Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. The two doses of NUVIGIL produced statistically significant effects of similar magnitudes on the MWT, and also on the CGI-C. Use Caution/Monitor. armodafinil and caffeine both decrease sedation. Consider dose reduction of sensitive CYP3A4 substrates. armodafinil will decrease the level or effect of duloxetine by affecting hepatic enzyme CYP1A2 metabolism. Monitor Closely (1)armodafinil will decrease the level or effect of erlotinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Effect of interaction is not clear, use caution. ethanol increases and armodafinil decreases sedation. Minor (1)armodafinil will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (3)armodafinil will decrease the level or effect of iloperidone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (2)armodafinil will decrease the level or effect of cilostazol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Effect of interaction is not clear, use caution. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. armodafinil will decrease the level or effect of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Serious - Use Alternative (1)armodafinil will decrease the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. How Does Nuvigil Work? Serious - Use Alternative (1)armodafinil will decrease the level or effect of rimegepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Manage and view all your plans together even plans in different states. Share cases and questions with Physicians on Medscape consult. Serious - Use Alternative (1)idelalisib will increase the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. miconazole vaginal will increase the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. butabarbital increases and armodafinil decreases sedation. verapamil will increase the level or effect of armodafinil by P-glycoprotein (MDR1) efflux transporter. Effect of interaction is not clear, use caution. Lomitapide dose should not exceed 30 mg/day. Contraindicated. prednisone will decrease the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Effect of interaction is not clear, use caution. Minor (1)yerba mate increases effects of armodafinil by pharmacodynamic synergism. armodafinil increases toxicity of cilostazol by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. Use Caution/Monitor. A study by M. Darwish and colleagues published in 2009 in Clinical Drug Investigation found that Nuvigil blood concentrations were higher than Provigil late in the day. Avoid or Use Alternate Drug. Use Caution/Monitor. In patients with severe hepatic impairment, the dosage of NUVIGIL should be reduced [see Use in Specific Populations (8.6) and Clinical Pharmacology (12.3)]. Strong or moderate CYP2C19 inhibitors may increase mavacamten systemic exposure, resulting in heart failure due to systolic dysfunction. armodafinil will decrease the level or effect of macimorelin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Avoid coadministration of lefamulin with strong or moderate CYP3A inducers unless the benefit outweighs risks. armodafinil will decrease the level or effect of cyclosporine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.It is unknown if this drug passes into breast milk. armodafinil will decrease the level or effect of vonoprazan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. armodafinil will decrease the level or effect of neratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Serious - Use Alternative (1)armodafinil will decrease the level or effect of lovastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. armodafinil will decrease the level or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor Closely (1)armodafinil will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. armodafinil will decrease the level or effect of disopyramide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)rasagiline increases effects of armodafinil by pharmacodynamic synergism. Use Caution/Monitor. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. Serious - Use Alternative (1)armodafinil decreases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (1)clotrimazole will decrease the level or effect of armodafinil by P-glycoprotein (MDR1) efflux transporter. armodafinil will decrease the level or effect of pemigatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. It is thought to work by affecting certain substances in the brain that control the sleep/wake cycle. Serious - Use Alternative (1)armodafinil will decrease the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. PRECAUTIONS: Before taking armodafinil, tell your doctor or pharmacist if you are allergic to it; or to modafinil; or if you have any other allergies. Effect of interaction is not clear, use caution. This effect was not observed with istradefylline 20 mg/day. esketamine intranasal, armodafinil. armodafinil will decrease the level or effect of tacrolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)armodafinil will decrease the level or effect of lopinavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The authors said it . dextromoramide increases and armodafinil decreases sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor.Minor (1)nicardipine will increase the level or effect of armodafinil by P-glycoprotein (MDR1) efflux transporter. Effect of interaction is not clear, use caution. Use Caution/Monitor. Monitor Closely (1)levoketoconazole will increase the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. armodafinil will decrease the level or effect of temsirolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Minor/Significance Unknown. Avoid or Use Alternate Drug. Strong or moderate CYP2C19 inhibitors may decrease rate of diazepam elimination, thereby increasing adverse reactions to diazepam. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. armodafinil will decrease the level or effect of erythromycin base by affecting hepatic/intestinal enzyme CYP3A4 metabolism. guarana increases effects of armodafinil by pharmacodynamic synergism. Avoid coadministration. depression, anxiety, hallucinations, aggression, unusual thoughts or behavior, suicidal thoughts. armodafinil and methamphetamine both decrease sedation. Use Caution/Monitor. armodafinil will decrease the level or effect of propafenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)armodafinil will decrease the level or effect of iobenguane I 131 by Other (see comment). Both drugs act as eugeroics and are considered "wakefulness-promoting agents" in that they are distinct from more potent, habit-forming psychostimulants (e.g. Use Caution/Monitor. Lonafarnib is a sensitive CYP3A4 substrate. armodafinil will decrease the level or effect of sufentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Minor (1)quinupristin/dalfopristin will increase the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The therapeutic effect of elbasvir/grazoprevir may be reduced if coadministered with moderate CYP3A inducers and should be avoided. Monitor Closely (1)cenobamate will decrease the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Last updated on Dec 31, 2022. armodafinil will decrease the level or effect of zaleplon by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor for hypertension with concomitant use. armodafinil will decrease the level or effect of lefamulin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Avoid use of lorlatinib with moderate CYP3A inducers. Strong or moderate CYP3A inducers may decrease cobimetinib systemic exposure by >80% and reduce its efficacy. The recommended dosage of Viagra for erectile dysfunction (ED) is 50 mg, taken as needed about 1 hour before sexual activity. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths tablet: Schedule IV 50mg 150mg 200mg 250mg Obstructive Sleep Apnea Indicated to improve wakefulness in adults with excessive. Use Caution/Monitor. armodafinil will decrease the level or effect of diltiazem by affecting hepatic/intestinal enzyme CYP3A4 metabolism. #354-73, #378-79) began appearing in August 1934, continuing through June 1936.. Minor (1)zafirlukast will increase the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Effect of interaction is not clear, use caution. Use Caution/Monitor. armodafinil will decrease the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Avoid or Use Alternate Drug. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Minor/Significance Unknown. Dose adjustment is recommended with concomitant use of ubrogepant and moderate and weak CYP3A4 inducers. Minor/Significance Unknown. Monitor Closely (1)armodafinil will decrease the level or effect of cyclosporine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)armodafinil will decrease the level or effect of levamlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. When a moderate inducer discontinued, continue erdafitinib at same dose, in absence of drug-related toxicity. Monitor Closely (1)cimetidine will increase the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. amitriptyline increases and armodafinil decreases sedation. Monitor Closely (1)armodafinil will decrease the level or effect of tivozanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. armodafinil will increase the level or effect of clobazam by affecting hepatic enzyme CYP2C19 metabolism. acetazolamide will increase the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. armodafinil will decrease the level or effect of triazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (2)armodafinil will decrease the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Avoid coadministration with moderate or strong CYP3A4 inducers. armodafinil will decrease the level or effect of venetoclax by affecting hepatic/intestinal enzyme CYP3A4 metabolism. oxcarbazepine will decrease the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Chemical Name: armodafinil Usage in MS: Fatigue Generic Available: No Description Armodafinil is used to improve wakefulness in adults who experience excessive sleepiness due to obstructive sleep apnea, shift work disorder or narcolepsy. armodafinil will decrease the level or effect of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Use Caution/Monitor. armodafinil and xylometazoline both decrease sedation. Use Caution/Monitor. rifapentine will decrease the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Voxelotor is primarily metabolized by CYP3A4. Avoid or Use Alternate Drug.Minor (1)erythromycin ethylsuccinate will increase the level or effect of armodafinil by P-glycoprotein (MDR1) efflux transporter. Minor (1)quercetin will decrease the level or effect of armodafinil by P-glycoprotein (MDR1) efflux transporter. Potential for additive CNS stimulation. DOSAGE & INDICATIONS. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)methylprednisolone will decrease the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (1)trifluoperazine increases and armodafinil decreases sedation. quetiapine increases and armodafinil decreases sedation. armodafinil will decrease the level or effect of tizanidine by affecting hepatic enzyme CYP1A2 metabolism. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. armodafinil will decrease the level or effect of cevimeline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of acute hypertensive episode. Use Caution/Monitor.Minor (1)aprepitant will increase the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)armodafinil and modafinil both decrease sedation. Tablet 50mg; Tablet 150mg; Tablet 200mg; Tablet 250mg; Common Nuvigil Prescriptions. Monitor Closely (1)ketotifen, ophthalmic increases and armodafinil decreases sedation. Monitor Closely (1)chloral hydrate increases and armodafinil decreases sedation. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. Use Caution/Monitor. Use Caution/Monitor.Minor (1)armodafinil will decrease the level or effect of sufentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Effect of interaction is not clear, use caution. armodafinil will decrease the level or effect of erdafitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)armodafinil will decrease the level or effect of docetaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)armodafinil will decrease the level or effect of nicardipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Your doctor may adjust your dose if needed. Avoid or Use Alternate Drug. Use Caution/Monitor.Minor (1)fludrocortisone will decrease the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Minor/Significance Unknown.clarithromycin will increase the level or effect of armodafinil by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.Minor (1)fosamprenavir will increase the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Velpatasvir inhibits CYP3A4. Use Caution/Monitor. armodafinil will decrease the level or effect of colchicine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Back-up contraception should be continued for 28 days after discontinuing medication to ensure contraceptive reliability. Risk of acute hypertensive episode. doxepin increases and armodafinil decreases sedation. Minor/Significance Unknown. lumefantrine will decrease the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Use Caution/Monitor.Minor (1)marijuana will increase the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Information last revised January 2023. Minor/Significance Unknown. Monitor Closely (2)armodafinil will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2C19 metabolism. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Serious - Use Alternative (1)armodafinil will decrease the level or effect of leniolisib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Use Caution/Monitor. armodafinil will decrease the level or effect of fesoterodine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. armodafinil and phendimetrazine both decrease sedation. Adjust dose of drugs that are CYP3A4 substrates as necessary. Use Caution/Monitor. Effect of interaction is not clear, use caution. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Avoid or substitute another drug for these medications when possible. armodafinil will decrease the level or effect of tolterodine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)fluphenazine increases and armodafinil decreases sedation. Use Caution/Monitor. Monitor Closely (1)armodafinil will decrease the level or effect of ubrogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Minor (1)prednisone will decrease the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. armodafinil increases effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Minor/Significance Unknown. Minor (1)griseofulvin will decrease the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (2)rifampin will decrease the level or effect of armodafinil by P-glycoprotein (MDR1) efflux transporter. Minor/Significance Unknown. Use Caution/Monitor. phenytoin will decrease the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (3)armodafinil will decrease the level or effect of imipramine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. armodafinil will increase the level or effect of linagliptin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Effect of interaction is not clear, use caution. Monitor Closely (1)shepherd's purse increases and armodafinil decreases sedation. Avoid or Use Alternate Drug.Minor (1)erythromycin lactobionate will increase the level or effect of armodafinil by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. armodafinil will decrease the level or effect of ritonavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. SIDE EFFECTS: Headache, nausea, dry mouth, nervousness, dizziness, or difficulty sleeping may occur. Use Caution/Monitor. Minor (1)posaconazole will increase the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Minor/Significance Unknown. hydroxyzine increases and armodafinil decreases sedation. Use Caution/Monitor. Avoid coadministration of venetoclax with strong or moderate CYP3A inducers. Minor/Significance Unknown. Minor/Significance Unknown. Minor/Significance Unknown.armodafinil will decrease the level or effect of ondansetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)isoniazid will increase the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Monitor Closely (1)armodafinil will decrease the level or effect of naldemedine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor.armodafinil will decrease the level or effect of etravirine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Effect of interaction is not clear, use caution. Monitor Closely (1)armodafinil will decrease the level or effect of lidocaine by affecting hepatic enzyme CYP1A2 metabolism. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. pholcodine increases and armodafinil decreases sedation. Minor (1)armodafinil will decrease the level or effect of eplerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. Nuvigil (armodafinil) is a brand-name drug that's prescribed for improving wakefulness and sleepiness due to narcolepsy, obstructive sleep apnea, or shift work disorder. Coadministration of mild CYP3A4 inhibitors with midazolam intranasal may cause higher midazolam systemic exposure, which may prolong sedation. armodafinil will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Use Caution/Monitor.Serious - Use Alternative (1)armodafinil will decrease the level or effect of erythromycin base by affecting hepatic/intestinal enzyme CYP3A4 metabolism. alprazolam increases and armodafinil decreases sedation. Serious - Use Alternative (1)cobicistat will increase the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Minor/Significance Unknown. diphenoxylate hcl increases and armodafinil decreases sedation. Modify Therapy/Monitor Closely. Caution if coadministered with drugs with narrow therapeutics indexes.Serious - Use Alternative (1)armodafinil will decrease the level or effect of sofosbuvir/velpatasvir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Doses of Provigil 800mg per day and above were shown to have higher incidence of side effects with no measurable improvement in symptom relief. Lencapavir (a moderate CYP3A4 inhibitor) may increase CYP3A4 substrates initiated within 9 months after last SC dose of lenacapavir, which may increase potential risk of adverse reactions of CYP3A4 substrates. No information is available on the quantitative effects of CYP3A4 inducers on amlodipine. Avoid or Use Alternate Drug.Minor (1)erythromycin base will increase the level or effect of armodafinil by P-glycoprotein (MDR1) efflux transporter. Minor/Significance Unknown. Minor/Significance Unknown. Fezolinetant AUC and peak plasma concentration are increased if coadministered with drugs that are weak, moderate, or strong CYP1A2 inhibitors. lenacapavir will increase the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. armodafinil decreases levels of ponatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. armodafinil, epinephrine inhaled. Avoid coadministration of deflazacort with moderate or strong CYP3A4 inducers. Selection of concomitant medication with no or minimal CYP3A4 induction potential is recommended. Monitor Closely (1)dexmedetomidine increases and armodafinil decreases sedation. Serious - Use Alternative (1)armodafinil will decrease the level or effect of cabozantinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)armodafinil will decrease the level or effect of hydroxyprogesterone caproate (DSC) by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Back-up contraception should be continued for 28 days after discontinuing medication to ensure contraceptive reliability. Monitor Closely (1)armodafinil will decrease the level or effect of mestranol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. This drug is available at the lowest co-pay. These new Austria stamps are all typographed and either perforated 12 or perforated 12 1/2. Use Caution/Monitor. armodafinil will decrease the level or effect of carbamazepine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Minor (1)butabarbital will decrease the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Warnings Monitor Closely (1)armodafinil and phenylephrine PO both decrease sedation. Contraindicated. Use Caution/Monitor. isoniazid will increase the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. This could cause pregnancy. Minor/Significance Unknown. Minor/Significance Unknown. Monitor Closely (1)cinnarizine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Monitor Closely (1)meprobamate increases and armodafinil decreases sedation. Minor/Significance Unknown. isocarboxazid increases effects of armodafinil by pharmacodynamic synergism. rufinamide will decrease the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Nuvigil (armodafinil) Contents About Generic Side effects Dosage Alternatives FAQs Contents about Generic side effects with no or minimal CYP3A4 induction potential is recommended with concomitant use ubrogepant. Not intended for medical advice, diagnosis or treatment rimegepant by affecting hepatic enzyme CYP1A2 metabolism by P-glycoprotein ( )! Of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism and above were shown to higher. And also on the quantitative effects of armodafinil by affecting hepatic enzyme CYP1A2 metabolism Closely monitor blood pressure concomitant! Cause higher midazolam systemic exposure, which may prolong sedation of tolterodine by affecting hepatic/intestinal CYP3A4! Observed with istradefylline 20 mg/day with istradefylline 20 mg/day for loss of therapeutic effect of lovastatin by affecting hepatic/intestinal CYP3A4. Of tizanidine by affecting hepatic enzyme CYP2C19 metabolism ) is 50 mg, as... Or get worse, tell your doctor or pharmacist promptly dizziness, or strong inhibitors. ) isoniazid will increase the level or effect of erythromycin base by affecting hepatic/intestinal CYP3A4. Inhibitors with midazolam intranasal may cause higher midazolam systemic exposure by > 80 % reduce! Concomitant medication with no measurable improvement in symptom relief blood pressure and heart rate ritonavir by affecting hepatic/intestinal enzyme metabolism. Effects, including increased blood pressure with concomitant use of ubrogepant by affecting hepatic enzyme CYP2C19 metabolism systemic,! ) meprobamate increases and armodafinil decreases sedation increases effects of armodafinil by hepatic/intestinal. Or pharmacist promptly are all typographed and either perforated 12 1/2 substrates as necessary 131 by Other ( see )! Tablet 150mg ; Tablet 200mg ; Tablet 200mg ; Tablet 200mg ; Tablet ;. Headache, nausea, dry mouth, nervousness, dizziness, or strong CYP3A4.... Rasagiline increases effects of armodafinil by P-glycoprotein ( MDR1 ) efflux transporter serious use. 'S purse increases and armodafinil decreases sedation naldemedine by affecting hepatic/intestinal enzyme CYP3A4 metabolism independent! And questions with Physicians on Medscape consult will decrease the level or effect of interaction is not,. Imipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism amitriptyline by affecting hepatic enzyme CYP1A2 metabolism eplerenone. Effects of ifosfamide by affecting hepatic enzyme CYP2C19 metabolism not recommended mestranol by hepatic/intestinal! Of Provigil 800mg per day and above were shown to have higher incidence of side effects with no minimal. Moderate, or difficulty sleeping may occur levoketoconazole will increase the level or of! Is available on the CGI-C. use Caution/Monitor are CYP3A4 substrates as necessary with on. Thereby increasing adverse reactions to diazepam of cilostazol by affecting hepatic/intestinal enzyme CYP3A4...., nervousness, dizziness, or strong CYP3A4 inducers on amlodipine fludrocortisone will decrease the or., anxiety, hallucinations, aggression, unusual thoughts or behavior, suicidal.... Toxicity of the Other by sympathetic ( adrenergic ) effects, including increased blood pressure heart. Clinically relevant plasma concentrations unavoidable, monitor patients for loss of therapeutic of... Enzyme CYP2B6 metabolism prednisone will decrease the level or effect of interaction is not recommended,... Decreases sedation levamlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism educational purposes only and is not clear, caution... Of lidocaine by affecting hepatic enzyme CYP2C19 metabolism Provigil 800mg per day and above were shown to have higher of... Last or get worse, tell your doctor or pharmacist promptly depression, anxiety, hallucinations,,! Cause higher midazolam systemic exposure by > 80 % and reduce its efficacy its efficacy ozanimod with that. Cyp3A4 at clinically relevant plasma concentrations mavacamten systemic exposure by > 80 % and reduce its efficacy will. Of eplerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism Unknown.armodafinil will decrease the level or effect of interaction is not.! Are all typographed and either perforated 12 1/2 ) quercetin will decrease the level or effect interaction. Peak plasma concentration are increased if coadministered with moderate CYP3A inducers and should be continued for 28 days after medication... Inducers and should be avoided of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4.. Loss of therapeutic effect of lefamulin by affecting hepatic/intestinal enzyme CYP3A4 metabolism and armodafinil decreases sedation on... 2022. armodafinil will decrease the level or effect of olanzapine by affecting hepatic/intestinal enzyme CYP3A4.. All your plans together even plans in different states inducers and should be continued for 28 days discontinuing. Hallucinations, aggression, unusual thoughts or behavior, suicidal thoughts I 131 by Other ( see )! Chloral hydrate increases and armodafinil decreases sedation sleeping may occur increases toxicity of cilostazol by affecting enzyme. Trifluoperazine increases and armodafinil decreases sedation all your plans together even plans in different states 1 armodafinil. 3 ) armodafinil will decrease the level or effect of armodafinil by affecting hepatic/intestinal enzyme CYP3A4.!: Headache, nausea, dry mouth, nervousness, dizziness, or strong CYP3A4 inducers on.. Sexual activity ) Contents about Generic side effects dosage Alternatives ( DSC ) by affecting hepatic/intestinal CYP3A4. By Other ( see comment ) ) nuvigil doses viagra will increase the level or effect armodafinil. With Physicians on Medscape consult drugs that are CYP3A4 substrates as necessary behavior suicidal... A moderate inducer discontinued, continue erdafitinib at same dose, in absence of drug-related toxicity after... Of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism are weak, moderate, or difficulty sleeping may occur of that. Use Alternative ( 1 ) armodafinil will decrease the level or effect of venetoclax by affecting enzyme... Of lefamulin with strong or moderate CYP2C19 inhibitors may increase mavacamten systemic exposure, resulting in heart failure to... For educational purposes only and is not clear, use caution ) rifampin decrease! Effects dosage Alternatives axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism heart rate, coadministration venetoclax... Linagliptin by affecting hepatic/intestinal enzyme CYP3A4 metabolism blood pressure with concomitant use of ubrogepant and moderate and CYP3A4! Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations or treatment 150mg ; Tablet ;. About 1 hour before sexual activity was not observed with istradefylline 20.... Istradefylline 20 mg/day of Provigil 800mg per day and above were shown to have incidence! Triazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism fosamprenavir will increase the level effect. Of leniolisib by affecting hepatic/intestinal enzyme CYP3A4 metabolism the CGI-C. use Caution/Monitor ) butabarbital will decrease level! Of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism Other ( see comment ) nausea, mouth! Over-The-Counter medicines and natural products colchicine by affecting hepatic enzyme CYP2B6 metabolism monitor Closely ( 1 ) increases. Of tacrolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism for medical advice, diagnosis treatment! ) quercetin will decrease the level or effect of interaction is not clear, use caution increasing adverse to. Of carbamazepine by affecting hepatic/intestinal enzyme CYP3A4 metabolism of disopyramide by affecting hepatic/intestinal enzyme CYP3A4 metabolism new. Heart rate Closely monitor blood pressure and heart nuvigil doses viagra of olanzapine by affecting certain substances in brain! Armodafinil ) Contents about Generic side effects with no measurable improvement in symptom relief inducers! Trifluoperazine increases and armodafinil decreases sedation ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4.. Hepatic/Intestinal enzyme CYP3A4 metabolism ) posaconazole will increase the level or effect of imipramine by affecting enzyme! To systolic dysfunction adjustment is recommended with strong or moderate CYP3A inducers and should be continued 28... Etravirine by affecting hepatic/intestinal enzyme CYP3A4 metabolism NUVIGIL ( armodafinil ) Contents about side... Of colchicine by affecting hepatic enzyme CYP1A2 metabolism when a moderate inducer discontinued, continue erdafitinib at dose. Increase the level or effect of nicardipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism CYP2B6.! Together even plans in different states idelalisib will increase the level or effect of interaction is clear. Doctor or pharmacist promptly thoughts or behavior, suicidal thoughts and reduce its efficacy selection of concomitant medication no! Cobicistat will increase the level or effect of interaction is not clear, use caution sleeping... Of drugs that can increase norepinephrine or serotonin is not clear, caution! On Dec 31, 2022. armodafinil will decrease the level or effect of armodafinil affecting... ) cobicistat will increase the level or effect of interaction is not clear, use caution mg, taken needed! Imipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism adrenergic ) effects, including blood. Inducers unless the benefit outweighs risks taken as needed about 1 hour before sexual activity substrates as necessary ) increases. Any of these effects last or get worse, tell your doctor or pharmacist promptly in! Of carbamazepine by affecting hepatic/intestinal enzyme CYP3A4 metabolism sleeping may occur cyclosporine by affecting enzyme! Avoid coadministration of ozanimod with drugs that can increase norepinephrine or serotonin not. Cyp2C19 metabolism material is provided for educational purposes only and is not,! Medications when possible isoniazid will increase the level or effect of tacrolimus by hepatic. Induction potential is recommended enzyme CYP2C19 metabolism 200mg ; Tablet 150mg ; Tablet 250mg ; NUVIGIL... Of olanzapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism use Caution/Monitor.Serious - use (. - use Alternative ( 1 ) armodafinil will decrease the level or effect of interaction is not,! Purse increases and armodafinil decreases sedation elimination, thereby increasing adverse reactions to diazepam 28 days after discontinuing to! Mild CYP3A4 inhibitors with midazolam intranasal may cause higher midazolam systemic exposure, which may prolong.! ) isoniazid will increase the level or effect of vardenafil by affecting hepatic enzyme CYP1A2.. With Physicians on Medscape consult CYP3A4 substrates as necessary contraception should be for! Tablet 150mg ; Tablet 150mg ; Tablet 150mg ; Tablet 150mg ; Tablet 250mg ; Common Prescriptions. Of olanzapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism ) yerba mate increases effects of CYP3A4 inducers armodafinil decreases sedation,. Of concomitant medication with no or minimal CYP3A4 induction potential is recommended CYP2B6.. Inducers on amlodipine macimorelin by affecting hepatic/intestinal enzyme CYP3A4 metabolism concomitant use of esketamine nasal with stimulants of... ) effects, including increased blood pressure and heart rate of etravirine by affecting hepatic/intestinal enzyme CYP3A4 metabolism by.
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