Minor/Significance Unknown. SSRIs inhib. Use Caution/Monitor. Contraindicated. It's thought to help improve mood and pain by raising the level of chemicals called serotonin and norepinephrine in your brain. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Either increases effects of the other by sedation. Use Caution/Monitor. Minor (1)pleurisy root decreases effects of duloxetine by unspecified interaction mechanism. Monitor Closely (2)duloxetine will increase the level or effect of morphine by affecting hepatic enzyme CYP2D6 metabolism. duloxetine, indomethacin. Serious - Use Alternative (1)primidone will decrease the level or effect of duloxetine by affecting hepatic enzyme CYP1A2 metabolism. Mechanism: pharmacodynamic synergism. Duloxetine is a medication used to manage major depressive disorder (MDD), generalized anxiety disorder (GAD), fibromyalgia, diabetic peripheral neuropathy, and chronic musculoskeletal pain. Contraindicated. Use Caution/Monitor. Mechanism: unknown. Avoid leniolisib with CYP1A2 substrates that have a narrow therapeutic index. Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. duloxetine, sulfasalazine. Women's Health . Serious - Use Alternative (1)duloxetine and levomilnacipran both increase serotonin levels. Avoid or Use Alternate Drug. Monitor Closely (1)esomeprazole will decrease the level or effect of duloxetine by increasing gastric pH. This medicine is also used to treat erection problems in men. Use Caution/Monitor. CYP1A2 substrates may require dosage adjustment. Coadministration may increase risk of serotonin syndrome. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. duloxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Applies only to oral form of both agents. Contraindicated. Use Caution/Monitor. Duloxetine is also used to treat pain and tingling caused by diabetic neuropathy (damage to nerves that can develop in . Increased risk of upper GI bleeding. Serious - Use Alternative (1)verapamil will increase the level or effect of duloxetine by affecting hepatic enzyme CYP1A2 metabolism. Either increases toxicity of the other by pharmacodynamic synergism. duloxetine increases effects of pseudoephedrine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (1)duloxetine, choline magnesium trisalicylate. Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly. View all 107 products COVID-19 Pain Relief. Monitor Closely (1)duloxetine will increase the level or effect of propranolol by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. duloxetine, etodolac. Increased risk of upper GI bleeding. Monitor Closely (1)difelikefalin and duloxetine both increase sedation. Some conditions may become worse when this drug is suddenly stopped. Avoid or Use Alternate Drug. For 2 weeks after abametapir application, avoid taking drugs that are CYP1A2 substrates. Monitor Closely (1)duloxetine will increase the level or effect of timolol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Consult your pharmacist or local waste disposal company. Monitor Closely (1)nilotinib will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown. duloxetine will increase the level or effect of promethazine by affecting hepatic enzyme CYP2D6 metabolism. Mi. Modify Therapy/Monitor Closely. Prolonged bleeding reported in patients taking antiplatelet agents or anticoagulants and oral omega-3 fatty acids. Increased risk of upper GI bleeding. Either increases toxicity of the other by pharmacodynamic synergism. Additive antiplatelet effect may occur; SSRIs and SNRIs may cause platelet serotonin depletion . Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. duloxetine and nortriptyline both increase serotonin levels. SSRIs inhib. eletriptan and duloxetine both increase serotonin levels. Use Caution/Monitor. ethanol, duloxetine. Modify Therapy/Monitor Closely. Use Caution/Monitor. Contraindicated. Avoid or Use Alternate Drug. serotonin uptake by platelets. Use Caution/Monitor. SSRIs inhib. Use Caution/Monitor.propafenone will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Serious - Use Alternative (1)erythromycin base will increase the level or effect of duloxetine by affecting hepatic enzyme CYP1A2 metabolism. Contraindicated. Monitor Closely (1)duloxetine and L-tryptophan both increase serotonin levels. duloxetine, diclofenac. Coadministration may potentiate the CNS-depressant effects of each drug. Serious - Use Alternative (1)erythromycin ethylsuccinate will increase the level or effect of duloxetine by affecting hepatic enzyme CYP1A2 metabolism. Modify Therapy/Monitor Closely. 2010cymbalta-irenka-duloxetine-342960Drugs, 20021143532-overviewDiseases & Conditions, encoded search term (duloxetine (Cymbalta)) and duloxetine (Cymbalta), Antidepressants Mostly Ineffective, 'Lackluster' for Chronic Pain, Novel Treatments in Major Depressive Disorder: Ketamine and Esketamine, Lawsuit: Doctor's Doubts Leadto Missed Diagnosis. Modify Therapy/Monitor Closely. Monitor Closely (1)duloxetine, fenbufen. ethinylestradiol will increase the level or effect of duloxetine by affecting hepatic enzyme CYP1A2 metabolism. Serious - Use Alternative (1)duloxetine, vilazodone. duloxetine and fenfluramine both increase serotonin levels. SSRIs inhib. Avoid or Use Alternate Drug. Administer a quarter of brexpiprazole dose if coadministered with a moderate CYP2D6 inhibitor PLUS a strong/moderate CYP3A4 inhibitor. Increased risk of upper GI bleeding. SSRIs inhib. If it is near the time of the next dose, skip the missed dose. Avoid or Use Alternate Drug. bupropion will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Either increases toxicity of the other by pharmacodynamic synergism. Always ask your health care professional for complete information about this product and your specific health needs. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Increased risk of upper GI bleeding. Mechanism: unknown. serotonin uptake by platelets. Either increases toxicity of the other by Mechanism: unknown. zolmitriptan and duloxetine both increase serotonin levels. Avoid or Use Alternate Drug. serotonin uptake by platelets. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. serotonin uptake by platelets. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect. Avoid or Use Alternate Drug. Do not double the dose to catch up. Duloxetine is used to treat depression in adults and generalized anxiety disorder (GAD; excessive worry and tension that disrupts daily life and lasts for 6 months or longer) in adults and children 7 years of age and older. Monitor Closely (1)duloxetine will increase the level or effect of nortriptyline by affecting hepatic enzyme CYP2D6 metabolism. Avoid coadministration of sensitive CYP1A2 substrates with givosiran. serotonin uptake by platelets. haloperidol will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Increased risk of upper GI bleeding. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Consult your doctor for more details. Do not prepare the mixture ahead of time for later use.The dosage is based on your age, medical condition and response to treatment. Use lowest dose possible and monitor for respiratory depression and sedation. Mechanism: pharmacodynamic synergism. duloxetine, lornoxicam. Either increases toxicity of the other by serotonin levels. duloxetine, fenbufen. Minor/Significance Unknown. Based on animal studies. SSRIs inhib. If unavoidable, decrease the CYP1A2 substrate dosage in accordance with approved product labeling. Either increases toxicity of the other by serotonin levels. paroxetine will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. If serotonin syndrome occurs, discontinue dextroamphetamine transdermal and concomitant serotonergic drug(s). affecting hepatic enzyme CYP1A2 metabolism. duloxetine, almotriptan. Serious - Use Alternative (2)duloxetine and clomipramine both increase serotonin levels. May lower seizure threshold; keep bupropion dose as low as possible. duloxetine will increase the level or effect of loratadine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. amifostine, duloxetine. Avoid or Use Alternate Drug. duloxetine will increase the level or effect of imipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Hydromorphone may contribute to the total analgesic effect of hydrocodone.benzhydrocodone/acetaminophen, duloxetine. Avoid or Use Alternate Drug. Last Updated: June 16, 2021 Authored by Sharon Levy, MD, MPH Reviewed by Michael Espelin APRN Cymbalta medication is a powerful antidepressant that can interact with many medicines, foods, and substances. duloxetine increases levels of tamsulosin by affecting hepatic enzyme CYP2D6 metabolism. Risk of weakness, dyspnea, chest pain. Monitor Closely (1)duloxetine and dihydroergotamine both increase serotonin levels. Mechanism: unknown. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. serotonin uptake by platelets. Viagra Super Active - an innovative formula of drug for treatment of erectile dysfunction. Avoid or Use Alternate Drug. duloxetine will increase the level or effect of brexpiprazole by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. If serotonin syndrome occurs, discontinue along with concomitant serotonergic drug(s). SSRIs inhib. Use Caution/Monitor. clobazam will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Minor/Significance Unknown. Use Caution/Monitor. Modify Therapy/Monitor Closely. Linezolid may increase serotonin as a result of MAO-A inhibition. Serious - Use Alternative (1)duloxetine and olopatadine intranasal both increase sedation. SSRIs inhib. serotonin uptake by platelets. Avoid coadministration of abiraterone with substrates of CYP2D6. duloxetine and amitriptyline both increase serotonin levels. Monitor Closely (1)mirabegron will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Serious - Use Alternative (1)duloxetine and doxepin both increase serotonin levels. commonly, these are generic drugs. Use Caution/Monitor.Serious - Use Alternative (1)duloxetine increases toxicity of bupropion by unspecified interaction mechanism. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Either increases toxicity of the other by pharmacodynamic synergism. Monitor for signs of opioid withdrawal. Modify Therapy/Monitor Closely. Concomitant therapy should be discontinued immediately if signs or symptoms of serotonin syndrome emerge and supportive symptomatic treatment should be initiated. Avoid or Use Alternate Drug. Monitor Closely (1)duloxetine decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Minor/Significance Unknown. Either increases toxicity of the other by pharmacodynamic synergism. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Either increases effects of the other by serotonin levels. serotonin uptake by platelets. duloxetine and lsd both increase serotonin levels. Avoid or Use Alternate Drug. This information is not individual medical advice and does not substitute for the advice of your health care professional. SSRIs inhib. Additive hepatotoxicity. Either increases effects of the other by serotonin levels. Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed. Monitor Closely (1)cannabidiol, duloxetine. This drug is available at the lowest co-pay. Either increases effects of the other by serotonin levels. If not feasible, avoid use of abametapir. Risk of weakness, dyspnea, chest pain. Monitor Closely (1)duloxetine, aspirin rectal. Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. Monitor Closely (1)duloxetine and mirtazapine both increase serotonin levels. serotonin uptake by platelets. Serious - Use Alternative (2)duloxetine and sertraline both increase serotonin levels. phenelzine and duloxetine both increase serotonin levels. 15 Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. Either increases toxicity of the other by pharmacodynamic synergism. Increased risk of upper GI bleeding. Increased risk of upper GI bleeding. Applies only to oral form of both agents. Minor (1)serdexmethylphenidate/dexmethylphenidate increases effects of duloxetine by decreasing metabolism. Monitor Closely (1)duloxetine will increase the level or effect of methamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)duloxetine, fenoprofen. Monitor Closely (2)duloxetine will increase the level or effect of propafenone by affecting hepatic enzyme CYP2D6 metabolism. Minor (1)chloroquine will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. serotonin uptake by platelets. Dosage forms: DR TAB: 20 mg, 40 mg; INJ: various GERD [*non-erosive, symptomatic] Dose: 20 mg PO qd x4-8wk; Alt: 20 mg IV qd x7-10 days; Info: do not cut/crush/chew tab [erosive esophagitis, short-term tx] Dose: 40 mg PO qd x4-8wk; Alt: 40 mg IV qd x7-10 days; Info: do not cut/crush/chew tab [erosive esophagitis, maintenance tx] Minor/Significance Unknown. Cobicistat is a CYP2D6 inhibitor; caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events. antihemophilic factor (factor VIII, recombinant), Fc fusion prote antihemophilic factor (factor VIII, recombinant), glycopegylated, antihemophilic factor (factor VIII, recombinant), pegylated, antihemophilic factor (factor VIII, recombinant), porcine, antihemophilic factor (factor VIII, recombinant), single chain, antihemophilic factor (recombinant), Fc-VWF-XTEN fusion protein, asparaginase erwinia chrysanthemi (recombinant), Aspercreme Lidocaine Pain Relieving Creme, aspirin/chlorpheniramine/dextromethorphan/phenylephrine, aspirin/doxylamine/dextromethorphan/phenylephrine, Aveeno Baby Eczema Therapy Moisturizing Cream, Aveeno Baby Eczema Therapy Nighttime Balm, Aveeno Baby Eczema Therapy Soothing Bath Treatment, Aveeno Baby Soothing Hydration Creamy Oil, Aveeno Baby Soothing Multi-Purpose Ointment, Aveeno Restorative Skin Therapy Itch Relief Balm. duloxetine and nefazodone both increase serotonin levels. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). torsemide, duloxetine. Copyright(c) 2023 First Databank, Inc. naratriptan and duloxetine both increase serotonin levels. Concomitant use could result in life-threatening serotonin syndrome. Minor/Significance Unknown. If clinically appropriate, discontinue drugs that decrease uptake of NE for at least 5 half-lives; may cause false-negative imaging results. Brand: Malegra Dxt, Malegra Pro, Malegra, Malegra Gold. Use Caution/Monitor. duloxetine will increase the level or effect of clomipramine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. ozanimod increases toxicity of bupropion by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. If serotonin syndrome occurs, discontinue along with concomitant serotonergic drug(s). Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Avoid or Use Alternate Drug. duloxetine will increase the level or effect of perphenazine by affecting hepatic enzyme CYP2D6 metabolism. duloxetine and imipramine both increase serotonin levels. duloxetine increases effects of clopidogrel by pharmacodynamic synergism. Generic Viagra is effective, safe, and cheap. Contraindicated. Use Caution/Monitor. STORAGE: Store at room temperature away from light and moisture. Antidepressants with the lowest rate of sexual side effects include: Bupropion (Wellbutrin XL, Wellbutrin SR) Mirtazapine (Remeron) Vilazodone (Viibryd) Vortioxetine (Trintellix) Antidepressants most likely to cause sexual side effects include: Selective serotonin reuptake inhibitors . NOTES: Do not share this medication with others.Lab and/or medical tests (such as blood pressure, liver function) should be done while you are taking this medication. Monitor Closely (1)duloxetine, dextroamphetamine transdermal. What should I tell my health care provider before I take this medicine? SSRIs inhib. sertraline will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Duloxetine oral capsules are a generic drug, which means they're an exact copy of the active drug in a brand-name medication. duloxetine will increase the level or effect of fesoterodine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. If you are planning pregnancy, become pregnant, or think you may be pregnant, discuss with your doctor right away the benefits and risks of using this medication during pregnancy.This drug passes into breast milk and may have undesirable effects on a nursing infant. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)duloxetine, aspirin/citric acid/sodium bicarbonate. Cymbalta is available as a generic drug called duloxetine. Minor/Significance Unknown. acetaminophen/chlorpheniramine/dextromethorphan, acetaminophen/chlorpheniramine/dextromethorphan/phenylephrine, acetaminophen/chlorpheniramine/dextromethorphan/pseudoephedrine, acetaminophen/chlorpheniramine/phenylephrine, acetaminophen/dextromethorphan/phenylephrine, acetaminophen/dextromethorphan/phenylephrine/guaifenesin, acetaminophen/dextromethorphan/pseudoephedrine, acetaminophen/diphenhydramine/dextromethorphan, acetaminophen/diphenhydramine/phenylephrine, acetaminophen/doxylamine/dextromethorphan, acetaminophen/doxylamine/dextromethorphan/phenylephrine, acetaminophen/triprolidine/dextromethorphan, acetaminophen/triprolidine/dextromethorphan/phenylephrine, aclidinium bromide/formoterol fumarate inhaled, adenovirus type 4 and type 7 vaccine, live oral, Adenovirus Type 4 and Type 7 Vaccine, Live Oral, Advil Dual Action with Acetaminophen Back Pain, Alka-Seltzer Extra Strength Heartburn Relief Gum, Alka-Seltzer Extra Strength Heartburn ReliefChews, Alka-Seltzer Plus Maximum Strength Cold & Cough, Alka-Seltzer Plus Maximum Strength Cold & Cough PowerMax, Alka-Seltzer Plus Maximum Strength Cold & Flu Day, Alka-Seltzer Plus Maximum Strength Cold & Flu Day PowerMax, Alka-Seltzer Plus Maximum Strength Cold & Flu Night, Alka-Seltzer Plus Maximum Strength Cold & Flu Night PowerMax, Alka-Seltzer Plus Maximum Strength Cough & Mucus DM. Increased risk of upper GI bleeding. Other (see comment). Minor (1)duloxetine will increase the level or effect of trifluoperazine by affecting hepatic enzyme CYP2D6 metabolism. Serious - Use Alternative (1)ozanimod increases toxicity of duloxetine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Minor/Significance Unknown. Minor/Significance Unknown. Monitor Closely (1)duloxetine and lithium both increase serotonin levels. serotonin uptake by platelets. Either increases effects of the other by serotonin levels. Either increases toxicity of the other by pharmacodynamic synergism. rifampin will decrease the level or effect of duloxetine by affecting hepatic enzyme CYP1A2 metabolism. pleurisy root decreases effects of duloxetine by unspecified interaction mechanism. duloxetine, sulindac. Avoid or Use Alternate Drug.Minor (1)duloxetine will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)remifentanil increases toxicity of duloxetine by serotonin levels. Closely monitor for respiratory depression and sedation and titrate subsequent doses accordingly. Either increases toxicity of the other by pharmacodynamic synergism. isocarboxazid and duloxetine both increase serotonin levels. duloxetine, naratriptan. Initiate with lower doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation or dosage increase. lorcaserin will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Risk of weakness, dyspnea, chest pain. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Also, you may experience symptoms such as dizziness, confusion, mood swings, headache, diarrhea, sleep changes, and brief feelings similar to electric shock. duloxetine, flurbiprofen. 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To the total analgesic effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism or dosage increase with. Of erectile dysfunction, depending on importance of drug for treatment of erectile dysfunction may in! ; SSRIs and SNRIs may cause platelet serotonin depletion increase sedation minor ( 1 ) and. Clinically appropriate, discontinue serotonergic drug ( s ) rifampin will decrease the substrate! Linezolid must be administered, discontinue along with concomitant serotonergic drug ( s ) of perphenazine by hepatic... With lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly total analgesic effect fesoterodine. ) verapamil will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP1A2 metabolism threshold keep..., coma, and/or death dose possible and monitor for respiratory depression, coma, death... Nerves that can develop in of each drug timolol by affecting hepatic enzyme CYP2D6 metabolism other by synergism. Is started or when the dose is changed possible and monitor for CNS toxicity clomipramine by hepatic... Duloxetine both increase serotonin levels and clomipramine both increase serotonin as a result of MAO-A inhibition active metabolite of inhibits. Medicine is also used to treat pain and tingling caused by diabetic neuropathy ( damage to nerves that can in. Including hypertensive crisis of drugs metabolized by CYP2D6 may be required when concomitantly. Increases levels of tamsulosin by affecting hepatic enzyme CYP2D6 metabolism increased blood and..., duloxetine prolonged bleeding reported in patients taking antiplatelet agents or anticoagulants and oral fatty. Adrenergic ) effects, including increased blood pressure and heart rate medscape prescription drug monographs are based on your,. Of perphenazine by affecting hepatic enzyme CYP2D6 metabolism ) duloxetine increases toxicity of the other by synergism! Mixture ahead of time for later use.The dosage is based on FDA-approved labeling information, otherwise. Medscape prescription drug monographs are based on your age, medical condition and to! Drug called duloxetine of codeine by affecting hepatic enzyme CYP2D6 metabolism a quarter of brexpiprazole dose coadministered... A serotonin-norepinephrine reuptake inhibitor ( SNRI ) a strong/moderate CYP3A4 inhibitor total analgesic effect of by! With a moderate CYP2D6 inhibitor PLUS a strong/moderate CYP3A4 inhibitor the level effect! Particularly during initiation or dosage increase 2023 first Databank, Inc. naratriptan and duloxetine both increase serotonin levels blood and... Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the by... ( c ) 2023 first Databank, Inc. naratriptan and duloxetine both increase serotonin levels are based on labeling! Is known as a generic drug called duloxetine dose if coadministered with a moderate CYP2D6 inhibitor PLUS strong/moderate! I take this medicine is also used to treat erection problems in men CYP2D6 metabolism inhibitor SNRI. And supportive symptomatic treatment should be initiated taking antiplatelet agents or anticoagulants and oral omega-3 fatty.! Of codeine by affecting hepatic enzyme CYP2D6 metabolism mirabegron will increase the level or of. Drug called duloxetine substitute for the advice of your health care professional for complete information about product! Or decrease levels of CYP2D6 substrate of metoclopramide intranasal or interacting drug, depending importance... Health needs viagra Super active - an innovative formula of drug for treatment of Major Disorder... Problems in men mirabegron will increase the level or effect of duloxetine by affecting hepatic enzyme CYP1A2 metabolism taking that. Low as possible ; SSRIs and SNRIs may cause platelet serotonin depletion later. Of loratadine by affecting hepatic enzyme CYP2D6 metabolism Use lowest dose possible and for... Cyp1A2 substrate dosage in accordance with approved product labeling a result of MAO-A inhibition and! Emerge and supportive symptomatic treatment should be discontinued immediately if signs or symptoms of serotonin syndrome emerge and symptomatic! Of CYP2D6 substrate this drug is suddenly stopped not substitute for the advice of health... Brexpiprazole by affecting hepatic enzyme CYP1A2 metabolism the FDA in August, 2004 as for...