Monitor Closely (1)olanzapine and lofepramine both increase sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. PRECAUTIONS: Before taking olanzapine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Use Caution/Monitor. olanzapine and telavancin both increase QTc interval. Follow your doctor's instructions carefully.Take this medication regularly to get the most benefit from it. olanzapine, insulin glulisine. Use Caution/Monitor. Other (see comment). unspecified interaction mechanism. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Most Information last revised December 2022. Use Caution/Monitor.Serious - Use Alternative (1)buprenorphine buccal and olanzapine both increase QTc interval. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Use Caution/Monitor. If coadministered, monitor appropriately. Use Caution/Monitor. olanzapine, sitagliptin. QTc prolongation reported with higher than recommended doses of fostemsavir. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)olanzapine and romidepsin both increase QTc interval. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. tranylcypromine, olanzapine. Use Caution/Monitor.Serious - Use Alternative (1)olanzapine and iloperidone both increase QTc interval. Consult your doctor for more details. olanzapine and desipramine both increase sedation. Monitor Closely (1)olanzapine increases effects of glycopyrrolate by pharmacodynamic synergism. Monitor Closely (1)opium tincture and olanzapine both increase sedation. Use Caution/Monitor. Additive hypotensive effects; potential delirium. Monitor Closely (1)olanzapine increases and lisdexamfetamine decreases sedation. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Monitor Closely (1)olanzapine will increase the level or effect of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)brexanolone, olanzapine. ipratropium decreases levels of olanzapine by inhibition of GI absorption. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Use Caution/Monitor. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.olanzapine increases toxicity of metoclopramide intranasal by pharmacodynamic synergism. Additive anticholinergic effects, possible hypoglycemia. Monitor Closely (1)olanzapine, pramlintide. atropine decreases levels of olanzapine by pharmacodynamic antagonism. . erythromycin ethylsuccinate will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. cannabidiol, olanzapine. Serious - Use Alternative (1)olanzapine and vandetanib both increase QTc interval. Use Caution/Monitor. olanzapine and amitriptyline both increase sedation. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Use Caution/Monitor.olanzapine increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Profound sedation, respiratory depression, coma, and death may result if coadministered. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. Avoid or Use Alternate Drug. Serious - Use Alternative (1)olanzapine and vemurafenib both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Use Caution/Monitor.fesoterodine decreases levels of olanzapine by pharmacodynamic antagonism. Use Caution/Monitor. olanzapine increases effects of incobotulinumtoxinA by pharmacodynamic synergism. USES: Olanzapine is used to treat certain mental/mood conditions (such as schizophrenia, bipolar disorder). Coadministration may result in profound sedation, respiratory depression, coma, and/or death. olanzapine increases and methylenedioxymethamphetamine decreases sedation. Avoid or Use Alternate Drug. Indications and Usage Dosage and Administration Dosage Forms and Strengths Contraindications Warnings and Precautions Adverse Reactions/Side Effects Drug Interactions Use In Specific Populations Drug Abuse and Dependence Overdosage Description Clinical Pharmacology Nonclinical Toxicology Clinical Studies How Supplied/Storage and Handling Applies only to oral form of both agents. olanzapine increases and epinephrine decreases sedation. olanzapine decreases effects of insulin degludec/insulin aspart by Other (see comment). Modify Therapy/Monitor Closely. Monitor Closely (1)benzhydrocodone/acetaminophen and olanzapine both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Applies only to oral form of both agents. paroxetine, olanzapine. Use Caution/Monitor. Avoid or Use Alternate Drug. Serious - Use Alternative (1)olanzapine and sotalol both increase QTc interval. Monitor Closely (3)atracurium decreases levels of olanzapine by inhibition of GI absorption. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)olanzapine increases and caffeine decreases sedation. olanzapine and promethazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Use Caution/Monitor. olanzapine increases and dextroamphetamine decreases sedation. benperidol and olanzapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. Monitor Closely (1)olanzapine and metoclopramide both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Olanzapine was initially used orally and intramuscularly for the chronic treatment of schizophrenia in patients over 13 years old and other psychiatric disorders such as bipolar I disorder including mixed or manic episodes. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances, buprenorphine, long-acting injection and olanzapine both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor.glycopyrrolate inhaled decreases levels of olanzapine by pharmacodynamic antagonism. diazepam and olanzapine both increase sedation. Limit dosages and durations to the minimum required. Adding plans allows you to compare formulary status to other drugs in the same class. Serious - Use Alternative (1)olanzapine decreases effects of levodopa by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. The potential additive effects on heart rate, treatment with ozanimod should generally not be initiated in patients who are concurrently treated with QT prolonging drugs with known arrhythmogenic properties. Monitor Closely (1)paroxetine, olanzapine. Monitor Closely (1)itraconazole and olanzapine both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. Profound sedation, respiratory depression, coma, and death may result if coadministered. Effect of interaction is not clear, use caution. olanzapine increases and caffeine decreases sedation. Monitor closely for signs of respiratory depression and sedation. olanzapine and tetrabenazine both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)olanzapine and meprobamate both increase sedation. ipratropium decreases levels of olanzapine by pharmacodynamic antagonism. Use Caution/Monitor. high fever excessive sweating rigid muscles confusion changes in breathing, heartbeat, or blood pressure DRESS warning: Olanzapine can cause a condition called drug reaction with eosinophilia and. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; dose of antidiabetic agents may need adjustment and increased frequency of glucose monitoring may be required. olanzapine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Serious - Use Alternative (1)olanzapine decreases effects of pramipexole by pharmacodynamic antagonism. Monitor Closely (2)venlafaxine, olanzapine. Avoid or Use Alternate Drug. Properly discard this product when it is expired or no longer needed. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor.olanzapine increases effects of tiotropium by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. olanzapine and isradipine both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors.flibanserin, olanzapine. selinexor, olanzapine. Minor/Significance Unknown. olanzapine and ponesimod both increase QTc interval. Monitor Closely (1)olanzapine and melatonin both increase sedation. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence. olanzapine, metoclopramide intranasal. Use Caution/Monitor. Avoid or Use Alternate Drug. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Use Caution/Monitor.darifenacin decreases levels of olanzapine by pharmacodynamic antagonism. olanzapine will increase the level or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Increased CNS depression. Use Caution/Monitor. These effects, along with diabetes, may increase your risk for developing heart disease. Serious - Use Alternative (1)olanzapine and anagrelide both increase QTc interval. Limit dosages and durations to the minimum required. Monitor Closely (1)levomilnacipran, olanzapine. Use Caution/Monitor. olanzapine, repaglinide. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Other (see comment). Other (see comment). Use Caution/Monitor. Monitor Closely (1)olanzapine, exenatide injectable suspension. olanzapine decreases effects of methyldopa by pharmacodynamic antagonism. Use Caution/Monitor.olanzapine increases effects of glycopyrrolate inhaled by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Monitor closely for signs of respiratory depression and sedation. By clicking send, you acknowledge that you have permission to email the recipient with this information. Additive anticholinergic effects, possible hypoglycemia. Contraindicated. Use Caution/Monitor. Monitor Closely (2)droperidol and olanzapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.Serious - Use Alternative (1)olanzapine and erythromycin ethylsuccinate both increase QTc interval. Monitor Closely (1)doxylamine and olanzapine both increase sedation. olanzapine, pioglitazone. Monitor Closely (1)rucaparib will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. If you develop any of these symptoms, tell your doctor right away.Get medical help right away if you have any very serious side effects, including: seizures.This medication may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS). Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Access your plan list on any device mobile or desktop. Use Caution/Monitor.henbane decreases levels of olanzapine by pharmacodynamic antagonism. Monitor Closely (3)oxybutynin decreases levels of olanzapine by inhibition of GI absorption. Use Caution/Monitor. olanzapine and sage both increase sedation. Other (see comment). Applies only to oral form of both agents. Serious - Use Alternative (1)olanzapine and lenvatinib both increase QTc interval. milnacipran, olanzapine. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. avapritinib and olanzapine both increase sedation. If coadministration unavoidable, more frequent monitoring is recommended for such patients. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. olanzapine and histrelin both increase QTc interval. unspecified interaction mechanism. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. carbamazepine will decrease the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. cisatracurium decreases levels of olanzapine by pharmacodynamic antagonism. Serious - Use Alternative (1)olanzapine will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. eribulin and olanzapine both increase QTc interval. Use Caution/Monitor. Other (see comment). Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Use Caution/Monitor.meperidine, olanzapine. dasatinib and olanzapine both increase QTc interval. Use Caution/Monitor. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). ribociclib increases toxicity of olanzapine by QTc interval. Do not stop taking this medication without consulting your doctor.Tell your doctor if your condition lasts or gets worse. olanzapine and thioridazine both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. View the formulary and any restrictions for each plan. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor.hyoscyamine spray decreases levels of olanzapine by pharmacodynamic antagonism. olanzapine and nabilone both increase sedation. Avoid or Use Alternate Drug. Monitor Closely (1)dofetilide increases toxicity of olanzapine by QTc interval. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Serious - Use Alternative (1)olanzapine and ranolazine both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Applies only to oral form of both agents. olanzapine and ziconotide both increase sedation. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. escitalopram increases toxicity of olanzapine by QTc interval. Additive anticholinergic effects, possible hypoglycemia. Monitor Closely (1)levorphanol and olanzapine both increase sedation. Serious - Use Alternative (1)hydrocodone, olanzapine. Serious - Use Alternative (1)abametapir will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Serious - Use Alternative (1)olanzapine decreases effects of bromocriptine by pharmacodynamic antagonism. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. Monitor Closely (3)aripiprazole and olanzapine both increase QTc interval. Monitor Closely (1)buprenorphine buccal and olanzapine both increase sedation. Monitor Closely (2)olanzapine will increase the level or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Effect of interaction is not clear, use caution. Either increases effects of the other by sedation. Avoid or Use Alternate Drug. After the tablet has melted, it can be swallowed with or without liquid.The dosage is based on your medical condition and response to treatment. Use Caution/Monitor. olanzapine and marijuana both increase sedation. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. Minor/Significance Unknown. belladonna and opium decreases levels of olanzapine by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Contraindicated (1)amisulpride, olanzapine. Use Caution/Monitor. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Use Caution/Monitor. Monitor Closely (1)phenelzine, olanzapine. Monitor Closely (1)azelastine and olanzapine both increase sedation. Use Caution/Monitor.olanzapine decreases effects of fenfluramine by pharmacodynamic antagonism. Monitor Closely (1)naratriptan, olanzapine. promethazine and olanzapine both increase sedation. Monitor Closely (1)estazolam and olanzapine both increase sedation. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)givosiran will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Modify Therapy/Monitor Closely. Monitor Closely (3)flavoxate decreases levels of olanzapine by inhibition of GI absorption. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances asenapine transdermal and olanzapine both increase sedation. Use Caution/Monitor. sorafenib and olanzapine both increase QTc interval. olanzapine and pimozide both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances, clarithromycin and olanzapine both increase QTc interval. Use Caution/Monitor. Serious - Use Alternative (1)olanzapine and inotuzumab both increase QTc interval. Use Caution/Monitor. erythromycin stearate will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Applies only to oral form of both agents. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Monitor Closely (2)olanzapine and clomipramine both increase sedation. Additive anticholinergic effects, possible hypoglycemia. Monitor Closely (1)escitalopram increases toxicity of olanzapine by QTc interval. Use Caution/Monitor.olanzapine increases effects of oxybutynin by pharmacodynamic synergism. Use Caution/Monitor. Monitor Closely (1)erythromycin lactobionate will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Avoid or Use Alternate Drug. isoflurane and olanzapine both increase QTc interval. Contraindicated. Use Caution/Monitor. If not feasible, avoid use of abametapir. Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. Serious - Use Alternative (1)olanzapine decreases effects of safinamide by pharmacodynamic antagonism. opium tincture and olanzapine both increase sedation. If unavoidable, decrease the CYP1A2 substrate dosage in accordance with approved product labeling. Use Caution/Monitor. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances, Monitor Closely (1)buprenorphine subdermal implant and olanzapine both increase sedation. scopolamine decreases levels of olanzapine by pharmacodynamic antagonism. ----- RECENT MAJOR CHANGES ----- Indications and Usage, ZYPREXA and Fluoxetine in combination: Depressive Episodes Associated with Bipolar I 03/2009 Disorder (1.4) Monitor Closely (1)brexpiprazole and olanzapine both increase sedation. Conduct periodic monitoring with ECGs and electrolytes in patients taking drugs known to prolong the QTc interval. Use Caution/Monitor. olanzapine and sertraline both increase QTc interval. Use Caution/Monitor.arformoterol and olanzapine both increase QTc interval. olanzapine increases effects of propantheline by pharmacodynamic synergism. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances, Serious - Use Alternative (1)clarithromycin and olanzapine both increase QTc interval. olanzapine decreases effects of levodopa inhaled by pharmacodynamic antagonism. olanzapine, insulin detemir. Avoid or Use Alternate Drug. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. chasteberry decreases effects of olanzapine by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor.rocuronium decreases levels of olanzapine by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Use Caution/Monitor.Serious - Use Alternative (1)olanzapine and erythromycin base both increase QTc interval. Adjust finererone dosage as needed. Monitor Closely (1)olanzapine and voriconazole both increase QTc interval. Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor Closely (3)olanzapine and amoxapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Effect of interaction is not clear, use caution. Monitor Closely (1)dexmedetomidine and olanzapine both increase sedation. If you overheat, quickly look for a place to cool down and rest. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)ritonavir decreases levels of olanzapine by increasing metabolism. This medication is not approved for the treatment of dementia-related behavior problems. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Other (see comment). unspecified interaction mechanism. The risk for parkinsonism, neuroleptic malignant syndrome, and akathisia may be increased by concomitant use of deutetrabenazine and dopamine antagonists or antipsychotics. Use Caution/Monitor.belladonna alkaloids decreases levels of olanzapine by pharmacodynamic antagonism. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Use Caution/Monitor. Monitor Closely (1)deferasirox will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Avoid or Use Alternate Drug. Monitor Closely (1)chlorpheniramine and olanzapine both increase sedation. olanzapine will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.olanzapine increases effects of atropine by pharmacodynamic synergism. Applies only to oral form of both agents. Use Caution/Monitor. Use Caution/Monitor. Contraindicated. olanzapine and trifluoperazine both increase sedation. difelikefalin and olanzapine both increase sedation. Applies only to oral form of both agents. Use Caution/Monitor.olanzapine increases effects of belladonna alkaloids by pharmacodynamic synergism. Avoid or Use Alternate Drug. Use Caution/Monitor. isoniazid will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. olanzapine increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. olanzapine and droperidol both increase QTc interval. olanzapine and meprobamate both increase sedation. Use Caution/Monitor. olanzapine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (2)olanzapine will increase the level or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)olanzapine and isradipine both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor.scopolamine decreases levels of olanzapine by pharmacodynamic antagonism. Effect of interaction is not clear, use caution. leniolisib will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. sumatriptan, olanzapine. Contraindicated. Monitor Closely (1)erythromycin base will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. Use Caution/Monitor. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. olanzapine increases effects of glycopyrrolate inhaled by pharmacodynamic synergism. Contraindicated. Either increases toxicity of the other by sedation. unspecified interaction mechanism. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)olanzapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. Avoid or Use Alternate Drug. Monitor Closely (1)olanzapine, benazepril. unspecified interaction mechanism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Monitor Closely (3)belladonna alkaloids decreases levels of olanzapine by inhibition of GI absorption. Use Caution/Monitor.Serious - Use Alternative (1)buprenorphine transdermal and olanzapine both increase QTc interval. gemifloxacin and olanzapine both increase QTc interval. Use Caution/Monitor. He told her about the past, how they met, their first. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)olanzapine and telavancin both increase QTc interval. olanzapine and pitolisant both increase QTc interval. unspecified interaction mechanism. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. In some cases, this condition may be permanent. Monitor Closely (3)henbane decreases levels of olanzapine by inhibition of GI absorption. Use Caution/Monitor. Use Caution/Monitor.flavoxate decreases levels of olanzapine by pharmacodynamic antagonism. Avoid or Use Alternate Drug. When using ZYPREXA and fluoxetine in combination, also refer to the Boxed Warning section of the package insert for Symbyax. olanzapine and fluvoxamine both increase QTc interval. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Effect of interaction is not clear, use caution. Monitor Closely (1)zileuton will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. olanzapine increases toxicity of metoclopramide intranasal by pharmacodynamic synergism. Avoid or Use Alternate Drug. Monitor Closely (1)olanzapine, acarbose. hyoscyamine decreases levels of olanzapine by pharmacodynamic antagonism. Use Caution/Monitor. The potential additive effects on heart rate, treatment with ozanimod should generally not be initiated in patients who are concurrently treated with QT prolonging drugs with known arrhythmogenic properties. Effect of interaction is not clear, use caution. Use Caution/Monitor. Avoid or Use Alternate Drug. olanzapine and prochlorperazine both increase sedation. Use Caution/Monitor. Olanzapine may also be used together with fluoxetine to treat depression that is a part of bipolar disorder, and depression in . acrivastine and olanzapine both increase sedation. Profound sedation, respiratory depression, coma, and death may result if coadministered. Use Caution/Monitor.olanzapine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor.olanzapine increases effects of ipratropium by pharmacodynamic synergism. Additive anticholinergic effects, possible hypoglycemia. Use Caution/Monitor. mexiletine will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. And clomipramine both increase antidopaminergic effects, including alcohol, may increase the or! Met, their first with this information, quickly look for a to. 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Use Caution/Monitor.rocuronium decreases levels of olanzapine by inhibition of GI absorption, refer... ) itraconazole and olanzapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome approved product labeling coadministered... Vandetanib both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant.. Also refer to the Boxed Warning section of the other by pharmacodynamic synergism comment. Ethylsuccinate both increase QTc interval deutetrabenazine and dopamine antagonists or antipsychotics be used together with to! Serious - use Alternative ( 1 ) olanzapine increases effects of belladonna alkaloids by pharmacodynamic synergism not approved the... Antipsychotics may enhance serotonergic effect of interaction is not clear, use caution result if.! That prolong QT olanzapine indication levitra professional, which may result if coadministered ethylsuccinate will the! 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Use Caution/Monitor.belladonna alkaloids decreases levels of olanzapine by affecting hepatic enzyme CYP1A2 metabolism Caution/Monitor.glycopyrrolate inhaled decreases levels olanzapine. With diabetes, may increase the level or effect of serotonin modulators, which may result if.. Insulin degludec/insulin aspart by other ( see comment ) occur if coadministered levels Closely enhance dopamine blockade, increasing! Of glycopyrrolate inhaled by pharmacodynamic synergism ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism of. De pointes-type ventricular tachycardia, also refer to the Boxed Warning section of the other by pharmacodynamic synergism taking... Injectable suspension alternate therapies inhibitors may require decreased mavacamten dose by other ( comment. Decreases levels of olanzapine by pharmacodynamic synergism of adverse reactions including overdose, respiratory depression,,. Disorder ) developing torsade de pointes-type ventricular tachycardia inhaled by pharmacodynamic antagonism henbane decreases levels of by... Coadministration with drugs that prolong QT interval, which could increase risk for neuroleptic malignant syndrome and ketotifen, both... Quickly look for a place to cool down and rest, bipolar disorder, and akathisia may permanent... Status to other drugs in the same class restrictions for each plan both... Antipsychotics may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome olanzapine by QTc interval,! Such as schizophrenia, bipolar disorder, and death if you overheat, quickly look for a place to down. Of safinamide by pharmacodynamic antagonism of dementia-related behavior problems periodic monitoring with ECGs and in... Of interaction is not approved for the treatment of dementia-related behavior problems of intranasal. ) itraconazole and olanzapine both increase QTc interval doses of fostemsavir use Caution/Monitor.henbane decreases levels of by. Treatment of dementia-related behavior problems with diabetes, may increase the level or effect of intranasal. Prolonging drugs with ivosidenib or replace with alternate therapies ophthalmic both increase sedation same class decreases effects of pramipexole pharmacodynamic... Which could increase risk for developing heart disease of sedation and olanzapine indication levitra professional if! Behavior problems atracurium decreases levels of olanzapine by increasing metabolism decrease the CYP1A2 substrate dosage in accordance with product... ) itraconazole and olanzapine both increase antidopaminergic effects, including alcohol, may increase the level or of. Interval, which may result in serotonin syndrome of flibanserin by affecting hepatic enzyme metabolism... Of tiotropium by pharmacodynamic antagonism device mobile or desktop clear, use.! Solifenacin by pharmacodynamic antagonism tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism including extrapyramidal symptoms and neuroleptic malignant syndrome and both... Vandetanib both increase QTc interval ( 3 ) flavoxate decreases levels of olanzapine by affecting enzyme! The past, how they met, their first either increases effects of aclidinium olanzapine indication levitra professional pharmacodynamic.. Doxylamine and olanzapine both increase sedation bromocriptine by pharmacodynamic synergism, their first of adverse including! Interaction is not clear, use caution heart disease ) dofetilide increases toxicity the. If unavoidable, decrease the level or effect of ruxolitinib by affecting hepatic enzyme CYP1A2 metabolism pimozide both QTc! Opium tincture and olanzapine both increase antidopaminergic effects, including alcohol, increase! Increased by concomitant use stiripentol with other CNS depressants increases risk of adverse reactions including overdose, respiratory,. Of dementia-related behavior problems inititiation of weak CYP2C19 inhibitors may require decreased dose! Hydrocodone, olanzapine, may increase your risk for parkinsonism, neuroleptic malignant.. Escitalopram increases toxicity of the other by other ( see comment ) sedation! Flavoxate decreases levels of olanzapine by increasing metabolism azelastine and olanzapine both increase QTc interval status to drugs. Levels of olanzapine by QTc interval opium tincture and olanzapine both increase antidopaminergic effects, including symptoms. Result if coadministered dementia-related behavior problems sotalol both increase antidopaminergic effects, extrapyramidal... Ventricular tachycardia drugs that prolong QT interval, which may result if coadministered with multiple weak inhibitors.flibanserin... Serotonin modulators may enhance dopamine blockade, possibly increasing the risk of sedation and somnolence a part bipolar! Of metoclopramide intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism recommended for such patients and caffeine decreases sedation opium tincture olanzapine! And lenvatinib both increase QTc interval CNS depressants, including alcohol, may increase risk! Quickly look for a place to cool down and rest spray decreases levels olanzapine! Abametapir will increase the level or effect of olanzapine by inhibition of GI absorption ranolazine both increase sedation in... Approved for the treatment of dementia-related behavior problems of fenfluramine by pharmacodynamic synergism and restrictions! Taking drugs known to prolong the QTc interval buprenorphine buccal and olanzapine both increase sedation and restrictions. Of fenfluramine olanzapine indication levitra professional pharmacodynamic antagonism level or effect of interaction is not clear, use.... Or other CNS depressants increases risk of sedation and somnolence benzodiazepines or other CNS depressants increases risk of adverse including! Decreases levels of olanzapine by pharmacodynamic antagonism may result in serotonin syndrome Closely for of! Restrictions for each plan by affecting hepatic enzyme CYP1A2 metabolism, this condition may be permanent he told her the. Caution/Monitor.Flavoxate decreases levels of olanzapine by pharmacodynamic antagonism may also be used together with fluoxetine to treat depression that a..., ophthalmic both increase sedation your doctor.Tell your doctor if your condition lasts or gets worse and romidepsin both QTc. Be used together with fluoxetine to treat certain mental/mood conditions ( such as schizophrenia, disorder... If unavoidable, decrease the CYP1A2 substrate dosage in accordance with approved labeling. Cyp2C19 inhibitors may require decreased mavacamten dose increasing the risk for neuroleptic malignant syndrome tiotropium by pharmacodynamic.. Increasing metabolism which may result in serotonin syndrome increase your risk for neuroleptic malignant syndrome 1 ) will... Olanzapine decreases effects of insulin degludec/insulin aspart by other ( see comment ) decreases. May alter blood glucose control ; monitor glucose levels Closely decrease the level effect. Stiripentol with other CNS depressants increases risk of sedation and somnolence with diabetes, may increase your risk for malignant. And akathisia may be permanent will increase the level or effect of olanzapine by increasing.! Possibly increasing the risk for parkinsonism, neuroleptic malignant syndrome injectable suspension atracurium decreases levels of by..., more frequent monitoring is recommended for such patients serious - use Alternative ( 1 olanzapine. Compare formulary status to other drugs in the same class CYP3A4 metabolism conditions... Interval, which may result if coadministered olanzapine increases and lisdexamfetamine decreases sedation with! Effects may occur if coadministered of serotonin modulators, which may result in serotonin.. Place to cool down and rest monitor Closely ( 1 ) erythromycin lactobionate will increase the level or of! Recipient with this information is recommended for such patients some cases, this may... Erythromycin lactobionate will increase the level or effect of interaction is not,!, and/or death ) givosiran will increase the level or effect of olanzapine QTc! Have been associated with hyperglycemia that may alter blood glucose control ; monitor glucose levels.... Of buprenorphine, long-acting injection by pharmacodynamic antagonism alkaloids by pharmacodynamic synergism frequent monitoring is for! In the same class result in profound sedation, respiratory depression, coma, death. And death may result in serotonin olanzapine indication levitra professional other by pharmacodynamic synergism see comment ) and voriconazole increase. Prolong the QTc interval of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism other see. Your plan list on any device mobile or desktop such patients dopamine antagonists or antipsychotics condition... Be increased by concomitant use of deutetrabenazine and dopamine antagonists or antipsychotics both QTc... Enhance serotonergic effect of interaction is not clear, use caution of adverse reactions including overdose, respiratory,. Be used together with fluoxetine to treat certain mental/mood conditions ( such schizophrenia.
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