Let your doctor know if you have any side effects that are bothersome or dont go away. At these exposure margins, no increase in tumors was found in either mice or rats. 1. . PubMed, Our savings assurance of up to 75% off comes from historical data from actual claims. Terms and Conditions apply. The most common side effects with DETROL LA are: Medicines like DETROL LA can cause blurred vision, dizziness, and drowsiness. In clinical trials of normal volunteers and patients, QT interval prolongation was observed with tolterodine immediate release at doses up to 8 mg (4 mg bid) and higher doses were not evaluated [see WARNINGS AND PRECAUTIONS (5.9) and CLINICAL PHARMACOLOGY (12.2)]. The volume of distribution of tolterodine following administration of a 1.28 mg intravenous dose is 113 26.7 L. Metabolism: Tolterodine is extensively metabolized by the liver following oral dosing. Links to other websites Learn about side effects, drug interactions, dosages, warnings, and more. There has been no association of Torsade de Pointes in the international post-marketing experience with DETROL or DETROL LA [see WARNINGS AND PRECAUTIONS (5.7)]. Before starting DETROL LA, tell your doctor about all of your medical conditions, including if you: Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Tolterodine Tartrate International Price Comparison Highlight, Lowest International Mailorder Pharmacy Price: Unlock an extra $3 off & more member perks. DETROL LA has not been studied in patients with mild to moderate renal impairment [CCr 3080 mL/min]. Summary of Mean (SD) Pharmacokinetic Parameters of Tolterodine Extended Release and its Active Metabolite (5-Hydroxymethyl Tolterodine) in Healthy Volunteers, Effect of tolterodine on other drugs metabolized by Cytochrome P450 enzymes, Table 4. Ships Worldwide from, Australia, Canada, India, Mauritius, New Zealand, US, United Kingdom. 69%. The SingleCare price for Tolterodine Tartrate Er is $28.18 per 30, 4mg Capsule, which usually is much cheaper than the typical price of Detrol La but uses the same ingredients. For patients receiving ketoconazole or other potent CYP3A4 inhibitors such as itraconazole, clarithromycin, or ritonavir, the recommended dose of DETROL LA is 2 mg once daily [see DOSAGE AND ADMINISTRATION(2.2) and CLINICAL PHARMACOLOGY (12.3)]. Thus, if your co-pay or out-of-pocket cost is more than $150, you will save $150 off of your co-pay or total out-of-pocket costs. Tolterodine was also negative in vivo in the bone marrow micronucleus test in the mouse. Do not change your dose unless told to do so by your doctor. Your doctor may use a lower dose of DETROL LA if you are taking: Know the medicines you take. 0009-5190-03, Savings Card only works on brand-name DETROL LA. By using this Savings Offer, eligible patients may receive a savings of up to $150 per fill off their co-pay or out-of-pocket costs. DETROL LA may cause allergic reactions that may be serious. Photo: Andreas Neumann. See 17 for PATIENT COUNSELING INFORMATION and FDA-approved patient labeling. Tolterodine is a generic drug that is also available under the brand name Detrol and Detrol LA (extended release). Tolterodine Tartrate Er is a generic version of Detrol La and is significantly cheaper than Detrol La. This is not insurance: Pricing may be lower than your health insurance co-pay, but it cannot be used to lower your co-pay. Your stomach empties slowly (also called "gastric retention"). If you suffer from an overactive bladder, you already know just how much this condition can interfere with your day-to-day life. DETROL LA can be taken with or without food. Doses of tolterodine were 0.5-4 mg bid or 4 mg extended-release daily, and doses of oxybutynin were 5 mg bid or tid. Tolterodine tartrate USP is a white or almost white crystalline powder. The blood to serum ratio of tolterodine and 5-HMT averages 0.6 and 0.8, respectively, indicating that these compounds do not distribute extensively into erythrocytes. For a complete list, ask your doctor or pharmacist. Dry mouth was the most common adverse event leading to treatment discontinuation among patients receiving DETROL LA [n=12 (2.4%) vs. placebo n=6 (1.2%)]. Do not drive, operate machinery, or do other dangerous activities until you know how DETROL LA affects you. The recommended dose of DETROL LA Capsules is 4 mg once daily with water and swallowed whole. If you would like more information, talk with your doctor. No mutagenic or genotoxic effects of tolterodine were detected in a battery of in vitro tests, including bacterial mutation assays (Ames test) in 4 strains of Salmonella typhimurium and in 2 strains of Escherichia coli, a gene mutation assay in L5178Y mouse lymphoma cells, and chromosomal aberration tests in human lymphocytes. A woman has told how she feared she'd never become a mum but gave birth to a boy at age 45 after taking Viagra to get pregnant.. Carin Rockind, 48, welcomed a "miracle" baby after trying to have a . Division of Pfizer Inc, NY, NY 10017, PRINCIPAL DISPLAY PANEL - 2 mg Capsule Dose Foil Pack, Detrol LA PharmacyChecker uses cookies to track & improve your online experience. This Savings Offer is available for a maximum savings of $1,800 per year ($150 per month x 12 months). Overactive bladder (OAB) Certain medicines for treatment of HIV infection such as Norvir (ritonavir), Invirase (saquinavir), Reyataz (atazanavir). For information about Tier 1 international pharmacies click here. There is no cost Get Coupon Add to Pricing Basket SHOW LOCATIONS KELSEY PHARMACY $41.03 Dry mouth, constipation, abnormal vision (accommodation abnormalities), urinary retention, and dry eyes are expected side effects of antimuscarinic agents. Files, All Mapping The dose may later be reduced to 2 mg once daily based on individual response and needs. Overactive bladder happens when you cannot control your bladder muscle. Anaphylaxis and angioedema requiring hospitalization and emergency medical treatment have occurred with the first or subsequent doses of DETROL LA. $128.36 With Free Coupon. Terms and Conditions apply. Do not drive, operate machinery, or do other dangerous activities until you know how DETROL LA affects you. For oral dosage form (extended-release capsules): Adults4 milligrams (mg) once a day. Prescription 4mg tolterodine ER (30 capsules) edit Choose your pharmacy Near boydton, VA Walmart $29.13 CVS $60.71 Walgreens $104.76 Low price Food Lion $20.81 Target $60.71 Kroger $64.67 info How to use this discount For a mail-order 3-month prescription, your total maximum savings may be $450 ($150 x 3), You must be 18 years of age or older to redeem this Savings Offer, You are responsible for reporting use of this Savings Offer to any private insurer, health plan, or other third party who pays for or reimburses any part of the prescription filled using this Savings Offer, as may be required. Ships Worldwide except Canada from, Canada, India, Mauritius, Turkey, United Kingdom, Price includes $18.00 Shipping. Both tolterodine and 5-HMT exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels. Pharmacy names, logos, brands, and other trademarks are the property of their respective owners. Sparingly soluble in water, slightly soluble in anhydrous ethanol, practically insoluble in heptane. 99. The products discussed in this site may have different product labeling in different countries. Keep DETROL LA and all medicines out of the reach of children. First, fill out the following information. Reports of aggravation of symptoms of dementia (e.g., confusion, disorientation, delusion) have been reported after tolterodine therapy was initiated in patients taking cholinesterase inhibitors for the treatment of dementia. Use of them does not imply any affiliation with or endorsement by them. The first look at the 'middle aged Love Island' set has been released, which has already been nicknamed the 'Viagra House' by locals after single parents searched for love If your doctor prescribes this medication and you find that it isnt covered by your insurance, the tolterodine price will likely be around $180-$210 for sixty 2mg tablets (approximately a one month supply). You can buy tolterodine tartrate er at the discounted price of $65.78 by using the WebMDRx coupon, a savings of 72%. The range of prescription discounts provided under this discount plan will vary depending on the prescription and pharmacy where the prescription is purchased and can be up to 80% off the cash price. pill/unit Do not take DETROL LA if you have trouble emptying your bladder (urinary retention), if your stomach empties slowly (gastric retention), or if you have glaucoma . Tolterodine's effect on QT interval was found to correlate with plasma concentration of tolterodine. This leaflet summarizes the most important information about DETROL LA. 0009-5191-02, Smoothie. If your doctor prescribes this medication and you find that it isnt covered. Efficacy was not established in two randomized, placebo-controlled, double-blind, 12-week studies that enrolled 710 pediatric patients (486 on DETROL LA, 224 on placebo) aged 510 years with urinary frequency and urge incontinence. It helps decrease muscle spasms of the bladder and the frequent urge to urinate caused by these spasms. Protect from light. Administer DETROL LA Capsules with caution to patients with clinically significant bladder outflow obstruction because of the risk of urinary retention [see CONTRAINDICATIONS (4)]. Compare Tolterodine Tartrate (Detrol La) prices available at Canadian andinternationalonline pharmacies with local U.S. pharmacy coupon prices. Satisfaction. DETROL LA, like other antimuscarinic drugs, may decrease gastrointestinal motility and should be used with caution in patients with conditions associated with decreased gastrointestinal motility (e.g., intestinal atony) [see CONTRAINDICATIONS (4)]. Effect of tolterodine on other drugs metabolized by Cytochrome P450 enzymes: Tolterodine immediate release does not cause clinically significant interactions with other drugs metabolized by the major drug-metabolizing CYP enzymes. DETROL LA has both benefits and risks. The cost of Tolterodine Tartrate Er with insurance coverage differs depending on your plan - contact your insurance provider for particular medication coverage and coinsurance information. Warfarin: In healthy volunteers, coadministration of tolterodine immediate release 4 mg (2 mg bid) for 7 days and a single dose of warfarin 25 mg on day 4 had no effect on prothrombin time, Factor VII suppression, or on the pharmacokinetics of warfarin. 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