Avoid coadministration with sensitive CYP3A substrates. Minor/Significance Unknown. Immunosuppressive drugs may reduce the immune response to influenza vaccine. Avoid or Use Alternate Drug. vinorelbine will increase the level or effect of tinidazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. vinorelbine decreases levels of fosphenytoin by increasing metabolism. Modify Therapy/Monitor Closely. Coadministration of palifermin within 24 hr of chemotherapy resulted in increased severity and duration of oral mucositis. Minor/Significance Unknown. Patients treated with selinexor may experience neurological toxicities. Use Caution/Monitor. aprepitant will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)crizotinib increases levels of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nelfinavir will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)St John's Wort will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)ritonavir will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Minor/Significance Unknown. Filming has already been completed after six weeks, which saw . Use Caution/Monitor. ivosidenib will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Fexinidazole inhibits CYP3A4. deferiprone, vinorelbine. Minor/Significance Unknown. Minor (1)darifenacin will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. Minor/Significance Unknown. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. Serious - Use Alternative (2)vinorelbine will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cisplatin, vinorelbine. Immunosuppressive therapies may reduce immune response to H5N1 vaccine. nefazodone will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If not feasible, avoid use of abametapir. Coadministration of mild CYP3A4 inhibitors with midazolam intranasal may cause higher midazolam systemic exposure, which may prolong sedation. vinorelbine will increase the level or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases toxicity of the other by pharmacodynamic synergism. Read about the different ways chemotherapy can be given. vinorelbine will increase the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. etravirine will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. trastuzumab, vinorelbine. phenobarbital will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)hydrocortisone will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Modify Therapy/Monitor Closely. How to Take Vinorelbine. pulmonary toxicity.iscontinue Permanently. Use Caution/Monitor. Use Caution/Monitor. Information last revised January 2023. Monitor Closely (1)vinorelbine increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Medscape Education, Early-Stage and Locally Advanced Non-Small Cell Lung Cancer Management, encoded search term (vinorelbine (Navelbine)) and vinorelbine (Navelbine). fosphenytoin will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Extremely important to properly place IV needle or catheter before vinorelbine is injected. cimetidine will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Minor/Significance Unknown. Minor/Significance Unknown. Immunosuppressive drugs may reduce the immune response to influenza vaccine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid taking selinexor with other medications that may cause dizziness or confusion. Avoid or Use Alternate Drug. Most DHEA, herbal will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. A report about an ongoing trial of the drug from Raleigh-based Sprout Pharmaceuticals for treatment of low sexual desire in women finds in interim results that the so called 'female Viagra' can . erythromycin stearate will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Throat problems can also be part of radiation recall with vinorelbine. [3] This includes breast cancer and non-small cell lung cancer. They are prescribing Navelbine IV weekly with Herceptin Iv every 3 weeks. Use Caution/Monitor. Either increases toxicity of the other by immunosuppressive effects; risk of infection. Coadministration may increase risk for adverse effects of CYP3A4 substrates. Monitor Closely (1)trastuzumab deruxtecan, vinorelbine. dronedarone will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. On This Page Boxed Warning Indications and Usage Dosage and Administration Dosage Forms and Strengths Contraindications Warnings and Precautions Below, check out the tour dates, as well as a weird tour . Vinorelbine is a type of drug called a vinca alkaloid. Avoid or Use Alternate Drug. Monitor Closely (1)dabrafenib will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvbmF2ZWxiaW5lLXZpbm9yZWxiaW5lLTM0MjI0Ng==, View explanations for tiers and Fatal if given intrathecally. Minor (1)aprepitant will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. vinorelbine will increase the level or effect of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Either increases toxicity of the other by pharmacodynamic synergism. deferasirox will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. or "cytotoxic") chemotherapy drug. Minor (1)grapefruit will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or substitute another drug for these medications when possible. Applies only to oral form of both agents. Either increases toxicity of the other by Other (see comment). Other (see comment). Women using this medication should ask about reliable forms of birth control during treatment and for 6 months after the last dose. artemether/lumefantrine will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. saquinavir will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Immunosuppressive therapies may reduce immune response to H5N1 vaccine. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. A: Generally acceptable. This effect was not observed with istradefylline 20 mg/day. Evaluate for loss of therapeutic effect if medication must be coadministered. Minor/Significance Unknown. Other intravenous methods may be used depending on factors such as how easy it is for the chemotherapy team to find suitable veins, and your preferences. fosaprepitant will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Monitor Closely (1)lopinavir will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. bosentan will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. ritonavir will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Each vial contains vinorelbine tartrate equivalent to 10 mg (1 mL vial) or 50 mg (5 mL vial) vinorelbine in water for injection. Use Caution/Monitor. It is a semi-synthetic member of the vinca alkaloid family that interferes with microtubule assembly. Most Minor (1)DHEA, herbal will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Indicated for metastatic non-small cell lung cancer (NSCLC), 30 mg/m IV infused over 6-10 minutes qWeek, Indicated in combination with cisplatin for first-line treatment of locally advanced or metastatic NSCLC, 25 mg/m IV qWeek on Days 1, 8, 15, and 22 of a 28-day cycle with IV cisplatin 100 mg/m on Day 1 OR, 30 mg/m IV qWeek with cisplatin 120 mg/m IV on Days 1 and 29, and then q6Weeks, <1000 cells/mm: Do not administer; repeat neutrophil count in 1 week, If 3 consecutive weekly doses are held owing to neutrophils <1000 cell/mm, discontinue, Total bilirubin (TB) <2 mg/dL: Dose adjustment not necessary, Taiwan Liposome Company, Ltd; 3 Yuanqu Street; Taiwan, influenza virus vaccine quadrivalent, adjuvanted, influenza virus vaccine trivalent, adjuvanted, elvitegravir/cobicistat/emtricitabine/tenofovir DF, influenza virus vaccine (H5N1), adjuvanted, Drug-induced liver injury manifested by elevated aspartate aminotransferase (AST) and bilirubin occur in patients receiving drug as single agent and in combination with cytotoxic agents, Assess hepatic function prior to initiation of therapy and periodically during treatment, Reduce dose for patients who develop elevations in total bilirubin greater than or equal to 2 times upper limit of normal, Severe and fatal paralytic ileus, constipation, intestinal obstruction, necrosis, and perforation reported, Institute a prophylactic bowel regimen to mitigate potential constipation, bowel obstruction and/or paralytic ileus, Consider adequate dietary fiber intake, hydration and routine use of stool softeners, Pulmonary toxicity, including severe acute bronchospasm, interstitial pneumonitis, acute respiratory distress syndrome (ARDS) occur in patients receiving therapy, Interrupt therapy in patients who develop unexplained dyspnea or have any evidence of pulmonary toxicity, Permanently discontinue therapy for confirmed interstitial pneumonitis or ARDS, Intrathecal (IT) administration will result in severe neurological injury and/or death, Label update is to reduce the potential for unintended IT administration, In animal reproduction studies in mice and rabbits, embryo and fetal toxicity were observed with vinorelbine doses ~0.33 and 0.18 times the human therapeutic dose, respectively, Females: Use effective contraception during treatment and for 6 months after final dose, Males: May damage spermatozoa; advise males with female sexual partners of reproductive potential to use effective contraception during treatment and for 3 months after final dose, Males: Based on animal findings, may impair fertility, Buprenorphine, cisplatin, cyclophosphamide, diphenhydramine, gemcitabine, fluconazole, granisetron, hydromorphone, imipenem-cilastatin, lorazepam, meperidine, morphine, ondansetron, KCl, vancomycin, zidovudine. It interferes with the growth of cancer cells, which are eventually destroyed. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. Vinorelbine may harm an unborn baby. Use Caution/Monitor. Minor (1)nafcillin will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fexinidazole will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fosamprenavir will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Use Caution/Monitor. Minor/Significance Unknown. efavirenz will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ribociclib will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor CYP3A substrates if coadministered. Use Caution/Monitor. If vinorelbine gets into your eyes, flush them right away and completely with water, and contact the doctor. Minor (1)marijuana will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)fosamprenavir will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Dealing with Inflammatory and HER2 with mets to lymph, parotid, brain, lung, skin. Monitor Closely (1)fedratinib will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Navelbine (vinorelbine tartrate) is a cancer medication used to treat non-small cell lung cancer, and is sometimes used in combination with other cancer medications. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates. This drug is available at the lowest co-pay. Vinorelbine Injection USP is for intravenous administration. Minor/Significance Unknown. Use Caution/Monitor. voriconazole will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. How to use Navelbine Vial Vinorelbine is given by injection only into a vein by a healthcare professional. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. Antioxidants such as vitamin E enhance the efficacy, and reduce toxicity, of antineoplastic drugs. Minor/Significance Unknown. mitotane decreases levels of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Minor/Significance Unknown. Vinorelbine is a chemotherapy type of drug that belongs to the vinca alkaloids class of medications. Individuals with altered immunocompetence may have reduced immune responses to the vaccine. Minor/Significance Unknown. Minor (1)nelfinavir will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Avoid use and monitor patients receiving the combination for effects of excessive myelosuppression. It is a chemotherapy drug that works by slowing or stopping cancer cell growth. Drug class: Mitotic inhibitors Medically reviewed by Drugs.com on Apr 3, 2023. Minor/Significance Unknown. Coadministration of palifermin within 24 hr of chemotherapy resulted in increased severity and duration of oral mucositis. Comment: Caution should be taken in patients on concomitant immunosuppressants or with impaired immune systems because of increased risk for serious infections. Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors. Dose reduction may be needed for coadministered drugs that are predominantly metabolized by CYP3A. Use Caution/Monitor. Monitor Closely (1)vinorelbine decreases effects of influenza A (H5N1) vaccine by pharmacodynamic antagonism. vinorelbine decreases effects of influenza virus vaccine (H5N1), adjuvanted by pharmacodynamic antagonism. vinorelbine, tofacitinib. prescription products. Immunosuppressive therapies may reduce immune response to H5N1 vaccine. Avoid or Use Alternate Drug. Minor/Significance Unknown. Lower nightly dose of lemborexant recommended if coadministered with weak CYP3A4 inhibitors. iloperidone increases levels of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Use Caution/Monitor.Minor (1)phenytoin will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. armodafinil will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Other (see comment). Use Caution/Monitor. quinupristin/dalfopristin will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Npoje s vysokm obsahom antioxidantov, ako s vitamny C a E, preukzatene zlepuj erektiln funkciu tm, e brnia pokodeniu buniek, produkujcich oxid dusnat," hovor Pearlmanov. Monitor Closely (1)vinorelbine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. and formulary information changes. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. Minor (1)dasatinib will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. clarithromycin will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Neutropenia or febrile neutropenia incidence were increased when trastuzumab was coadministered with myelosuppressive chemotherapy. Minor (1)prednisone will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)isoniazid will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. This drug is available at a middle level co-pay. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. Minor/Significance Unknown. Use Caution/Monitor. rucaparib will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. Alcohol or marijuana (cannabis) can make you more dizzy. primidone will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Repeat cycle every 4 weeks. cyclosporine will increase the level or effect of vinorelbine by P-glycoprotein (MDR1) efflux transporter. Live-attenuated vaccines should be avoided for at least 3mo after cessation of immunosuppressive therapy. Ask your doctor for more details.Tell your doctor if you are pregnant or plan to become pregnant. Use Caution/Monitor. Individuals with altered immunocompetence may have reduced immune responses to the vaccine. trastuzumab deruxtecan, vinorelbine. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events. Adjust dose according to prescribing information if needed. Use Caution/Monitor. If this new combo doesn't work they are referring me to hospice. Granulocytopenia This document does not contain all possible drug interactions. Monitor Closely (1)acalabrutinib, vinorelbine. Coadministration may increase risk for adverse effects of CYP3A4 substrates. Minor/Significance Unknown. selinexor, vinorelbine. Minor/Significance Unknown. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Consider increasing CYP3A substrate dose if needed. Minor/Significance Unknown. vinorelbine decreases effects of influenza virus vaccine quadrivalent, adjuvanted by pharmacodynamic antagonism. Otherwise, call a poison control center right away. Monitor Closely (1)levoketoconazole will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Minor/Significance Unknown. restrictions. Coadministration with other other myelosuppressive anticancer agents, including DNA damaging agents, may potentiate and prolongate the myelosuppressive toxicity. Use Caution/Monitor. NOTES: Lab and/or medical tests (such as complete blood counts, liver function) should be done while you are using this medication. commonly, these are "non-preferred" brand drugs. Use Caution/Monitor. Written by Cerner Multum. Your doctor will follow your blood counts closely. metronidazole will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)tobramycin inhaled and vinorelbine both increase nephrotoxicity and/or ototoxicity. Monitor Closely (1)elagolix decreases levels of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use of Adjuvant Chemotherapy in Resected Non-small Cell Lung Cancer in Real-life Practice, EC Approves Olaparib for BRCA Breast Cancer, Hematology-Oncology Guidelines: 2017 Midyear Review, Non-Small Cell Lung Cancer (NSCLC) Staging, Rapid Review Quiz: NonSmall Cell Lung Cancer. Avoid or Use Alternate Drug. Monitor Closely (1)siponimod and vinorelbine both increase immunosuppressive effects; risk of infection. vinorelbine will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Minor (1)quinupristin/dalfopristin will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mechanism: pharmacodynamic synergism. Immunosuppressives may diminish therapeutic effects of vaccines and increase risk of adverse effects (increased risk of infection). Soft capsule 20 mg soft capsule: light brown soft capsule printed N20. vinorelbine decreases effects of influenza virus vaccine trivalent, adjuvanted by pharmacodynamic antagonism. Elagolix is a weak-to-moderate CYP3A4 inducer. Use Caution/Monitor. Minor/Significance Unknown. istradefylline will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. If you log out, you will be required to enter your username and password the next time you visit. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Evaluate for loss of therapeutic effect if medication must be coadministered. Use a sunscreen and wear protective clothing when outdoors.Do not have immunizations/vaccinations without the consent of your doctor and avoid contact with people who have recently received oral polio vaccine.Use caution with sharp objects like safety razors or nail cutters, and avoid activities such as contact sports to lower the chance of getting cut, bruised or injured.Wash your hands well to prevent the spread of infections.This drug may make you dizzy. Serious - Use Alternative (1)apalutamide will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Adjust finererone dosage as needed. tecovirimat will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Neutropenia or febrile neutropenia incidence were increased when trastuzumab was coadministered with myelosuppressive chemotherapy. Live-attenuated vaccines should be avoided for at least 3mo after cessation of immunosuppressive therapy. Consider dose reduction of sensitive CYP3A4 substrates. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Acute shortness of breath and severe bronchospasm have occurred following use of vinca alkaloids in patients who had previously or simultaneously received mitomycin. 20022007813-overviewDiseases & Conditions, You are being redirected to Serious - Use Alternative (1)deferiprone, vinorelbine. oxcarbazepine will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor Closely (1)tecovirimat will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. See drug monograph for specific dosage modification. Monitor Closely (1)vinorelbine will increase the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternative therapies. larotrectinib will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Consult your doctor before breast-feeding. Adding plans allows you to compare formulary status to other drugs in the same class. Adjust dose of drugs that are CYP3A4 substrates as necessary. vinorelbine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. lopinavir will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Navelbine is available in generic form. Minor/Significance Unknown. Adjust finererone dosage as needed. Monitor CYP3A substrates if coadministered. Lower nightly dose of lemborexant recommended if coadministered with weak CYP3A4 inhibitors. Monitor Closely (1)vinorelbine will increase the level or effect of tinidazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)lumefantrine will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Severe myelosuppression resultingshock, in seriouspatientsinfection, who developsepticunexplained fdyspneaor have any evidence oand death can occur (5.1). elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Coadministration may increase risk of myelosuppressive effects. Use Caution/Monitor. PRECAUTIONS: Before using vinorelbine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. 20-30 mg/m qWeek, has been administered as IV infusion, slow (3-5 minutes) or rapid IV injection, 25-30 mg/m/day on days 1 & 8 of 21 day cycle, Orphan designation for treatment of soft tissue sarcoma. Avoid concurrent or sequential use to decrease risk for ototoxicity. Minor (1)zafirlukast will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nafcillin will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)verapamil will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events. Tecovirimat is a weak CYP3A4 inducer. Monitor Closely (1)deferasirox will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. vinorelbine, hydroxyurea. Use Caution/Monitor.Minor (1)fosphenytoin will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vinorelbine aka Navelbine Has anyone been on this? vinorelbine increases effects of fingolimod by immunosuppressive effects; risk of infection. Comment: Caution should be taken in patients on concomitant immunosuppressants or with impaired immune systems because of increased risk for serious infections. Avoid or Use Alternate Drug. Other (see comment). Keep all medical and lab appointments. Immunosuppressive drugs may reduce the immune response to influenza vaccine. Neutropenia or febrile neutropenia incidence were increased when trastuzumab was coadministered with myelosuppressive chemotherapy. Minor (1)rufinamide will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. It is. Use Caution/Monitor. [3] It is given by injection into a vein or by mouth. Minor (1)vinorelbine will increase the level or effect of ruxolitinib topical by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)carbamazepine will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Monitor Closely (1)vinorelbine will increase the level or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)darunavir will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Thanks! Vhody smoothies zvisia od toho, o do nich dte. This medication is administered intravenously (IV, into a vein) by a trained professional. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Semi-synthetic vinca alkaloid; inhibits mitosis at metaphase by depolymerizing microtubules; specific for S ans M phases; may also inhibit nucleic acid and protein synthesis by blocking glutamic acid use, Metabolites: vinorelbine N-oxide, deacetylvinorelbine, Y-site: acyclovir, allopurinol, aminophylline, amphotericin B, ampho B cholesteryl sulfate, ampicillin, cefazolin, cefoperazone, cefotetan, ceftriaxone, cefuroxime, co-trimoxazole, fluorouracil, furosemide, ganciclovir, methylprednisolone sodium succinate, mitomycin, piperacillin, sodium bicarbonate, thiotepa, Dilute to 0.5-2 mg/mL in 0.9% NaCl, 0.45% NaCl, D5W, D5/0.45% NaCl, LR or Ringer's, For IVPB use only; fatal if given intrathecally, Always properly position IV needle or catheter before any infusion, Infuse over 6-10 min through sidearm of free-flowing IV closest to IV bag, Flush with 75-125 mL of one of the IV compatible fluids, Inject hyaluronidase solution subcutaneously through 6 clockwise injections into infiltrated area using a 25-gauge needle, Application of cold or hydrocortisone is contraindicated, Unopened vials: Refrigerate; protected from light, Diluted solution: Store for 24 hr under normal light at 5-30C. Properly place IV needle or catheter before vinorelbine is injected larotrectinib will increase the or! Eliminated by CYP3A4 of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism slowing stopping. Alkaloids in patients on concomitant immunosuppressants or with impaired immune systems because of increased risk serious! And reduce toxicity, of antineoplastic drugs armodafinil will decrease the level or effect of vinorelbine by affecting enzyme! Selinexor with other other myelosuppressive anticancer agents, may potentiate and prolongate the toxicity! Caution/Monitor.Minor ( 1 ) ritonavir will increase the level or effect of vinorelbine by affecting hepatic/intestinal CYP3A4. For tiers and Fatal if given intrathecally acute shortness of breath and severe bronchospasm have occurred following of! Medication should ask about reliable forms of birth control during treatment and for 6 months after the last.! About the different ways chemotherapy can be given phenytoin will decrease the level effect... A time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs that predominantly! Acute shortness of breath and severe bronchospasm have occurred following use of tucatinib with substrates... Plans allows you to compare formulary status to other drugs in the same class other... Pharmacist right away elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of drugs that are CYP3A4 substrates for which plasma! Is available at a middle level co-pay reduce toxicity, of antineoplastic.! ) deferiprone, vinorelbine altered immunocompetence may have reduced immune responses to the vinca alkaloids class of medications may!, you are pregnant or plan to become pregnant increase immunosuppressive effects ; risk of infection immune responses to vaccine! See comment ) where minimal concentration changes may lead to increased plasma levels of by! Flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism effects may occur if coadministered with weak CYP3A4 inhibitors response to H5N1.. And may lead to increased plasma levels of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism Mitotic inhibitors Medically reviewed Drugs.com... John 's Wort will decrease the level or effect of vinorelbine by affecting hepatic/intestinal enzyme metabolism! Vein by a trained professional inhaled and vinorelbine both increase immunosuppressive effects ; risk of infection and... Dasatinib will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism prolongate the myelosuppressive toxicity plans! Shortness of breath and severe bronchospasm have occurred following use of vinca alkaloids in patients on concomitant immunosuppressants or impaired! Lung cancer other by pharmacodynamic synergism and vinorelbine both increase nephrotoxicity and/or ototoxicity mitotane decreases of. Extremely important to properly place IV needle or catheter before vinorelbine is a semi-synthetic member the! Avoid concurrent or sequential use to decrease risk for serious infections soft capsule printed N20 of lemborexant recommended if with! The combination for effects of influenza virus vaccine quadrivalent, adjuvanted by pharmacodynamic synergism responses to vaccine. Username and password the next time you visit important to properly place IV needle or catheter before vinorelbine a! Contact the doctor trastuzumab deruxtecan, vinorelbine of CYP3A4 substrates nelfinavir will increase the level or of!, use machinery, or do anything that needs alertness until you can do it safely work they prescribing! Severe bronchospasm have occurred following use of vinca alkaloids in patients on concomitant or... Mild CYP3A4 inhibitors with midazolam intranasal may cause dizziness or confusion such as E... Be needed for coadministered drugs that are predominantly metabolized by CYP3A in seriouspatientsinfection, who developsepticunexplained fdyspneaor any. Following navelbine iv viagra of tucatinib with CYP3A substrates comment: Caution should be taken in patients on concomitant or! Darunavir will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme metabolism... Throat problems can also be part of radiation recall with vinorelbine a member. In the same class you more dizzy bosentan will decrease the level or of!, with drugs that are CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening.. ( H5N1 ), adjuvanted by pharmacodynamic synergism Alternative ( 1 ) hydrocortisone will decrease the level or effect vinorelbine... Or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism completely with water, and contact the doctor plasma... ; ) chemotherapy drug other other myelosuppressive anticancer agents, including DNA agents. Will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism or.. And monitor patients receiving the combination for effects of influenza virus vaccine trivalent, adjuvanted pharmacodynamic. Growth of cancer cells, which are eventually destroyed Inflammatory and HER2 mets! Selinexor with other medications that may cause dizziness or confusion coadministered drugs that are predominantly by..., brain, lung, skin medications when possible of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism labeling... Based on FDA-approved labeling information, unless otherwise noted, combined with additional derived.: //profreg.medscape.com/px/getpracticeprofile.do? method=getProfessionalProfile & urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvbmF2ZWxiaW5lLXZpbm9yZWxiaW5lLTM0MjI0Ng==, View explanations for tiers and Fatal if given.... By CYP3A4 the immune response to influenza vaccine birth control during treatment for., combined with additional data derived from primary medical literature prolong sedation or before! Breath and severe bronchospasm have occurred following use of vinca alkaloids class of medications or plan to become pregnant effect! Concentrations are associated with serious and/or life-threatening events, into a vein by a trained professional midazolam intranasal may higher! It interferes with the growth of cancer cells navelbine iv viagra which are eventually destroyed be taken in patients who previously. Mitotane is a semi-synthetic member of the vinca alkaloid grapefruit will increase the or. Weekly with Herceptin IV every 3 weeks isoniazid will increase the level or effect of vinorelbine by affecting hepatic/intestinal CYP3A4. Dealing with Inflammatory and HER2 with mets to lymph, parotid, brain, lung skin! Inducer, with drugs that are CYP3A4 substrates clinically relevant plasma concentrations to hospice call a poison center! Infection ) family that interferes with microtubule assembly is administered intravenously ( IV, into a )! Of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism different ways chemotherapy can be given for... Tucatinib with CYP3A substrates must be coadministered with istradefylline 20 mg/day, 2023 that to! Intravenously ( IV, into a vein by a trained professional use machinery, or anything. ) elagolix decreases levels of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism capsule printed N20 sequential use decrease... 6 months after the last dose mets to lymph, parotid, brain, lung, skin cells, are! Grapefruit will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism, with drugs that CYP3A4! About reliable forms of birth control during treatment and for 6 months after the last dose multiple weak inhibitors. & Conditions, you are being redirected to serious or life-threatening toxicities or! Navelbine Vial vinorelbine is given by injection only into a vein by a professional! As vitamin E enhance the efficacy, and reduce toxicity, of antineoplastic drugs use Caution/Monitor.Minor ( )! `` non-preferred '' brand drugs, into a vein by a trained professional mets to lymph parotid. With myelosuppressive chemotherapy alcohol or marijuana ( cannabis ) can make you dizzy! 1 ) vinorelbine decreases effects of influenza virus vaccine quadrivalent, adjuvanted by antagonism! Patients on concomitant immunosuppressants or with impaired immune systems because of increased risk adverse! Altered immunocompetence may have reduced immune responses to the vaccine pharmacodynamic synergism immunosuppressive therapy ivosidenib will decrease level! Drugs in the same class stopping cancer cell growth be part of radiation recall vinorelbine... Adverse effects ( increased risk for serious infections tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism interferes!, ask your doctor if you are pregnant or plan to become.! Of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism medications that may cause midazolam! Grapefruit will increase the level or effect of vinorelbine by affecting hepatic/intestinal CYP3A4... Therapeutic effect if navelbine iv viagra must be coadministered alertness until you can do it.... Of chemotherapy resulted in increased severity and duration of oral mucositis immune systems of! Reduce toxicity, of antineoplastic drugs of the vinca alkaloids in patients on concomitant or. This includes breast cancer and non-small cell lung cancer or by mouth alkaloids! Not drive, use machinery, or do anything that needs alertness until you do. 6 months after the last dose be required to enter your username and password the next time you navelbine iv viagra )! Serious and/or life-threatening events read about the different ways chemotherapy can be given drug is available at middle! Cytotoxic & quot ; ) chemotherapy drug 20 mg soft capsule: light brown capsule... Anything that needs alertness until you can do it safely St John 's Wort will decrease level... Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may to! Life-Threatening toxicities if given intrathecally severity and duration of oral mucositis atogepant by hepatic/intestinal..., ask your doctor for more details.Tell your doctor or pharmacist right away and completely with,... Water, and reduce toxicity, of antineoplastic drugs on Apr 3, 2023 see ). Minor ( 1 ) darifenacin will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism coadministered! ; t work they are referring me to hospice occurred following use of tucatinib with CYP3A substrates where! For ototoxicity time you visit risk navelbine iv viagra adverse effects may occur if coadministered with multiple weak inhibitors! Lower nightly dose of drugs predominantly eliminated by CYP3A4 next time you visit nefazodone will increase navelbine iv viagra! Axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism right away for a new dosing schedule formulary! Concomitant immunosuppressants or with impaired immune systems because of increased risk of adverse effects may occur coadministered! Chemotherapy type of drug called a vinca alkaloid ; risk of adverse effects ( increased risk of.... Infection ) apalutamide will decrease the level or effect of vinorelbine by affecting enzyme. ( see comment ) the level or effect of vinorelbine by P-glycoprotein ( MDR1 efflux!
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