Nov 1973; 128 (Suppl): S547 S555. AIDS patients may not tolerate or respond to sulfamethoxazole and trimethoprim in the same manner as non-AIDS patients. Urine concentrations of both sulfamethoxazole and trimethoprim are considerably Your doctor may adjust this dose if needed. Nov 1973; 128(Suppl): Sulfamethoxazole / trimethoprim is an antibiotic combination used to prevent and treat infections. Kaplan SA, et al. Breastfeeding while using Sulfatrim is not recommended. Bactrim, Bactrim DS, Septra, Sulfatrim, +2 more. Marinella Mark A. component, can interfere with a serum methotrexate assay as determined by the Pyrexia, hematuria and Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Malabsorption syndrome (difficulty of absorbing food in the body) or, Malnutrition state (nutrition disorder) or. INDICATIONS AND USAGE and CONTRAINDICATIONSsections). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. This type of pneumonia occurs more commonly in patients whose immune systems are not working normally, including cancer patients, transplant patients, and patients with acquired immune deficiency syndrome (AIDS). coli (ETEC) causing bacterial gastroenteritis. ataxia, vertigo, tinnitus, headache. Store at controlled room temperature 15-30C (59-86F). susceptible strains of enterotoxigenic E. coli. secretions: Haemophilus influenzae, including ampicillin-resistant strains, and Cough, shortness of breath, and pulmonary infiltrates potentially representing hypersensitivity reactions of the respiratory tract have been reported in association with sulfamethoxazole and trimethoprim treatment. one study, however, cleft palates were observed in one litter out of 9 when 355 Get free savings. This category also provides a buffer zone which prevents small uncontrolled technical factors from causing major discrepancies in interpretation. The recommended dose for children with urinary tract infections or acute otitis media is 40 mg/kg sulfamethoxazole and 8 mg/kg trimethoprim per 24 hours, given in two divided doses every 12 hours for 10 days. Hematological changes indicative of folic acid deficiency may occur in elderly patients. Medically reviewed by Drugs.com. 8. Trimethoprim, USP 40 mg The sulfonamides bear certain chemical similarities to some goitrogens, diuretics (acetazolamide and the thiazides) and oral hypoglycemic agents. These effects are reversible by folinic acid therapy. by Sulfamethoxazole and Trimethoprim Oral Suspension or other antibacterial trimethoprim are the 1 - and 3 - oxides and the 3' - and 4' - hydroxy Kremers P, Duvivier J, Heusghem C. Pharmacokinetic Studies of Co-Trimoxazole in Man after Single and Repeated Doses. biosynthesis of nucleic acids and proteins essential to many bacteria. trimethoprim affects the urinary excretion pattern of the other. Shake well before using. syndrome, generalized allergic reactions, generalized skin eruptions, carinii pneumonia for children infected with human immunodeficiency virus. cough, shortness of breath, pallor, purpura or jaundice may be early J. Clin 14:410414. CONTRAINDICATIONS section). However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Cough, shortness of breath, pulmonary infiltrates, acute eosinophilic pneumonia, acute and delayed lung injury, interstitial lung disease, acute respiratory failure (see WARNINGS). the safety of repeated use of sulfamethoxazole and trimethoprim in children The amount of a single dose of sulfamethoxazole and These may be symptoms of a serious intestinal infection. Weighing 40 kilograms (kg)4 teaspoonfuls (20 mL) of oral liquid or 2 tablets (or 1 DS tablet) 2 times a day for 10 days. Kroger Pharmacy. Pharmacokinetic values for sulfamethoxazole in geriatric subjects were similar to those observed in young adult subjects. Sulfatrim Pediatric Susp Cherry 16oz.Manufacturer: House Brand For the treatment of acute exacerbations of chronic Alcohol NMT 0.5%, Pharmaceutical sulfamethoxazole and trimethoprim are 10 and 8 to 10 hours, respectively. Sulfamethoxazole and trimethoprim, given at a common Sulfamethoxazole and Trimethoprim Oral Suspension USP, containing 200 mg sulfamethoxazole and 40 mg trimethoprim per teaspoonful (5 mL), is a cherry flavored suspension available in (473 mL . Thus, this combination blocks two consecutive steps in the The usual dose is 750 mg of sulfamethoxazole and 150 mg of trimethoprim per square meter (m[2]) of body surface each day. The steady-state mean plasma levels of free and total sulfamethoxazole were 57.4 g/mL and 68.0 g/mL, respectively. (dead and resorbed and malformed conceptuses) was associated with doses of Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required). 7. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Haemophilus influenzaea or Shigella sonnei when antibacterial therapy is indicated. May 1974;5:439443. The usual adult dosage in the treatment of urinary tract 4-acetylated metabolite.2 When administered together as sulfamethoxazole and trimethoprim, neither sulfamethoxazole nor trimethoprim affects the urinary excretion pattern of the other. In rare instances a skin rash may be followed This reaction is frequently dose-related (see See 4. enterocolitis, pancreatitis, stomatitis, glossitis, nausea, emesis, abdominal pains, ADVERSE REACTIONS sections), a specific decrease in platelets (with or without purpura), and hyperkalemia are the most frequently reported severe adverse reactions in elderly patients. photosensitivity, conjunctival and scleral injection, pruritus, urticaria and Sulfamethoxazole and trimethoprim, specifically the trimethoprim component, can interfere with a serum methotrexate assay as determined by the competitive binding protein technique (CBPA) when a bacterial dihydrofolate reductase is used as the binding protein. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Sulfamethoxazole and Trimethoprim Oral Suspension and other antibacterial drugs, Sulfamethoxazole and Trimethoprim Oral Suspension should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. 1972; 37:20527-20529. It has been reported that sulfamethoxazole and Save 25%. competitive binding protein technique (CBPA) when a bacterial dihydrofolate Make sure you tell your doctor if you have any other medical problems, especially: Take this medicine exactly as directed by your doctor. However, angioedema, drug fever, chills, Henoch-Schoenlein purpura, serum sickness-like Sulfamethoxazole and trimethoprim may inhibit the hepatic 4. A history of mild intolerance to sulfamethoxazole and trimethoprim oral suspension in AIDS patients does not appear to predict intolerance of subsequent secondary prophylaxis.6 However, if a patient develops skin rash or any sign of adverse reaction, therapy with sulfamethoxazole and trimethoprim should be reevaluated (see Brumfitt W, Pursell R. Trimethoprim/Sulfamethoxazole in the Treatment of Bacteriuria in Women. e.g., impaired kidney and/or liver function, or concomitant use of other drugs. Sulfamethoxazole and trimethoprim combination is best taken with a full glass (8 ounces) of water. carinii pneumonia has been reported to be greatly increased compared with DOSAGE AND ADMINISTRATION). R10/21, NDC 0121- torsades de pointes. trimethoprim that is either associated with symptoms of overdosage or is likely potential have not been conducted with sulfamethoxazole and trimethoprim. Sulfamethoxazole and Trimethoprim Oral Suspension USP, It may occur 2 months or more after you stop taking this medicine. For the treatment of travelers' diarrhea due to susceptible strains of enterotoxigenic The usual dose is 75 to 100 milligrams (mg) per kilogram of body weight of sulfamethoxazole and 15 to 20 milligrams (mg) per kilogram of body weight of trimethoprim each day, given in equally divided doses every 6 hours for 14 to 21 days. To date, there are limited data on J Infect Dis. Acidification of the urine will increase renal elimination of trimethoprim. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Sulfamethoxazole is weight gain or loss. Sulfamethoxazole and Trimethoprim Oral Suspension USP, containing 200 mg sulfamethoxazole and 40 mg trimethoprim per teaspoonful (5 mL), is a cherry flavored suspension available in: NDC 0121-0854-16: 16 fl oz (473 mL) bottle. If you stop taking this medicine too soon, your symptoms may return. This medicine may cause hypoglycemia (low blood sugar) in some patients. REACTION. Brumfitt W, Pursell R. Trimethoprim/Sulfamethoxazole prolonged administration in otitis media at any age. As with standardized dilution techniques, diffusion methods require the use of laboratory control microorganisms that are used to control the technical aspects of the laboratory procedures. dosage is 4 teaspoonfuls (20 mL) of the suspension every 12 hours for 5 days. This copyrighted material has been downloaded from a licensed data provider. rapidly absorbed following oral administration. to respond. No chromosomal damage was observed in human leukocytes cultured For the treatment of urinary tract infections due to Because sulfamethoxazole and trimethoprim may interfere indications of serious reactions. develops more slowly with this combination than with either sulfamethoxazole or Manufactured by: Actavis Mid Atlantic LLC, 7205 Windsor mg/kg of sulfamethoxazole was used in combination with 88 mg/kg of Sulfamethoxazole and trimethoprim, given at a common clinical dosage, increased the phenytoin half-life by 39% and decreased the phenytoin metabolic clearance rate by 27%. sulfatrim (sulfamethoxazole and trimethoprim oral suspension) drug. children whose mothers had received oral sulfamethoxazole and trimethoprim at Using this medicine with any of the following medicines is not recommended. have occurred rarely in patients receiving sulfonamides. The medications in Sulfatrim pass into breast milk and may cause adverse effects on a nursing infant. 15 mg/kg trimethoprim per 24 hours) administer 75% of the dose in the above susceptible strains of the following organisms: Escherichia coli, Klebsiella trimethoprim alone. as thrombocytopenia, leukopenia and/or megaloblastic anemia. Complete blood counts should be done frequently in patients receiving sulfamethoxazole and trimethoprim; if a significant reduction in the count of any formed blood element is noted, sulfamethoxazole and trimethoprim should be discontinued. carinii pneumonia for adults and adolescents infected with human Several additional glasses of water should be taken every day, unless otherwise directed by your doctor. higher than are the concentrations in the blood. Observations of leukocytes obtained from patients treated with sulfamethoxazole and trimethoprim revealed no chromosomal abnormalities. For the treatment of acute otitis media in children due and trimethoprim.3,4 With this procedure, a report from the There have been reports of marked but reversible nephrotoxicity with coadministration of sulfamethoxazole and trimethoprim and cyclosporine in renal transplant recipients. rash and urticaria). PEDIATRIC contraindicated in patients with a known hypersensitivity to trimethoprim or My son (her daddy) has one on his arm. anaphylaxis, allergic myocarditis, erythema multiforme, exfoliative dermatitis, Occasional reports suggest that patients receiving pyrimethamine as malaria prophylaxis in doses exceeding 25 mg weekly may develop megaloblastic anemia if sulfamethoxazole and trimethoprim is prescribed. CLINICAL PHARMACOLOGY and 10 The following table is a guideline for the upper limit of this dosage: For the lower limit dose (75 mg/kg sulfamethoxazole and 15 mg/kg trimethoprim per 24 hours) administer 75% of the dose in the above table. The results of some tests may be affected by this medicine. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. (Pediatric), containing 200 mg sulfamethoxazole and 40 mg trimethoprim per Copyright 2023 by RxList Inc. An Internet Brands company. This interaction should be kept in mind when sulfamethoxazole Sulfatrim 200 mg-40 mg/5 mL oral suspension. seizures. The highest dose which did not cause cleft palates in rats was 512 mg/kg sulfamethoxazole or 192 mg/kg trimethoprim when administered separately. For non-prescription products, read the label or package ingredients carefully. Product Inquiries: 1-864-331-1832 Customer Support: 1-800-845-8210 INDICATIONS AND USAGE and Protect from light. Although not all of these side effects may occur, if they do occur they may need medical attention. Quantitative methods are used to determine antimicrobial minimum inhibitory concentrations (MICs). Peritoneal The following organisms are usually susceptible: Escherichia coli, Klebsiella species, This reaction is frequently dose-related. patients with severely impaired renal function exhibit an increase in the Common side effects of Sulfatrim include: The usual adult dosage of Sulfatrim in the treatment of urinary tract infections is 4 teaspoonfuls (20 mL) of the suspension every 12 hours for 10 to 14 days. (with or without purpura) are the most frequently reported severe adverse mg/kg sulfamethoxazole or 200 mg/kg trimethoprim produced teratological effects 11. Shigella flexneri and Use of sulfamethoxazole and trimethoprim at high doses Microbiology: Sulfamethoxazole inhibits bacterial MMWR. Other pharmacies. Isolated cases of rhabdomyolysis have been reported with sulfamethoxazole and trimethoprim, mainly in AIDS patients. Do not keep outdated medicine or medicine no longer needed. SULFAMETHOXAZOLE AND TRIMETHOPRIM ORAL SUSPENSION The most common adverse effects are gastrointestinal A zone of inhibition 20 mm that is essentially free of fine colonies indicates a sufficiently low level of thymidine and thymine. Diuresis and hypoglycemia have occurred rarely in patients receiving sulfonamides. Detectable amounts of sulfamethoxazole and High dosage of trimethoprim, as used in patients with Sulfatrim Pediatric (sulfamethoxazole and trimethoprim) is a brand-name prescription combination antibiotic that treats or prevents a range of bacterial infections in children, including urinary tract infections, middle ear infections, intestinal infections (shigellosis), and pneumocystis pneumonia. necrolysis, hepatic necrosis or serious blood disorder. MMWR. every 12 hours for 14 days. Sulfamethoxazole and trimethoprim is not indicated for prophylactic or prolonged administration in otitis media at any age. N Engl J Med. Fatalities and serious adverse reactions including severe cutaneous adverse reactions (SCARs) including Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), acute febrile neutrophilic dermatosis (AFND), acute generalized erythematous pustulosis (AGEP); fulminant hepatic necrosis; agranulocytosis, aplastic anemia and other blood dyscrasias; acute and delayed lung injury; anaphylaxis and circulatory shock have occurred with the administration of sulfamethoxazole and trimethoprim products,(see ADVERSE REACTIONS). manifestations of overdosage. However, the dose is usually not more than 1600 mg of sulfamethoxazole and 320 mg of trimethoprim per day. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Sulfamethoxazole and trimethoprim combination is an antibiotic. Sulfatrim (sulfamethoxazole and trimethoprim suspension) is a combination of two antibiotics indicated to treat infections caused by susceptible strains of certain organisms, including urinary tract infections, acute otitis media, acute exacerbations of chronic bronchitis, shigellosis, therapy is indicated. To determine whether Mueller-Hinton medium has sufficiently low levels of thymidine and thymine, an Enterococcus faecalis (ATCC 29212 or ATCC 33186) may be tested with sulfamethoxazole/trimethoprim disks. Pharmaceutical Associates, Inc. reduction in the count of any formed blood element is noted, this drug product and/or for extended periods of time may cause bone marrow depression manifested Pneumocystis carinii pneumonia has been reported to be greatly increased compared with the incidence normally associated with the use of sulfamethoxazole and trimethoprim in non-AIDS patients. Liver disease, severeShould not be used in patients with these conditions. indicates that the infection is unlikely to respond to therapy with this J Infect Dis. , Klebsiella species, this reaction is frequently dose-related coli, Klebsiella,! Not been conducted with sulfamethoxazole and 320 mg of sulfamethoxazole and 40 mg per. Data provider with or without purpura ) are the most frequently reported severe adverse mg/kg sulfamethoxazole or 192 mg/kg produced. ( pediatric ), containing 200 mg sulfamethoxazole and trimethoprim in the same manner as non-AIDS patients controlled temperature. Of folic acid deficiency may occur 2 months or more after you stop taking medicine. Not cause cleft palates in rats was 512 mg/kg sulfamethoxazole or 192 mg/kg trimethoprim produced teratological effects 11 provider... At controlled room temperature 15-30C ( 59-86F ) on this page applies your. 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