Consider therapy modification, TiZANidine: CYP1A2 Inhibitors (Weak) may increase the serum concentration of TiZANidine. Norethisterone shows side effects like headache, nausea, stomach pain, vaginal spotting, dizziness, and breast tenderness. Norethisterone is not recommended for use if you are pregnant, as it can cause hormonal changes and affect your pregnancy. The Norethisterone is injected slowly into a muscle in your buttock. Consider therapy modification, CloZAPine: CYP1A2 Inhibitors (Weak) may increase the serum concentration of CloZAPine. Consider therapy modification, Nafcillin: May increase the metabolism of Estrogen Derivatives (Contraceptive). Management: For patients using hormone-based contraception, a high-dose oral contraceptive containing at least 30 mcg of ethinyl estradiol combined with norethindrone acetate/norethindrone is recommended during treatment with asunaprevir. Avoid combination, Growth Hormone Analogs: Estrogen Derivatives may diminish the therapeutic effect of Growth Hormone Analogs. As a routine, any hormonal Therapy dise not have to do anything with food schedule, some doctors recommend them to take after a specified meal so as to schedule the drug intake and regularity is thus achieved. Consider therapy modification, Bosentan: May decrease the serum concentration of Progestins (Contraceptive). This medication should be consumed, until the complete eradication of the disease. During a menstrual cycle, the level of progesterone hormone falls which causes your womb lining to shed and your period to occur. Consider therapy modification, Nonsteroidal Anti-Inflammatory Agents (COX-2 Selective): May enhance the thrombogenic effect of Estrogen Derivatives. Allergic reactions are rare; however, contact a doctor immediately if you experience symptoms like rashes, itching/swelling (particularly of the face/tongue/throat), severe dizziness, and breathing difficulty, etc. If combined, monitor for changes in coagulation status. Management: Consider the use of an alternative (i.e., non-hormonal) means of contraception in all women of childbearing potential who are using artemether. Administer at the same time each day at intervals not >24 hours; without regard to meals. Monitor therapy, Cosyntropin: Estrogen Derivatives may diminish the diagnostic effect of Cosyntropin. If you suffer from kidney disorders, let the doctor know. Do not perform activities such as driving vehicles or operating machines if you experience any of these symptoms. Consider therapy modification, Aprepitant: May decrease the serum concentration of Progestins (Contraceptive). Tablet Solution for injection Indications and dose Endometriosis By mouth Adult 10-15 mg daily for 4-6 months or longer, to be started on day 5 of cycle; increased to 20-25 mg daily if required, dose only increased if spotting occurs and reduced once bleeding has stopped. Risks vs benefits: When used for the relief of menopausal symptoms or increased risk of bone fracture/loss, the benefit-risk of hormone therapy is most favorable if started in patients who have no contraindications to therapy, are <60 years of age, within 10 years of menopause onset, have a favorable lipid profile, and do not have the factor V Leiden genotype or metabolic syndrome. Thyroid replacement therapy: Estrogens may increase thyroid-binding globulin (TBG) levels leading to increased circulating total thyroid hormone levels. (ETH in il es tra DYE ole & nor eth IN drone), Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Injected depot medroxyprogesterone acetate does not appear to participate in this interaction. Consider therapy modification, Retinoic Acid Derivatives: May diminish the therapeutic effect of Progestins (Contraceptive). Management: Women of childbearing potential who are receiving mycophenolate mofetil should consider using an alternative and/or additional form of contraception. endobj Additional contraceptive precautions (such as a condom) should be taken for the . Consider therapy modification, Colesevelam: May decrease the serum concentration of Norethindrone. We comply with the HONcode standard for trustworthy health information. Consider adding an additional (non-hormonal) contraceptive method. Consider therapy modification, Bile Acid Sequestrants: May decrease the serum concentration of Progestins (Contraceptive). Documentation of allergenic cross-reactivity for estrogens and progestins is limited. Aygestin belongs to a class of drugs called Progestin. What are the contraindications of Norethisterone ? It is also an appropriate bone-active therapy for women with vasomotor symptoms who are <60 years of age or within 10 years of menopause onset. Breakthrough bleeding, though an important sign regarding the diminished effect of oral contraceptives, might not be present in spite of the occurrence of an interaction. Norethisterone Adult Medication Guideline Page 2 of 4 Menstrual disorders (e.g. Additional contraceptive dosing considerations: Switching from a different contraceptive: Oral contraceptive: Start on the same day that a new pack of the previous oral contraceptive would have been taken. Avoid combination, Anthrax Immune Globulin (Human): Estrogen Derivatives may enhance the thrombogenic effect of Anthrax Immune Globulin (Human). Acne: Adolescent females 15 years: Oral (Estrostep Fe, Tilia Fe, Tri-Legest Fe): Refer to adult dosing for contraception; not to be used prior to menarche. Use of combination hormonal contraceptives in women between 21 and 42 days after delivery should take into consideration the individual woman's risk factors for VTE (eg, age 35 years, previous VTE, thrombophilia, immobility, preeclampsia, transfusion at delivery, cesarean delivery, peripartum cardiomyopathy, BMI 30 kg/m2, postpartum hemorrhage, smoking) (Curtis 2016b). Consider therapy modification, Carfilzomib: May enhance the thrombogenic effect of Progestins (Contraceptive). If any of these symptoms occur often or on daily basis, a doctor should be urgently consulted. What are the possible side effects of Aygestin? Nostra-CR 10 Tablet is used to treat various menstrual problems including painful, heavy, or irregular periods, premenstrual syndrome (PMS), and a condition called endometriosis. Management: Contraceptive failure is possible. Hello, If menses have resumed, then pregnancy is unlikely but to confirm get a home urine pregnancy test done. The active metabolite aprepitant is likely responsible for this effect. The WHI Memory Study (WHIMS) estrogen-alone ancillary study of the WHI reported an increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 5.2 years of treatment with daily conjugated estrogens (0.625 mg) alone, relative to placebo. Your doctor may ask you to discontinue the medicine. Management: Patients receiving any hormonal contraceptive (oral or non-oral) should use an additional, nonhormonal contraceptive method during and for 7 days following sugammadex treatment. In addition, combination hormonal contraceptives produce alterations in the genital tract, including changes in the cervical mucus, rendering it unfavorable for sperm penetration even if ovulation occurs. Therefore, consult your doctor to understand whether it is safe to consume alcohol along with the medication. Norethisterone 5mg tablets are prescribed to treat various menstrual problems, including painful, heavy or irregular periods, endometriosis and premenstrual syndrome (PMS). Risk factors should be managed appropriately; discontinue use immediately if adverse cardiovascular events occur or are suspected. Management: Use an alternative or additional method of contraception due to possibly decreased contraceptive effectiveness. Monitor therapy, Selegiline: Estrogen Derivatives (Contraceptive) may increase the serum concentration of Selegiline. Talk to your doctor if you have questions. Inform your doctor if this happens regularly. Estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman. Metreleptin may increase the serum concentration of Estrogen Derivatives (Contraceptive). Abnormal or persistent vaginal bleeding. Fosamprenavir may decrease the serum concentration of Progestins (Contraceptive). Otosclerosis: Use caution in patients with otosclerosis. Management: Use an effective non-hormonal form of contraception. Malignant transformation of residual endometrial implants has been reported posthysterectomy with unopposed estrogen therapy. Management: Oral contraceptives containing ethinyl estradiol and norethindrone should be administered at least 4 hours before colesevelam. Consider therapy modification, CYP3A4 Inhibitors (Moderate): May increase the serum concentration of Estrogen Derivatives. y8PX :7 2023 Lybrate, Inc. All rights reserved. Theoretically, use may affect prognosis of existing disease. The risks of side effects are significantly high if you smoke cigarettes. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. It is used to treat conditions such as Allergic reactions and vomiting. Hepatic adenomas or carcinomas: Use of combination hormonal contraceptives is associated with hepatic adenomas (rare); rupture may cause fatal intra-abdominal hemorrhage. Monitor therapy, Theophylline Derivatives: CYP1A2 Inhibitors (Weak) may increase the serum concentration of Theophylline Derivatives. Thromboembolism is a condition in which a blood clot gets dislodged from another location in the circulation and causes obstruction in the blood flow. Monitor therapy, Topiramate: May decrease the serum concentration of Estrogen Derivatives (Contraceptive). Management: Use of an additional or alternative (nonhormonal) method of contraception should be considered. endobj If you experience any other symptoms which you think may be due to taking this medicine, speak to your doctor for advice. It is unknown whether this finding applies to younger postmenopausal women. Management: Initiate somapacitan at 2 mg once weekly in patients receiving oral estrogens. In women at risk for breast cancer due to family history or susceptibility genes (BRCA1, BRCA2), the use of combination hormonal contraceptives has not been shown to modify the risk for breast cancer. Inform your doctor if any of these side effects worsen or persist for a long time. Management: Females of childbearing potential should use an alternative, non-hormonal contraceptive during brigatinib therapy and for at least 4 months after the final brigatinib dose. Management: Women of childbearing potential should use an effective, nonhormonal means of contraception during and 4 weeks following mifepristone treatment. Norethisterone is not recommended during breastfeeding as it may affect your infant. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. Before starting the course of the drug, you should stop breastfeeding to protect your baby from unforeseen threats from the medicine. For this reason, combination oral contraceptives should not be used in women who are over 35 years and smoke. Depression: Use with caution in patients with a history of depression; discontinue if serious depression recurs. Contraceptive failure is possible. Diabetes is a condition in which there is an increase in blood sugar levels. Weve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. However, if there are no side effects, you can safely operate heavy machinery and drive after the medicine is administered. Consider therapy modification, Brigatinib: May decrease the serum concentration of Estrogen Derivatives (Contraceptive). Avoid combination, Triazolam: Hormonal Contraceptives may increase the serum concentration of Triazolam. Use of an alternative, nonhormonal contraceptive is recommended. Management: Doses of CYP3A4 substrates may need to be adjusted substantially when used in patients being treated with mitotane. Hormonal contraceptives: Assessment of pregnancy status (prior to therapy); blood pressure (prior to therapy and yearly); weight (optional; BMI at baseline may be helpful to monitor changes during therapy); assess potential health status changes at routine visits (Curtis 2016a). Solid organ transplant: Although data is limited, serious medical complications have been reported in women with complicated organ transplants (eg, graft failure, rejection, cardiac allograft vasculopathy); use of combination hormonal contraceptives is not recommended in women with complicated organ transplants (Curtis 2016b). Inform your doctor about this medicine before you plan the surgery. 1 0 obj The risk of ovarian cancer is decreased in women using combination hormonal contraceptives (Curtis 2016b; Walker 2015). Osteoporosis prevention: Females: Oral (femhrt, Jevantique Lo, Jinteli): One tablet daily. However, use in women with concomitant nephropathy, neuropathy, retinopathy, other vascular disease, or diabetes >20 years' duration should be evaluated for contraceptive use based on the severity of the condition (Curtis 2016b). HIV infection protection: Combination hormonal contraceptives do not protect against HIV infection or other sexually transmitted diseases (Curtis 2016a; Curtis 2016b). Of 4 menstrual disorders ( e.g therapy, Selegiline: Estrogen Derivatives ( Contraceptive.! A blood clot gets dislodged from another location in the blood flow in using! Y8Px:7 2023 Lybrate, Inc. All rights reserved speak to your doctor for advice another... If serious depression recurs in which there is an increase in blood sugar levels ) be. Use if you are pregnant, as it may affect prognosis of disease. 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