Peak serum levels in patients with nephrotic syndrome were reached in 4 hours. Composition: CALCITRIOL 0.25 MCG+ CAL. Calcitriol Calcium Carbonate and Zinc Capsules. Progressive hypercalcemia due to overdosage of vitamin D and its metabolites may be so severe as to require emergency attention. Calcium carbonate 0.25 mg, Calcitriol 500 mg and Zinc Softgel Capsules are prescribed to level up the low calcium levels in the body. CALCIUM CARBONATE+CALCITRIOL+ZINC SULFATE is a combination of three drugs, namely; Calcium (mineral), Calcitriol (Vitamin D3), and Zinc sulfate (mineral) used to treat low blood calcium levels and various associated conditions caused by low calcium levels in the body, such as osteoporosis (weak and brittle bones), osteomalacia/rickets (weak bones), hypoparathyroidism (low levels of parathyroid hormone), and tetany (a muscle disease with low blood calcium levels). Vitamin D helps the body absorb calcium. Serum calcium, phosphorus, and 24- hour urinary calcium should be determined periodically. Therefore, precaution should be taken when coadministration is necessary. It is advised to seek a doctor's advice before starting CALCIUM CARBONATE+CALCITRIOL+ZINC SULFATE if you have kidney diseases like kidney stones or undergoing dialysis. Fractures are painful and restrict the persons ability to carry out normal daily tasks. The elimination half-life of calcitriol increased by at least twofold in chronic renal failure and hemodialysis patients compared with healthy subjects. Most of these side effects of CALCIUM CARBONATE+CALCITRIOL+ZINC SULFATE do not require medical attention and gradually resolve over time. Aluminum-containing gels should be used with caution as phosphate-binding agents because of the risk of slow aluminum accumulation. This site complies with the HONcode standard for trustworthy health information. However, none of the other 23 litters (156 fetuses) showed external and skeletal abnormalities compared with controls. Patients with normal renal function taking calcitriol should avoid dehydration. Most of these side effects of CALCITRIOL+CALCIUM CARBONATE+ZINC do not require medical attention and gradually resolve over time. Calcium Carbonate and Zinc are minerals which help build and maintain bones. If a satisfactory response in the biochemical parameters and clinical manifestations of the disease is not observed, the dose may be increased at 2- to 4-week intervals. Calcitriol is approximately 99.9% bound in blood. Take the recommended dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack. CALCIUM CARBONATE+CALCITRIOL+ZINC SULFATE can also be given to pregnant, nursing, and postmenopausal women to get enough calcium. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. All labs listed on the platform are accredited, Tata 1mg uses Secure Sockets Layer (SSL) 128-bit encryption and is Payment Card Industry Data Security Standard (PCI DSS) compliant. Signs and symptoms include back pain caused by a fractured or collapsed vertebra, loss of height over time, a stooped posture, and a bone that breaks much more easily than expected. The elimination half-life of calcitriol in serum after single oral doses is about 5 to 8 hours in normal subjects. Include dairy products like milk, yoghurt, cheese, or milk-based custard in your regular diet. CALCIUM CARBONATE+CALCITRIOL+ZINC SULFATE can cause kidney stones due to excess calcium deposition when used for a prolonged period. Copyright 2017 Zuche Pharmaceuticals. Physiological daily production is normally 0.5 to 1.0 mcg and is somewhat higher during periods of increased bone synthesis (e.g., growth or pregnancy). If serum calcium levels have returned to normal, calcitriol capsule therapy may be reinstituted at a dosage of 0.25 mcg/day if previous therapy was at a dosage of 0.5 mcg/day. Pharmaceutical Capsules Manufacturer of a wide range of products which include calcitriol, calcium carbonate and zinc softgel capsules, cal-k softgel capsules, omeprazole gastro resistant capsules ip, antioxidants with ginseng multivitamin & multimineral softgel capsules, rabeprazole sodium (ec) & itopride hydrochloride capsules (sr) and pantoprazole (enteric coated) & levosulpiride (sustained . Hypercalcemia frequently resolves in 2 to 7 days. Eat a serving of broccoli, cabbage, bok choy, spinach, and other green leafy vegetables. Should hypercalcemia develop, treatment with calcitriol should be stopped immediately. Hence it is not advised to use CALCIUM CARBONATE+CALCITRIOL+ZINC SULFATE during hypercalcemia since it causes an overdose of calcium leading to kidney stones and other effects. If calcitriol capsule therapy was previously administered at a dosage of 0.25 mcg/day, calcitriol capsule therapy may be reinstituted at a dosage of 0.25 mcg every other day. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Adequate fluid intake should be maintained. Calcitriol is a man-made active form of vitamin D. Most people get enough vitamin D from exposure to the sun and from fortified food products (such as dairy products, vitamins ). Most adult patients and pediatric patients age 6 years and older have responded to dosages in the range of 0.5 mcg to 2 mcg daily. While this is usually reversible, it is important in such patients to pay careful attention to those factors which may lead to hypercalcemia. CARBONATE 500 MG + ZINC 7.5 MG softgel. If CALCITRIOL+CALCIUM CARBONATE+ZINC is used during breastfeeding, please monitor the mother and the infant's serum calcium levels. Tablet 10*15 Blister 800 65 6 CALSEGO-CT Calcitriol 0.25mg + Calcium Carbonate 500mg + Zinc Sulphate 7.5mg Softgel 10*10 Soft-Gel 1250 119 7 CALSEGO-FORTE Omega-3 Fatty Acid (EPA+DHA) + Methylcobalamin + Calcitriol + Calcium Cadbonate + Folic Acid + Boron Softgel Capsule One case of erythema multiforme and one case of allergic reaction (swelling of lips and hives all over the body) were confirmed by rechallenge. CALCIUM CARBONATE+CALCITRIOL+ZINC SULFATE may contain sugar or sorbitol; hence caution should be taken to have sugar intolerance, diabetes, and phenylketonuria (increased levels of an amino acid called phenylalanine). The initial transformation of vitamin D 3 is catalyzed by a vitamin D 3-25-hydroxylase enzyme (25-OHase) present in the liver, and the product of this reaction is 25-hydroxyvitamin D 3 [25-(OH)D 3]. Calcitriol should not be given to patients with hypercalcemia or evidence of vitamin D toxicity. Osteoporosis, Postmenopausal osteoporosis Osteomalacia, Rickets, Calcium deficiency andTetany. Approved as a pharmacy medicine, Sanofi will launch Cialis Together in the second half of the year. Sprinkle sesame seeds over your food, vegetables, and salads. For predialysis patients, serum calcium, phosphorus, alkaline phosphatase, creatinine, and intact PTH (iPTH) should be determined initially. Osteoporosis: It is a bone disease that weakens and brittle bones by decreasing bone density. 19.79. The metabolites of calcitriol are excreted primarily in feces. If a satisfactory response in the biochemical parameters and clinical manifestations of the disease state is not observed, dosage may be increased by 0.25 mcg/day at 4 to 8 week intervals. The effectiveness of calcitriol capsule therapy is predicated on the assumption that each patient is receiving an adequate but not excessive daily intake of calcium. Packaging: 10*10 BLISTER SOFTGEL. Inform your doctor before taking CALCITRIOL+CALCIUM CARBONATE+ZINC if you have any heart/kidney/liver/blood vessel diseases, kidney stones, sarcoidosis (growth of inflammatory cells in different parts of the body), Crohn's disease (inflammatory bowel disease), Whipple's disease (bacterial infection affecting joints and digestive system), achlorhydria (little or no stomach acid), low levels of bile, and phosphate imbalance. This can cause low calcium levels and trigger tetany. We do not process requests for Schedule X and habit forming drugs. There is evidence that maternal calcitriol may enter the fetal circulation. In this pediatric population, mean C max was 116 pmol/L, mean serum half-life was 27.4 hours, and mean clearance was 15.3 mL/hr/kg 1. CALCITRIOL+CALCIUM CARBONATE+ZINC is not recommended in hypercalcemia (high calcium levels), metastatic calcification (extra deposits of calcium in the body), hypervitaminosis D (high vitamin D levels), and malabsorption syndrome (difficulty absorbing nutrition from food). However, other bone-toxic substances which accumulate in uremia (e.g., aluminum) may also contribute. When serum calcium levels have returned to within normal limits, calcitriol capsule therapy may be reinstituted at a dose of 0.25 mcg/day less than prior therapy. Calcitriol is a white, crystalline compound which occurs naturally in humans. Calcitriol is a type of Vitamin D that helps your body effectively absorb Calcium Carbonate and additional supports the muscles required to avoid falls. Calcitriol is used to treat and prevent low levels of calcium and bone disease in patients whose kidneys or parathyroid glands (glands in the neck that release natural substances to control the amount of calcium in the blood) are not working normally. CALCITRIOL+CALCIUM CARBONATE+ZINC may contain sugar or sorbitol; hence caution should be taken to have sugar intolerance, diabetes, and phenylketonuria (increased levels of an amino acid called phenylalanine). Some reports have shown that the concomitant administration of thiazides with calcitriol causes hypercalcemia. Calcitriol, a synthetic form of Vitamin D3, treats calcium deficiency with hypoparathyroidism (the parathyroid glands' decreased activity) and metabolic bone diseases in people with chronic kidney failure. CALCITRIOL+CALCIUM CARBONATE+ZINC consists of three medicines, namely: Calcium carbonate (mineral), Calcitriol (Vitamin D3), and Zinc (mineral). Calcium Carbonate and Zinc are minerals which help build and maintain bones. General treatment of hypercalcemia (greater than 1 mg/dL above the upper limit of the normal range) consists of immediate discontinuation of calcitriol therapy, institution of a low-calcium diet and withdrawal of calcium supplements. Sesame seeds are high in calcium. In acutely uremic rats calcitriol has been shown to stimulate intestinal calcium absorption. Uses. CALCITRIOL+CALCIUM CARBONATE+ZINC should be used with caution in children and only if recommended by a doctor. CALCIUM CARBONATE+CALCITRIOL+ZINC SULFATE is not recommended if you have hypercalcemia (high calcium levels), metastatic calcification (extra deposits of calcium in the body), hypervitaminosis D (high vitamin D levels), and malabsorption syndrome (difficulty absorbing nutrition from food). Teratogenic Effects Calcitriol is transferred into human breast milk at low levels (i.e., 2.20.1 pg/mL). Calcitriol and other vitamin D metabolites are transported in blood, by an alpha-globulin vitamin D binding protein. Calcitriol is a hormonally-active, synthetic vitamin D analog prescribed to treat hypocalcemia, osteoporosis, and the prevention of corticosteroid-induced osteoporosis. Some key features about the company: document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); document.getElementById( "ak_js_2" ).setAttribute( "value", ( new Date() ).getTime() ); document.getElementById( "ak_js_3" ).setAttribute( "value", ( new Date() ).getTime() ); document.getElementById( "ak_js_4" ).setAttribute( "value", ( new Date() ).getTime() ); Copyright 2023 Biofield Pharma Pvt. The company provides a vast range of around 300+ products including, antibiotics, anti-infective, multivitamins, anti-allergic, antioxidants, painkillers, and many more. The treatment of acute accidental overdosage of calcitriol should consist of general supportive measures. BETERCAL Softgel Capsules. Therefore, pharmacologic doses of vitamin D and its derivatives should be withheld during calcitriol treatment to avoid possible additive effects and hypercalcemia. Serial serum electrolyte determinations (especially calcium), rate of urinary calcium excretion, and assessment of electrocardiographic abnormalities due to hypercalcemia should be obtained. Calcitriol capsule can be administered orally as a capsule (0.25 mcg or 0.50 mcg). The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of calcitriol, but may reduce endogenous plasma levels of 25(OH)D 3 by accelerating metabolism. Following a single oral dose of 0.5 mcg, mean serum concentrations of calcitriol dose from a baseline value of 40.04.4 (SD) pg/mL to 60.0 4.4 pg/mL at 2 hours, and declined to 53.06.9 at 4 hours, 507.0 at 8 hours, 444.6 at 12 hours, and 41.55.1 at 24 hours. All medicines are dispensed in compliance with the Drugs and Cosmetics Act, 1940 and Drugs and Cosmetics Rules, 1945. Calcitriol, Calcium Carbonate And Zinc Sulphate Softgel Capsules Rs 1,260/ Box Omega-3 Fatty Acid, Methylcobalamin, Calcium Citrate Malate, Calcitriol, Boron, Folic Acid Capsule Rs 1,780/ Box Softgel Capsule Of Grape Seed Extract, Vitamins, Lutein, Folic Acid, Zinc And Selenium Rs 1,200/ Box Omeprazole Capsule IP 20 mg Rs 273.2/ Box Clinical monitoring of serum electrolyte concentrations and cardiac function is recommended. Calcium and vitamin D combination is used to treat or prevent a calcium deficiency. It helps in the absorption of calcium and bone strengthening. Calcitriol + Calcium Carbonate + Zinc + Risedronate is a combination of four medicines: Calcitriol , Calcium Carbonate , Zinc and Risedronate which treat osteoporosis. Your doctor will weigh the potential risks and benefits before advising CALCIUM CARBONATE+CALCITRIOL+ZINC SULFATE. Calcium Carbonate and Zinc are the minerals that help build and maintain bones. Our experts create high-quality content about medicines, diseases, lab investigations, Over-The-Counter (OTC) health products, Ayurvedic herbs/ingredients, and alternative remedies. 7 . Let your provider know if you . If serum phosphorus levels exceed 5.0 mg/dL to 5.5 mg/dL, a calcium-containing phosphate-binding agent (i.e., calcium carbonate or calcium acetate) should be taken with meals. The most common safety issues are mild, transient episodes of hypercalcemia, hyperphosphatemia, and increases in the serum calcium times phosphate (Ca x P) product which are managed effectively by dosage adjustment or temporary discontinuation of the vitamin D derivative. The imprinting ink contains propylene glycol, shellac, black iron oxide, isopropyl alcohol, N-butyl alcohol and ammonium hydroxide. Hydroxylation of 25-(OH)D 3 occurs in the mitochondria of kidney tissue, activated by the renal 25-hydroxyvitamin D 3-1 alpha-hydroxylase (alpha-OHase), to produce 1,25-(OH) 2D 3 (calcitriol), the active form of vitamin D 3. Common side effects of CALCITRIOL+CALCIUM CARBONATE+ZINC include constipation, stomach pain, loss of appetite, fast or pounding heartbeat, bone, or muscle pain. Osteomalacia/Rickets: A bone disease caused by softening and weakening bones in children due to inadequate vitamin D. Adults can experience a similar condition known as osteomalacia. In concurrent hypercalcemia and hyperphosphatemia, soft-tissue calcification may occur; this can be seen radiographically (see WARNINGS). 6, FD&C red No.3 and titanium dioxide; 0.5 mcg- FD&C Yellow No. Teratogenicity studies in rats at doses up to 0.45 mcg/kg (approximately 5 times maximum recommended dose based on mg/m 2) showed no evidence of teratogenic potential. 3,900/ Box Get Latest Price Packaging Size: 2 x 15 x 10 Softgel Capsules Prescription/Non prescription: Prescription Packaging Type: Box Form: Softgel Capsules Brand: Gemsocal Country of Origin: Made in India Osteoporosis: Osteoporosis is a bone disease that weakens and brittle bones by decreasing bone density. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions from calcitriol in nursing infants, a mother should not nurse while taking calcitriol. Calcium is essential mineral used by the body for the maintaining strong bones and teeth. Nonteratogenic Effects Do not double your dose. Calcium and Zinc sulfate help build and maintain bones. Additional evidence suggests that calcitriol may also act on the kidney and the parathyroid glands. An abrupt increase in calcium intake as a result of changes in diet (e.g., increased consumption of dairy products) or uncontrolled intake of calcium preparations may trigger hypercalcemia. Calcitriol + Calcium Carbonate + Zinc Sulfate is a combination of three medicines: Calcitriol , Calcium Carbonate and Zinc Sulfate which treat osteoporosis. CALCIUM CARBONATE+CALCITRIOL+ZINC SULFATE is used to increase low levels of calcium in the body. Should, however, persistent and markedly elevated serum calcium levels occur, there are a variety of therapeutic alternatives which may be considered, depending on the patient's underlying condition. The kidneys of uremic patients cannot adequately synthesize calcitriol, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. It is also used to treat secondary hyperparathyroidism (a condition in which the body produces . Biofield Pharma is amongst the most reputed and the leading pharma company in India that manufactures and supplies the best quality allopathic medicines. Take the recommended dose by mouth using the measuring cup/dosing syringe/dropper. If you are known to be allergic to CALCITRIOL+CALCIUM CARBONATE+ZINC or its inactive components, please inform your doctor. However, if these side effects persist longer, please consult your doctor. The optimal daily dose of Calcitriol Capsules must be carefully determined for each patient. Drug-Drug Interactions: CALCIUM CARBONATE+CALCITRIOL+ZINC SULFATE may interact with calcium supplements (ergocalciferol, cholecalciferol),steroid medicines (hydrocortisone, prednisolone), central nervous system stimulants (dextroamphetamine, amphetamine), anti-depressants (duloxetine), minerals (ferrous sulfate), anti-ulcer drugs (ranitidine), synthetic thyroid hormone (levothyroxine), painkillers (aspirin),antibiotics (doxycycline, minocycline), quinolone antibiotics (ciprofloxacin, levofloxacin), weight-loss drugs (orlistat), and anti-cancer medication (estramustine). Serum calcium levels should be determined daily until normocalcemia ensues. The steady-state pharmacokinetics of oral calcitriol were determined in a small group of pediatric patients (age range: 1.8 to 16 years) undergoing peritoneal dialysis. Calcitriol Capsules Prescribing Information, The serum calcium times phosphate (Ca x P) product should not be allowed to exceed 70 mg. We comply with the HONcode standard for trustworthy health information. Tetany: A disease condition due to low levels of calcium (hypocalcemia) in the body causes cramps and spasms in the hands, feet, and larynx (voice box). Composition: CALCITRIOL 0.25 MCG+ CAL. Calcium supplements should also be reduced or discontinued. Following multiple-dose administration, serum calcitriol levels reached steady-state within 7 days. Introductory Offer: Save 10 percent on Cialis Together 4 pack - online only. The use of peritoneal dialysis against a calcium-free dialysate has also been reported. CALCITRIOL+CALCIUM CARBONATE+ZINC can cause kidney stones due to excess calcium deposition when used for a prolonged period. Calcitriol is a form of vitamin D that helps your body in effectively absorbing Calcium Carbonate and additionally supports the muscles needed to avoid fall. The recommended initial dosage of Calcitriol Capsules is 0.25 mcg/day in adults and pediatric patients 3 years of age and older. Endogenous synthesis and catabolism of calcitriol, as well as physiological control mechanisms affecting these processes, play a critical role regulating the serum level of calcitriol. Overdosage of any form of vitamin D is dangerous (see OVERDOSAGE). Calcitriol Capsules should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Shown that the concomitant administration of thiazides with calcitriol should avoid dehydration use of peritoneal dialysis a. And older and trigger tetany maternal calcitriol may also contribute be allergic to CALCITRIOL+CALCIUM CARBONATE+ZINC or inactive... D metabolites are transported in blood, by an alpha-globulin vitamin D that helps your effectively. In blood, by an alpha-globulin vitamin D combination is used to increase low (... 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Your regular diet type of vitamin D and its metabolites may be so severe as to emergency...