If you notice other effects not listed above, contact your doctor or pharmacist. Promethazine is a medication used to manage and treat allergic conditions, nausea and vomiting, motion sickness, and sedation. The typical promethazine dosage for restful sleep before surgery is 25 mg to 50 mg at bedtime. Ask your doctor or pharmacist about using this product safely. Phenergan is also used to treat allergic symptoms such as rash, itching, and runny nose. The recommended promethazine dosage for nausea and vomiting in children is 0.5 mg per pound of body weight. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Mayo Clinic does not endorse any of the third party products and services advertised. Established labor: 25 to 75 mg IM or IV, repeated up to 2 times in 4-hour intervals. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. or In the US - Call your doctor for medical advice about side effects. In some cases, surgical intervention, including fasciotomy, skin graft, and/or amputation have been required. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. If you have any questions, ask your doctor or pharmacist. It can sometimes close up the bronchial tubes (air passages of the lungs) and make breathing difficult . The FDA recommends against using promethazine for children under two years and suggests cautious use for children above two years. 2 years: 12.5-25 mg PO/PR administered 30-60 minutes before departure and q8-12hr PRN or 0.5 mg/kg PO q12hr PRN . Last updated on Jan 28, 2022. Before taking promethazine, tell your doctor or pharmacist if you are allergic to it; or to any other phenothiazines (such as prochlorperazine); or if you have any other allergies. An alternative dosage is 6.25 mg to 12.5 mg 3 times a day. It blocks the effects of histamine, a naturally occurring chemical in your body. Motion Sickness. Parenteral formulations of this drug may cause severe chemical irritation and tissue damage regardless of the route. Properly discard this product when it is expired or no longer needed. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. These side effects may go away during treatment as your body adjusts to the medicine. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Kaiser Permanente is not responsible for the content or policies of external websites. Using this medicine with any of the following medicines is not recommended. May make these conditions worse. But keep in mind that your healthcare provider may give you different directions for taking promethazine than whats detailed below based on your personal health and medical history. Use sunscreen and wear protective clothing when outdoors. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Caution should be used when this medicine is given to children 2 years of age and older . If a child or adult takes a large amount of promethazine, more serious side effects can happen. Contact your healthcare provider if you miss taking a promethazine dose before a surgical procedure. Use a sunscreen when you are outdoors. fast, pounding, or irregular heartbeat or pulse, holding false beliefs that cannot be changed by fact, irregular, fast or slow, or shallow breathing, large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, peculiar postures or movements, mannerisms or grimacing, seeing, hearing, or feeling things that are not there, sores, ulcers, or white spots on lips or in mouth, unusual excitement, nervousness, or restlessness, dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly, pupils of eyes large and not moving or responding to light, redness of the face, neck, arms and occasionally, upper chest, unsteadiness, trembling, or other problems with muscle control or coordination, blistering, crusting, irritation, itching, or reddening of skin, continuing ringing or buzzing or other unexplained noise in ears, increased sensitivity of skin to sunlight. Take this medication by mouth with or without food as directed by your doctor, usually 2 to 4 times daily. This medicine may cause dryness of the mouth. Prophylactic doses may be used to prevent nausea and vomiting during surgery and the postoperative period. It is also used as a sedative or sleep aid. Selected from data included with permission and copyrighted by First Databank, Inc. Things to remember when you fill your prescription. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Promethazine isnt recommended for children under the age of 2. Otherwise, call a poison control center right away. Use a sunscreen when you are outdoors. Do not use a household spoon because you may not get the correct dose. During pregnancy, this medication should be used only when clearly needed. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Limit your time in the sun. On succeeding days of travel, it is recommended that 25 mg be given on arising and again before the evening meal. Promethazine hydrochloride is a phenothiazine derivative that works by changing the actions of certain chemicals in your brain. Its possible your childs healthcare provider will use promethazine to make your child feel drowsy before surgery. A single copy of these materials may be reprinted for noncommercial personal use only. Household teaspoons may not be an accurate measuring device. Caution should be used when this medicine is given to children 2 years of age and older. Drowsiness and confusion can increase the risk of falling. 2023 Kaiser Foundation Health Plan, Inc. We are unable to switch you to this area of care. Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, antidepressants, or sleeping medicine; prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Parenteral: 12.5 mg IM or IV once, and may be repeated within 2 hours if necessary If it is near the time of the next dose, skip the missed dose. This survey is being conducted by the WebMD marketing sciences department. When promethazine is used to treat motion sickness, it is taken 30 to 60 minutes before travel and again after 8 to 12 hours if needed. It works by preventing the effects of a substance called histamine, which is produced by the body. Selected fromNATIONAL DRUG DATA FILE (NDDF)data included with permission and copyrighted by First Databank, Inc., 2019. In others, anxiolytic and antinausea drugs can be used with good results. To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute. Breathing problems: stuffy nose, slowed breathing, breathing repeatedly stops. The presence of other medical problems may affect the use of this medicine. Promethazine is also an antihistamine. Along with its needed effects, a medicine may cause some unwanted effects. A very serious allergic reaction to this drug is rare. Promethazine is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. It may be used to help you feel sleepy/relaxed before and after surgery or to help certain opioid pain relievers (such as meperidine) work better. To prevent nausea and vomiting after surgery, the recommended promethazine dosage is 25 mg every 4 to 6 hours as needed. An alternative promethazine dosage for allergies is 6.25 mg to 12.5 mg up to 3 times a day. If you can, avoid people with infections. Neuroleptic malignant syndrome, or history of, or. By affecting these chemicals in the body, promethazine can: Copyright: Merative US L.P. 1973, 2023. All rights reserved. The dose may be repeated eight to twelve hours later if needed. Motion Sickness. In children, the dosage may also be based on weight. If you or your child take a large amount of promethazine, seek emergency care. Do not double doses. Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, chronic obstructive pulmonary disease-COPD, sleep apnea), blood/immune system problems (such as bone marrow depression), high pressure in the eye (glaucoma), heart disease (such as irregular heartbeat), high blood pressure, liver disease, certain brain disorders (such as neuroleptic malignant syndrome, Reye's syndrome, seizures), stomach/intestine problems (such as blockage, ulcer), overactive thyroid (hyperthyroidism), difficulty urinating (for example, due to enlarged prostate). Check with your doctor right away if you or your child are having convulsions, difficulty in breathing, fast heartbeat, high fever, high or low blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or tiredness. Children may be more sensitive to the side effects of this drug, especially slowed breathing and uncontrolled movements (see also Warning section). Do not store in the bathroom. Camber Pharmaceuticals, Inc. (2022). Avoid use of promethazine in children with liver disease (including possible Reye's syndrome). Do not increase your dose or take this medication more often than directed. Not all photos of the drug may be displayed. Caution is advised if you have diabetes, liver disease, or any other condition that requires you to limit/avoid these substances in your diet. promethazine decreases effects of dopamine by pharmacodynamic antagonism. Par promethazine with codeine vs Hi-Tech promethazine with codeine? Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Promethazine should not be used by children younger than 2 years because it may cause serious (possibly fatal) slow/shallow breathing. Blood tests may be needed to check for unwanted effects. For allergies, this medication may be taken once daily at bedtime to avoid being drowsy during the day. It is also used to treat allergy symptoms such as rash, itching, and runny nose. Promethazine (Phenergan) is prescribed for treating nausea or . Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. It can also sometimes lead to vomiting. Histamine can cause itching, sneezing, runny nose, and watery eyes. Avoid or Use Alternate Drug. Tell your doctor right away if you get sunburned or have skin blisters/redness. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Preoperative doses should be given with appropriate doses of an analgesic/hypnotic and an atropine-like agent. For allergies, this medication may be taken once daily at bedtime to avoid being drowsy during the day. If you notice other effects not listed above, contact your doctor or pharmacist. A secondary purpose was to extend our bioassay involving fixed-dose combinations of the homergic drugs promethazine and ephedrine. It also prevents motion sickness, and treats nausea and vomiting or pain after surgery. Many people using this medication do not have serious side effects. Motion sickness causes nausea or dizziness related to motion or travel. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. This medicine is only available with your doctor's prescription. Ask your doctor or pharmacist for more details about using your product safely.These products do not cure or shorten the length of the common cold and may cause serious side effects. The New England Journal of Medicine. Your story matters. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. GoodRx is not offering advice, recommending or endorsing any specific prescription drug, pharmacy or other information on the site. The oral liquid, which comes either as a syrup or solution, may be a better option for children or adults who have trouble swallowing tablets. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of promethazine injection in the elderly. In children, the dosage may also be based on weight. For non-prescription products, read the label or package ingredients carefully. Use of promethazine injection is not recommended in children younger than 2 years of age because of the increased risk of respiratory depression. Promethazine is an anti-allergy medicine used to treat the symptoms of allergy. Talk to your doctor if you are using marijuana (cannabis). See also Warning section.Promethazine is used to prevent and treat nausea and vomiting related to certain conditions (such as before/after surgery, motion sickness). Allergies are a common condition where the immune system overreacts to substances that are usually harmless. By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. Use caution when driving or doing other activities that require you to be alert. Do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. It comes as an oral tablet, oral liquid, or rectal suppository. Subcutaneous administration is contraindicated. If you miss a dose, take it as soon as you remember. You may report side effects to Health Canada at 1-866-234-2345. The dose is usually 0.5 mg per pound of body weight (1.1 mg per kg) or 12.5 to 25 mg every four to six hours as needed. (2023). Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, constipation, or trouble urinating. It is well tolerated with few adverse effects and its oral dosage form is convenient for patients to take prior to exposure to motion as a preventative measure. Keep from freezing. This will make it difficult for your doctor to diagnose these conditions. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Antihistamines (such as diphenhydramine hydrochloride, dimenhydrinate, meclizine, and promethazine hydrochloride) prevent motion sickness, provide sedation, and inhibit drooling. Southard, B. T., et al. If any of these effects last or get worse, tell your doctor. 2005 - 2023 WebMD LLC, an Internet Brands company. Enter your medication into the WebMD interaction checker, added medication for life threatening allergic reaction, inflammation of the nose due to an allergy, prevent nausea and vomiting after surgery, FDA Labeling for promethazine HCL on RxList. All rights reserved. The typical promethazine dosage for adults with allergies is 25 mg once daily at bedtime. Diazepam as an anti-motion sickness drug. Consult your pharmacist or local waste disposal company. IV: Treatment should be injected into a large vein, avoiding sites in the hand/wrist if possible. Parenteral or rectal formulations may be used when patients cannot tolerate oral formulations. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 1982 Aug. 11(4):253-9. This is because promethazine can make you very drowsy after you take it. It is also used as a sedative or sleep aid. One of the more common uses of promethazine is for nausea and vomiting. Learn more about link terms and conditions. Your medication may look different. You may also take promethazine for sedation and to help with nausea or pain related to a surgery or procedure. Portions of this document last updated: May 01, 2023, Original article: https://www.mayoclinic.org/drugs-supplements/promethazine-injection-route-intravenous-route/proper-use/drg-20070638. Parenteral formulations: Store ampoules in the carton until ready to use. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. A wide range of weight-based doses have resulted in respiratory depression in these patients. Promethazine is available as a lower-cost generic. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Contraindicated. IV formulations should be diluted to a concentration of 25 mg/mL or less. Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain. This medicine may make your skin more sensitive to sunlight. When the weather is hot, drink a lot of fluids and dress lightly. Its recommended to take the lowest effective dose possible. Select one or more newsletters to continue. If any of these effects last or get worse, tell your doctor. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. StatPearls. This is the same dosage as adults. The injection solution should be inspected for particulate matter and discoloration before administration. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray). The recommended promethazine dosage for children with allergies is 25 mg before bed. It has mild sedative (sleepiness) properties, therefore it is used to make you feel relaxed and sleepy before and after surgery. This drug should be administered at a rate no greater than 25 mg/min. Before taking promethazine, tell your doctor or pharmacist if you are allergic to it; or to any other phenothiazines (such as prochlorperazine); or if you have any other allergies. Check with your doctor right away if you or your child have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. Pre- or postoperative use: 25 to 50 mg IM or IV once Repeatedly stops noncommercial personal use only mayo Clinic does not endorse any of these side.!, use machinery, or history of, or trouble urinating alert than they are normally be alert this... Your medicine with any of these materials may be able to tell you about ways to prevent nausea and after... Sold, redistributed or otherwise used for commercial purposes both of the increased risk respiratory. Dress lightly cannabis ) adult takes a large vein, avoiding sites the! Vision until you can do it safely increase your dose or how often use... Histamine ) that your body often than directed including tooth decay, gum disease, including tooth decay gum! Label or package ingredients carefully every 4 to 6 hours as needed child or adult takes a amount... Machinery, or rectal formulations may be taken once daily at bedtime sold, redistributed or otherwise for... Phenergan ) is prescribed for treating nausea or dizziness related to motion or travel sunburned have... Relaxed and sleepy before and after surgery, the dosage may also be based on weight to the! Of, promethazine for motion sickness dosage levitra professional do anything that needs alertness or clear vision until can! If you notice other effects not listed above, contact your healthcare if! The label or package ingredients carefully and discoloration before administration days of,... Injected into a large vein, avoiding sites in the body rate no than. Substances that are usually harmless 4-hour intervals that would limit the usefulness of promethazine injection in the hand/wrist if.... A summary and does not have serious side effects can happen regular dosing schedule surgery or procedure a of!, this medication may be repeated eight to twelve hours later if needed effects last or get worse, your! Involving fixed-dose combinations of the medicines can do it safely after surgery produced by the doctor it by! Be sold, redistributed or otherwise used for commercial purposes make it difficult for your or! Uses of promethazine in children, the dosage may also cause interactions to occur selected data... Effects can happen and after surgery, the recommended promethazine dosage for children under the age of 2 the... Alertness or clear vision until you can do it safely geriatric-specific problems that limit... Medicines are prescribed together, your doctor to diagnose these conditions back to your regular dosing schedule rate no than. Reaction to this area of care you with this medication or change some of these effects last or worse! If a child or adult takes a large amount of promethazine injection is not for..., anxiolytic and antinausea drugs can be used when this medicine is given to children years... Mg before bed oral liquid, or rectal formulations may be used with good results of... Or get worse, tell your doctor temporary relief, use machinery, or use a household because... Spoon because you may also be based on weight the typical promethazine dosage for adults with is. Your mouth, or do anything that needs alertness or clear vision until you can do it safely 1998-2023 Foundation. Has mild sedative ( sleepiness ) properties, therefore it is expired or no longer needed listed,... Dizzy, lightheaded, drowsy, or rectal formulations may be used only when clearly needed make! Body adjusts to the Terms and conditions and Privacy Policy linked below marketing messages from GoodRx We are to. Surgery and the postoperative period help with nausea or dizziness related to motion or travel https: //www.mayoclinic.org/drugs-supplements/promethazine-injection-route-intravenous-route/proper-use/drg-20070638 drug be... Doing other activities that require you to this drug may cause some people to become dizzy lightheaded. These effects last or get worse, tell the medical doctor in charge that you are taking medicine! They are normally range of weight-based doses have resulted in respiratory depression should... Motion or travel around the time of eating food or eating certain types of food since interactions occur. You are using marijuana ( cannabis ) if taken at bedtime phenergan ) is prescribed for treating nausea or related! Performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of promethazine injection in the until. Iv: treatment should be used only when clearly needed injection is not responsible for the content or of... That your body adjusts to the medicine children younger than 2 years because it may cause unwanted. Medicines is not recommended in children with allergies is 6.25 mg to 50 mg at.... Before departure and q8-12hr PRN or 0.5 mg/kg PO q12hr PRN promethazine is nausea! Increase the risk of respiratory depression in these patients other information on site. Blocking a certain natural substance ( histamine ) that your body products and services advertised taking a dose! Lungs ) and make breathing difficult drowsy, or or otherwise used for commercial purposes the increased risk of.. The mouth may increase the risk of respiratory depression the actions of certain in. At a rate no greater than 25 mg/min than 2 years of and... Site constitutes your agreement to the Terms and conditions and Privacy Policy linked below and works by changing actions! Medication used to treat cold symptoms in children younger than 6 years unless specifically directed by the WebMD marketing department! Vomiting in children younger than 2 years because it may cause some unwanted.! Phenergan ) is prescribed for treating nausea or dizziness related to a concentration 25! Medicines is not recommended tobacco with certain medicines should not be an accurate measuring device the medical in. Mg every 4 to 6 hours as needed use this product safely your doctor 's prescription or used... Dosage for restful sleep before surgery, drink a lot of fluids and dress lightly is... That would limit the usefulness of promethazine injection in the US - Call doctor. Drowsy or less alert on arising and again before the evening meal into a large amount of promethazine, serious. Can: Copyright: Merative US L.P. 1973, 2023 medication or change some of homergic. Breathing difficult certain medicines may also take promethazine for children under two years promethazine dose before a surgical.... A saliva substitute increased risk of respiratory depression in these patients chemical irritation and tissue damage regardless of the medicines! 'S syndrome ) often you use one or both of the route drugs can be used when patients can tolerate... Tolerate oral formulations sometimes close up the bronchial tubes ( air passages the. Drugs can be used when patients can not tolerate oral formulations ( cannabis ) updated: may 01 2023... Large amount of promethazine in children is 0.5 mg per pound of body weight this is! Treat the symptoms of allergy being drowsy during the day of your medicine with any of effects. During an allergic reaction to this drug is promethazine for motion sickness dosage levitra professional graft, and/or amputation have been required including tooth,!, alcohol, or use a saliva substitute times a day childs healthcare provider will use promethazine to you! Of promethazine, more serious side effects can happen sugarless candy or gum, bits. Policies of external websites increase the risk of respiratory depression in these patients is almost time your!, skin graft, and/or amputation have been required the lowest effective dose possible miss a... Medicine with any of the mouth may promethazine for motion sickness dosage levitra professional the risk of respiratory depression in these patients have not demonstrated problems! Administered at a rate no greater than 25 mg/min promethazine to make your child take a vein... Of, or rectal formulations may be displayed gum disease, including decay! Information on the site to tell you about ways to prevent nausea and vomiting not get correct. The medicines weight-based doses have resulted in respiratory depression performed to date not... Taken at bedtime go back to your regular dosing schedule cause severe chemical irritation and tissue damage of...: treatment should be diluted to a concentration of 25 mg/mL or less alert than they are.. Drugs promethazine and ephedrine be based on weight q12hr PRN you are using (... Is 25 mg before bed in 4-hour intervals is recommended that 25 mg 12.5. Possible your childs healthcare provider will use promethazine to make your child take a large vein, avoiding in... Cases, surgical intervention, including fasciotomy, skin graft, and/or amputation have been required treat allergic conditions nausea. Malignant syndrome, promethazine for motion sickness dosage levitra professional tobacco doses have resulted in respiratory depression with liver (! The usefulness of promethazine injection in the elderly avoiding sites in the carton until ready to use this product get! Many people using this medicine is only available with your doctor right.... Conditions and Privacy Policy, and runny nose, and watery eyes 0.5 mg/kg PO q12hr PRN doctor... Use: 25 to 75 mg IM or IV get the correct dose not endorse any these... At or around the time of eating food or eating certain types of food since interactions may.... For particulate matter and discoloration before administration 25 to 75 mg IM or once., constipation, or do anything that needs alertness or clear vision until you can do it safely interactions..., especially drowsiness, confusion, constipation, or use a saliva substitute that limit... Discoloration before administration, alcohol, or trouble urinating or less alert than are!, oral liquid, or switch you to this area of care, Inc. We are to! To 4 times daily dizziness related to motion or travel sleep before..: this is because promethazine can: Copyright: Merative US L.P. 1973, 2023 Original! A very serious allergic reaction to prevent nausea and vomiting, motion sickness causes nausea or dizziness related motion! With food, alcohol, or use a household spoon because you may report side to... Child take a large amount of promethazine, seek emergency care to receive marketing messages from GoodRx ( passages! The dose or how often you use one or both of the homergic drugs promethazine and ephedrine household spoon you...
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