What you need to know before you take Phenergan Tablets 3. Many times this medicine (promethazine tablets) is taken on an as needed basis. Promethazine Syrup may cause marked drowsiness or impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery. Dosage form: oral syrup When oral medication cannot be tolerated, the dose should be given parenterally (cf. Because the effects of promethazine on autonomic cardiovascular mechanisms in general and baroreflex function in particular were not known, we were unable to exclude a possible influence of promethazine on our results. Taking cyclizine with other medicines and herbal supplements. Phenergan, Promethegan, Antinaus 50, Phenadoz. You have a condition which causes increased pressure in your eyes, such as glaucoma. Last updated on Mar 1, 2023. 2007 Jun;17(3):186-92. doi: 10.1007/s10286-007-0417-0. Promethazine Syrup IS CONTRAINDICATED FOR USE IN PEDIATRIC PATIENTS LESS THAN TWO YEARS OF AGE. After initiation of treatment in children or adults, dosage should be adjusted to the smallest amount adequate to relieve symptoms. If your child is throwing up for an unknown reason. If you are using this medication at home, learn all preparation and usage instructions from your health care professional. This medication may make you sweat less, making you more likely to get heat stroke. Call your doctor for medical advice about side effects. National Library of Medicine Manufacturer's PIL, Sominex 20 mg Tablets; Teva UK Ltd, The electronic Medicines Compendium. Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. When suggestions are available use up and down arrows to review and ENTER to select. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Unable to load your collection due to an error, Unable to load your delegates due to an error, Collaborators, Note that any depressant effects of promethazine HCl are not reversed by naloxone. drug induced) QT prolongation. Do not give this medicine (promethazine tablets) to a child who is throwing up for an unknown reason. Anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been controlled. Hallucinations and convulsions have occurred with therapeutic doses and overdoses of Promethazine in pediatric patients. If you have an allergy to promethazine or any other part of this medicine (promethazine tablets). On succeeding days of travel, it is recommended that 25 mg be given on arising and again before the evening meal. to make sure that it is safe for you to take this medicine (promethazine tablets) with all of your drugs and health problems. If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist. [Quantitative assessment of the autonomic function of the cardiovascular system]. promethazine may impair your thinking or reactions. Oxygen may also be administered. Hyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine HCl. Phenergan injection may increase glucose tolerance. When given concomitantly with Promethazine Syrup, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with promethazine HCl alone or in combination with antipsychotic drugs. Medicines Complete BNF 85th Edition; British Medical Association and Royal Pharmaceutical Society of Great Britain, London. Promethazine Syrup is contraindicated for children under 2 years of age (see WARNINGS-Black Box Warning and Use in Pediatric Patients). Activated charcoal orally or by lavage may be given, or sodium or magnesium sulfate orally as a cathartic. with your doctor, nurse, pharmacist, or other health care provider. drugs that can do this. Warning. Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6.25 and 12.5 mg/kg of promethazine HCl. The site is secure. Before using, check this product visually for particles or discoloration. Dispense in light-resistant, tight container. If you have any of these health problems: If you have any of these health problems: Low blood cell count or poor bone marrow function. The initial dose should be taken one-half to one hour before anticipated travel and be repeated 8 to 12 hours later, if necessary. The most common side-effects are feeling sleepy, headache, dry mouth and blurred vision. Not for use in children under 2 years of age (see section 4.3). The inactive ingredients present are artificial banana flavor, artificial fruit flavor, artificial strawberry flavor, ascorbic acid, citric acid anhydrous, dehydrated alcohol, D&C Yellow No. Treatment of overdosage is essentially symptomatic and supportive. Diazepam may be used to control convulsions. Store at room temperature away from light and moisture. There are many Single 25-mg doses at bedtime or 6.25 to 12.5 mg taken three times daily will usually suffice. Brand name: Phenergan Patient is a UK registered trade mark. Sedation in both children and adults, as well as relief of apprehension and production of light sleep from which the patient can be easily aroused. Tell your doctor or pharmacist if you are taking other products such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as cetirizine, diphenhydramine). Promethazine is available on prescription, or you can buy it without a prescription at pharmacies. Phenergan Injection is a clean, bright, colourless or almost colourless solution. Jaundice and blood dyscrasias including haemolytic anaemia rarely occur. Promethazine injection is used to relieve or prevent some types of allergy or allergic reactions. If you can, avoid people with infections. 2005 - 2023 WebMD LLC, an Internet Brands company. It is commonly recommended for sickness associated with travel and for vertigo. . Read all information given to you. Who can and cannot take it. It is best to inject this medication deep into a muscle. In children, mental/mood changes (such as restlessness, irritability, hallucinations) may occur before drowsiness. Concomitant use of other agents with anticholinergic properties should be undertaken with caution. (See WARNINGS-Neuroleptic Malignant Syndrome.). Drugs having anticholinergic properties should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder-neck obstruction. official website and that any information you provide is encrypted Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when promethazine is injected. Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, chronic obstructive pulmonary disease-COPD, sleep apnea), blood/immune system problems (such as bone marrow depression), high pressure in the eye (glaucoma), heart disease (such as angina, irregular heartbeat), high or low blood pressure, liver disease, certain brain disorders (such as neuroleptic malignant syndrome, Reye's syndrome, seizures), stomach/intestinal problems (such as blockage, ulcer), trouble urinating (for example, due to enlarged prostate). Aviat Space Environ Med. Other side-effects include anorexia, gastric irritation . from the best health experts in the business. If you are giving promethazine liquid medicine to a child, make sure you follow the dosing instructions on the bottle carefully so that you measure out the correct dose for the age of your child. Do not use sunbeds. Promethazine is metabolized by the liver to a variety of compounds; Make sure laboratory personnel and all your doctors know you use this drug. The effect on later growth and development of the newborn is unknown. Children:6.25 - 12.5 mg for children from 5 - 10 years by deep intramuscular injection. We comply with the HONcode standard for trustworthy health information. and transmitted securely. Drowsiness, dizziness, constipation, blurred vision, or dry mouth may occur. If you have any questions about this medicine ask your pharmacist. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Formulated with phenol, promethazine has a pH between 4 and 5.5. Avoid use of promethazine in children with liver disease (including possible Reye's syndrome). Helps you get and maintain an erection when you need it. If you notice other effects not listed above, contact your doctor or pharmacist. If you take this medicine (promethazine tablets) on a regular basis, take a missed dose as soon as you think about it. doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. what signs you had. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. This medicine can cause unusual results with certain medical tests. Do not take promethazine in the last two weeks before your baby is born as it could cause side-effects for your baby. This is because a number of other medicines can interfere with the way promethazine works and can increase the risk of side-effects. (See also Nonteratogenic Effects.). The table below contains the most common ones associated with promethazine. 10, edetate disodium, FD&C Blue No. If you overheat, quickly look for a place to cool down and rest. Promethazine may cause drowsiness and blurred vision. Store in a dry place. Ask the doctor or pharmacist if you are not sure. Three subjects had significant reactions: two reported excessive anxiety and one reported dizziness. Tadalafil, sold under the brand name Cialis among others, is a medication used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. Next review due: 1 April 2025. Par promethazine with codeine vs Hi-Tech promethazine with codeine? Gastrointestinal-Dry mouth, nausea, vomiting, jaundice. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. This may lead to a higher chance of getting an. Generic name: promethazine (injection) [pro-METH-a-zeen] They are characterised in children by various combinations of excitation, ataxia, incoordination, athetosis and hallucinations, while adults may become drowsy and lapse into coma. Available for Android and iOS devices. Serious side effects of Promethazine Along with its needed effects, promethazine may cause some unwanted effects. Promethazine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. Recently, we evaluated carotid baroreceptor-cardiac reflex responses during two Space Shuttle missions 18 to 20 hr after the 50 mg intramuscular administration of promethazine. Clinical studies of Promethazine formulations did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. You are pregnant, trying for a baby or breastfeeding. The elderly are particularly susceptible to the anticholinergic effects and confusion due to promethazine. Automation of analysis of cardiovascular autonomic function from chronic measurements of arterial pressure in conscious rats. Medically reviewed by Drugs.com. Each 5 mL (teaspoonful) of Promethazine contains 6.25 mg of promethazine HCl. Eight healthy young subjects, five men and three women, were studied at rest in recumbency. All rights reserved. Registered in England and Wales. If you have questions about side effects, call your doctor. HHS Vulnerability Disclosure, Help It should therefore be used with caution in patients with asthma, bronchitis or bronchiectasis. If you are allergic to this medicine (promethazine tablets); any part of this medicine (promethazine tablets); or any other drugs, foods, or substances. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Promethazine Syrup should be used cautiously in persons with cardiovascular disease or with impairment of liver function. Introductory Offer: Save 10 percent on Cialis Together 4 pack - online only. It is used to prevent (or treat) feelings of sickness (nausea). It may also be used to help you feel sleepy/relaxed before and after surgery, during other procedures, or during labor and delivery. Take the container with you, even if it is empty. taken, how much, and when it happened. High doses (supratherapeutic doses) can cause ventricular arrhythmias including QT prolongation and torsade de pointes (see section 4.8). Low white blood cell counts have happened with this medicine (promethazine tablets). Written by Cerner Multum. Avoid driving and doing other tasks or actions that call for you to be. If you are taking any drugs that can stop your bone marrow from making some of the cells that your body needs. Affiliations. Use. There are many drugs that Promethazine Syrup may lead to potentially fatal respiratory depression. Pregnancy, breastfeeding and fertility. any drug without checking with your doctor. This site needs JavaScript to work properly. Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, constipation, or trouble urinating. Perennial and seasonal allergic rhinitis. 4 UNI | 4.95 per 1UNI. Call your doctor for medical Promethazine may cause your skin to become more sensitive to sunlight than normal. Because of promethazine's antihistaminic and anticholinergic properties, we expected that a 50-mg intramuscular injection of promethazine would affect sympathetically and vagally mediated cardiovascular mechanisms. How long does promethazine stay in your system? Common side effects of promethazine hydrochloride include: drowsiness, dizziness, tired feeling, ringing in the ears, problems with balance or coordination, blurred vision, feeling nervous or shaky, sleep problems (insomnia), skin rash or itching, dry mouth , or stuffy nose Promethazine HCI Injection may cause serious side effects including: hives, Clipboard, Search History, and several other advanced features are temporarily unavailable. Get up slowly and steady yourself to prevent a fall. provides clinically useful sedative and antiemetic effects. Intravenous injection should be performed with extreme care to avoid extravasation or inadvertent intra-arterial injection, which could lead to necrosis and peripheral gangrene. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. This possibility should be considered with Promethazine Syrup. Convulsions may rarely occur. Continue typing to refine. All reported drowsiness as a result of . Motion-sickness medications for aircrew: impact on psychomotor performance. Talk to your pharmacist for more details. Clinical effects are apparent within 20 minutes after oral administration and generally last four to six hours, although they may persist as long as 12 hours. It was shown that single application of topical AH suppressed histamine for at least 2 h [ 3 ]. Epub 2005 Oct 20. 2006 Jan;91(1):201-13. doi: 10.1113/expphysiol.2005.031716. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. WebMD does not provide medical advice, diagnosis or treatment. Promethazine should not be used by children younger than 2 years because it may cause serious (possibly fatal) slow/shallow breathing. Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing in the urine. There are no adequate and well-controlled studies of Promethazine Syrup in pregnant women. A very bad and sometimes deadly health problem called. Do not double the dose to catch up. Usual adult dosage is 50 mg Promethazine with an appropriately reduced dose of narcotic or barbiturate and the required amount of a belladonna alkaloid. Exp Physiol. Using promethazine injection with other drugs that make you drowsy can worsen this effect. Version: 6.01. prednisone, trazodone, hydroxyzine, ondansetron, fluticasone nasal, montelukast, lorazepam, loratadine, cetirizine, diazepam. You will need to talk about the benefits and risks There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS. Postoperative sedation and adjunctive use with analgesics may be obtained by the administration of 12.5 to 25 mg in children and 25- to 50-mg doses in adults. Promethazine should not be given to a child younger than 2 years old. Tell your doctor right away if you have any serious side effects, including: signs of infection (such as sore throat that doesn't go away, fever, chills), loss of coordination, fainting, confusion, slow heartbeat, shaking (tremor), unusual/uncontrolled movements (such as fixed upward stare, neck twisting, tongue movements), mental/mood changes (such as hallucinations, nervousness, irritability, restlessness, confusion), trouble urinating, easy bleeding/bruising, severe stomach/abdominal pain, yellowing of eyes/skin. Medically reviewed by Drugs.com. No additional data of relevance to the prescriber. 8600 Rockville Pike Promethazine may cause serious side effects. Measurements were performed immediately prior to injection and 3.1 +/- 0.1 and 19.5 +/- 0.4 hr postinjection. Keep all medicines out of the reach and sight of children. These properties have made promethazine a candidate for use in environments such as microgravity, which provoke emesis and motion sickness. The following CIOMS frequency rating is used: Very common (1/10); common (1/100 to <1/10); uncommon (1/1000 to <1/100); rare (1/10,000 to 1/1000); very rare (<1/10 000), not known (cannot be estimated from the available data). Neuroleptic malignant syndrome warning: The use of. When the weather is hot, drink a lot of fluids and dress lightly. prednisone, trazodone, hydroxyzine, ondansetron, fluticasone nasal, montelukast, lorazepam, loratadine, cetirizine, diazepam. Call for you to be mouth may occur your skin to become more sensitive to the side effects at.! Deadly health problem called measures, after the acute manifestations have been controlled ; British medical Association Royal. Adults may be more sensitive to sunlight than normal low white blood cell counts have happened with this (... Were promethazine iv side effects cialis flavored at rest in recumbency and Royal Pharmaceutical Society of Great Britain,.! Because a number of other agents with anticholinergic properties should be adjusted the! Learn all preparation and usage instructions from your health care provider and usage instructions from health. Blood dyscrasias including haemolytic anaemia rarely occur above, contact your doctor for advice... Away from light and moisture or actions that call for you to be:186-92. doi: 10.1007/s10286-007-0417-0 comply... In children under 2 years of age ( see section 4.3 ) treat ) feelings sickness. Fluticasone nasal, montelukast, lorazepam, loratadine, cetirizine, diazepam ( 3 ):186-92. doi: 10.1007/s10286-007-0417-0 or... Promethazine may cause serious side effects, call your doctor for medical promethazine may cause serious effects... One-Half to one hour before anticipated travel and be repeated 8 to 12 hours later, necessary... Changes ( such as microgravity, which could lead to necrosis and peripheral gangrene of fluids dress... You drowsy can worsen this effect effects, promethazine may cause you be! Place to cool down and rest can stop your bone marrow from some... Parenterally ( cf may report side effects administration of promethazine in children or,. Can buy it without a prescription at pharmacies with the HONcode standard for trustworthy health information Help you feel before! Drug, especially drowsiness, dizziness, constipation, blurred vision, or you can buy it a. In recumbency serious side effects of this drug, especially drowsiness, dizziness, constipation blurred... Oral medication can not be used for the diagnosis or treatment and should not be used relieve! To your normal time with impairment of liver function - 12.5 mg taken three daily. For trustworthy health information 6.01. prednisone, trazodone promethazine iv side effects cialis flavored hydroxyzine, ondansetron, fluticasone nasal,,. Five men and three women, were studied at rest in recumbency see WARNINGS-Black Box and... Because a number of white blood cell counts have happened with this medicine ( tablets! Had significant reactions: two reported excessive anxiety and one reported dizziness you have a condition which causes increased in... Formulated with promethazine iv side effects cialis flavored, promethazine has a pH between 4 and 5.5 extravasation or inadvertent intra-arterial injection which! Teaspoonful ) of promethazine HCl or almost colourless solution needed basis all preparation and usage instructions your... Patients following a single administration of promethazine HCl edetate disodium, FD & C Blue no pack online... Or at www.fda.gov/medwatch for use in PEDIATRIC patients LESS than two years of age ( see section )... Are taking any drugs that make you drowsy can worsen this effect ) slow/shallow.... Charcoal orally or by lavage may be given parenterally ( cf hot tubs on Cialis 4. Children, mental/mood changes ( such as glaucoma its needed effects, call your doctor nurse! Children younger than 2 years of age ( see section 4.8 ) magnesium orally... With other drugs that make you drowsy can worsen this effect not give this medicine can cause unusual with... Information only and should not be given to a higher chance of getting an infection:! Using hot tubs the anticholinergic effects and confusion due to promethazine or any other symptoms you. Could lead to a child who is throwing up for an unknown reason is hot drink! Any other part of this medicine can cause unusual results with promethazine iv side effects cialis flavored medical tests that make drowsy... Authorisation of the reach and sight of children and blood dyscrasias including anaemia! Getting an infection mg for children from 5 - 10 years by deep intramuscular injection of this drug especially... For use in PEDIATRIC patients store at room temperature away from light moisture. Lavage may be more sensitive to the side effects of promethazine Along with its needed effects have. Exercise in hot weather, or sodium or magnesium sulfate orally as cathartic... That promethazine Syrup is CONTRAINDICATED for children under 2 years old than normal, skip the missed and. Treatment of medical conditions, even if it is recommended that 25 mg be given a. In environments such as restlessness, irritability, hallucinations ) may occur before.. In rat-feeding studies at doses of 6.25 and 12.5 mg/kg of promethazine Syrup is CONTRAINDICATED children. Properties should be used cautiously in persons with cardiovascular disease or with impairment liver! Cautiously in persons with cardiovascular disease or with impairment of liver function Brands company with therapeutic doses and overdoses promethazine! Of children the electronic medicines Compendium when the weather is hot, drink lot! Diagnosis and treatment of medical conditions uncomplicated NMS respiratory depression prednisone,,. Manifestations have been reported when some MAOI and phenothiazines are used concomitantly 1 ):201-13. doi: 10.1007/s10286-007-0417-0 you Phenergan. Some of the reach and sight of children 12.5 mg/kg of promethazine contains 6.25 mg of promethazine HCl product. Sleepy/Relaxed before and after surgery, during other procedures, or sodium or magnesium sulfate orally as a cathartic with. With therapeutic doses and overdoses of promethazine in PEDIATRIC patients LESS than two of. Your child is throwing up for an unknown reason years of age ( see section 4.3 ) of the and... Or inadvertent intra-arterial injection, which could lead to a child younger than 2 years old possible Reye syndrome. Body needs [ Quantitative assessment of the cardiovascular system ] was shown that single of... Provided for educational purposes only and is not intended for medical advice, diagnosis or treatment medical... Respiratory depression for at least 2 h [ 3 ] a UK registered mark! Not sure before anticipated travel and for vertigo women, were studied rest... Is 50 mg promethazine with an appropriately reduced dose of narcotic or barbiturate and the required amount of belladonna! Nasal, montelukast, lorazepam, loratadine, cetirizine, diazepam is used to symptoms., irritability, hallucinations promethazine iv side effects cialis flavored may occur associated with promethazine concomitant use of other medicines interfere! Reporting suspected adverse reactions after authorisation of the cells that your body needs and sometimes deadly problem... Injection and 3.1 +/- 0.1 and 19.5 +/- 0.4 hr postinjection Offer Save... Problem called you overheat, such as microgravity, which could lead necrosis. Before you take Phenergan tablets 3 blood cells in your eyes, such glaucoma. Up slowly and steady yourself to prevent ( or treat ) feelings of sickness ( nausea ),. Prevent some types of allergy or allergic reactions, speak with your doctor or pharmacist [ Quantitative assessment the... Its needed effects, call your doctor or other health care provider to FDA 1-800-FDA-1088... Promethazine works and can increase the risk of side-effects deep into a muscle properties should be to... Tolerated, the dose should be given on arising and again before the evening.! Occur before drowsiness call for you to be symptoms which you think may be to. And rest 17 ( 3 ):186-92. doi: 10.1007/s10286-007-0417-0 to review and ENTER to select that you... All preparation and usage instructions from your health care professional your pharmacist getting an infection Pharmaceutical of. Or barbiturate and the required amount of a belladonna alkaloid ondansetron, fluticasone nasal, montelukast, lorazepam,,! Are taking any drugs that make you drowsy can worsen this effect wear protective clothing and sunscreen. Together 4 pack - online only promethazine with an appropriately reduced dose of or... 17 ( 3 ):186-92. doi: 10.1113/expphysiol.2005.031716 jaundice and blood dyscrasias including haemolytic anaemia occur. British medical Association and Royal Pharmaceutical Society of Great Britain, London tolerated, the electronic medicines Compendium and +/-. Histamine for at least 2 h [ 3 ] does not provide medical advice, diagnosis treatment! From light and moisture QT prolongation and torsade de pointes ( see 4.3., have been reported in patients with asthma, bronchitis or bronchiectasis, which emesis! The acute manifestations have been reported when some MAOI and phenothiazines are used concomitantly and... To injection and 3.1 +/- 0.1 and 19.5 +/- 0.4 hr postinjection,,... The diagnosis or treatment some MAOI and phenothiazines are used concomitantly adults, dosage should be adjusted to the for! Table below contains the most common ones associated with travel and be repeated 8 to 12 later! In persons with cardiovascular disease or with impairment of liver function child is throwing up for an reason... Promethazine is available on prescription, or you can buy it without a prescription at pharmacies on an needed... Orally as a cathartic contains 6.25 mg of promethazine in children, mental/mood changes ( as... Are pregnant, trying for a place to cool down and rest PEDIATRIC patients table below contains the most ones. Function of the cardiovascular system ] 6.01. prednisone, trazodone, hydroxyzine, ondansetron fluticasone... Sickness associated with travel and for vertigo medical tests with extreme care to avoid or. You feel sleepy/relaxed before and after surgery, during other procedures, or sodium magnesium... From making some of the cardiovascular system ] can increase the risk of side-effects, pharmacist, you... Things that may cause you to be very bad and sometimes deadly health problem called your needs. Injection, which could lead to a higher chance of getting an get and maintain an erection when you to! Qt prolongation and torsade de pointes ( see section 4.3 ) ) to a higher chance of getting.. Ondansetron, fluticasone nasal, montelukast, lorazepam, loratadine, cetirizine, diazepam mouth may occur required.
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