[4][5] Extrapyramidal symptoms are also common and include tremor, dystonia (sustained or repetitive muscle contractions), akathisia (the feeling of a need to be in motion), parkinsonism, and muscle rigidity; in a 2013 meta-analysis of 15 antipsychotic drugs, ziprasidone ranked 8th for such side effects. Canada residents can call a provincial poison control center. To use the sharing features on this page, please enable JavaScript. sildenafil brand name Revatio, Viagra simvastatin brand name Zocor sitagliptin brand name Januvia solifenacin brand name Vesicare sotalol brand name Betapace spironolactone brand name Aldactone sucralfate brand name Carafate [25] Rarely tardive dyskinesia can occur when the medication is stopped. [7][8], Ziprasidone is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia as well as acute mania and mixed states associated with bipolar disorder. Ziprasidone injection is used to treat episodes of agitation in people who have schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. Tell your doctor immediately if you have any of the following symptoms while you are taking ziprasidone: extreme thirst, frequent urination, extreme hunger, blurred vision, or weakness. Ziprasidone is used to treat symptoms of psychotic (mental) disorders, such as schizophrenia, mania, or bipolar disorder. This helps my mania a lot. What should I know about storage and disposal of this medication? Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Exposure increases in a dose-related manner and following three days of intramuscular dosing, little accumulation is observed. Do not let anyone else take your medication. If it is near the time of the next dose, skip the missed dose. These side effects may go away during treatment as your body adjusts to the medicine. It works by balancing the levels of dopamine and serotonin in your brain, substances that help regulate mood, behaviors, and thoughts. Ziprasidone (Geodon) may interact with certain medications or supplements. [59] Pfizer had illegally promoted Geodon and submitted false claims to government health care programs for uses that were not medically accepted indications. AHFS Patient Medication Information. In December 2014, the FDA warned that ziprasidone could cause a potentially fatal skin reaction, Drug Reaction with Eosinophilia and Systemic Symptoms, although this was believed to occur only rarely. QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Take it with food. [4][5] Although it can also cause weight gain, the risk is much lower than for other atypical antipsychotics. Some products that may interact with this drug are: dolasetron, metoclopramide, saquinavir. Drug information provided by: Merative, Micromedex US Brand Name. Most of the deaths were linked to heart disease or infection. Ziprasidone is an atypical antipsychotic drug used to treat schizophrenia. [6] How it works is not entirely clear but is believed to involve effects on serotonin and dopamine in the brain. For males, it may result in decreased sexual ability, inability to produce sperm, or enlarged breasts. Generic Name Ziprasidone DrugBank Accession Number DB00246 Background. Pain or trouble swallowing. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Infectionfever, chills, cough, or sore throat. Unless there is a specific reason you need the brand, the generic medication will be a better value. By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. The dosage is based on your medical condition and response to treatment. The relatively weak antagonistic actions of ziprasidone on the 1-adrenergic receptor likely in part explains some of its side effects, such as orthostatic hypotension. What Are Dosages of Ziprasidone? Discuss the risks and benefits of treatment with your doctor. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Store at room temperature away from moisture, light, and heat. [4][5], Common adverse effects (110%), include producing too much saliva or having dry mouth, runny nose, respiratory disorders or coughing, nausea and vomiting, stomach aches, constipation or diarrhea, loss of appetite, weight gain (but the smallest risk for weight gain compared to other antipsychotics[6]), rashes, fast heart beats, blood pressure falling when standing up quickly, muscle pain, weakness, twitches, dizziness, and anxiety. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. GoodRx works to make its website accessible to all, including those with disabilities. Ziprasidone (Geodon) can lower the amount of white blood cells in your body. [3], Common side effects include dizziness, drowsiness, dry mouth, and twitches. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Some items may interact with your medicine. Get medical help right away if you have a fever that does not go away, mental/mood changes, headache, or dizziness. To get rid of medications that are no longer needed or have expired: NOTE: This sheet is a summary. Geodon Dosage The dosage of Geodon varies according to the condition being treated. Swallow the capsule whole. Weight gain is also less of a concern with ziprasidone compared to other atypical antipsychotics. Find patient medical information for ziprasidone oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. When the weather is hot, drink a lot of fluids and dress lightly. Select a condition to view a list of medication options. Duplication for commercial use must be authorized by ASHP. If you're not on it yet, prepare to become psychologically if not physically addicted to it, as when you miss doses you go through withdrawal symptoms right away and they can be severe. Tell your doctor right away if you have any serious side effects, including: difficulty swallowing, muscle spasms, shaking (tremor), mental/mood changes (such as restlessness), vision changes, interrupted breathing during sleep. Talk to your doctor about using ziprasidone safely. A very serious allergic reaction to this drug is rare. 6 These mental illnesses can often be accompanied by comorbidities such as depression and substance abuse, and can significantly impact the quality of life of patients and caregivers. [38][39] It also somewhat inhibits reuptake of serotonin and norepinephrine, though not dopamine. 15% more effective than lurasidone and iloperidone, approximately as effective as chlorpromazine and asenapine, and 913% less effective than haloperidol, quetiapine, and aripiprazole. Alcohol may interfere with the effect of this medication. If you're sensitive to low blood pressure, change positions slowly until your body is used to the medication. This includes prescription and over-the-counter medicines, vitamins, and herbal products. [55][56] After the FDA raised concerns about long QT syndrome, more clinical trials were conducted and submitted to the FDA, which approved the drug on February 5, 2001.[54][57][58]. [12], Recently, the FDA required the manufacturers of some atypical antipsychotics to include a warning about the risk of hyperglycemia and Type II diabetes with atypical antipsychotics. In a second 3-week placebo-controlled trial (n=205), the dose of ziprasidone was 40 mg twice daily on Day 1.Titration within the range of 40 to 80 mg twice daily (in 20 mg twice daily increments) was permitted for the duration of study (beginning on Day 2). I take ziprasidone. Put it in the trash. Ask your pharmacist for a list of the ingredients. Continue to take ziprasidone even if you feel well. Other side effects not listed may also occur in some patients. Drowsiness, dizziness, and lightheadedness can increase the risk of falling. Do not double the dose to catch up. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Otherwise, call a poison control center right away. If you develop any of these symptoms, tell your doctor right away. White blood cells help your body fight off infections and diseases. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urination. Since untreated mental/mood problems (such as schizophrenia, bipolar disorder, depression) can be a serious condition, do not stop taking this medication unless directed by your doctor. Take the missed dose as soon as you remember it. Ziprasidone treats mental health conditions like schizophrenia and bipolar disorder by balancing the levels of dopamine and serotonin in your brain. Using this medicine with any of the following medicines is not recommended. Ziprasidone may cause problems in newborns following delivery if it is taken during the last months of pregnancy. Check with your pharmacy or law enforcement to find a location. You may report side effects to the FDA at 1-800-FDA-1088. [12] According to the manufacturer insert, ziprasidone caused an average weight gain of 2.2kg (4.8lbs), which is significantly lower than other atypical antipsychotics, making this medication better for patients that are concerned about their weight. Keep all appointments with your doctor and the laboratory. Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. Now, youll enjoy a streamlined experience created specifically for healthcare providers. Avoid driving and doing other tasks that require you to be alert until you see how this drug affects you. Rarely, males may have a painful or prolonged erection lasting 4 or more hours. Do not take more or less of it or take it more often than prescribed by your doctor. Language links are at the top of the page across from the title. Call your doctor if you have any unusual problems while taking this medication. Ziprasidone (Geodon) can cause a sudden drop in blood pressure. To avoid side effects like dizziness, sleepiness, and confusion, you should limit alcohol while taking this medication. Intramuscular: Recommended dose: 10 to 20 mg IM; may repeat 10 mg IM every 2 hours or 20 mg IM every 4 hours up to maximum daily doseMaximum dose: 40 mg IM per dayDuration of therapy: Use beyond 3 consecutive days has not been studied Comments: -Coadministration of IM ziprasidone to patient's already taking oral ziprasidone has not been studied and is not recommended. If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. Avoid alcoholic drinks. This medication may make you sweat less, making you more likely to get heat stroke. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. If you are not sure, ask your care team. The brand name of this medication is Geodon. Properly discard this product when it is expired or no longer needed. [13], Ziprasidone is known to trigger mania in some bipolar patients. Mayo Clinic on Incontinence - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Do not stop using ziprasidone suddenly, even if you feel fine. Keep this medication in the container it came in, tightly closed, and out of reach of children. If I had known that when missing a dose I would not be able to sleep for 2 days, I never would have started taking this medication. This document does not contain all possible drug interactions. Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV. Drink plenty of fluids, especially in hot weather and during exercise. It can also lower the response of your body to heat. This medicine is available only with your doctor's prescription. Ziprasidone may cause a condition that affects the heart rhythm (QT prolongation). Information is also available online at https://www.poisonhelp.org/help. Get medical help right away if you have any very serious side effects, including: severe dizziness, fainting, seizures, signs of liver damage (such as nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin). Do not open, crush, or chew the capsules. If you're currently pregnant and taking ziprasidone (Geodon), it's encouraged that you enroll in the registry. Take ziprasidone (Geodon) twice a day with food to make sure your body absorbs enough of the medication. [49][50], Its biological half-life time is 10 hours at doses of 80120 milligrams. Policy. These effects, along with diabetes, may increase your risk for developing heart disease. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. In September 2009, the U.S. Justice Department announced that Pfizer had been ordered to pay a historic fine of $2.3billion as a penalty for fraudulent marketing of several drugs, including Geodon. The mechanism of action of ziprasidone in schizophrenia and bipolar disorder is unknown. All rights reserved. [21], The British National Formulary recommends a gradual withdrawal when discontinuing antipsychotics to avoid acute withdrawal syndrome or rapid relapse. US residents can call their local poison control center at 1-800-222-1222. Avoid driving or hazardous activity until you know how ziprasidone will affect you. But the different medications in this class work differently. Do not take two doses at one time. If you overheat, quickly look for a place to cool down and rest. Ziprasidone is not approved by the Food and Drug Administration (FDA) for the treatment of behavior problems in older adults with dementia. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. This is a rare but life-threatening condition associated with all antipsychotic medications. Take ziprasidone exactly as directed. If you miss a dose, take it as soon as you remember. Older adults may be more sensitive to the effects of this medicine. It is unknown if this drug passes into breast milk. It is not intended as medical advice for individual conditions or treatment. Dosage forms: intramuscular powder for injection (20 mg), oral capsule (20 mg; 40 mg; 60 mg; 80 mg) [3] The pills are made up of the hydrochloride salt, ziprasidone hydrochloride. Ziprasidone is marketed under the brand name Geodon, and as generics. Click on the brand name to view . [24] It may also result in reoccurrence of the condition that is being treated. [11], Ziprasidone (and all other second generation antipsychotics (SGAs)) received a black box warning due to increased mortality in elderly patients with dementia-related psychosis. Do not take this medication with any of the following: This medication may also interact with the following: This list may not describe all possible interactions. Tell your provider right away if you notice any unusual movements or restlessness. [17][18][19][20] In fact, in a trial of long term therapy with ziprasidone, overweight patients (BMI > 27) actually had a mean weight loss overall. tell your doctor if you have or have had thoughts about harming or killing yourself, breast cancer, an irregular heartbeat, a stroke or ministroke, seizures, diabetes, dyslipidemia (high cholesterol levels), trouble keeping your balance, or heart or liver disease. Keep using the medication as directed and tell your doctor if your symptoms do not improve. Ziprasidone brand names. Make sure to chew your food completely and swallow carefully if you notice tightening of your throat or neck area. Keep out of the sun. It works by helping to restore the balance of certain natural substances in the brain. Description and Brand Names. Things to remember when you fill your prescription. The use of the Truven Health products is at your sole risk. -Monotherapy has not been systematically evaluated for maintenance treatment of bipolar I disorder.Uses: -As monotherapy for the acute management of manic or mixed episodes associated with bipolar I disorder-As adjunct to lithium or valproate for the maintenance treatment of bipolar I disorder. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Brand name: Geodon Drug class: atypical antipsychotics Ziprasidone systemic is used in the treatment of: Autism Bipolar Disorder Body Dysmorphic Disorder Obsessive Compulsive Disorder Paranoid Disorder Schizoaffective Disorder Schizophrenia Tourette's Syndrome Chemical structure Chemical structure of ziprasidone See also Keep taking this medication even if you feel well. Ask your pharmacist any questions you have about refilling your prescription. 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