diazepam and oxycodone both increase sedation. Atropine, scopolamine, and other premedications should be administered in separate syringes. Monitor Closely (1)lapatinib will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. diazepam and methocarbamol both increase sedation. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Always ask your health care professional for complete information about this product and your specific health needs. Use Caution/Monitor. affecting hepatic/intestinal enzyme CYP3A4 metabolism. diazepam increases effects of abobotulinumtoxinA by pharmacodynamic synergism. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Lencapavir (a moderate CYP3A4 inhibitor) may increase CYP3A4 substrates initiated within 9 months after last SC dose of lenacapavir, which may increase potential risk of adverse reactions of CYP3A4 substrates. Modify Therapy/Monitor Closely. diazepam decreases effects of rocuronium by pharmacodynamic antagonism. diazepam will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)rifabutin will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmFsaXVtLXZhbHRvY28tZGlhemVwYW0tMzQyOTAy, View explanations for tiers and Use Caution/Monitor. Monitor Closely (1)diazepam and butorphanol both increase sedation. Modify Therapy/Monitor Closely. alprazolam and diazepam both increase sedation. fluconazole will increase the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and reduces efficacy related to these substrates. Minor/Significance Unknown. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates. diazepam and sage both increase sedation. diazepam and trimipramine both increase sedation. Monitor Closely (1)diazepam and trimipramine both increase sedation. Pediatric IV administration: The IV should be given slowly, over a 3-minute period at a rate of 0.25 mg/kg or slower. Monitor Closely (1)zafirlukast will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Limit dosages and durations to the minimum required. Use Caution/Monitor. Monitor Closely (1)diazepam and lormetazepam both increase sedation. Monitor Closely (2)oliceridine, diazepam. Use Caution/Monitor. Doses may be increased gradually as needed and tolerated, but should be limited to the smallest effective amount. Closely monitor for increased neuromuscular blockade. Monitor Closely (1)esketamine intranasal, diazepam. Avoid or Use Alternate Drug.Minor (1)rifampin will decrease the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. diazepam will increase the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. phenytoin will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. diazepam decreases levels of acetaminophen by increasing metabolism. 4 While the physiological effects may only last between four to six hours, the drug will be detectable in the body for much . Lonafarnib may increase the AUC and peak concentration of CYP2C19 substrates. Monitor Closely (1)diazepam and loprazolam both increase sedation. diazepam and apomorphine both increase sedation. Use Caution/Monitor. Either increases effects of the other by Other (see comment). Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Monitor Closely (1)dronedarone will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Inform patients that this drug may cause drowsiness, and they should avoid driving or operating machinery until the full effects of the drug are seen. Monitor Closely (2)tazemetostat will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Minor/Significance Unknown. Monitor Closely (1)diazepam and dextromoramide both increase sedation. Elagolix is a weak CYP2C19 inhibitor. Minor (1)diazepam increases effects of vinpocetine by unspecified interaction mechanism. diazepam and pholcodine both increase sedation. Minor/Significance Unknown. quinupristin/dalfopristin will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. green tea decreases effects of diazepam by pharmacodynamic antagonism. Monitor Closely (1)lurasidone, diazepam. Sharing it is against the law. Minor/Significance Unknown. Get medical help right away if any of these very serious side effects occur: slow/shallow breathing, unusual lightheadedness, severe drowsiness/dizziness, difficulty waking up.Suddenly stopping this medication may cause serious (possibly fatal) withdrawal, especially if you have used it for a long time or in high doses. Use Caution/Monitor. Consider lowering benzodiazepine dose. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. serdexmethylphenidate/dexmethylphenidate increases effects of diazepam by decreasing metabolism. Learn how to store and discard medical supplies safely.The dosage is based on your medical condition, age, and response to treatment. Use Caution/Monitor. Be sure you know how to use diazepam and what other drugs you should avoid taking with it. Modify Therapy/Monitor Closely. Monitor Closely (1)diazepam and oxymorphone both increase sedation. Monitor Closely (1)diazepam and cyclobenzaprine both increase sedation. Use Caution/Monitor. Monitor Closely (1)saquinavir increases levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. diazepam and trazodone both increase sedation. RECTAL: PARENTERAL: Use Caution/Monitor.Serious - Use Alternative (1)fexinidazole will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)diazepam and carisoprodol both increase sedation. Use Caution/Monitor. Monitor Closely (1)DHEA, herbal will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: Drug combination has been found to be incompatible. Use Caution/Monitor. azelastine and diazepam both increase sedation. Monitor Closely (1)istradefylline will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. diazepam decreases effects of rapacuronium by pharmacodynamic antagonism. Minor/Significance Unknown.sage decreases effects of diazepam by pharmacodynamic antagonism. Minor/Significance Unknown. dasatinib will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)diazepam decreases levels of acetaminophen rectal by increasing metabolism. Use Caution/Monitor. Use Caution/Monitor.Minor (1)armodafinil will increase the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect. Avoid or Use Alternate Drug. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Other (see comment). mitotane decreases levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Minor (1)efavirenz will increase the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Muscle relaxants may enhance botulinum toxin effects. Use Caution/Monitor. fedratinib will increase the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. Monitor Closely (1)diazepam and apomorphine both increase sedation. Coadministration of apalutamide, a strong CYP2C19 inducer, with drugs that are CYP2C19 substrates can result in lower exposure to these medications. Monitor Closely (1)diazepam and flurazepam both increase sedation. Serious - Use Alternative (1)erythromycin base will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. chlorpheniramine and diazepam both increase sedation. Modify Therapy/Monitor Closely. lasmiditan, diazepam. Monitor Closely (1)diazepam and pholcodine both increase sedation. primidone will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use Caution/Monitor. metoprolol increases effects of diazepam by decreasing metabolism. crofelemer increases levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. dabrafenib will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (2)phenobarbital will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. etravirine will increase the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Monitor Closely (1)fosaprepitant will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use: Adjunct in status epilepticus and severe recurrent convulsive seizures, PARENTERAL: Minor/Significance Unknown. Compare formulary status to other drugs in the same class. Minor/Significance Unknown. teduglutide increases levels of diazepam by Other (see comment). IV: Usually less than 10 mg, but some patients require up to 20 mg IV, especially when narcotics are omitted. diazepam increases effects of prabotulinumtoxinA by pharmacodynamic synergism. Monitor Closely (1)diazepam and prochlorperazine both increase sedation. idelalisib will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. diazepam increases and xylometazoline decreases sedation. Using this medication with alcohol or other drugs that can cause drowsiness or breathing problems (especially opioid medications such as codeine, hydrocodone) may cause very serious side effects, including death. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate. Use Caution/Monitor. Monitor closely for signs of respiratory depression and sedation.benzhydrocodone/acetaminophen and diazepam both increase sedation. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. Monitor Closely (1)diazepam and ramelteon both increase sedation. Limit dosages and durations to the minimum required. Monitor Closely (1)grapefruit will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. diazepam and lormetazepam both increase sedation. Avoid or Use Alternate Drug. Caution with sensitive CYP2C19 substrates. diazepam and flibanserin both increase sedation. Lomitapide dose should not exceed 30 mg/day. ceritinib will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. fosphenytoin will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If plasma concentrations of the CYP2C19 substrates are elevated during triclabendazole, recheck plasma concentration of the CYP2C19 substrates after discontinuation of triclabendazole. If a third IV dose does not relieve symptoms in pediatric patients, adjunctive therapy appropriate to the condition should be used. 5 years and older: 1 mg slow IV injection every 2 to 5 minutes, up to a maximum dose of 10 mg. Repeat in 2 to 4 hours if needed. Use Caution/Monitor. Use Caution/Monitor. Last updated on Oct 20, 2021. Limit dosages and durations to the minimum required. Effect of interaction is not clear, use caution. Monitor Closely (2)diazepam will increase the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. tecovirimat will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents. Minor/Significance Unknown. Monitor Closely (1)clonidine, diazepam. Closely monitor for increased neuromuscular blockade. Either increases effects of the other by sedation. Use lowest dose possible and monitor for respiratory depression and sedation. Management of anxiety disorders and short-term relief of anxiety symptoms, Symptomatic relief of acute agitation, tremor, impending/acute delirium tremens, and hallucinations in acute alcohol withdrawal, Adjunctive treatment for the relief of skeletal muscle spasm due to reflex spasm to local pathology, spasticity caused by upper motor neuron disorders, athetosis, and stiff-man syndrome (e.g., inflammation of the muscles/joints secondary to trauma, cerebral palsy, paraplegia), Initial dose: 1 to 2.5 mg orally 3 to 4 times a day, Initial dose: 0.5 mg/kg rectally, rounded upward to the next available dose. Modify Therapy/Monitor Closely. diazepam and protriptyline both increase sedation. Modify Therapy/Monitor Closely. Use Caution/Monitor. Avoid or Use Alternate Drug. Use alternatives if available. To prevent withdrawal, your doctor may lower your dose slowly. Use Caution/Monitor. lumefantrine will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. Modify Therapy/Monitor Closely. Use Caution/Monitor. Monitor Closely (1)indinavir increases levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Consider a dose reduction of CYP2C19 substrates, as clinically appropriate, when used concomitantly with cenobamate. erythromycin ethylsuccinate will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Effect of interaction is not clear, use caution. Either increases toxicity of the other by sedation. etravirine will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 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