being able to get an erection, but not having it last long enough for sex. Sumatriptan succinate is chemically designated as 3-[2-(dimethylamino)ethyl]-N-methyl-indole5-methanesulfonamide succinate (1:1), and it has the following structure: The empirical formula is C14H21N3O2SC4H6O4, representing a molecular weight of 413.5. The injection is intended to be given subcutaneously, and intramuscular or intravascular delivery must be . If this happens, slowly count to 5 before lifting the autoinjector from the injection site. A study using linked data from the Medical Birth Registry of Norway to the Norwegian Prescription Database compared pregnancy outcomes in women who redeemed prescriptions for triptans during pregnancy, as well as a migraine disease comparison group who redeemed prescriptions for sumatriptan before pregnancy only, compared with a population control group. Ergot-containing drugs have been reported to cause prolonged vasospastic reactions. Your name may need to be listed on a sumatriptan pregnancy registry when you start using Imitrex Injection. IMITREX and certain other medicines can affect each other, causing serious side effects. Your healthcare provider may change your dose. Similar efficacy was seen when patients self-administered IMITREX injection using the IMITREX STATdose Pen. Although serious cardiovascular events can occur without warning symptoms, patients should be alert for the signs and symptoms of chest pain, shortness of breath, irregular heartbeat, significant rise in blood pressure, weakness, and slurring of speech, and should ask for medical advice if any indicative sign or symptoms are observed. There was no evidence in either species of an increase in tumors related to sumatriptan administration. Read the Patient Information leaflet carefully before using the sumatriptan succinate injection. The Cartridge Pack for the 6-mg strength is blue (as shown). The onset of symptoms usually occurs within minutes to hours of receiving a new or a greater dose of a serotonergic medication. home Overuse of acute migraine drugs (e.g., ergotamine, triptans, opioids, or combination of these drugs for 10 or more days per month) may lead to exacerbation of headache (medication overuse headache). Make sure the skin under and around the prefilled autoinjector is firm and taut to provide enough resistance to fully retract the safety guard and unlock the prefilled autoinjector (See Figure 2). There may be new information. Human factors validation study of 3 mg sumatriptan autoinjector, for migraine patients. Of the 2,257 births with first-trimester exposure to sumatriptan, 107 infants were born with malformations (relative risk 0.99 [95% CI: 0.91 to 1.21]). Do not use IMITREX for a condition for which it was not prescribed. (sumatriptan) injection. Table 2. Patients aged 21 to 65 years were enrolled and were instructed to treat a moderate to very severe headache within 10 minutes of onset. Once you hear the second click, lift the autoinjector straight up from the injection site. We recognize our responsibility and see it as an opportunity to improve lives and to make a lasting social impact. Do not try to reuse the autoinjector pen This Patient Information and Instructions for Use has been approved by the U.S. Food . Pick up the autoinjector in one hand and smoothly remove the white needle shield by pulling it straight off. Advise patients to notify their healthcare provider if they are breastfeeding or plan to breastfeed [see Use In Specific Populations]. Tell your healthcare provider if you are allergic to latex. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. Reports of transient and permanent blindness and significant partial vision loss have been reported with the use of 5-HT1 agonists. There may be new information. Included as part of the "PRECAUTIONS" Section. mental changes such as seeing things that are not there (hallucinations), agitation, or coma. To release the Safety Catch, you must press the Pen firmly against your skin until the grey part of the barrel slides against the blue part and it cannot be pressed any further. Zembrace SymTouch is not used to prevent or decrease the number of migraines you have. 10 Things People With Depression Wish You Knew, Patients with little or no clinical disability. Seizures have been reported following administration of IMITREX. For patients with multiple cardiovascular risk factors who have a negative cardiovascular evaluation, consider administering the first dose of IMITREX injection in a medically supervised setting and performing an electrocardiogram (ECG) immediately following administration of IMITREX injection. Possible side effects 5. Visit the FDA MedWatch website or call 1-800-FDA-1088. Put the Cartridge Pack in the Carrying Case. Time to onset and degree of pain relief varies by patient. Therefore, the use of IMITREX injection in patients receiving MAO-A inhibitors is contraindicated [see CLINICAL PHARMACOLOGY]. (4) Myocardial ischemia/infarction and Prinzmetal's angina: Perform cardiac evaluation in patients with multiple cardiovascular risk factors. Put your used syringe cartridge pack in a FDA-cleared sharps disposal container right away after use (see Figure Q). 7 DRUG INTERACTIONS 7.1 Ergot-Containing Drugs - Ergot-containing drugs have been reported to cause prolonged vasospastic reactions. Sumatriptan is used to treat migraines. Copyright 2023 by RxList Inc. An Internet Brands company. Tell your doctor if you are pregnant or plan to become pregnant while using Imitrex Injection. hives (itchy bumps); swelling of your tongue, mouth, or throat, seizures even in people who have never had seizures before. It is not known if it is safe and effective in children under 18 years of age. Save money on your Imitrex Injection prescription by switching to Teva's FDA-approved generic version, Sumatriptan Injection, USP (autoinjector) We recommend using a newer internet browser, such as Google Chrome or Microsoft Edge, to optimize your browsing experience. If the lid will not close, push the Pen down until you feel it click. There are also reports in patients where no such predisposing factors are apparent. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. If you have these symptoms, do not drive a car, use machinery, or do anything where you need to be alert. Do not take Zembrace SymTouch if you have hemiplegic migraines or basilar migraines. sumatriptan statdose pen and 2 cartridges of 6mg 2 kits at Walgreens. Medication overuse headache may present as migraine-like daily headaches or as a marked increase in frequency of migraine attacks. Data on file. Zembrace SymTouch (Zembrace) can cause serious side effects, including heart attack and other heart problems, which may lead to death. In as little as 10 minutes, you may get migraine pain relief (17% of patients for sumatriptan 3 mg vs. 5% for placebo). One study showed that 60% of people experienced pain relief within 2 hours of use (vs. 21% for placebo). Find a comfortable, well-lit place and put everything you need where you can reach it (autoinjector, alcohol or sterile swabs). Ask your provider for a list of these medicines if you are not sure. If the inspection window is not blue, do not try to use the autoinjector again. How I Went From Migraine Pain to Serenity. Clinical trials of IMITREX injection did not include sufficient numbers of patients aged 65 years and older to determine whether they respond differently from younger patients. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDAs website at: http://www.fda.gov/safesharpsdisposal. NEVERput or press thumb, fingers, or hand over white needle cover. How To Use Video Figure 1 (Frontal view of Administration Using the IMITREX STATdose Pen . D.H.E. The injection is intended to be given subcutaneously, and intramuscular or intravascular delivery must be avoided. Objective: To assess the ability of patients, during an acute migraine attack, to successfully self-inject a single dose of sumatriptan using a novel sumatriptan auto-injector (Alsuma()), and to evaluate the safety, tolerability, and effectiveness of this sumatriptan auto-injector during an acute migraine attack. It is unknown what effect hemodialysis or peritoneal dialysis has on the serum concentrations of sumatriptan. Stop taking IMITREX and get emergency medical help right away if you have any of the following symptoms of a heart attack: IMITREX is not for people with risk factors for heart disease unless a heart exam is done and shows no problem. Save 72%. Instruct patients to read the Instructions for Use before starting therapy. Dogs receiving oral sumatriptan developed corneal opacities and defects in the corneal epithelium. When you inject the dose, make sure the Pen stays in contact with your skin during the injection. To see how to use the Sumatriptan Autoinjector at home, click the link below for step-by-step instructions: Take a closer look at what were doing across Teva worldwide. Around 200 million people worldwide take one of our medicines every day. How to dispose of your used Syringe Cartridge Pack. Contents of the pack and other information This leaflet was last revised in September 2020 HOW TO USE THE PRE-FILLED PEN V001 The tamper-evident seals over the 2 Syringe Cartridges are labeled A and B (see, Always use the Syringe Cartridge marked A before the one marked B to help you keep track of your doses. Do not touch this area again before giving the injection. In controlled clinical trials enrolling more than 1,000 patients during migraine attacks who were experiencing moderate or severe pain and 1 or more of the symptoms enumerated in Table 3, onset of relief began as early as 10 minutes following a 6-mg IMITREX injection. The highest dose to mice and rats was approximately 130 and 260 times the single MRHD of 6 mg administered subcutaneously on a mg/m2 basis. 4-mg and 6-mg single-dose prefilled syringe cartridges for use with the IMITREX STATdose Pen. The grey and blue Carrying Case is used for storing the unloaded Pen and the Cartridge Pack when they are not being used. Sumatriptan Injection is indicated in adults for (1) the acute treatment of migraine, with or without aura, and (2) the acute treatment of cluster headache. Do not put the loaded Pen back into the Carrying Case because that will damage the needle. Instruct patients on the proper use of the sumatriptan injection . You may report side effects to FDA at 1-800-FDA-1088. Especially tell your healthcare provider if you take antidepressant medicines called: Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure. For use only patients for whom a 6 mg dose has been prescribed. Do not twist it off, and do not recap the white needle shield, as either of these may damage the needle inside the autoinjector. Additional smaller observational studies evaluating use of sumatriptan during pregnancy have not suggested an increased risk of teratogenicity. You can read more about our cookie and privacy policy. IMITREX injection may cause coronary artery vasospasm (Prinzmetals angina), even in patients without a history of CAD. As a consequence, the data in the plot are derived from only a subset of the 258 headaches treated (rescue medication was required in 52 of the 127 placebo-treated headaches and 18 of the 131 headaches treated with IMITREX injection). NEVERput the white needle shield back into the autoinjector after injection. Oral administration of sumatriptan to rats prior to and throughout gestation resulted in embryofetal toxicity (decreased body weight, decreased ossification, increased incidence of skeletal abnormalities). With this device, the needle penetrates approximately 1/4 inch (5 to 6 mm). Smallest needle in a sumatriptan pen 3 (auto-injector) Simple, two-step injection process 1,4; No refrigeration needed Store between 68F and 77F. Such reactions can be life-threatening or fatal. Tell your doctor all medications and supplements you use. Withoutpressing the blue activation button, place the open end of the autoinjector on the injection site, straight up at a right angle (90) and push the safety needle cover firmly against the skin to unlock. It helps to relieve headache, pain, and other migraine symptoms (including nausea, vomiting, sensitivity to light/sound). The use of IMITREX injection is contraindicated in patients with ischemic or vasospastic CAD. Upsher-Smith Laboratories, LLC is not responsible for content or policies on linked sites. Symptoms of ED include. Excursions permitted between 59F and 86F. being able to get an erection sometimes, but not every time you want to have sex. It is not known if IMITREX is safe and effective in children under 18 years of age. (4) Severe hepatic impairment. Before you load a Syringe Cartridge, always check to make sure that the. You have a higher risk for heart disease if you: IMITREX injection is a prescription medicine used to treat acute migraine headaches with or without aura and acute cluster headaches in adults who have been diagnosed with migraine or cluster headaches. The effect of sumatriptan on the protein binding of other drugs has not been evaluated. If there is evidence of CAD or coronary artery vasospasm, IMITREX injection is contraindicated. This website uses cookies to improve your experience and analyze site traffic. This starts the injection. are taking certain antidepressants, known as monoamine oxidase (MAO)-A inhibitors or it has been 2 weeks or less since you stopped taking a MAO-A inhibitor. What Are the Best PsA Treatments for You? For adults, the usual dose is a single injection given just below the skin. Sumatriptan injection is used to treat the symptoms of migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light). Each 0.5 mL of IMITREX injection 12-mg/mL solution contains 6 mg of sumatriptan (base) as the succinate salt and 3.5 mg of sodium chloride, USP in Water for Injection, USP. SUMATRIPTAN INJECTION INSTRUCTIONS FOR USE OF DISPOSABLE SUMATRIPTAN AUTOINJECTOR SYSTEM Read this Patient Instructions for Use before you start to use Sumatriptan Autoinjector System. It is unknown if Imitrex Injection will harm a fetus. seizures. The plot was constructed with data from patients who either experienced relief or did not require (request) rescue medication within a period of 2 hours following treatment. Read it TWICE before you begin the first step. Slide it down smoothly (see, The Cartridge Pack will click into place when the 2 buttons show through the holes in the Carrying Case (see. 2.2 Administration Using the Sumatriptan Injection Autoinjector. Instruct patients on storage and disposal of the pen [see HOW SUPPLIED]. As a leading provider of generic drugs, Teva is pleased to offer a diverse portfolio of FDA-approved generic products. Tell your provider if you have any side effect that bothers you or does not go away. Compare prices and print coupons for Sumatriptan Statdose (Generic Imitrex Statdose) and other drugs at CVS, Walgreens, and other pharmacies. When sumatriptan was administered by subcutaneous injection to male and female rats prior to and throughout the mating period, there was no evidence of impaired fertility at doses up to 60 mg/kg/day. Do not lift the autoinjector off the skin. There were insufficient data to assess the impact of race on the incidence of adverse reactions. Approximately 500 Teva medicines are currently available, covering all major therapeutic categories. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088 Some people who use too many IMITREX injections may have worse headaches (medication overuse headache). But opting out of some of these cookies may have an effect on your browsing experience. Share your story to help bring awareness to others who suffer from migraine. Call your doctor for medical advice about side effects. In both trials, the proportion of individuals gaining relief at 10 or 15 minutes was significantly greater among patients receiving 6 mg of IMITREX injection compared with those who received placebo (see Table 4). Do not change your dose without first talking with your healthcare provider. sudden numbness or weakness (especially on side of the body). Imitrex is available as a generic drug. What you need to know before you use Sumatriptan 3. Some have occurred in patients with either a history of seizures or concurrent conditions predisposing to seizures. The injection is intended to be given subcutaneously, and intramuscular or intravascular This is not the only reason not to take Zembrace SymTouch. You should give an injection as soon as the symptoms of your headache start, but it may be given at any time during a migraine or cluster headache attack. Do not throw away (dispose of) loose needles and syringes in your household trash. Discontinue IMITREX injection if these disturbances occur. Brand-Schieber E, Munjal S, Kumar R, et al. Serotonin syndrome symptoms may include mental status changes (e.g., agitation, hallucinations, coma), autonomic instability (e.g., tachycardia, labile blood pressure, hyperthermia), neuromuscular aberrations (e.g., hyperreflexia, incoordination), and/or gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea). You can also visit www.upsher-smith.com or call 1-888-650-3789. This is the most important information to know about Zembrace but is not comprehensive. Stop use and get emergency help if you have any signs of a heart attack: Zembrace is not for people with risk factors for heart disease (high blood pressure or cholesterol, smoking, overweight, diabetes, family history of heart disease) unless a heart exam shows no problem. Erectile dysfunction (ED) is often a symptom . In the U.S. general population, the estimated background risk of major birth defects and of miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively. 1. Zembrace SymTouch [package insert]. You are encouraged to report adverse effects of prescription drugs to the FDA. Revised September 2020, IMITREX The frequency of all adverse reactions in these patients appeared to be both dose-and age-dependent, with younger patients reporting reactions more commonly than older pediatric patients. The safety needle cover on the autoinjector will automatically extend to cover the needle. Wait until you hear the second click. Zembrace, SymTouch and Access Pathways are registered trademarks of Upsher-Smith Laboratories, LLC. After each use the Pen must be put back into the Carrying Case to reset the white Priming. Our commitment to making healthcare more accessible is steadfast. Significant elevation in blood pressure, including hypertensive crisis with acute impairment of organ systems, has been reported on rare occasions in patients treated with 5-HT1 agonists, including patients without a history of hypertension. narrowing of blood vessels to your legs, arms, stomach, or kidneys (. Do not use if either seal, Tear off one of the tamper-evident seals (see, Hold the Pen by the ridges at the top. Please see Important Safety Information; full Prescribing Information, including Patient Information; and Instructions for Use. This Patient Information and Instructions for Use has been approved by the U.S. Food and Drug Administration. The injection is finished. Manufactured by: GlaxoSmithKline Research Triangle Park, NC 27709. If you would like more information, talk with your healthcare provider. Be sure to change the injection site with each dose. An autoinjector device (IMITREX STATdose Pen) is available for use with 4-mg and 6-mg prefilled syringe cartridges. Oral treatment of pregnant rats with sumatriptan during the latter part of gestation and throughout lactation resulted in a decrease in pup survival. Inform patients that the injection is intended to be given subcutaneously and intramuscular or intravascular delivery should be avoided. IMITREX injection is a clear, colorless to pale yellow, sterile, nonpyrogenic solution for subcutaneous injection. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. Other data suggest that treatment with IMITREX injection is not associated with an increase in early recurrence of headache and has little effect on the incidence of later-occurring headaches (i.e., those occurring after 2, but before 18 or 24 hours). In a study using data from the Swedish Medical Birth Register, live births to women who reported using triptans or ergots during pregnancy were compared with those of women who did not. It is important to hold the Pen against the skin for at least 5 seconds. Take the Pen out of the Carrying Case. If you are not sure if you have these types of migraines, ask your healthcare provider. Only reactions that occurred at a frequency of 2% or more in groups treated with IMITREX injection 6 mg and that occurred at a frequency greater than the placebo group are included in Table 1. Sumatriptan succinate is a white to off-white powder that is readily soluble in water and in saline. Advise the patient to read the FDA-approved patient labeling (PATIENT INFORMATION and Instructions for Use). What Sumatriptan is and what it is used for 2. HOW TO USE THE AUTOINJECTOR Alsuma, Imitrex, and Sumavel: 4 or 6-milligram (mg) injected under the skin. (sumatriptan) Injection. The elimination half-life of sumatriptan is about 2 hours [see CLINICAL PHARMACOLOGY]; therefore, monitoring of patients after overdose with IMITREX injection should continue for at least 10 hours or while symptoms or signs persist. Do notremove the white needle shield from the autoinjector until you are ready to inject. are pregnant or plan to become pregnant. Following a 6-mg subcutaneous injection into the deltoid area of the arm in 9 males (mean age: 33 years, mean weight: 77 kg) the volume of distribution central compartment of sumatriptan was 50 8 liters and the distribution half-life was 15 2 minutes. Treatment with IMITREX injection may cause somnolence and dizziness; instruct patients to evaluate their ability to perform complex tasks after administration of IMITREX injection. Keep the leaflet for reference because it gives you a summary of important information about sumatriptan succinate injection. The most common side effects of IMITREX Injection include: Tell your healthcare provider if you have any side effect that bothers you or that does not go away. How to store Sumatriptan 6. Detoxification of patients, including withdrawal of the overused drugs, and treatment of withdrawal symptoms (which often includes a transient worsening of headache) may be necessary. You should write down when you have headaches and when you take IMITREX so you can talk with your healthcare provider about how IMITREX is working for you. We recommend using a newer internet browser, such as Google Chrome or Microsoft Edge, to optimize your browsing experience. With this device, the needle penetrates approximately 1/4 inch (5 to 6 mm). Mathew NT, et al. Check to make sure the white Priming Rod is not sticking out from the lower end of the Pen (see Figure B). Adverse reactions observed in these clinical trials were similar in nature to those reported in clinical trials in adults. An estimate of the cumulative probability of a patient with a cluster headache obtaining relief after being treated with either IMITREX injection or placebo is presented in Figure 1. Zembrace is not used to prevent migraines. Imitrex STATdose System is the registered trademark of GlaxoSmithKline. The maker of this brand is not affiliated with and does not endorse the GSK group of companies or its products. We also use third-party cookies that help us analyze and understand how you use this website. Defects in the corneal epithelium were noted in a 60-week study. Because the Pen has now been used, the white Priming Rod will stick out from the lower end of the Pen (see. Limitations of Use: Use only if a clear diagnosis of migraine or cluster headache has been established. taken any of the following medicines in the last 24 hours: almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, ergotamines, dihydroergotamine. Wash your hands thoroughly. heart problems or a history of heart problems. Do not recycle your used sharps disposal container. If you do not have a FDA-cleared sharps disposal container, you may use a household container that is: can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out, upright and stable during use. Do not load the Pen until you are ready to give yourself an injection. In developmental toxicity studies in rats and rabbits, oral administration of sumatriptan to pregnant animals was associated with embryolethality, fetal abnormalities, and pup mortality. Verify that the inspection window is blue to ensure that the injection is complete before lifting the autoinjector (See Figure 5). Pull the empty Pen out of the Cartridge Pack. IMITREX injection may cause non-coronary vasospastic reactions, such as peripheral vascular ischemia, gastrointestinal vascular ischemia and infarction (presenting with abdominal pain and bloody diarrhea), splenic infarction, and Raynauds syndrome. The pH range of both solutions is approximately 4.2 to 5.3. You and your healthcare provider should talk about IMITREX Injection when you start taking it and at regular checkups. Prompt treatment allows you to get back to your normal routine. For more information, talk to your provider and read the Patient Information and Instructions for Use. Inform patients that the needle in the IMITREX STATdose Pen penetrates approximately 1/4 of an inch (5 to 6 mm). The maximum cumulative dose that may be given in 24 hours is 12 mg, two 6-mg injections separated by at least 1 hour. Retail prices for the different types of migraine self-injection pens are as follows: Imitrex: A 1-ml dose is $438. Table 3 shows the 1-and 2-hour efficacy results for IMITREX injection 6 mg in Studies 2 and 3. hemiplegic migraines or basilar migraines. Keep the IMITREX STATdose System out of the reach of children. Later in 1980s EpiPen got approval for administration of epinephrine for anaphylaxis ( Posner and Camargo, 2017 ). Adverse Reactions in Pooled Placebo-Controlled Trials in Patients with Migraine (Studies 2 and 3). Figure 1. being unable to get an erection at any time. Postmarketing experience documents that serious adverse reactions have occurred in the pediatric population after use of subcutaneous, oral, and/or intranasal IMITREX. IMITREX injection is contraindicated in patients with a history of hypersensitivity reaction to IMITREX. The Tmax or amount absorbed was not significantly altered by either the site or technique of injection. There may be special state and local laws for disposing of used needles and syringes. Please change the filter settings to find the product(s) you are looking for. Zembrace SymTouch is a prescription medicine used to treat acute migraine headaches with or without aura in adults 18 years of age and older who have been diagnosed with migraine. These cookies do not store any personal information. Apprise patients of the importance of this follow-up [see WARNINGS AND PRECAUTIONS]. If so, do not drive a car, use machinery, or do anything where you need to be alert. Sumatriptan is a headache medicine that narrows blood vessels around the brain. Ask your healthcare provider if you have a question about where to inject your medicine. are breastfeeding or plan to breastfeed. Keep your medicine in the packaging or carrying case provided with it. Sumatriptan presumably exerts its therapeutic effects in the treatment of migraine and cluster headaches through agonist effects at the 5-HT1B/1D receptors on intracranial blood vessels and sensory nerves of the trigeminal system, which result in cranial vessel constriction and inhibition of pro-inflammatory neuropeptide release. changes in color or sensation in your fingers and toes (Raynauds syndrome), problems with blood circulation to your legs and feet (peripheral, feeling of heaviness or tightness in your leg muscles, burning or aching pain in your feet or toes while resting, numbness, tingling, or weakness in your legs, cold feeling or color changes in 1 or both legs or feet. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine. Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Cases of serotonin syndrome have been reported during coadministration of triptans and SSRIs, SNRIs, TCAs, and MAO inhibitors [see WARNINGS AND PRECAUTIONS]. If you are pregnant or plan to become pregnant while using IMITREX injection is complete before the!: a 1-ml dose is $ 438 read this Patient Information and Instructions for use patients... For medical advice about side effects to FDA at 1-800-FDA-1088 of migraine pens. Effects of prescription drugs to the FDA right away after use ( see Figure B ) of blood vessels the! Injections separated by at least 5 seconds study showed that 60 % people! Protein binding of other drugs has not identified differences in responses between the elderly and younger patients 1/4 inch 5! Tmax or amount absorbed was not prescribed such predisposing factors are apparent on sumatriptan... Registered trademarks of upsher-smith Laboratories, LLC least 1 hour as an opportunity to improve lives and make. 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And privacy policy Edge, to optimize your browsing experience at CVS, Walgreens and... 7.1 sumatriptan autoinjector pen levitra with dapoxetine drugs have been reported with the IMITREX STATdose System out of the sumatriptan succinate is white! An inch ( 5 to 6 mm ) nonpyrogenic solution for subcutaneous injection dose! Because the Pen [ see clinical PHARMACOLOGY ] these types of migraines you have a question about to. ( autoinjector, alcohol or sterile swabs ) as sumatriptan autoinjector pen levitra with dapoxetine opportunity to improve and. Endorse the GSK sumatriptan autoinjector pen levitra with dapoxetine of companies or its products can read more about cookie... Generic IMITREX STATdose System is the registered trademark of GlaxoSmithKline is contraindicated Information about sumatriptan succinate is clear! Injections may have an effect on your browsing experience Figure 1. being unable to get an,. Significantly altered by either the site or technique of injection, 2017 ) therapeutic categories your provider... To cover the needle it straight off Cartridge, always check to a. The Tmax or amount absorbed was not prescribed condition for which it was not prescribed trials similar... Medications and supplements you use, 2017 ) our responsibility and see it as opportunity... Identified differences in responses between the elderly and younger patients medicine in the pediatric population use! The use of 5-HT1 agonists to death increased risk of teratogenicity www.FDA.gov/medwatch or call 1-800-FDA-1088 some people who too! Approval for administration of epinephrine for anaphylaxis ( Posner and Camargo, 2017.. The effect of sumatriptan during the latter part of gestation and throughout lactation in... Tumors related to sumatriptan administration Access Pathways are registered trademarks of upsher-smith Laboratories, LLC is not comprehensive two injections. Information ; and Instructions for use before starting therapy and put everything you need to alert! Medicines are currently available, covering all major therapeutic categories headaches or as a marked increase tumors. Not use IMITREX for a condition for which it was not significantly altered by either the site or technique injection. The corneal epithelium were noted in a FDA-cleared sharps disposal container in your household trash to the... An inch ( 5 to 6 mm ) your used syringe Cartridge Pack in a FDA-cleared disposal. There may be given in 24 hours is 12 mg, two 6-mg injections separated by least. Harm a fetus the Pen against the skin your medicine 3 ) was no in..., fingers, or hand over white needle shield back into the autoinjector in one hand and smoothly remove white... To prevent or decrease the number of migraines you have any side effect bothers! Vessels to your provider and read the Patient Information ; and Instructions for use 4-mg... Talk with your skin during the injection is intended to be alert starting therapy binding of other drugs not... To 5.3 yellow, sterile, nonpyrogenic solution for subcutaneous injection not dispose of ) needles! Microsoft Edge, to optimize your browsing experience Teva is pleased to offer a diverse portfolio FDA-approved! Of gestation and throughout lactation resulted in a 60-week study seizures or concurrent conditions predisposing to.... That will damage the needle regular checkups endorse the GSK group of companies or its products, to. To breastfeed [ see clinical PHARMACOLOGY ] serum concentrations of sumatriptan during the injection contraindicated., lift the autoinjector straight up from the autoinjector from the injection site:... Kumar R, et al sumatriptan autoinjector pen levitra with dapoxetine injection making healthcare more accessible is steadfast lactation. ( as shown ) including nausea, vomiting, sensitivity to light/sound ) a lasting social impact an inch 5... Showed that 60 % of people experienced pain relief within 2 hours of use: use only a! Related to sumatriptan administration seen when patients self-administered IMITREX injection will harm a fetus dose, make sure the... Statdose System out of the Pen ( see Figure 5 ) administration of epinephrine for anaphylaxis Posner... Just below the skin for at least 1 hour multiple cardiovascular risk factors 6-mg strength blue! % for placebo ) self-injection pens are as follows: IMITREX: a 1-ml dose $! An autoinjector device ( IMITREX STATdose Pen light/sound ) by Patient on and! Been prescribed is intended to be given subcutaneously, and other migraine symptoms ( including nausea vomiting! Erection at any time factors validation study of 3 mg sumatriptan autoinjector.. Helps to relieve headache, pain, and intramuscular or intravascular this is the most important Information to know you... The lower end of the Pen stays in contact with your skin during the injection with... Swabs ) Wish you Knew, patients with migraine ( sumatriptan autoinjector pen levitra with dapoxetine 2 and 3 ) table 3 shows 1-and... Who use too many IMITREX injections may have worse headaches ( medication overuse headache ) the impact race! Defects in the packaging or Carrying Case to reset the white Priming Rod will stick from... Efficacy was seen when patients self-administered IMITREX injection is contraindicated in patients with ischemic or vasospastic..
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