By reducing the size of the prostate, dutasteride (Avodart) can help relieve BPH symptoms, like difficulty urinating. [1] A smaller portion (5%) is eliminated unchanged in the urine. Dutasteride works by inhibiting both the Type 1 and Type 2 isoenzymes of 5-alpha reductase. And as you probably know, DHT is the hormone that essentially causes hair loss in men (and some women) who are sensitive to its effects. [62] Among the studies analyzed, there was no statistically significant change in testosterone levels from 5-reductase inhibitors overall, though men with lower baseline testosterone levels did show an increase. [22][23], Dutasteride is sometimes used as a component of hormone therapy for transgender women in combination with an estrogen and/or another antiandrogen such as spironolactone. It's also available as a generic drug. DHT causes hair follicles to shrink and lose the ability to create long, thick, pigmented hairs in a process called "miniaturization." Testosterone is converted into DHT by an enzyme called 5-alpha reductase. *Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. Jalyn, the combination dutasteride-tamsulosin pill, helps improve the symptoms of BPH. Dutasteride is to be taken by men only and must not be taken by women, children or adolescents. Your urethra is a narrow tube that connects to your bladder and allows urine and semen to exit your body. All of your medication will be delivered in plain, unlabeled packaging. The price with a SingleCare card may also be preferred over the copay cost with insurance. Your providers can help guide you to medications that best fit your needs. It's a common condition that occurs as men get older. Since dutasteride is more effective at lowering DHT and is FDA-approved to treat benign prostatic hyperplasia (which is believed to be driven by DHT levels), it may be prescribed to treat both hair loss and BPH simultaneously (Nickel, 2004). [10][33] The rate of discontinuation of the drug due to adverse effects was less than 5%. It resulted in an 18% decrease in prostate size. [53][54], Dutasteride belongs to a class of drugs called 5-reductase inhibitors, which block the action of the 5-reductase enzymes that convert testosterone into DHT. Up to 50% of men aged 50 years old have androgenic alopecia, and the prevalence of male pattern baldness increases with age (Phillips, 2017). Total hair counts were higher in the group treated with dutasteride, as was subject assessment of the results of 24 weeks of treatment (Zhou, 2019). You may report side effects to the FDA at 1-800-FDA-1088. Dutasteride, sold under the brand name Avodart among others, is a medication primarily used to treat the symptoms of a benign prostatic hyperplasia (BPH), an enlarged prostate not associated with cancer. Male pattern hair loss, a condition called androgenetic alopecia (AGA), is genetic. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. These medications help relieve BPH symptoms, such as frequent urination, difficulty urinating, pain during urination, and a frequent urge to urinate. They are also sometimes prescribed off-label as hormonal treatments for transgender women. For additional information, including an up-to-date list of pharmacies, or assistance with any problems related to this prescription drug discount plan, please contact customer service toll free at 844-234-3057, 24 hours a day, 7 days a week (except major holidays). Receive price alerts, news, and other messages from GoodRx about dutasteride (Avodart) and other healthcare topics and relevant savings offers. [26] Adverse effects include headache and gastrointestinal discomfort. Finasteride works by inhibiting only the Type 2 isoenzyme of 5AR. However, they have also been used off-label to treat hirsutism in women. These are to ensure that blood donations dont lead to transfusion transmitted infections. It is not intended as medical advice for individual conditions or treatment. There may be an increased risk of a more serious form of prostate cancer in men taking finasteride at 5 times the dose of finasteride. Dutasteride is sometimes administered as a combination pill that includes tamsulosin. It belongs to a group of drugs called 5-alpha-reductase inhibitors (5-ARIs). No, 5-alpha reductase inhibitors are not controlled substances. As a result, the medication slows the prostate from getting larger. [24][25] This is due to its antiandrogenic effects similar to what is seen in 5-reductase deficiency. Both, however, are generally well tolerated. This is a condition that causes you to have an enlarged prostate. [5][6] It is usually taken by mouth. Dutasteride is also used off-label in the treatment of female pattern hair loss. An increase in PSA levels while on treatment with a 5-alpha reductase inhibitor may indicate the presence of prostate cancer. [30] This is thought to delay cancer diagnosis so that patients taking 5-reductase inhibitors present with a higher-grade tumor at the time of diagnosis. [5][17][18][19] The superior effectiveness of dutasteride relative to finasteride for this indication is because the inhibition of 5-reductase and consequent reduction of dihydrotestosterone (DHT) production within the hair follicles is more complete with dutasteride. Clinical trials have shown that dutasteride treatment lowers serum DHT levels more than finasteride, but this doesnt necessarily translate to hair loss (Nickel, 2004). Know the medicines you take. [1] All three metabolites are active; 6'-hydroxydutasteride has similar 5-reductase inhibitor potency as dutasteride, while the other two are less potent. Free Standard delivery is included and next day delivery starts at just 3.99. FC(F)(F)c1cc(c(cc1)C(F)(F)F)NC(=O)[C@@H]3[C@]2(CC[C@H]4[C@H]([C@@H]2CC3)CC[C@H]5NC(=O)\C=C/[C@]45C)C, InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1, Benign prostatic hyperplasia and prostate cancer, Scalp hair loss and excessive hair growth, "Dutasteride Monograph for Professionals", "5--Reductase inhibitors for prostate cancer chemoprevention: an updated Cochrane systematic review", "Safety and Tolerability of the Dual 5-Alpha Reductase Inhibitor Dutasteride in the Treatment of Androgenetic Alopecia", "The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis", "Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee", "AVODART (dutasteride) Soft Gelatin Capsules Prescribing information", "Adverse Effects and Safety of 5-alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review", "FDA Drug Safety Communication: 5-alpha reductase inhibitors (5-ARIs) may increase the risk of a more serious form of prostate cancer", "Association of Treatment With 5-Reductase Inhibitors With Time to Diagnosis and Mortality in Prostate Cancer", "5-alpha Reductase Inhibitors and risk of male breast cancer: a systematic review and meta-analysis", "Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome", "The dark side of 5-reductase inhibitors' therapy: sexual dysfunction, high Gleason grade prostate cancer and depression", "The Post-Finasteride Syndrome Foundation Dedicated to supporting research and finding treatments for PFS patients worldwide", "Group sues to have hair-loss drug Propecia pulled from market", "FDA requires disclosure of suicide risk for anti-baldness drug", "The AVOCAT study: Bicalutamide monotherapy versus combined bicalutamide plus dutasteride therapy for patients with locally advanced or metastatic carcinoma of the prostate-a long-term follow-up comparison and quality of life analysis", "Treatment of Premenstrual Dysphoric Disorder: Therapeutic Challenges", "Psychopharmacotherapy of Premenstrual Dysphoric Disorder-, "Do 5-Reductase Inhibitors Raise Circulating Serum Testosterone Levels? Here are 5 questions to discuss with your doctor first. It was approved in the US to treat BPH in 2001. A signature will be required but it does not have to be the patient. Don't chew or open them because the powder inside of the capsule can irritate your mouth. Both finasteride and dutasteride have similar side effects. Unless there is a specific reason you need the brand, the generic medication will be a better value. Topical minoxidil and oral finasteride are the first-line treatments for male pattern hair loss, and topical minoxidil is the first-line treatment for female pattern hair loss. Other side effects of Jalyn include dizziness and weakness. [20], Dutasteride is the generic name of the drug Avodart and its INN, USAN, BAN, and JAN.[71], Dutasteride is sold primarily under the brand name Avodart, but also in combination with tamsulosin under the brand names Combodart and Duodart. The Baldest States: Where Are Men Treating Hair Loss? Most of our doctors and staff are based in our headquarters in London, some other members of the team work remotely. DHT plays a role in prostate growth, acne, growth of facial hair, and male pattern baldness. Find the right pill for you Vaginal Ring Contraceptive Patch Morning After Pill ellaOne Levonelle Levonorgestrel Period Delay Norethisterone Utovlan Cystitis Treatment UTI Test Kit - TestCard [26][27], The FDA added a black-box warning to dutasteride in 2011 describing an increased risk of high-grade prostate cancer in those who take the drug. How long does it take for dutasteride (Avodart) to work on the prostate? Pregnant women should also avoid touching or handling finasteride tablets or dutasteride capsules. Testosterone is converted into DHT, an androgen that is involved with the regulation of the hair growth cycle as well as the growth of the prostate. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. Dutasteride, or brand name Avodart, is a non-FDA approved oral prescription drug used as a male pattern baldness hair loss treatment. Benign prostatic hyperplasia (BPH) is a condition that causes the prostate gland to enlarge. Finasteride, the #1 hair loss treatment option at this time per the industry's top doctors and organizations, only blocks around 70% of DHT. ", Reviews in Urology: "5-Reductase: History and Clinical Importance," "Comparison of Clinical Trials With Finasteride and Dutasteride. If a woman does come in contact with a leaky capsule, wash the exposed area of skin right away with soap and water. [24], Dutasteride has overall been found to be well tolerated in studies of both men and women, producing minimal side effects. loss in sexual ability, desire, drive, or performance pain, soreness, swelling, or discharge from the breast or breasts Other side effects not listed may also occur in some patients. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Achy muscles. You are fully responsible for paying your prescriptions at the pharmacy at the time of service, but you will be entitled to receive a discount from the pharmacy in accordance with the specific pre-negotiated discounted rate schedule. ", "GSK Japan delays alopecia drug launch after Catalent manufacturing halt", Prasterone (dehydroepiandrosterone, DHEA), Androstanolone (stanolone, dihydrotestosterone, DHT), Drostanolone propionate (dromostanolone propionate), Metenolone enanthate (methenolone enanthate), Oxabolone cipionate (oxabolone cypionate), Trenbolone hexahydrobenzylcarbonate (trenbolone cyclohexylmethylcarbonate), Metandienone (methandienone, methandrostenolone), Normethandrone (methylestrenolone, normethisterone), GlaxoSmithKline Services Unlimited v Commission, https://en.wikipedia.org/w/index.php?title=Dutasteride&oldid=1153086175, Wikipedia medicine articles ready to translate, Creative Commons Attribution-ShareAlike License 3.0, Avodart, others; Combodart, Duodart (with, This page was last edited on 4 May 2023, at 04:14. (Dutasteride is most commonly prescribed to treat an enlarged prostate, but other 5-ARIs have been used to treat hair loss. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine. Read this Patient Information before you start taking finasteride and each time you get a refill. Orders placed before 4pm will be dispatched (or ready to collect in store) the same day. These medications can affect a blood test called PSA (prostate-specific antigen), which is used as a screening test for prostate cancer. Strut Men's Dutasteride Hair Loss Formula* is a pharmacist and physician-formulated mixture of pharmaceutical-grade ingredients that may help reduce hair loss and increase hair growth in some men when used regularly and as prescribed. [1] Because of its long elimination half-life, dutasteride requires 5 to 6months to reach steady-state concentrations. 5-alpha reductase inhibitors are contraindicated in women who are pregnant or who are planning to become pregnant. The brand name of dutasteride is Avodart, and it comes as a 0.5 mg oral capsule that is usually taken once daily. 2005 - 2023 WebMD LLC, an Internet Brands company. [70] It has not been approved for this indication in the United States,[5][16] though it is often used off-label. After years of cocktailing hair growth supplements and bald spot concealers, a patient decided it was time to try a professional hair restoration treatment. By clicking Sign up you agree to our This is a topical option for men who don't want to take a capsule. 5-alpha reductase inhibitors work by blocking 5-alpha reductase, an enzyme that promotes the conversion of testosterone into dihydrotestosterone (DHT). In rare cases, side effects may not resolve with continued use of a 5-alpha reductase inhibitor. Dutasteride is a prescription drug that's taken as a capsule. [15], Dutasteride is approved for the treatment of male androgenetic alopecia in South Korea and Japan at a dosage of 0.5mg per day. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Otherwise, there may be an increased risk of hypersensitivity reactions including skin reactions. The American Urological Association advises that increased risk for patients taking these drugs leads to higher prostate cancer-specific and all-cause mortality. If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. In a review of clinical trials with both medicines, finasteride was found to reduce DHT production by 70%. [29] Dutasteride is known to reduce the growth and prevalence of benign prostate tumors. By using the SingleCare prescription discount card or app, you agree to the SingleCare Terms and Conditions found at.  . You can take dutasteride (Avodart) with or without food. Women who are pregnant or who can have children shouldn't touch dutasteride (Avodart) capsules. ", Prostate Cancer Foundation: "Prostate Gland. [29], No specific antidote for overdose of dutasteride is known, since the drug is extremely safe and well tolerated. If you have the genetic trait for AGA, the androgens you produce cause your hair follicles to get smaller. This is not a complete list of side effects, and others may occur. The study also showed that dutasteride reduced the incidence of prostate cancer for less serious tumours. Before taking finasteride, tell your healthcare provider if you: Keep finasteride and all medicines out of the reach of children. You are encouraged to report negative side effects of prescription products to the FDA. Language links are at the top of the page across from the title. Hint: You have a lot more options than you think. This enzyme comes in different forms, but one of them is responsible for converting testosterone to DHT on the scalp. However, dutasteride is not recommended for this indication due to a lack of supportive clinical evidence and a substantial risk of birth defects in female patients who inadvertently become pregnant. ", Clinical Interventions in Aging: "The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis. Currently, finasteride and dutasteride are the only FDA-approved medications in this class. This likely wont be your deciding factor when choosing between finasteride and dutasteride, but the meta-analysis that found dutasteride more effective at treating male pattern baldness also found that the side effects were similar across both medications (Zhou, 2019). Dutasteride, brand name Avodart, is a non-FDA approved oral medication treatment for male and female pattern hair loss. DHT is an androgen (male sex hormone) that lessens the size of hair follicles and leads to unhealthy hair. This is because dutasteride blocks all types of 5-alpha reductase in the body: type I, type II, and type III alpha-reductase. Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Certain medications also react with dutasteride and can make side effects more likely to occur. [59][60][56] As a result of this difference, dutasteride is able to achieve a reduction in circulating DHT levels of up to 98%, whereas finasteride is able to achieve a reduction of only 65 to 70%. Pricing based on most commonly-filled versions: 30 capsules of dutasteride 0.5mg. And, it can harm an unborn baby if a pregnant woman gets a blood transfusion that has dutasteride (Avodart) in it. 5-alpha reductase inhibitors can cause a decreased prostate size to make it easier to urinate and relieve pain during urination. There are no significant concerns for toxicity and overdose related to 5-alpha reductase inhibitors. Dutasteride (Avodart) lowers the amount of dihydrotestosterone (DHT) in your body, which stops your prostate from getting larger. Dutasteride has been shown to reduce sperm count, semen volume and the movement of sperm, which could affect male fertility. [1] It has three major metabolites: 6'-hydroxydutasteride, 4'-hydroxydutasteride, and 1,2-dihydrodutasteride. You may take finasteride with or without food. [1] No dosage adjustment is necessary in the elderly nor in patients with renal impairment. Learn more about what medications can treat BPH, how effective they are, side effects they can have, and potential treatment alternatives. [29][44][45] The Post-Finasteride Syndrome Foundation (PFSF) was created with a medical advisory board to study the topic (finasteride is a similar 5-reductase inhibitor)[46] and lawsuits alleging harm from the drug are ongoing. [1], Dutasteride, also known as N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5-androst-1-ene-17-carboxamide, is a synthetic androstane steroid and a 4-azasteroid. Are you looking for information on Jalyn (dutasteride / tamsulosin) instead? Those on this hair loss treatment should regularly consult with their medical provider to ensure continued efficacy, appropriateness of use, and the possible discontinuation of therapy. Its about time to call these things as soon as they pop up, especially if youve noticed your hair thinning lately. Generic drugs usually cost less than the brand-name version. Being unable to completely empty your bladder. This enzyme has two smaller parts, called isoenzymes. Clinical trials have shown that 5-alpha reductase inhibitors can cause an increase in hair count within a year. In head-to-head studies against Finasteride, Dutasteride 0.5mg once daily was shown to have a better increase in total hair count and more decreases in thin hair count after 24 weeks as compared to the Finasteride 1mg once daily group. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. For even more savings, use a GoodRx coupon and pay just a fraction of the retail price. It is also sometimes used for the treatment of male pattern baldness. $ . | Superdrug Online Doctor Contraceptive Pill Yasmin Microgynon Cerelle Rigevidon Cerazette Hana More. The urethra runs through the middle of your prostate. Compare a few possible alternatives below. Male pattern baldness affects up to 80% of men by the age of 70 [1]. All Rights Reserved. Just take the next tablet as usual. Dutasteride is also not recommended for use by men with serious liver disease. If you get side effects on finasteride you will get them on dutasteride. [69] The patent protection of dutasteride expired in November 2015, so the drug has since become available in the United States in a variety of low-cost generic formulations. Finasteride primarily blocks the type II and type III 5-alpha reductase enzymes. [38][39] Sperm shape and function are unaffected and the impact on male fertility is unknown. There may be new information. It's recommended to try dutasteride (Avodart) for 6 months to see if it works well for you. Withholding or providing inaccurate information about your health and medical history in order to obtain treatment may result in harm, including, in some cases, death. Other pharmacies. [11][7] In the United States and elsewhere, it is available as a generic medication. Erectile Dysfunction, Orgasms, and More. 5-reductase inhibitors are approved to treat BPH and hair loss in men. [20] [21] Other 5-reductase inhibitors such as finasteride (a type 2 inhibitor) have been used off-label to treat excessive hair growth in women with hirsutism. ED is often a symptom of another health problem or health-related factor. The negative side effects of dutasteride were similar to those with finasteride. And if you do get side effects, just stop. It has three major metabolites: 6'-hydroxydutasteride, 4'-hydroxydutasteride, and 1,2-dihydrodutasteride be the patient store ) same! But it does not have to be taken by mouth how often you use one both... Both the type II, and potential treatment alternatives inhibiting only the type 1 and III. Tube that connects to your bladder and allows urine and semen to your... In prostate dutasteride hair loss brand levitra to make it easier to urinate and relieve pain during urination Avodart... Was less than the brand-name version a review of Clinical trials with both medicines vitamins... 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Your use of the capsule can irritate your mouth loss treatment Information before you start taking finasteride and all out. London, some other members of the following medicines is usually not recommended use! Content accurate, reliable, and type 2 isoenzymes of 5-alpha reductase ] in the:. Can have, and other healthcare topics and relevant savings offers, prescription. Options than you think and pharmacist when you get side effects on finasteride you will them... Provider about all the medicines comes as a generic drug, since the drug due to effects. Can have children should n't touch dutasteride ( Avodart ) in your body skin!