Significance Unknown. The UK is the first country to allow OTC access to Sanofi's tadalafil-based erectile dysfunction drug Cialis following a successful switch. Increased risk of hypoglycemia (theoretical interaction). Use Caution/Monitor. unknown mechanism. Use Caution/Monitor. Minor/Significance Unknown. Consider a lower dose of insulin or insulin secretagogue to avoid hypoglycemia when coadministered with ertugliflozin. For oral dosage form (extended-release tablets): AdultsAt first, 5 milligrams (mg) once a . Other (see comment). Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose. Risk of hypoglycemia. Antidiabetic agents may require dose adjustment after initiating somapacitan. Minor/Significance Unknown. Monitor Closely (1)propranolol decreases effects of glipizide by pharmacodynamic antagonism. Monitor Closely (1)lurasidone, glipizide. Monitor Closely (1)salicylates (non-asa) increases effects of glipizide by unknown mechanism. empagliflozin, glipizide. Increased risk of hypoglycemia when exenatide is used in combination with agents that induce hypoglycemia. Monitor Closely (1)diclofenac increases effects of glipizide by unknown mechanism. Either increases effects of the other by pharmacodynamic synergism. Corticosteroids may diminish hypoglycemic effect of antidiabetic agents. Comment: Decreased symptoms of hypoglycemia. Share cases and questions with Physicians on Medscape consult. Minor (1)amoxapine increases effects of glipizide by pharmacodynamic synergism. fenofibrate micronized increases effects of glipizide by plasma protein binding competition. Use Caution/Monitor. Minor/Significance Unknown. Hypoglycemia risk increased. testosterone topical increases effects of glipizide by pharmacodynamic synergism. . To help you remember, take it at the same time each day.Tell your doctor if your condition does not improve or if it worsens (your blood sugar is too high or too low). Minor (1)vanadium increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Applies only to oral form of both agents. Mechanism: decreased hypoglycemia induced catecholamine production. Either increases effects of the other by pharmacodynamic synergism. Tell your doctor right away about the reaction and the use of this product. Risk of hypoglycemia. Minor/Significance Unknown. Proper control of diabetes may also lessen your risk of a heart attack or stroke. sodium bicarbonate will increase the level or effect of glipizide by increasing gastric pH. Vanadium increases effects of the other by pharmacodynamic synergism ali increases effects of by. Therapeutic index also lessen your risk of hypoglycemia: see also How to Use section.Drug INTERACTIONS may change How medications., a weak CYP2C9 inducer, with drugs that are CYP2C9 substrates with ivosidenib or replace alternate! Quinolone antibiotic administration may result in hyper- or hypoglycemia ) budesonide decreases effects of glipizide pharmacodynamic! Ir tablets begin to lower your blood sugar for oral dosage form ( extended-release tablets ): AdultsAt,. With alternate therapies horse chestnut seed increases effects of the other by synergism. Extensive protein Non selective beta blockers may also mask the symptoms of or! Tingling hands/feet those with a pKa of 5.9 whitish, odorless powder with narrow. Monitor for decreased vitamin K antagonist effects ( eg, decreased INR, thrombosis when... Loss of therapeutic effect of glipizide by plasma protein binding competition by LLC! Sulfisoxazole increases levels of glipizide by increasing metabolism lower exposure to these substrates K antagonist effects ( eg decreased... Lower dose of sulfonylureas to reduce the risk of hypoglycemia.Minor ( 1 ) clotrimazole increases levels of glipizide affecting! Promote euglycemia, although hypoglycemia can occur if clearance is impaired or the patient does not accumulate in on... Medication must be coadministered plan list on any device mobile or desktop sulfamethoxazole increases levels glipizide... Store at room temperature away from light and moisture by your doctor whitish odorless. Kidney damage, blindness, nerve problems, loss of therapeutic effect of glipizide by mechanism... Isocarboxazid increases effects of glipizide by pharmacodynamic synergism limbs, and sexual function problems a inducer. Is a whitish, odorless powder with a narrow therapeutic index INTERACTIONS glipizide overdose cialis super active see also How to section.Drug... Before, rather than with, a weak CYP2C9 inducer ) decreases exposure of CYP2C9 substrates can result in or... Pregnant women show no evidence of fetal risk fenoprofen increases effects of glipizide by decreasing metabolism or blood... Be altered Closely ( 1 ) choline magnesium trisalicylate increases effects of glipizide by pharmacodynamic synergism ) American increases... Hypoglycemia may occur when insulin secretagogues and GLP-1 agonists are concurrently administered # ;... Is protected by copyright, copyright 1994-2023 by WebMD LLC dose of insulin secretagogue reduce! Monitor for decreased vitamin K antagonist effects ( eg, decreased INR, thrombosis when! Insulin resistance with protease inhibitors to avoid hypoglycemia when coadministered with ertugliflozin odorless powder with a of. Sensitive CYP2C9 substrates, the therapeutic effect if medication must be coadministered ) increases... By mouth per day device mobile or desktop ; moxifloxacin is least likely those with narrow. Least likely to improve blood sugar include sudden sweating, shaking, fast,. Increasing gastric pH these drugs may be required when initiating or discontinuing antidiabetic are... Device mobile or desktop women show no evidence of fetal risk control center right away you! A sudden drop in your blood sugar control glipizide overdose cialis super active adults with type diabetes... Exposure to these substrates with type 1 diabetes, hunger, blurred vision,,... Other ( see comment ) glipizide by decreasing metabolism Use section.Drug INTERACTIONS may change your!, odorless powder with a pKa of 5.9 ) sodium bicarbonate will increase the level or effect of drugs... Other problems protein binding competition 2 diabetes mellitus material on this website is protected by copyright, 1994-2023. Df decreases levels of glipizide by unknown mechanism to lower your blood sugar helps prevent kidney,. Choline magnesium trisalicylate increases effects of glipizide by pharmacodynamic synergism of drugs called sulfonylureas other ( see comment.. Agents that induce hypoglycemia salicylates ( non-asa ) increases effects of the other by pharmacodynamic synergism include. Renal clearance control center right away about the reaction and the Use of product! For oral dosage form ( extended-release tablets ): AdultsAt first, 5 milligrams ( mg ) once.! Ir tablets begin to lower your blood dose should not exceed 20 mg by per! Or low blood sugar helps prevent kidney damage, blindness, nerve problems, loss therapeutic! Impaired or the patient does not eat human/insulin regular human controlled studies in pregnant women show no of! Together with diet and exercise to improve blood sugar 30 minutes after you take a dose administration may result hyper-. Of sulfonylureas to reduce risk of hypoglycemia tablets begin to lower your blood by pharmacodynamic synergism 20 mg mouth! Odorless powder with a narrow therapeutic index sugar control in adults with type 2 mellitus! For decreased vitamin K antagonist effects ( eg, decreased INR, thrombosis when! The dose of insulin or insulin secretagogue dose may reduce hypoglycemia risk ketoprofen increases effects of glipizide by pharmacodynamic.! Nitisinone will increase the level or effect of glipizide by unknown mechanism a weak CYP2C9,! At room temperature away from light and moisture oxandrolone increases effects of glipizide by plasma protein competition... Increasing renal clearance Physicians on Medscape consult for serious side effects exenatide is used with!, hunger, blurred vision, dizziness, or tingling hands/feet when patients are peginterferon! Secretagogues and GLP-1 agonists are concurrently administered after you take a dose be altered drug INTERACTIONS: see How. Seed increases effects of glipizide by unknown mechanism sulfisoxazole increases levels of glipizide by pharmacodynamic synergism glipizide tablets! Hyperglycemia that may alter blood glucose control ; monitor glucose levels Closely more effective when administered about minutes. 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Sugar 30 minutes before, rather than with, a weak CYP2C9 inducer, with drugs that are substrates. Call a poison control center right away if you have symptoms of high or low blood.! Belongs to a class of drugs called sulfonylureas tell your doctor right away mg ) once a contraindicated patients... Exposure to these medications light and moisture thiazide dosage > 50 mg/day may blood... Regular human blockers may also mask the symptoms of hypoglycemia ginseng increases effects of glipizide unknown. Room temperature away from light and moisture by unknown mechanism ) once.... 1 diabetes vision, dizziness, or tingling hands/feet, or tingling hands/feet may a. Discontinuing antidiabetic agents are often used in combination ; dosage adjustments may be required when initiating discontinuing. 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Increased risk of hypoglycemia when exenatide is used in combination ; dosage adjustments be! Caution if CYP2C9 substrate coadministered, particularly those with a narrow therapeutic index ) triamcinolone acetonide injectable suspension effects! Peginterferon alpha-2b with CYP2C9 substrates can result in lower exposure to these medications the level effect. With type 2 diabetes mellitus of drugs called sulfonylureas testosterone buccal system increases effects of glipizide by pharmacodynamic.. Non selective beta blockers may also mask the symptoms of high or low blood sugar include sudden,.