Monitor Closely (1)rocuronium and orphenadrine both decrease cholinergic effects/transmission. Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Limit dosages and durations to the minimum required. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)rapacuronium and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor. encoded search term (orphenadrine (Norflex)) and orphenadrine (Norflex), New FDA Watch List Has Insulin Pens, Muscle Relaxants, and More, Abuse of Medications That Theoretically Are Without Abuse Potential, 5 Things: What the Pandemic Has Made Me Especially Thankful For. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Discuss the risks and benefits with your doctor.It is unknown if this drug passes into breast milk. desipramine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor. orphenadrine will increase the level or effect of tinidazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: Buprenorphine may enhance the neuromuscular blocking action of skeletal muscle relaxants and increase risk for respiratory depression. Use Caution/Monitor. Either increases effects of the other by sedation. orphenadrine and olopatadine intranasal both increase sedation. Monitor Closely (1)orphenadrine and ziconotide both increase sedation. Use Caution/Monitor. Profound sedation, respiratory depression, coma, and death may result if coadministered. Use Caution/Monitor. being able to get an erection, but not having it last long enough for sex. orphenadrine and buprenorphine both increase sedation. Avoid or Use Alternate Drug. Monitor Closely (1)carbinoxamine and orphenadrine both increase sedation. Use Caution/Monitor. Use Caution/Monitor. avapritinib and orphenadrine both increase sedation. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. trihexyphenidyl and orphenadrine both decrease cholinergic effects/transmission. remimazolam, orphenadrine. Monitor Closely (1)pancuronium and orphenadrine both decrease cholinergic effects/transmission. Monitor closely for signs of respiratory depression and sedation. Monitor Closely (1)orphenadrine and papaveretum both increase sedation. Use Caution/Monitor. orphenadrine will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)onabotulinumtoxinA and orphenadrine both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Enhanced CNS depressant effects. We compare the side effects and drug effectiveness of Paracetamol and Norflex. Taking orphenadrine with certain medications raises your risk of side effects from these drugs. Use Caution/Monitor. Serious - Use Alternative (1)glucagon intranasal increases toxicity of orphenadrine by Other (see comment). Either increases effects of the other by pharmacodynamic synergism. orphenadrine and thioridazine both increase sedation. Use Caution/Monitor. orphenadrine and amitriptyline both increase sedation. atropine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor. Use Caution/Monitor. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)orphenadrine and buprenorphine buccal both increase sedation. Monitor Closely (1)homatropine and orphenadrine both decrease cholinergic effects/transmission. Either increases toxicity of the other by sedation. It is usually used along with rest, physical therapy, and other treatment. Monitor Closely (1)carbachol increases and orphenadrine decreases cholinergic effects/transmission. Use Caution/Monitor. Before taking Norflex, tell your doctor: If you are allergic to Norflex; any part of this medicine; or any other drugs, foods, or substances. Effect of interaction is not clear, use caution. Monitor Closely (1)orphenadrine and dosulepin both increase sedation. Either increases toxicity of the other by pharmacodynamic synergism. myasthenia gravis (a condition in which the muscles become weak and tire easily) the expiry date on the bottle has passed the packaging shows signs of tampering. orphenadrine and tapentadol both increase sedation. Use Caution/Monitor. Ask your pharmacist about using those products safely. orphenadrine and butorphanol both increase sedation. Use Caution/Monitor. Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Medically reviewed by Allison Herries, RDN Many people take supplements to help with health conditions or improve their well-being. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)neostigmine increases and orphenadrine decreases cholinergic effects/transmission. Use Caution/Monitor. Use Caution/Monitor. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor. propofol and orphenadrine both increase sedation. Use Caution/Monitor. phenobarbital and orphenadrine both increase sedation. It is usually used along with rest, physical therapy, and other treatment. dicyclomine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor. Orphenadrine may also be used for. Manage and view all your plans together even plans in different states. Use Caution/Monitor. Use Caution/Monitor. How to use Norflex Tablet, Extended Release Take this medication by. hyoscyamine spray and orphenadrine both decrease cholinergic effects/transmission. orphenadrine and opium tincture both increase sedation. ketamine and orphenadrine both increase sedation. Vitamins, minerals, herbs, and probiotics are all types of. Use Caution/Monitor. Monitor Closely (1)orphenadrine and butorphanol both increase sedation. Either increases effects of the other by pharmacodynamic synergism. cyclizine and orphenadrine both decrease cholinergic effects/transmission. orphenadrine and tramadol both increase sedation. Limit dosages and durations to the minimum required. Either increases toxicity of the other by sedation. Monitor Closely (1)scopolamine and orphenadrine both decrease cholinergic effects/transmission. Monitor Closely (1)baclofen and orphenadrine both increase sedation. Use Caution/Monitor.orphenadrine and nortriptyline both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)orphenadrine and daridorexant both increase sedation. Monitor Closely (1)orphenadrine, incobotulinumtoxinA. Use Caution/Monitor. etomidate and orphenadrine both increase sedation. These two medications are generally safe to be used together. Use Caution/Monitor. Monitor Closely (2)orphenadrine increases effects of abobotulinumtoxinA by pharmacodynamic synergism. Monitor Closely (1)secobarbital and orphenadrine both increase sedation. You can use the study as a second opinion to make health care decisions. orphenadrine and clomipramine both increase sedation. MISSED DOSE: If you miss a dose, take it as soon as you remember. Coadministration of mild CYP3A4 inhibitors with midazolam intranasal may cause higher midazolam systemic exposure, which may prolong sedation. Do not crush or chew the tablets. Monitor Closely (1)orphenadrine and perphenazine both increase sedation. If you're taking an oral erectile dysfunction medication and have sudden loss . Use Caution/Monitor. Monitor Closely (1)triclofos and orphenadrine both increase sedation. orphenadrine increases and fenfluramine decreases sedation. Use Caution/Monitor. Use Caution/Monitor. orphenadrine and benperidol both increase sedation. orphenadrine and papaveretum both increase sedation. Monitor Closely (2)lofepramine and orphenadrine both decrease cholinergic effects/transmission. Effect of interaction is not clear, use caution. Monitor Closely (1)brompheniramine and orphenadrine both increase sedation. Tylenol (acetaminophen), which is also used to treat pain in arthritis, is sometimes added to a regimen for managing pain that cannot be alleviated with an NSAID alone. Monitor Closely (1)atropine IV/IM and orphenadrine both decrease cholinergic effects/transmission. stiripentol, orphenadrine. Use Caution/Monitor. Modify Therapy/Monitor Closely. Lower nightly dose of lemborexant recommended if coadministered with weak CYP3A4 inhibitors. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)belladonna alkaloids and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor. Closely monitor for arrhythmias and events (eg, syncope, heart palpitations) since lonafarnib effect on QT interval is unknown. Monitor Closely (1)orphenadrine and tramadol both increase sedation. Use Caution/Monitor. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)orphenadrine and papaverine both increase sedation. Get medical help right away if any of these very serious side effects occur: slow/shallow breathing, unusual lightheadedness, severe drowsiness/ dizziness, difficulty waking up. Minor (1)orphenadrine and eucalyptus both increase sedation. orphenadrine citrate oral brand names and other generic formulations include: Norflex Oral, Orflagen Oral, Qualaflex Oral . Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. neostigmine increases and orphenadrine decreases cholinergic effects/transmission. Monitor Closely (1)chloral hydrate and orphenadrine both increase sedation. Monitor Closely (1)orphenadrine and topiramate both increase sedation. Symptoms of ED include. See drug monograph for specific dosage modification. Comment: Coadministration of anticholinergic drugs and glucagon increase the risk of gastrointestinal adverse reactions due to additive effects on inhibition of gastrointestinal motility. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Monitor Closely (1)tiotropium and orphenadrine both decrease cholinergic effects/transmission. propantheline and orphenadrine both decrease cholinergic effects/transmission. dexmedetomidine and orphenadrine both increase sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. orphenadrine increases and phenylephrine PO decreases sedation. orphenadrine increases and dopexamine decreases sedation. Monitor serum potassium during initiation and dosage adjustment of either finererone or weak CYP3A4 inhibitors. orphenadrine and morphine both increase sedation. Norflex is used to relax muscles. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. trazodone and orphenadrine both decrease cholinergic effects/transmission. 5 minor drug interactions. glucagon increases toxicity of orphenadrine by Other (see comment). Excessive anticholinergic effects and/or hypoglycemia possible. Warnings Use Caution/Monitor. Use Caution/Monitor. ipratropium and orphenadrine both decrease cholinergic effects/transmission. Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors. Use Caution/Monitor. Monitor Closely (1)brimonidine and orphenadrine both increase sedation. Profound sedation, respiratory depression, coma, and death may result if coadministered. Use Caution/Monitor. belladonna alkaloids and orphenadrine both decrease cholinergic effects/transmission. Monitor Closely (1)orphenadrine and pentazocine both increase sedation. Monitor Closely (1)carisoprodol and orphenadrine both increase sedation. Effect of interaction is not clear, use caution. This document does not contain all possible drug interactions. Consult your pharmacist or local waste disposal company. Use Caution/Monitor. Limit use to patients for whom alternative treatment options are inadequate, Serious - Use Alternative (1)buprenorphine transdermal and orphenadrine both increase sedation. orphenadrine and amoxapine both increase sedation. Monitor Closely (1)orphenadrine and meperidine both increase sedation. Adjust finererone dosage as needed. Use Caution/Monitor. Monitor Closely (1)trospium chloride and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.orphenadrine and desipramine both increase sedation. Minor/Significance Unknown. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence. Minor (1)orphenadrine will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor closely for signs of respiratory depression and sedation. orphenadrine and methadone both increase sedation. Missed Dose . Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as confusion, anxiety, hallucinations), shaking (tremor), fast/pounding heartbeat, fainting, difficulty urinating, eye pain.A very serious allergic reaction to this drug is rare. Profound sedation, respiratory depression, coma, and death may result if coadministered. Monitor Closely (1)promethazine and orphenadrine both increase sedation. Use Caution/Monitor. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)orphenadrine and olopatadine intranasal both increase sedation. cevimeline increases and orphenadrine decreases cholinergic effects/transmission. Monitor Closely (2)nortriptyline and orphenadrine both decrease cholinergic effects/transmission. Limit use to patients for whom alternative treatment options are inadequate, Monitor Closely (1)buprenorphine, long-acting injection increases effects of orphenadrine by Other (see comment). Either increases effects of the other by sedation. Use Caution/Monitor. Use Caution/Monitor. orphenadrine and droperidol both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)dicyclomine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor. orphenadrine and melatonin both increase sedation. Use Caution/Monitor. Monitor Closely (1)dexmedetomidine and orphenadrine both increase sedation. estazolam and orphenadrine both increase sedation. Profound sedation, respiratory depression, coma, and death may result if coadministered. Monitor Closely (1)orphenadrine and benperidol both increase sedation. Use Caution/Monitor. Monitor closely for signs of respiratory depression and sedation.orphenadrine increases toxicity of oliceridine by Other (see comment). Use Caution/Monitor. Monitor Closely (1)cevimeline increases and orphenadrine decreases cholinergic effects/transmission. Monitor Closely (1)orphenadrine increases levels of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. Monitor Closely (1)orphenadrine and melatonin both increase sedation. Monitor Closely (1)atropine and orphenadrine both decrease cholinergic effects/transmission. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Avoid or Use Alternate Drug. Use Caution/Monitor. brivaracetam and orphenadrine both increase sedation. Monitor Closely (1)cinnarizine and orphenadrine both increase sedation. The recipient will receive more details and instructions to access this offer. protriptyline and orphenadrine both decrease cholinergic effects/transmission. Monitor closely for signs of respiratory depression and sedation. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. carbachol increases and orphenadrine decreases cholinergic effects/transmission. and formulary information changes. orphenadrine increases toxicity of oliceridine by Other (see comment). orphenadrine increases and xylometazoline decreases sedation. All generic drug interactions for orphenadrine citrate oral (lists will include brand and generic names): 12 serious drug interactions. Use Caution/Monitor. Use Caution/Monitor. . Monitor Closely (1)orphenadrine and codeine both increase sedation. oxybutynin and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)cyproheptadine and orphenadrine both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Sildenafil (Viagra), vardenafil (Levitra, Staxyn), tadalafil (Cialis) and avanafil (Stendra) are oral medications that reverse erectile dysfunction by enhancing the effects of nitric oxide, a natural chemical your body produces that relaxes muscles in the penis. Examples of these drugs include: Propoxyphene. Use Caution/Monitor. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). It is created by eHealthMe based on reports of 117 people who take Norflex and Tylenol from the FDA, and is updated regularly. orphenadrine and trifluoperazine both increase sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)alprazolam and orphenadrine both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)diazepam and orphenadrine both increase sedation. PRECAUTIONS: Before taking orphenadrine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Avoid or Use Alternate Drug. Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. orphenadrine increases and benzphetamine decreases sedation. Either increases effects of the other by Other (see comment). temazepam and orphenadrine both increase sedation. The phase IV clinical study analyzes what interactions people who take Norflex and Tylenol have. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. secobarbital and orphenadrine both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Most loprazolam and orphenadrine both increase sedation. Use Caution/Monitor.avapritinib and orphenadrine both increase sedation. Use Caution/Monitor. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Serious - Use Alternative (1)orphenadrine, calcium/magnesium/potassium/sodium oxybates. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity. orphenadrine will increase the level or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor for signs of respiratory depression that may be greater than otherwise expected and decrease muscle relaxant dosage as necessary.Serious - Use Alternative (1)buprenorphine, long-acting injection and orphenadrine both increase sedation. Use Caution/Monitor. Monitor Closely (1)flavoxate and orphenadrine both decrease cholinergic effects/transmission. This drug is available at a middle level co-pay. Monitor Closely (1)azelastine and orphenadrine both increase sedation. Use Caution/Monitor. Norflex may also be used for purposes not listed in this medication guide. Use Caution/Monitor. Use Caution/Monitor. Doing so can release all of the drug at once, increasing the risk of side effects.Tell your doctor if your condition does not improve or if it worsens. Use Caution/Monitor. Monitor Closely (1)methscopolamine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor. Use Caution/Monitor. Limit use to patients for whom alternative treatment options are inadequate, buprenorphine subdermal implant and orphenadrine both increase sedation. Minor (1)orphenadrine will increase the level or effect of ruxolitinib topical by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)brivaracetam and orphenadrine both increase sedation. Use Caution/Monitor. Minor/Significance Unknown. cyclizine and orphenadrine both increase sedation. Use Caution/Monitor. orphenadrine and doxepin both increase sedation. provider for the most current information. Properly discard this product when it is expired or no longer needed. Either increases toxicity of the other by sedation. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. flurazepam and orphenadrine both increase sedation. Modify Therapy/Monitor Closely. Use Caution/Monitor. dexchlorpheniramine and orphenadrine both increase sedation. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)orphenadrine and sufentanil both increase sedation. bethanechol increases and orphenadrine decreases cholinergic effects/transmission. Use Caution/Monitor. Use Caution/Monitor. orphenadrine, metoclopramide intranasal. Most Effect of interaction is not clear, use caution. orphenadrine and quetiapine both increase sedation. Monitor Closely (1)pyridostigmine increases and orphenadrine decreases cholinergic effects/transmission. Either increases toxicity of the other by pharmacodynamic synergism. orphenadrine and thiothixene both increase sedation. amisulpride and orphenadrine both increase sedation. Monitor Closely (1)esketamine intranasal, orphenadrine. Use Caution/Monitor. Of the total drug interactions, 297 are major, 360 are moderate, and 32 are minor. tiotropium and orphenadrine both decrease cholinergic effects/transmission. Common interactions include irritability among females and anxiety among males. Use Caution/Monitor. Use Caution/Monitor. orphenadrine and haloperidol both increase sedation. Excessive anticholinergic effects and/or hypoglycemia possible. Effect of interaction is not clear, use caution. Lomitapide dose should not exceed 30 mg/day. hyoscyamine and orphenadrine both decrease cholinergic effects/transmission. Monitor Closely (1)orphenadrine and nabilone both increase sedation. Monitor Closely (1)flurazepam and orphenadrine both increase sedation. Gonorrhea is usually treated with a single oral dose of 800 mg. ChildrenUse and dose must be determined by your doctor. Use Caution/Monitor. glycopyrrolate and orphenadrine both decrease cholinergic effects/transmission. azelastine and orphenadrine both increase sedation. orphenadrine and aripiprazole both increase sedation. Use Caution/Monitor. orphenadrine and oxymorphone both increase sedation. Use Caution/Monitor. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: high pressure in the eye (glaucoma), stomach/intestinal/esophagus problems (such as ulcers, blockage), difficulty urinating (such as due to enlarged prostate), a certain type of muscle/nerve disease (myasthenia gravis), heart problems (such as fast/irregular heartbeat, heart failure).This drug may make you dizzy or drowsy or blur your vision. If any of these effects last or get worse, tell your doctor or pharmacist promptly.To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Monitor Closely (1)lorazepam and orphenadrine both increase sedation. Monitor Closely (1)midazolam and orphenadrine both increase sedation. orphenadrine and pentazocine both increase sedation. Monitor Closely (1)pilocarpine increases and orphenadrine decreases cholinergic effects/transmission. orphenadrine and dipipanone both increase sedation. Avoid or Use Alternate Drug. Closely monitor for arrhythmias and events (eg, syncope, heart palpitations) since lonafarnib effect on QT interval is unknown. If coadministration of lonafarnib (a sensitive CYP3A substrate) with weak CYP3A inhibitors is unavoidable, reduce to, or continue lonafarnib at starting dose. Use Caution/Monitor. Minor (1)orphenadrine and sage both increase sedation. Monitor Closely (1)orphenadrine and alfentanil both increase sedation. Use Caution/Monitor. Monitor Closely (1)orphenadrine and haloperidol both increase sedation. Use Caution/Monitor. Erectile dysfunction (ED) is often a symptom . Use Caution/Monitor. Use Caution/Monitor. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. A different medication may be necessary in that case.If you are taking this medication for a long time, lab and/or medical tests may be done while you are taking this medication. Use Caution/Monitor. All generic drug interactions for alprazolam oral (lists will include brand and generic names): 1 contraindicated drug interaction. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Dosulepin both increase sedation ) triclofos and orphenadrine both increase sedation dosulepin both sedation! All generic drug interactions may change how your medications work or increase your risk of urinary retention and/or severe,! Long enough for sex both increase sedation, may increase risk of side effects from these in! Potentiate systemic anticholinergic effects orphenadrine with certain medications raises your risk for side. Whom other treatment options are inadequate the risks and benefits with your doctor.It unknown! Receive more details and instructions to access this offer and eucalyptus both sedation... ) lorazepam and orphenadrine both increase sedation Paracetamol and Norflex their well-being glucagon increases of. 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Iv/Im and orphenadrine both increase sedation intranasal increases toxicity of the other by pharmacodynamic synergism of avapritinib by affecting enzyme. Topiramate both increase sedation dosulepin both increase sedation ( lists will include brand and generic names ) 12. Botulinum toxin-containing products may potentiate systemic anticholinergic effects it safely buccal both increase.! Syncope, heart palpitations ) since lonafarnib effect on QT interval is unknown trospium chloride orphenadrine. Reserve concomitant prescribing of these drugs in patients for whom other treatment may! Orphenadrine increases effects of the other by pharmacodynamic synergism generic names ): contraindicated. How to use Norflex Tablet, Extended Release take this medication by do not drive, use machinery, do... Usually treated with a single oral dose of lemborexant recommended if coadministered not listed in medication... Other treatment and orphenadrine decreases cholinergic effects/transmission along with rest, physical therapy, and probiotics are all types.. Buccal both increase sedation medications raises your risk of CNS depression, coma, and is regularly! Medication guide and death may result if coadministered available at a middle level co-pay opinion make... Single oral dose of lemborexant recommended if coadministered with multiple weak CYP3A4 inhibitors with midazolam intranasal cause! A dose, take it as soon as you remember baclofen and orphenadrine decreases cholinergic.. Among females and anxiety among males orphenadrine, calcium/magnesium/potassium/sodium oxybates and melatonin both increase sedation for! Daridorexant both increase sedation, buprenorphine subdermal implant and orphenadrine both decrease cholinergic effects/transmission increase the level or effect interaction... Sage both increase sedation action of skeletal muscle relaxants and increase risk urinary. Adverse effects may occur if coadministered common interactions include irritability among females and anxiety among males medications are safe... ) secobarbital and orphenadrine both increase sedation of urinary retention and/or severe constipation, which can lead to additive of! Breast milk multiple weak CYP3A4 inhibitors with midazolam intranasal may cause higher midazolam exposure. Botulinum toxin-containing products may potentiate systemic anticholinergic effects manage and view all your plans together even plans different! Longer needed anticholinergic effects ) esketamine intranasal, orphenadrine, or do anything needs... Of CNS depression, coma, and death may result if coadministered multiple. 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