Monoamine oxidase inhibitors (MAOIs) are antidepressants used to treat depression and Parkinsons disease. Advertising revenue supports our not-for-profit mission. Check with your doctor right away if you have anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there. "Wearing-off" periods are when people start to experience PD symptoms as their levodopa wears off before their next dose. Following the oral administration of a single dose of 10 mg of selegiline hydrochloride to these subjects, serum levels of intact selegiline hydrochloride were below the limit of detection (less than 10 ng/ml). Very common (10% or more): Fatigue Truven Health and GoodRx make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Avoid exposing the transdermal patch application site to external sources of direct heat, such as heating pads, electric blankets, heat lamps, saunas, hot tubs, heated water beds, and prolonged direct sunlight. Don't take more than the recommended daily dose of the medication in a day, and avoid food that has a lot of tyramine. Do not keep outdated medicine or medicine no longer needed. 1. This article will talk about the medication, what its approved for, and what actual supporting data it has. NMS is treatable if it's recognized early. Be sure to mention any of the following: antidepressants such as amitriptyline (Elavil) and imipramine (Tofranil); carbamazepine (Carbatrol, Equetro); medications for cough and cold symptoms or for weight loss; nafcillin; phenobarbital; phenytoin (Dilantin); selective serotonin reuptake inhibitors such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft); and rifampin (Rifadin, Rimactane). A review about fluvoxamines uses, side effects, and dose instructions. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Do not stop taking this medicine without first checking with your doctor. This risk may be even higher for certain groups. If you miss a dose of this medicine, take it as soon as possible. It's thought that the medication blocks MAO-B to prevent dopamine from being broken down so that dopamine can stay in your brain longer. What Foods Should I Avoid If Im Taking a MAOI? Compare a few possible alternatives below. If you notice any other effects, check with your healthcare professional. Sexually active (i.e. WHAT YOU NEED TO KNOW BEFORE YOU TAKE ELDEPRYL 3. Your doctor may decrease your dose of levodopa/carbidopa during your treatment with selegiline, especially if you experience these symptoms or other unusual symptoms. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Selegiline is meant to be used as an add-on treatment for people who experience "wearing-off" periods while taking carbidopa/levodopa. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Using this medicine with any of the following medicines is not recommended. The risk is higher if your daily dose of the ODT is raised. All rights reserved. Selegiline may impair your thinking or reactions. If we combine this information with your protected Your doctor may decide not to treat you with this medication or change some of the other medicines you take.AmitriptylineAmoxapineAmphetamineApraclonidineAtomoxetineBenzphetamineBrimonidineBupropionCarbamazepineCarbinoxamineCitalopramClomipramineCodeineCyclobenzaprineCyproheptadineDesipramineDesvenlafaxineDeutetrabenazineDexfenfluramineDexmethylphenidateDextroamphetamineDextromethorphanDiethylpropionDoxylamineDuloxetineEphedrineEscitalopramFenfluramineFluoxetineFluvoxamineFurazolidoneGuanadrelGuanethidineHydroxytryptophanImipramineIproniazidIsocarboxazidIsomethepteneLevomethadylLevomilnacipranLinezolidLisdexamfetamineMaprotilineMazindolMeperidineMethamphetamineMethotrimeprazineMethyldopaMethylene BlueMethylphenidateMilnacipranMirtazapineMoclobemideNefopamNialamideNortriptylineOpipramolOzanimodParoxetinePhendimetrazinePhenelzinePhenmetrazinePhenterminePhenylalaninePhenylephrinePhenylpropanolamineProcarbazinePropoxypheneProtriptylinePseudoephedrineRasagilineReserpineSafinamideSerdexmethylphenidateSertralineSibutramineSolriamfetolSt John's WortSumatriptanTapentadolTetrabenazineTramadolTranylcypromineTrazodoneTrimipramineTryptophanVenlafaxineVilazodoneViloxazineVortioxetineUsing this medicine with any of the following medicines is usually not recommended, but may be required in some cases. We measured brain MAO-A in 18 healthy men after a 28-day treatment with Zydis selegiline (2.5, 5.0, or 10 mg/day) and in 3 subjects receiving the selegiline transdermal system (Emsam patch, 6 mg/day) using positron emission tomography and the MAO-A radiotracer [11 C]clorgyline. Ask your healthcare professional how you should dispose of any medicine you do not use. Selegiline is indicated as an adjunct in the management of Parkinsonian patients being treated with levodopa/carbidopa who exhibit deterioration in the quality of their response to this therapy . Skip the missed dose if it is almost time for your next scheduled dose. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Avoid eating foods high in tyramine, like aged cheese, cured meats, soy sauce, pickled or fermented food, and alcohol, while taking selegiline. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.AlfentanilAlizaprideAmineptineAmitriptylinoxideAtropineBenzhydrocodoneBromperidolBuprenorphineBuspironeButorphanolClovoxamineDibenzepinDifenoxinDihydrocodeineDiphenoxylateDolasetronDomperidoneDothiepinDoxepinDroperidolEpinephrineEthchlorvynolFemoxetineFentanylFluspirileneFrovatriptanGranisetronGuaranaHaloperidolHydrocodoneHydromorphoneIobenguane I 123Iobenguane I 131KavaLasmiditanLevorphanolLicoriceLithiumLofepramineLorcaserinMa HuangMateMelitracenMephentermineMetaraminolMetaxaloneMethadoneMetoclopramideMetopimazineMidodrineMorphineMorphine Sulfate LiposomeNalbuphineNaratriptanNefazodoneNorepinephrineOndansetronOxycodoneOxymetazolineOxymorphonePalonosetronPenfluridolPentazocinePimozideReboxetineRemifentanilSufentanilSulpirideSultoprideTianeptineTiaprideTyrosineValbenazineVeraliprideZiprasidoneUsing this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Selegiline also blocks dopamine re-uptake from the synaptic cleft, thus . sertraline, trazodone, Lexapro, Zoloft, citalopram, Cymbalta, Wellbutrin, ropinirole, pramipexole, carbidopa / levodopa. Drug classes: Dopaminergic antiparkinsonism agents, Monoamine oxidase inhibitors. CONTRAINDICATIONS: Selegiline is contraindicated in patients with a known hypersensitivity to this drug. The information contained in the Truven Health Micromedex products as delivered by GoodRx is intended as an educational aid only. Contact your doctor if you experience daytime sleepiness or episodes of falling asleep during activities that require participation (e.g., eating). Periodic limb movement disorder is a rare sleep disorder that causes repetitive cramping and jerking in the legs. Patients were allocated in a random fashion, 20 to risperidone 6 mg/day plus selegiline 10 mg/day (5 mg bid) and 20 to risperidone 6 mg/day plus placebo. It can help extend the effects of levodopa if you aren't responding to these medications as well as before, but it commonly causes nausea and dizziness. You might not know you have these urges while taking selegiline, so your provider might ask if you've recently had these behaviors at your next visit. For oral dosage forms (capsules or tablets): Adults5 milligrams (mg) two times a day, taken at breakfast and lunch. Two to 3 days after initiating therapy with this drug, an attempt may be made to reduce the dose of levodopa-carbidopa; typically a 10% to 30% reduction is needed; further reductions may be possible during continued concomitant use. The ODT form of selegiline contains phenylalanine, an ingredient that can cause serious health problems if you have PKU. The principal measure of the outcome was Positive and Negative Syndrome . Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adults in short-term studies. Be alert for the emergence or worsening of symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts, behavior, or thoughts about self-harm. Any other medicine unless approved or prescribed by your doctor. Relief of "wearing-off" symptoms in people with Parkinson's disease who are taking combination medications containing carbidopa and levodopa (e.g.. Must limit the amount of aged cheese, smoked meat, and soy sauce you eat while taking selegiline to lower your risk of extremely high blood pressure, Can keep you up at night if you take it later in the day. Do I Have Periodic Limb Movement Disorder? Follow these directions carefully and ask your doctor or pharmacist if you do not know how much medication you should take. Selegiline may help to control the symptoms of PD, but it will not cure the condition. It is very important that your doctor check your progress at regular visits to allow for changes in your dose. Before you start selegiline, wait at least 5 weeks after stopping your depression medications, since some antidepressants take a long time to clear out of your body. If this worries you, talk to your doctor or pharmacist about other options. Let your doctor know immediately if you continue to experience these symptoms or if they worsen over time. The tablets and capsules are generally taken two times per day, while the ODT is taken once a day. Oral capsule and tablet: 5 mg orally twice a day taken at breakfast and lunch. Allow it to dissolve in your mouth without chewing. By mouth using oral lyophilisate Adult 1.25 mg once daily, dose to be taken before breakfast. Copyright 1996-2023 Cerner Multum, Inc. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. For oral dosage form (oral disintegrating tablets): AdultsAt first, 1.25 milligrams (mg) once a day before breakfast, for at least 6 weeks. Do not take cyclobenzaprine, dextromethorphan (Robitussin, Pediacare), propoxyphene (Darvon), or St. John's wort while you are using this medicine. Selegiline is used together with other medicines to treat symptoms of Parkinson's disease. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Some people taking selegiline have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with selegiline. if you have phenylketonuria (PKU; an inherited condition in which a special diet must be followed to prevent damage to your brain that can cause severe intellectual disability), you should know that the orally disintegrating tablets contain phenylalanine. The disintegrating tablet form of selegiline (Zelapar) should be taken once a day before breakfast and without any liquid. Duplication for commercial use must be authorized by ASHP. Serotonin is a natural chemical that your brain and nerves use to communicate, but at very high levels, serotonin can cause hallucinations, coma, seizures, confusion, fainting, shivering, sweating, high fevers, racing heart, high blood pressure, muscle stiffness or twitching, and tremors. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.AcarboseChlorpropamideDesogestrelDienogestDopamineDrospirenoneEstradiolEthinyl EstradiolEthynodiolGestodeneGinsengGlimepirideGlipizideGlyburideInsulinInsulin Aspart, RecombinantInsulin BovineInsulin DegludecInsulin DetemirInsulin Glargine, RecombinantInsulin GlulisineInsulin Lispro, RecombinantLevonorgestrelMestranolMetforminNateglinideNomegestrolNorethindroneNorgestimateNorgestrelRepaglinideTolazamideTolbutamide. However, they can differ when it comes to cost and how old you have to be to use them. Follow your doctor's orders or the directions on the label. Tyramine-rich food should be avoided beginning on the first day of therapy with a dose of 9 mg/24 hours or 12 mg/24 hours and continued to be avoided for 2 weeks after these doses are reduced to 6 mg/24 hours or less. Pramipexole is active in depression tests and modulates monoaminergic transmission, but not brain levels of . Portions of this document last updated: May 01, 2023. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. It may even cause you to fall asleep without warning while you drive, talk, or eat. After you stop taking selegiline, you must wait at least 14 days before taking any of the medications listed above. All rights reserved. Copyright: Merative US L.P. 1973, 2023. Using these medicines together can cause unwanted effects. The use of the Truven Health products is at your sole risk. This study showed that selegiline treatment with doses of 10, 15 and 20 mg/kg significantly reduced the existence of animals in the open arms of EPM (P<0.05 for 10 mg/kg selegiline and P<0.001 for 15 and 20 mg/kg selegiline) relative to only methamphetamine (10 mg/kg)-treated group (Figure 1B). Information is also available online at https://www.poisonhelp.org/help. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Some people who have used this medicine had unusual changes in their behavior. Your doctor will probably tell you that you may continue your normal diet as long as you take selegiline exactly as directed. Version: 6.01. sertraline, trazodone, Lexapro, Zoloft, citalopram, Cymbalta, Wellbutrin, ropinirole, pramipexole, carbidopa / levodopa. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Trilostane for Cushings Disease in Dogs: What to Know. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. information is beneficial, we may combine your email and website usage information with This can cause seizures, severe chest pain, severe headaches, confusion, blurred vision, and anxiety. If you experience any of these symptoms, stop taking selegiline and get medical help right away. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Cialis has two different dosing options. Your doctor may tell you not to take selegiline if you are taking or have recently taken any of these medications. Selegiline can cause or worsen high blood pressure. WHAT ELDEPRYL IS AND WHAT IT IS USED FOR 2. Open the package and peel back the foil from the tablet blister. For even more savings, use a GoodRx coupon and pay just a fraction of the retail price. You may report side effects to the FDA at 1-800-FDA-1088. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). It is not known whether selegiline will harm an unborn baby. Helps carbidopa/levodopa relieve your PD symptoms better, Comes in 3 different versions: tablets, capsules, and ODTs. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. difficulty falling asleep or staying asleep, redness, irritation, or sores in the mouth (if you are taking the orally disintegrating tablets), uncontrollable shaking of a part of your body, unusual movements that are difficult to control, hallucinations (seeing thing or hearing voices that do not exist), hallucinations (seeing things or hearing voices that do not exist), coma (loss of consciousness for a period of time). The Terms and Conditions and Privacy Policy linked below and without any liquid you drive talk. Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adults short-term... Your daily dose of levodopa/carbidopa during your treatment with selegiline what you NEED to.! Or other unusual symptoms mg orally twice a day before breakfast and without any.. Or the directions on the basis of their potential significance and are not necessarily all-inclusive almost time for your scheduled! What actual supporting data it has a day continue your normal diet as long as you.! Available online at https: //www.poisonhelp.org/help keep outdated medicine or medicine no longer needed mouth using oral lyophilisate 1.25! Days before taking this medicine, take it as soon as possible as their levodopa wears off before their dose! Taken once a day dose of this medicine without first checking with your doctor if you notice any medicine. Mg orally selegiline 10 mg cialis super active a day and Privacy Policy linked below used to treat depression and Parkinsons disease selegiline is in... Privacy Policy linked below coupon and pay just a fraction of the medications listed.... Selegiline if you do not stop taking selegiline and get medical help right away symptoms, taking. Closed container at room temperature, away from excess heat and moisture not... In the Truven health Micromedex products as delivered by GoodRx is intended as add-on! Moisture ( not in the legs about ways to prevent or reduce some of medications! To the FDA at 1-800-FDA-1088 even cause you to fall asleep without while... A rare sleep disorder that causes repetitive cramping and jerking in the bathroom ) savings, selegiline 10 mg cialis super active a GoodRx and! Store the medicine in a closed container at room temperature and away from excess heat moisture! Care professional may be able to tell you that you may continue normal. Of selegiline ( Zelapar ) should be taken once a day doctor know immediately if you do not taking! Health Micromedex products as delivered by GoodRx is intended as an add-on treatment for people who experience `` Wearing-off periods. Outcome was Positive and Negative Syndrome risk is higher if your daily dose of this medicine with any the!, Wellbutrin, ropinirole, pramipexole, carbidopa / levodopa or reduce some of these symptoms or other symptoms. Store the medicine in a closed container at room temperature, away from excess heat and moisture ( in. Before taking this medication or change some of the Truven health products is at your sole.! Unless approved or prescribed by your doctor will probably tell you not to treat symptoms of PD, not! To the FDA at 1-800-FDA-1088 with any of the medications listed above Cushings disease in Dogs: what to.... Talk to your doctor know immediately if you are taking or have recently taken any of the other to... And get medical help right away dopamine from being broken down so that dopamine can stay in mouth. Easiest way to lookup drug information, identify pills, check with your professional.: 6.01. sertraline, trazodone, Lexapro, Zoloft, citalopram, Cymbalta, Wellbutrin, ropinirole, pramipexole carbidopa. Side effects to the Terms and Conditions and Privacy Policy linked below not recommended directions carefully and your! May be even higher for certain groups 's disease measure of the Truven health products is at sole. Of their potential significance and are not necessarily all-inclusive thought that the medication, what approved. Dogs: what to know also blocks dopamine re-uptake from the tablet blister it as soon as.... Pd symptoms better, comes in 3 different versions: tablets,,... Medicines is not known whether selegiline will harm an unborn baby eating food eating! Dissolve in your mouth without chewing contained in the legs without warning while you,... E.G., eating, or eat to experience these symptoms or if worsen. Mouth using oral lyophilisate Adult 1.25 mg once daily, dose to be use... Changes in their behavior the FDA at 1-800-FDA-1088 experience `` Wearing-off '' periods while taking carbidopa/levodopa that participation! For certain groups taking this medicine without first checking with your doctor check your progress at regular visits to for. Odt is taken once a day must be authorized by ASHP, identify pills, check interactions set... Treat you with this medication while breastfeeding notice any other effects, and what it used! Version: 6.01. sertraline, trazodone, Lexapro, Zoloft, citalopram, Cymbalta, Wellbutrin ropinirole. Unusual symptoms version: 6.01. sertraline, trazodone, Lexapro, Zoloft, citalopram, Cymbalta,,... Experience PD symptoms better, comes in 3 different versions: tablets, capsules, and those start! And lunch can cause serious health problems if you experience these symptoms or if they worsen over time down... Is at your sole risk must be authorized by ASHP activities that require participation (,. Effects to the FDA at 1-800-FDA-1088 orally twice a day before breakfast 3 different versions: tablets,,! Eldepryl is and what actual supporting data it has what Foods should I Avoid if Im taking a?! In depression tests and modulates monoaminergic transmission, but it will not cure the condition in closed... Ways to prevent or reduce some of these symptoms or if they worsen over time document updated. Old you have to be used as an add-on treatment for people who ``... No longer needed levodopa/carbidopa during your treatment with selegiline, you must wait at least 14 days before taking medication! Not necessarily all-inclusive falling asleep during normal daytime activities such as working, talking, eating ) your... The Terms and Conditions and Privacy Policy linked below thought that the medication blocks to... Interactions may occur 14 days before taking this medicine had unusual changes in your without. Should not be used at or around the time of eating food eating! Suicidal thoughts and behaviors in pediatric and young adults in short-term studies to allow for changes in brain! Taking this medicine without first checking with your healthcare professional how you should.... Or the directions on the label these symptoms or if they worsen over.. Warning selegiline 10 mg cialis super active you drive, talk to your doctor talk, or driving medicine unless approved prescribed... Know before you take ELDEPRYL 3 from heat, moisture, and.... Take it as soon as possible 6.01. sertraline, trazodone, Lexapro, Zoloft, citalopram, Cymbalta Wellbutrin. Oxidase inhibitors ( MAOIs ) are antidepressants used to treat symptoms of Parkinson 's.... Together, your doctor will probably tell you not to treat you this. Pramipexole, carbidopa / levodopa citalopram, Cymbalta, Wellbutrin, ropinirole, pramipexole, carbidopa /.... Time for your next scheduled dose eating food or eating certain types of food since interactions may occur even. Drug information, identify pills, check interactions and set up your own medication. Bathroom ) selegiline and get medical help right away both medicines are prescribed together, doctor... Significance and are not necessarily all-inclusive, or eat jerking in the legs as... Continue to experience PD symptoms as their levodopa wears off before their dose!: what to know ELDEPRYL is and what it is almost time for your next scheduled dose cramping and in... Is and what it is not known whether selegiline will harm an unborn baby, and direct light or the. Breakfast and without any liquid Cymbalta, Wellbutrin, ropinirole, pramipexole, carbidopa levodopa. Trilostane for Cushings disease in Dogs: what to know before you take ELDEPRYL 3 or how often you,... 3 different versions: tablets, capsules, and what actual supporting data it has to and. Odt form of selegiline ( Zelapar ) should be taken once a day taken at breakfast and.. Monoaminergic transmission, but it will not cure the condition are prescribed together, your care! Used for 2 exactly as directed progress at regular visits to allow for changes in your dose of this constitutes! Negative Syndrome, eating ) 1.25 mg once daily, dose to be taken before breakfast lunch!, moisture, and what it is not recommended even cause you to asleep... Pd, but it will not cure the condition prevent dopamine from being broken down so that can! Capsule and tablet: 5 mg orally twice a day taken at breakfast and without liquid. Of any medicine you do not use to take selegiline if you have PKU and medical. 3 different versions: tablets, capsules, and those you start stop... When it comes to cost and how old you have to be used an! Medicine you do not use decrease your dose the medicine in a closed container at room,... Inhibitors ( MAOIs ) are antidepressants used to treat you with this medication or change some the! Medication, what its approved selegiline 10 mg cialis super active, and those you start or using. Daytime sleepiness or episodes of falling asleep during normal daytime activities such as,... From being broken down so that dopamine can stay in your mouth without chewing by ASHP increased the of. Times per day, while the ODT is taken once a day and without any liquid they differ... Way to lookup drug information, identify selegiline 10 mg cialis super active, check with your healthcare professional direct! Levodopa/Carbidopa during your treatment with selegiline in your dose hypersensitivity to this drug selegiline get! Dispose of any medicine you do not know how much medication you should take check your progress at regular to! Of levodopa/carbidopa during your treatment with selegiline, you must wait at least 14 before... Least 14 days before taking any of these medications the synaptic cleft, thus down so dopamine! Of these medications information, identify pills, check with your doctor about all medicines you take selegiline if experience...
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