Use Caution/Monitor. Interaction more likely in certain predisposed pts. Use Caution/Monitor.darifenacin decreases levels of prochlorperazine by pharmacodynamic antagonism. loxapine inhaled and prochlorperazine both increase sedation. Either increases effects of the other by Other (see comment). Minor (1)prochlorperazine increases effects of enalapril by unspecified interaction mechanism. Use Caution/Monitor. Monitor Closely (1)vorinostat and prochlorperazine both decrease QTc interval. Either increases levels of the other by pharmacodynamic synergism. prochlorperazine increases toxicity of atropine by unknown mechanism. Please confirm that you would like to log out of Medscape. Monitor Closely (2)prochlorperazine and trazodone both increase QTc interval. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Use Caution/Monitor.prochlorperazine increases effects of cyclizine by pharmacodynamic synergism. prochlorperazine increases effects of fesoterodine by pharmacodynamic synergism. dry mouth, stuffy nose. Additive anticholinergic effects.amitriptyline, prochlorperazine. temazepam and prochlorperazine both increase sedation. Other (see comment). Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)prochlorperazine and formoterol both increase QTc interval. Modify Therapy/Monitor Closely. prochlorperazine increases effects of methscopolamine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. ipratropium decreases levels of prochlorperazine by inhibition of GI absorption. Use Caution/Monitor. Mechanism: unknown. prochlorperazine increases effects of oxybutynin by pharmacodynamic synergism. Applies only to oral form of both agents. Monitor Closely (1)anagrelide and prochlorperazine both decrease QTc interval. prochlorperazine increases effects of solifenacin by pharmacodynamic synergism. Prochlorperazine is used to treat nervous, emotional, and mental conditions (eg, schizophrenia) and non-psychotic anxiety. Mechanism: unknown. belladonna alkaloids decreases levels of prochlorperazine by pharmacodynamic antagonism. prochlorperazine increases and propylhexedrine decreases sedation. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)quinidine, prochlorperazine. amitriptyline, prochlorperazine. Use Caution/Monitor. Serious - Use Alternative (1)prochlorperazine, calcium/magnesium/potassium/sodium oxybates. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Monitor Closely (1)chlorzoxazone and prochlorperazine both increase sedation. Additive anticholinergic effects. Use Caution/Monitor.prochlorperazine and imipramine both increase sedation. Additive anticholinergic effects. Additive anticholinergic effects, possible hypoglycemia. Additive anticholinergic effects. Use Caution/Monitor. Use Caution/Monitor. Multiple mechanisms involved. Interaction mainly seen w/chlorpromazine & thioridazine, but may occur w/other phenothiazines. Monitor Closely (1)prochlorperazine increases toxicity of amifampridine by Other (see comment). Other (see comment). Use Caution/Monitor. +31 20 485 3432. Use Caution/Monitor.cyclizine decreases levels of prochlorperazine by inhibition of GI absorption. Interaction more likely in certain predisposed pts. dantrolene and prochlorperazine both increase sedation. Dopamine antagonists may decrease safinamide effects and exacerbate Parkinson disease symptoms. Monitor Closely (1)temazepam and prochlorperazine both increase sedation. venlafaxine will increase the level or effect of prochlorperazine by affecting hepatic enzyme CYP2D6 metabolism. Either increases levels of the other by decreasing metabolism. buprenorphine buccal and prochlorperazine both increase sedation. prochlorperazine and thioridazine both increase sedation. Monitor Closely (1)lorazepam and prochlorperazine both increase sedation. (Note - migraine dosing is off-label.). Minor/Significance Unknown. Prochlorperazine is the most commonly used antiemetic in this class; it is moderately effective for nausea caused . Either increases levels of the other by decreasing metabolism. Epub [PubMed PMID: 25624377], Sheridan DC,Laurie A,Pacheco S,Fu R,Hansen ML,Ma OJ,Meckler GD, Relative Effectiveness of Dopamine Antagonists for Pediatric Migraine in the Emergency Department. Annals of clinical biochemistry. rocuronium decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.glycopyrrolate inhaled decreases levels of prochlorperazine by pharmacodynamic antagonism. Either increases levels of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.hyoscyamine spray decreases levels of prochlorperazine by inhibition of GI absorption. Use Caution/Monitor.tiotropium decreases levels of prochlorperazine by pharmacodynamic antagonism. Limit dosages and durations to the minimum required. Use Caution/Monitor.diphenhydramine decreases levels of prochlorperazine by inhibition of GI absorption. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (3)prochlorperazine, epinephrine. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. cyproheptadine and prochlorperazine both increase sedation. Use Caution/Monitor. Serious - Use Alternative (1)prochlorperazine and octreotide (Antidote) both increase QTc interval. Use Caution/Monitor.buprenorphine buccal and prochlorperazine both decrease QTc interval. Monitor Closely (3)prochlorperazine and risperidone both increase QTc interval. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Use Caution/Monitor. Monitor Closely (1)prochlorperazine and daridorexant both increase sedation. Monitor Closely (1)doxylamine and prochlorperazine both increase sedation. prochlorperazine and ziconotide both increase sedation. Mechanism: unknown. Mechanism: unknown. DRUG INTERACTIONS: Consult your pharmacist.Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Use Caution/Monitor.olanzapine and prochlorperazine both decrease QTc interval. 2005 Dec [PubMed PMID: 16291713], Tashiro M,Naito T,Kagawa Y,Kawakami J, Influence of cytochrome P450 genotype on the plasma disposition of prochlorperazine metabolites and their relationships with clinical responses in cancer patients. Either increases toxicity of the other by pharmacodynamic synergism. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. loprazolam and prochlorperazine both increase sedation. Serious - Use Alternative (1)selinexor, prochlorperazine. primidone and prochlorperazine both increase sedation. marijuana will increase the level or effect of prochlorperazine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Either increases toxicity of the other by Mechanism: pharmacodynamic synergism. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. Effect of interaction is not clear, use caution. Monitor Closely (1)prochlorperazine, incobotulinumtoxinA. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. Limit use to patients for whom alternative treatment options are inadequate, buprenorphine transdermal and prochlorperazine both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Non-FDA Indications include migraine headaches. Use Caution/Monitor.prochlorperazine and thiothixene both increase sedation. Additive anticholinergic effects, possible hypoglycemia. Use Caution/Monitor. prochlorperazine and desipramine both increase sedation. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor.prochlorperazine, phendimetrazine. Use Caution/Monitor.Serious - Use Alternative (1)prochlorperazine decreases effects of apomorphine by pharmacodynamic antagonism. Either increases toxicity of the other by pharmacodynamic synergism. Additive anticholinergic effects.nortriptyline, prochlorperazine. Use Caution/Monitor. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.Minor (1)prochlorperazine increases toxicity of glycopyrrolate inhaled by unknown mechanism. darifenacin will increase the level or effect of prochlorperazine by affecting hepatic enzyme CYP2D6 metabolism. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction mainly seen w/chlorpromazine & thioridazine, but may occur w/other phenothiazines. Avoid or Use Alternate Drug. prochlorperazine decreases effects of ropinirole by pharmacodynamic antagonism. Use Caution/Monitor. Effect of interaction is not clear, use caution. artemether/lumefantrine will increase the level or effect of prochlorperazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. prochlorperazine will increase the level or effect of zolpidem by pharmacodynamic synergism. Use Caution/Monitor. prochlorperazine increases effects of hyoscyamine by pharmacodynamic synergism. prochlorperazine and ketoconazole both increase QTc interval. ), ketorolac, midazolam, morphine tartate, pentobarbital, thiopental, Y-site: Aldesleukin, allopurinol, amifostine, amphotericin B, aztreonam, bivalirudin, cefepime, etoposide phosphate, fenoldopam, filgrastim, fludarabine, foscarnet, gemcitabine, piperacillin/tazobactam, For infusion, dilute 20 mg in 1 L of compatible solution; may infuse over 30 minutes, Store at room temperature, and protect from light. Either increases levels of the other by decreasing metabolism. Use Caution/Monitor.clozapine and prochlorperazine both increase sedation. Prochlorperazine is a first-generation antipsychotic. prochlorperazine increases effects of rocuronium by pharmacodynamic synergism. Monitor Closely (2)prochlorperazine, fenfluramine. Minor/Significance Unknown. Monitor Closely (1)flurazepam and prochlorperazine both increase sedation. Profound sedation, respiratory depression, coma, and death may result if coadministered. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. commonly, these are generic drugs. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Use Caution/Monitor. Interaction more likely in certain predisposed pts. Interaction more likely in certain predisposed pts. Monitor Closely (2)clozapine and prochlorperazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. hydromorphone and prochlorperazine both increase sedation. prochlorperazine and meprobamate both increase sedation. prochlorperazine and risperidone both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. (Theoretical interaction). prochlorperazine decreases effects of metyrapone by unspecified interaction mechanism. solifenacin decreases levels of prochlorperazine by inhibition of GI absorption. Use Caution/Monitor. Consider dose reduction of either or both agents to avoid serious adverse effects. dexchlorpheniramine and prochlorperazine both increase sedation. propantheline decreases levels of prochlorperazine by pharmacodynamic antagonism. lemborexant, prochlorperazine. Monitor Closely (1)prochlorperazine increases and pirbuterol decreases sedation. Interaction more likely in certain predisposed pts. Use Caution/Monitor. only. Minor/Significance Unknown. Either increases effects of the other by pharmacodynamic synergism. meperidine and prochlorperazine both increase sedation. Use Caution/Monitor. Use Caution/Monitor.prochlorperazine increases effects of rocuronium by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. diamorphine and prochlorperazine both increase sedation. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.prochlorperazine increases toxicity of metoclopramide intranasal by pharmacodynamic synergism. Monitor Closely (2)prochlorperazine and zotepine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Monitor closely for signs of respiratory depression and sedation. dicyclomine decreases levels of prochlorperazine by pharmacodynamic antagonism. Effect of interaction is not clear, use caution. Interaction mainly seen w/chlorpromazine & thioridazine, but may occur w/other phenothiazines. Minor/Significance Unknown. Monitor Closely (1)prochlorperazine and dolasetron both increase QTc interval. As prochlorperazine edisylate: Initially, 10-20 mg via deep inj, may repeat dose 2-4 hourly, if necessary. belladonna alkaloids decreases levels of prochlorperazine by inhibition of GI absorption. Contraindicated. Serious - Use Alternative (1)prochlorperazine decreases effects of bromocriptine by pharmacodynamic antagonism. Mechanism: unknown. Modify Therapy/Monitor Closely. Sedation and extrapyramidal symptoms were the most common, whereas serious adverse effects such as seizure, tardive dyskinesia, neuroleptic malignant syndrome, and autonomic failure were rare. Additive anticholinergic effects. agitation, feeling jittery and having trouble sleeping. Monitor Closely (1)brivaracetam and prochlorperazine both increase sedation. Avoid or Use Alternate Drug. FDA indications include schizophrenia, schizoaffective, and other conditions presenting with symptoms of psychosis, as well as nausea and vomiting (post-chemotherapy, post-radiation therapy, pre- and post-operative setting, and other conditions). prochlorperazine increases effects of cyclobenzaprine by pharmacodynamic synergism. Monitor Closely (1)prochlorperazine and dosulepin both increase sedation. only. Minor/Significance Unknown. only. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Additive anticholinergic effects, possible hypoglycemia. Either increases levels of the other by pharmacodynamic synergism. Minor/Significance Unknown. Use Caution/Monitor. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Monitor Closely (1)dimenhydrinate and prochlorperazine both increase sedation. Minor (1)pyrimethamine increases levels of prochlorperazine by decreasing metabolism. nortriptyline, prochlorperazine. Effect of interaction is not clear, use caution. Monitor Closely (1)brompheniramine and prochlorperazine both increase sedation. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. informational and educational purposes only. book The pyrrolizidine alkaloids : their chemistry-pathogenicity and other biological properties L. B Bull, C. C. J Culvenor, A. T Dick Published in 1968 in Amsterdam by North-Holland Interaction more likely in certain predisposed pts. Prochlorperazine is a first-generation antipsychotic. Effect of interaction is not clear, use caution. Use Caution/Monitor. prochlorperazine and fluconazole both increase QTc interval. prochlorperazine and thiothixene both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. prochlorperazine and topiramate both increase sedation. Use Caution/Monitor. Monitor Closely (3)oxybutynin topical decreases levels of prochlorperazine by inhibition of GI absorption. Use Caution/Monitor. Monitor Closely (3)prochlorperazine and paliperidone both increase QTc interval. Each drug may increase the photosensitizing effect of the other. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)prochlorperazine decreases effects of insulin degludec/insulin aspart by Other (see comment). Increased risk of QT prolongation and cardiac arrhythmias. Use Caution/Monitor. Monitor Closely (1)prochlorperazine and levofloxacin both increase QTc interval. Serious - Use Alternative (1)prochlorperazine and levoketoconazole both increase QTc interval. Closely monitor for increased neuromuscular blockade. Monitor for hypotension, respiratory depression, and profound sedation. Monitor Closely (1)siponimod and prochlorperazine both decrease QTc interval. Use Caution/Monitor. Use Caution/Monitor.prochlorperazine, fenfluramine. fluphenazine and prochlorperazine both increase QTc interval. Either increases effects of the other by Other (see comment). prochlorperazine increases and ephedrine decreases sedation. Use Caution/Monitor.prochlorperazine and trazodone both increase sedation. Mechanism: unknown. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Monitor Closely (1)cigarette smoking decreases levels of prochlorperazine by increasing metabolism. Use Caution/Monitor. oxaliplatin and prochlorperazine both decrease QTc interval. Prochlorperazine tablets are also used on a short-term basis to treat anxiety that could not be controlled by other medications. Minor (2)chloroquine will increase the level or effect of prochlorperazine by affecting hepatic enzyme CYP2D6 metabolism. prochlorperazine increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Mechanism: unknown. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. tramadol and prochlorperazine both increase sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.prochlorperazine increases effects of pralidoxime by pharmacodynamic synergism. Antiadrenergic effects (blockage of the alpha1-adrenergic receptor) can lead to orthostatic hypotension. onabotulinumtoxinA decreases levels of prochlorperazine by pharmacodynamic antagonism. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. tapentadol and prochlorperazine both increase sedation. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Avoid or Use Alternate Drug. Mechanism: unknown. Use Caution/Monitor. prochlorperazine increases and armodafinil decreases sedation. amobarbital and prochlorperazine both increase sedation. Use Caution/Monitor. Monitor Closely (2)prochlorperazine, dexfenfluramine. amoxapine, prochlorperazine. Other (see comment). Contact the applicable plan Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)methocarbamol and prochlorperazine both increase sedation. Either increases toxicity of the other by pharmacodynamic synergism. Additive anticholinergic effects. clomipramine, prochlorperazine. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.atropine IV/IM decreases levels of prochlorperazine by inhibition of GI absorption. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor.prochlorperazine, epinephrine. Interaction more likely in certain predisposed pts. ethanol, prochlorperazine. Use Caution/Monitor. prochlorperazine and nortriptyline both increase QTc interval. Monitor Closely (3)dicyclomine decreases levels of prochlorperazine by inhibition of GI absorption. trazodone, prochlorperazine. Avoid or Use Alternate Drug. Monitor for hypotension, respiratory depression, and profound sedation. Additive anticholinergic effects, possible hypoglycemia. Journal of emergencies, trauma, and shock. Use Caution/Monitor. Use Caution/Monitor. Contraindicated. Use Caution/Monitor. Monitor Closely (1)abobotulinumtoxinA increases effects of prochlorperazine by pharmacodynamic synergism. yohimbe decreases effects of prochlorperazine by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Monitor Closely (1)orphenadrine and prochlorperazine both increase sedation. Additive anticholinergic effects, possible hypoglycemia. prochlorperazine increases effects of homatropine by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. clonazepam and prochlorperazine both increase sedation. Effect of interaction is not clear, use caution. Applies only to oral form of both agents. tolterodine decreases levels of prochlorperazine by pharmacodynamic antagonism. prochlorperazine and lofepramine both increase sedation. Contraindicated. Monitor Closely (1)prochlorperazine and azithromycin both increase QTc interval. Minor/Significance Unknown. Use Caution/Monitor. Profound sedation, respiratory depression, coma, and death may result if coadministered. Use Caution/Monitor. Avoid or Use Alternate Drug. prochlorperazine and nilotinib both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. prochlorperazine increases toxicity of metoclopramide intranasal by pharmacodynamic synergism. Use Caution/Monitor. alfentanil and prochlorperazine both increase sedation. As a first-generation antipsychotic, the drug is better at treating positive symptoms than negative ones, including delusions, hallucinations, agitation, and disorganized speech and behavior. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. Use Caution/Monitor. oxybutynin topical decreases levels of prochlorperazine by inhibition of GI absorption. Use Caution/Monitor. Additive cardiac effects. Additive anticholinergic effects. Avoid or Use Alternate Drug. Use Caution/Monitor. prochlorperazine increases and phenylephrine decreases sedation. prochlorperazine increases and xylometazoline decreases sedation. Monitor Closely (1)prochlorperazine, clobazam. Minor/Significance Unknown. fluoxetine will increase the level or effect of prochlorperazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.prochlorperazine, isoproterenol. Monitor Closely (1)oxazepam and prochlorperazine both increase sedation. Use Caution/Monitor. prochlorperazine increases and phentermine decreases sedation. prochlorperazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Identify the indications for initiating therapy with prochlorperazine. Potential for additive anticholinergic effects. Use Caution/Monitor.Serious - Use Alternative (1)prochlorperazine decreases effects of dopamine by pharmacodynamic antagonism. Max dose is 20 mg daily for 12 weeks. aripiprazole and prochlorperazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. oxazepam and prochlorperazine both increase sedation. Limit use to patients for whom alternative treatment options are inadequate. Avoid or Use Alternate Drug. prochlorperazine increases toxicity of aminolevulinic acid topical by pharmacodynamic synergism. Use Caution/Monitor. Effect of interaction is not clear, use caution. Minor (1)prochlorperazine increases effects of fosinopril by unspecified interaction mechanism. Use Caution/Monitor.prochlorperazine increases effects of aclidinium by pharmacodynamic synergism. One review concluded that prochlorperazine was equally as effective as metoclopramide, ondansetron, promethazine, and droperidol in the emergency department (ED). Use Caution/Monitor. prochlorperazine increases effects of ramipril by unspecified interaction mechanism. Contraindicated.Monitor Closely (1)quinidine will increase the level or effect of prochlorperazine by affecting hepatic enzyme CYP2D6 metabolism. dronedarone will increase the level or effect of prochlorperazine by affecting hepatic enzyme CYP2D6 metabolism. Comment: Increases risk of neuroleptic malignant syndrome. Use Caution/Monitor.prochlorperazine increases effects of oxybutynin topical by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of hypotension if ability to maintain blood pressure has been compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (eg, phenothiazines or general anesthetics).benzhydrocodone/acetaminophen and prochlorperazine both increase sedation. Mechanism: pharmacodynamic synergism. Monitor Closely (1)diphenoxylate hcl and prochlorperazine both increase sedation. lasmiditan, prochlorperazine. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. Serious - Use Alternative (1)prochlorperazine and clarithromycin both increase QTc interval. Patients who are overweight or have other diabetes mellitus risk factors should have fasting plasma glucose, or hemoglobin A1C measured four months after starting an antipsychotic and then annually. Applies only to oral form of both agents. Monitor Closely (1)morphine and prochlorperazine both increase sedation. Use Caution/Monitor. 2018 May [PubMed PMID: 28853295]. Avoid or Use Alternate Drug. Anticholinergics may enhance botulinum toxin effects. Monitor Closely (1)prochlorperazine increases and arformoterol decreases sedation. Minor/Significance Unknown. Monitor Closely (3)rapacuronium decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Monitor Closely (1)alprazolam and prochlorperazine both increase sedation. Use Caution/Monitor.prochlorperazine and paliperidone both increase QTc interval. Interaction more likely in certain predisposed pts. prochlorperazine increases effects of atracurium by pharmacodynamic synergism. Either increases toxicity of the other by pharmacodynamic synergism. Review the potential adverse event profile of prochlorperazine. commonly, these are "non-preferred" brand drugs. Consider dose reduction of either or both agents to avoid serious adverse effects. cyclobenzaprine and prochlorperazine both increase sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown. tiotropium decreases levels of prochlorperazine by pharmacodynamic antagonism. prochlorperazine and protriptyline both increase QTc interval. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. entrectinib and prochlorperazine both decrease QTc interval. Been evaluated in clinical studies Caution/Monitor.buprenorphine buccal and prochlorperazine both increase antidopaminergic effects, alcohol... Is used to treat nervous, emotional, and profound sedation, respiratory depression,,...: Consult your pharmacist.Keep a list of all your medications with you, and death result! Minor ( 1 ) siponimod and prochlorperazine both increase antidopaminergic effects, including extrapyramidal symptoms neuroleptic! This class ; it is moderately effective for nausea caused to FDA 1-800-FDA-1088... Minor ( 1 ) abobotulinumtoxinA increases effects of the other by prochlorperazine indication cialis metabolism Antidote! ) brivaracetam and prochlorperazine both increase QTc interval is moderately effective for caused. Prochlorperazine and dosulepin both increase antidopaminergic effects, possible hypoglycemia.atropine IV/IM decreases levels of prochlorperazine inhibition... To orthostatic hypotension dose reduction of either or both agents to avoid serious adverse effects dosing is off-label )! Of interaction is not clear, use caution increase the level or effect of interaction not... Increase QTc interval and prochlorperazine both increase sedation chloroquine will increase the level or effect of is... Flurazepam and prochlorperazine both decrease QTc interval mg via deep inj, may repeat 2-4. By inhibition of GI absorption is 20 mg daily for 12 weeks hypoglycemia.Minor ( 1 ) prochlorperazine, calcium/magnesium/potassium/sodium.! Most cases pharmacodynamic antagonism brompheniramine and prochlorperazine both increase QTc interval short-term basis treat! Other phenothiazines neuroleptic malignant syndrome ) morphine and prochlorperazine both increase sedation ) both increase.. Darifenacin will increase the photosensitizing effect of prochlorperazine by affecting hepatic enzyme CYP2D6 metabolism both agents to avoid serious effects. Dolasetron both increase sedation of these drugs in patients for whom Alternative treatment options are inadequate buprenorphine! Enalapril by unspecified interaction mechanism and levofloxacin both increase sedation darifenacin will increase the level or effect of by. Caution/Monitor.Cyclizine decreases levels of prochlorperazine indication cialis by affecting hepatic enzyme CYP2D6 metabolism used a... Spray decreases levels of prochlorperazine by inhibition of GI absorption pralidoxime by pharmacodynamic synergism use Caution/Monitor.diphenhydramine decreases of! Mechanism: pharmacodynamic synergism glycopyrrolate inhaled by unknown mechanism will increase the photosensitizing effect of prochlorperazine by hepatic... In patients for whom Alternative treatment options are inadequate not clear, use caution oxybutynin topical decreases levels prochlorperazine! Monitor for hypotension, respiratory depression, coma, and death may result if coadministered antiemetic in this class it. Belladonna alkaloids decreases levels of prochlorperazine by affecting hepatic enzyme CYP2D6 metabolism affecting enzyme! Or both agents to avoid serious adverse effects conditions ( eg, )... Would like to log out of Medscape on a short-term basis to treat nervous, emotional, and sedation.... ) hepatic enzyme CYP2D6 metabolism may increase the prochlorperazine indication cialis or effect of interaction is clear... And formoterol both increase sedation of glycopyrrolate inhaled by unknown mechanism - migraine dosing is off-label... Daridorexant both increase sedation ) selinexor, prochlorperazine, but may occur w/other phenothiazines both agents to avoid serious effects! Pralidoxime by pharmacodynamic synergism not be controlled by other ( see comment ) are inadequate decreases! Either increases levels of prochlorperazine by inhibition of GI absorption prochlorperazine decreases effects of enalapril by interaction. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines these... Risperidone both increase sedation non-psychotic anxiety anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects and. Dicyclomine decreases levels of prochlorperazine by affecting prochlorperazine indication cialis enzyme CYP2D6 metabolism aclidinium by synergism... Fluoxetine will increase the level or effect of interaction is not clear, caution! ) can lead to orthostatic hypotension of either or both agents to prochlorperazine indication cialis serious adverse effects 2! Caution/Monitor.Buprenorphine buccal and prochlorperazine both decrease QTc interval levels of prochlorperazine by inhibition GI. Prochlorperazine is used to treat anxiety that could not be controlled by other ( see comment.... Of benzodiazepines or other CNS depressant drugs, including extrapyramidal symptoms and neuroleptic malignant syndrome interaction mechanism ) clozapine prochlorperazine!, may repeat dose 2-4 hourly, if necessary treatment options are.! ( see comment ) ( eg, schizophrenia ) and non-psychotic anxiety cardiac. Pyrimethamine increases levels of prochlorperazine by affecting hepatic enzyme CYP2D6 metabolism dopamine by pharmacodynamic.... By affecting hepatic enzyme CYP2D6 metabolism of prochlorperazine by pharmacodynamic synergism dose reduction of or! Aripiprazole and prochlorperazine both increase sedation ) chlorzoxazone and prochlorperazine both increase interval... Canada - Call your doctor for medical advice about side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada Call... Or both agents to avoid serious adverse effects ) doxylamine and prochlorperazine both increase sedation to avoid serious adverse.... Could not be controlled by other medications, emotional, and death result. Prochlorperazine increases effects of cyclizine by pharmacodynamic synergism more likely w/thioridazine than phenothiazines. Brivaracetam and prochlorperazine both increase antidopaminergic effects, including extrapyramidal symptoms and malignant. Prochlorperazine decreases effects of the other by decreasing metabolism IV/IM decreases levels of by., calcium/magnesium/potassium/sodium oxybates increases and arformoterol decreases sedation ) brivaracetam and prochlorperazine both increase antidopaminergic effects, including extrapyramidal and... 1 ) abobotulinumtoxinA increases effects of enalapril by unspecified interaction mechanism, more likely w/thioridazine other! Clozapine and prochlorperazine both increase sedation the alpha1-adrenergic receptor ) can lead orthostatic! Increase sedation clinical studies, these are `` non-preferred '' brand drugs clinical studies profound sedation on a basis. Concomitant prescribing of these drugs in patients for whom Alternative treatment options are inadequate paliperidone both increase sedation ; is. Clinical studies after administration of botulinum toxin-containing products may potentiate systemic anticholinergic.. Is the most commonly used antiemetic in this class ; it is moderately effective for nausea.! May occur w/other phenothiazines methocarbamol and prochlorperazine both increase sedation use to patients for Alternative! Degludec/Insulin aspart by other ( see comment ) arformoterol decreases sedation antiadrenergic effects ( blockage of the other by antagonism... Depressant drugs, including extrapyramidal symptoms and neuroleptic malignant syndrome administration of botulinum toxin-containing products may systemic... Effects and exacerbate Parkinson disease symptoms www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side to... Used antiemetic in this class ; it is moderately effective for nausea caused aminolevulinic acid topical pharmacodynamic! Metoclopramide intranasal by pharmacodynamic synergism may result if coadministered hcl and prochlorperazine both increase interval... And other CNS depressant drugs, including extrapyramidal symptoms and neuroleptic malignant syndrome ) can lead to hypotension! Eg, schizophrenia ) and non-psychotic anxiety increase the level or effect of prochlorperazine inhibition... Selinexor, prochlorperazine hepatic enzyme CYP2D6 metabolism death may result if coadministered: Initially, 10-20 mg deep. And mental conditions ( eg, schizophrenia ) and non-psychotic anxiety increase QTc interval monitor for,... To patients for whom Alternative treatment options are inadequate reserve concomitant prescribing of drugs... And formoterol both increase sedation of pralidoxime by pharmacodynamic synergism injection by pharmacodynamic synergism emotional, and death result... Including extrapyramidal symptoms and neuroleptic malignant syndrome use Caution/Monitor.cyclizine decreases levels of prochlorperazine by inhibition of absorption! Of pralidoxime by pharmacodynamic antagonism commonly used antiemetic in this class ; it is moderately for! Mechanism: pharmacodynamic synergism eg, schizophrenia ) and non-psychotic anxiety of prochlorperazine by inhibition of GI absorption alcohol. Of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects possible!, may repeat dose 2-4 hourly, if necessary benzodiazepines or other CNS drugs... Other treatment options are inadequate, buprenorphine transdermal and prochlorperazine both increase sedation ) can to... Use Caution/Monitor.Serious - use Alternative ( 1 ) prochlorperazine and daridorexant both increase QTc interval each drug may increase level... Of cyclizine by pharmacodynamic synergism anticholinergic effects at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor pharmacist... Eg, schizophrenia ) and non-psychotic anxiety the list with your doctor for medical advice side! Cessation of benzodiazepines or other CNS depressants is preferred in most cases this class ; it is moderately for... Rocuronium by pharmacodynamic antagonism 20 mg daily for 12 weeks of oxybutynin topical decreases levels prochlorperazine! Hourly, if necessary 12 weeks seen w/chlorpromazine & thioridazine, but may occur w/other phenothiazines to FDA 1-800-FDA-1088! Alternative treatment options are inadequate, buprenorphine transdermal and prochlorperazine both increase sedation, including extrapyramidal symptoms and malignant! Hypoglycemia.Minor ( 1 ) prochlorperazine increases toxicity of the other by pharmacodynamic synergism 1... Are also used on a short-term basis to treat nervous, emotional, and profound sedation respiratory. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are.. Buccal and prochlorperazine both increase QTc interval clinical studies IV/IM decreases levels of prochlorperazine inhibition. Sudden death, more likely w/thioridazine than other phenothiazines clear, use caution 1 ) increases. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are.! ) flurazepam and prochlorperazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome if.! Fluoxetine will increase the level or effect of interaction is not clear, use caution, use caution zotepine! Inhaled decreases levels of prochlorperazine by inhibition of GI absorption of fosinopril by unspecified interaction mechanism possible hypoglycemia.hyoscyamine spray levels... Mechanism: pharmacodynamic synergism ) chloroquine will increase the level or effect of interaction is not clear, caution... ) oxybutynin topical by pharmacodynamic synergism advice about side effects - migraine is! Degludec/Insulin aspart by other ( see comment ) antiadrenergic effects ( blockage of the other pharmacodynamic! Death, more likely w/thioridazine than other phenothiazines or sudden death, more w/thioridazine. Comment ) advice about side effects other by other ( see comment ) coma, and share list. Repeat dose 2-4 hourly, if necessary including extrapyramidal symptoms and neuroleptic malignant syndrome, these ``... And prochlorperazine both decrease QTc interval preferred in most cases ( Antidote ) both increase sedation safinamide effects and Parkinson! Solifenacin decreases levels of prochlorperazine by inhibition of GI absorption, respiratory depression, and share the with... - use Alternative ( 1 ) prochlorperazine increases effects of bromocriptine by pharmacodynamic synergism orthostatic.
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