Monitor for potential adverse effects such as nausea, irregular uterine bleeding, breast tenderness and headache. QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Use Caution/Monitor. anagrelide and fluconazole both increase QTc interval. Use Caution/Monitor. . Applies only to oral form of both agents. Contraindicated. fluconazole will increase the level or effect of ramelteon by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fluconazole and ranolazine both increase QTc interval. Heart diseaseUse with caution. Belzutifan is a CYP2C19 substrate. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT. Use Caution/Monitor. Minor/Significance Unknown. pentobarbital decreases levels of fluconazole by inhibition of GI absorption. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. It belongs to a class of drugs called azole antifungals. Monitor naldemedine for potential adverse effects if coadministered with strong or moderate CYP3A4 inhibitors. Serious - Use Alternative (1)fluconazole and haloperidol both increase QTc interval. Minor (1)fluconazole decreases levels of streptomycin by unknown mechanism. Serious - Use Alternative (1)macimorelin and fluconazole both increase QTc interval. escitalopram increases toxicity of fluconazole by QTc interval. If unable to avoid coadministration with strong CYP2C9 inhibitors, monitor closely for adverse reactions and consider decreasing dose accordingly. Monitor Closely (1)fluconazole will increase the level or effect of nelfinavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Please do not keep it in your bathroom, as this is often a high-moisture environment. Monitor Closely (1)fluconazole will increase the level or effect of etonogestrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. These side effects may go away during treatment as your body adjusts to the medicine. Modify Therapy/Monitor Closely.fluconazole increases levels of ospemifene by affecting hepatic enzyme CYP2C9/10 metabolism. SIDE EFFECTS: Nausea, diarrhea, stomach pain, headache, or dizziness may occur. Do not double doses. Avoid or Use Alternate Drug. Serious - Use Alternative (1)fluconazole will increase the level or effect of fentanyl intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Specific recommendations for immediate-release (IR) guanfacine are not available. Serious - Use Alternative (1)epinephrine and fluconazole both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. The dose is usually 6 milligrams (mg) per kilogram (kg) of body weight on the first day, followed by 3 mg per kg of body weight once a day, for at least 2 weeks. Minor/Significance Unknown. Use Caution/Monitor. Contraindicated. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. amitriptyline and fluconazole both increase QTc interval. Monitor Closely (1)fluconazole will increase the level or effect of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)oxaliplatin will increase the level or effect of fluconazole by Other (see comment). Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Use Caution/Monitor. Minor (1)fluconazole will increase the level or effect of cevimeline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. It belongs to a drug class called triazole antifungals. Use Caution/Monitor. Inhibition of platelet aggregation by clopidogrel is entirely due to an active metabolite. mobocertinib and fluconazole both increase QTc interval. Contraindicated. Modify Therapy/Monitor Closely. Minor/Significance Unknown. fluconazole decreases effects of Saccharomyces boulardii by unspecified interaction mechanism. Monitor Closely (1)fluconazole will increase the level or effect of rimegepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Read more Did you find an answer to your question? Monitor Closely (1)fluconazole will increase the level or effect of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Use Caution/Monitor. Monitor Closely (1)fluconazole and sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol both decrease serum potassium. Monitor Closely (1)fluconazole will increase the level or effect of ethotoin by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. phenobarbital decreases levels of fluconazole by inhibition of GI absorption. chlorpromazine and fluconazole both increase QTc interval. fluconazole will increase the level or effect of parecoxib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor for adverse effects if lefamulin is coadministered with moderate CYP3A inhibitors.Serious - Use Alternative (1)lefamulin and fluconazole both increase QTc interval. Contraindicated. amoxapine and fluconazole both increase QTc interval. Minor/Significance Unknown. Symptoms of overdose may include: hallucinations, mental/mood changes. PRECAUTIONS: Before taking fluconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungal drugs (such as ketoconazole, itraconazole); or if you have any other allergies. Decrease suvorexant starting dose to 5 mg HS if coadministered with moderate CYP3A4 inhibitors. QTc interval. Although not all of these side effects may occur, if they do occur they may need medical attention. fluconazole will increase the level or effect of voclosporin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. The amount of medicine that you take depends on the strength of the medicine. fluconazole will increase the level or effect of clarithromycin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)fluconazole and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug. Monitor Closely (1)fluconazole will increase the level or effect of estrogens esterified by affecting hepatic/intestinal enzyme CYP3A4 metabolism. goserelin increases toxicity of fluconazole by QTc interval. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Monitor for anemia and hypoxia and reduce belzutifan dose as recommended. Avoid or Use Alternate Drug. fluconazole and venlafaxine both increase QTc interval. Avoid or Use Alternate Drug. For prevention of candidiasis during bone marrow transplantation: ChildrenUse and dose must be determined by your doctor. Minor/Significance Unknown. Minor/Significance Unknown. fluconazole decreases effects of mestranol by increasing metabolism. Serious - Use Alternative (1)fluconazole and moxifloxacin both increase QTc interval. Use Caution/Monitor. Decrease deflazacort dose to one-third of the recommended dose if coadministered with moderate or strong CYP3A4 inhibitors.fluconazole and deflazacort both decrease serum potassium. Avoid or Use Alternate Drug. A single copy of these materials may be reprinted for noncommercial personal use only. May inhibit the conversion of losartan to its active metabolite E-3174. Avoid coadministration of ivabradine with moderate CYP3A4 inhibitors. To do so may increase the chance of side effects. If coadministration with strong or moderate CYP3A4 inhibitors cannot be avoided, reduce selumetinib dosage (refer to selumetinib monograph for further information). Minor (1)rifabutin decreases levels of fluconazole by increasing metabolism. Only applies to oral preparations of both agents. Either increases toxicity of the other by QTc interval. Use Caution/Monitor. Serious - Use Alternative (1)perphenazine and fluconazole both increase QTc interval. Use Caution/Monitor. Most fluconazole increases levels of tolbutamide by decreasing metabolism. Use Caution/Monitor. Serious - Use Alternative (1)fluconazole increases levels of ibrutinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Serious - Use Alternative (1)fluconazole and lumefantrine both increase QTc interval. The mixed oral liquid should be kept in the refrigerator or at room temperature and used within 14 days. Avoid or Use Alternate Drug. Dronabinol is a CYP2C9 substrate. Avoid or Use Alternate Drug. After discontinuation of the strong or moderate CYP3A4 inhibitor for 3 elimination half-lives, resume selumetinib dose that was taken before initiating the inhibitor. fluconazole will increase the level or effect of cevimeline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Minor (1)fluconazole will increase the level or effect of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. in the urine. Contraindicated (1)fluconazole increases levels of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fluconazole and foscarnet both increase QTc interval. Either increases effects of the other by QTc interval. Before using fluconazole, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. Minor/Significance Unknown. Contraindicated (2)erythromycin lactobionate and fluconazole both increase QTc interval. Monitor Closely (1)fluconazole will increase the level or effect of ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)fluconazole increases levels of caffeine by decreasing metabolism. It may harm an unborn baby if taken during the first 3 months of pregnancy. fluconazole will increase the level or effect of estrogens conjugated synthetic by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Serious - Use Alternative (1)fluconazole and ziprasidone both increase QTc interval. By clicking send, you acknowledge that you have permission to email the recipient with this information. fluconazole will increase the level or effect of silodosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Consider decreasing lacosamide dose when coadministered with strong CYP2C9 inhibitors. Increases lomitapide levels several folds. mirtazapine and fluconazole both increase QTc interval. Use Caution/Monitor. fluconazole and entrectinib both increase QTc interval. Avoid or Use Alternate Drug. If coadministration with moderate CYP3A inhibitors cannot be avoided, reduce olaparib dose to 200 mg (capsule) or 150 mg (tablet) PO BID. 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