Monitor Closely (1)peginterferon alfa 2b decreases levels of glimepiride by affecting hepatic enzyme CYP2C9/10 metabolism. glimepiride, canagliflozin. Glimepiride use was approved by the FDA in 1995. Use Caution/Monitor. maprotiline increases effects of glimepiride by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Large dose of salicylate. cornsilk increases effects of glimepiride by pharmacodynamic synergism. Follow your doctor's directions carefully. Quinolone antibiotic administration may result in hyper- or hypoglycemia. . Use Caution/Monitor. Check with your doctor or pharmacist to find out what you should do if you miss a meal. Monitor Closely (1)risperidone, glimepiride. glimepiride increases levels of tacrolimus by unknown mechanism. Caution if CYP2C9 substrate coadministered, particularly those with a narrow therapeutic index. It may take up to 2 to 3 months before you get the full benefit of this drug. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. These side effects may go away during treatment as your body adjusts to the medicine. meclofenamate increases effects of glimepiride by unknown mechanism. glimepiride, insulin isophane human/insulin regular human. Use Caution/Monitor. Minor (1)budesonide decreases effects of glimepiride by pharmacodynamic antagonism. saquinavir decreases effects of glimepiride by Other (see comment). Minor (1)glimepiride increases levels of tacrolimus by unknown mechanism. Minor/Significance Unknown. Increased risk of hypoglycemia (theoretical interaction). methylprednisolone decreases effects of glimepiride by pharmacodynamic antagonism. Rare side effects of Glimepiride include: yellowing skin and eyes (jaundice) Postmarketing side effects of Glimepiride reported include: serious hypersensitivity reactions, including severe allergic reaction, rapid swelling ( angioedema ), and Stevens-Johnson Syndrome. Monitor Closely (1)fluoxetine increases effects of glimepiride by unspecified interaction mechanism. sparsentan will decrease the level or effect of glimepiride by affecting hepatic enzyme CYP2C9/10 metabolism. People feel different symptoms with low blood sugar. . Supplementing magnesium may enhance the blood-sugar-lowering effects of sulfonylurea drugs. Ask your healthcare professional how you should dispose of any medicine you do not use. Risk of hypoglycemia. Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Minor/Significance Unknown. Other (see comment). This information is not individual medical advice and does not substitute for the advice of your health care professional. Minor (1)lycopus increases effects of glimepiride by pharmacodynamic synergism. It is important that you learn which symptoms you have in order to treat it quickly. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. In these cases, consult your doctor because you may require a change in your treatment plan, medications, or blood sugar testing. Use Caution/Monitor. Other (see comment). In these cases, your doctor may want to change the dose, or other precautions may be necessary. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Minor (1)danazol increases effects of glimepiride by pharmacodynamic synergism. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Risk of hypoglycemia. Modify Therapy/Monitor Closely. Theoretical interaction. Coadministration of apalutamide, a weak CYP2C9 inducer, with drugs that are CYP2C9 substrates can result in lower exposure to these medications. Use Caution/Monitor. Use Caution/Monitor. Minor (1)metolazone decreases effects of glimepiride by pharmacodynamic antagonism. Consumer's Guides: Understand Your Treatments. Avoid tanning booths and sunlamps. Initial: 1-2 mg PO qAM after breakfast or with first meal; may increase dose by 1-2 mg every 1-2 weeks; not to exceed 8 mg/day, Renal impairment: 1 mg PO qDay; titrate dose based on fasting blood glucose levels, Hepatic impairment: Not studied; not recommended in severe impairment; initiate therapy with 1 mg PO qDay and titrate carefully, Prolonged hypoglycemia reported with use; titrate dose conservatively; monitor for hypoglycemic or hyperglycemic symptoms, 1 mg PO qDay; titrate dose at weekly intervals to avoid hypoglycemia. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Manage and view all your plans together even plans in different states. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. Use Caution/Monitor. empagliflozin, glimepiride. Use Caution/Monitor. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Monitor Closely (1)meclofenamate increases effects of glimepiride by unknown mechanism. Use Caution/Monitor. . Monitor Closely (1)ziprasidone, glimepiride. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Risk of hypoglycemia. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. Diminished symptoms of hypoglycemia. This medicine is not for treating type 1 diabetes. Minor/Significance Unknown. sulindac increases effects of glimepiride by unknown mechanism. Risk of hypoglycemia. glimepiride, insulin inhaled. Use Caution/Monitor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. difficult to control. However, the dose is usually not more than pioglitazone 45 mg plus glimepiride 8 mg per day. tipranavir decreases effects of glimepiride by Other (see comment). Use Caution/Monitor. Monitor Closely (1)gemfibrozil increases effects of glimepiride by plasma protein binding competition. Use Caution/Monitor. fenofibric acid increases effects of glimepiride by plasma protein binding competition. Use Caution/Monitor. Minor/Significance Unknown. This product may contain inactive ingredients, which can cause allergic reactions or other problems. lisinopril increases effects of glimepiride by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. perindopril increases effects of glimepiride by pharmacodynamic synergism. Monitor Closely (1)tranylcypromine increases effects of glimepiride by unknown mechanism. Avoid drinking alcohol. Sulfonylureas may increase the effects of cyclosporine. Comment: Both drugs have potential to increase hepatic enzymes; monitor LFTs. tolmetin increases effects of glimepiride by unknown mechanism. Use Caution/Monitor. Serious hypoglycemia may occur when insulin secretagogues and GLP-1 agonists are concurrently administered. Minor (1)potassium chloride increases effects of glimepiride by pharmacodynamic synergism. Do NOT rely solely on the information in this article. Minor (1)imipramine increases effects of glimepiride by pharmacodynamic synergism. Be sure your family or close friends know how to give you this injection in an emergency. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Use Caution/Monitor. Mechanism: decreased hypoglycemia induced catecholamine production. Risk of hypoglycemia.Minor (1)sulfasalazine increases effects of glimepiride by plasma protein binding competition. Large dose of salicylate. aceclofenac increases effects of glimepiride by unknown mechanism. For patients already taking pioglitazone alone: AdultsAt first, 1 tablet (pioglitazone 30 milligrams (mg) plus glimepiride 2 mg) once a day. Contraindicated. Monitor Closely (1)albiglutide, glimepiride. chloramphenicol increases levels of glimepiride by decreasing metabolism. salsalate increases effects of glimepiride by plasma protein binding competition. Either increases effects of the other by pharmacodynamic synergism. Monitor blood glucose levels carefully. Monitor Closely (1)sulfadiazine increases levels of glimepiride by plasma protein binding competition. Either increases effects of the other by pharmacodynamic synergism. Serious - Use Alternative (1)glimepiride increases toxicity of aminolevulinic acid topical by pharmacodynamic synergism. The presence of other medical problems may affect the use of this medicine. paliperidone, glimepiride. To view formulary information first create a list of plans. tolfenamic acid increases effects of glimepiride by unknown mechanism. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. It is unknown if this medication passes into breast milk, and it may have undesirable effects on a nursing infant. Minor (1)bendroflumethiazide decreases effects of glimepiride by pharmacodynamic antagonism. Minor (1)methyclothiazide decreases effects of glimepiride by pharmacodynamic antagonism. clonidine, glimepiride. Risk of hypoglycemia. Learn more about TraceGains, the company. It may also be used with other diabetes medications. Other medications can affect the removal of pioglitazone from your body, which may affect how pioglitazone works. Always ask your health care professional for complete information about this product and your specific health needs. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. albiglutide, glimepiride. Other signs may include changes in color of the skin of the face, very fast but irregular heartbeat or pulse, hive-like swellings on the skin, and puffiness or swellings of the eyelids or around the eyes. Minor/Significance Unknown. If these symptoms occur, tell your doctor right away. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Use alternatives if available. Use Caution/Monitor. Portions of this document last updated: May 01, 2023, Original article: https://www.mayoclinic.org/drugs-supplements/pioglitazone-and-glimepiride-oral-route/precautions/drg-20068956. The removal of pioglitazone from your body, which can cause allergic reactions or other.. 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