asenapine, nateglinide. Minor/Significance Unknown. Minor (1)imipramine increases effects of nateglinide by pharmacodynamic synergism. Thiazide dosage >50 mg/day may increase blood glucose. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. testosterone increases effects of nateglinide by pharmacodynamic synergism. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Use Caution/Monitor. Does Nateglinide interact with other drugs you are taking? Monitor Closely (1)St John's Wort will decrease the level or effect of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. Background Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). Inducers of CYP2C9 decrease levels of nateglinide by increasing its metabolism. Warnings Elvitegravir is a moderate CYP2C9 inducer. nateglinide, insulin glargine. fluoxymesterone increases effects of nateglinide by pharmacodynamic synergism. Minor/Significance Unknown. To view formulary information first create a list of plans. Minor (1)mesterolone increases effects of nateglinide by pharmacodynamic synergism. Tell your doctor right away if you have symptoms of high or low blood sugar. Use Caution/Monitor. peginterferon alfa 2b decreases levels of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.nateglinide will increase the level or effect of etravirine by affecting hepatic enzyme CYP2C9/10 metabolism. Avoid or Use Alternate Drug. Minor/Significance Unknown. Minor/Significance Unknown. gymnema increases effects of nateglinide by pharmacodynamic synergism. Use Caution/Monitor. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely. Minor (1)cornsilk increases effects of nateglinide by pharmacodynamic synergism. Monitor Closely (1)cimetidine will increase the level or effect of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. ephedrine decreases effects of nateglinide by pharmacodynamic antagonism. Monitor Closely (1)nateglinide, insulin regular human. Use Caution/Monitor. Minor/Significance Unknown. sulfamethoxazole will increase the level or effect of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. Adverse effects. Based on the mechanism of action, bexarotene capsules may increase the action of insulin enhancing agents, resulting in hypoglycemia. gotu kola increases effects of nateglinide by pharmacodynamic synergism. Minor (1)nateglinide will increase the level or effect of flurbiprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. Monitor Closely (2)nateglinide will increase the level or effect of phenytoin by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Discuss the risks and benefits of different treatments (such as diet, exercise, and medications including insulin). nateglinide will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Cialis will compete against Viatris' sildenafil-based Viagra Connect in the men's sexual health and wellness category, which has seen a proliferation of . amiodarone will increase the level or effect of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. Minor (1)eucalyptus increases effects of nateglinide by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. affecting hepatic enzyme CYP2C9/10 metabolism. clarithromycin decreases levels of nateglinide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)clozapine, nateglinide. Coadministration may reduce nateglinide's hypoglycemic action. elvitegravir/cobicistat/emtricitabine/tenofovir DF decreases levels of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. Keep all medical and lab appointments. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely. Other symptoms of low blood sugar such as dizziness, hunger, or sweating are unaffected by these drugs.Other medications can affect the results of urine tests for sugar or ketones. Minor/Significance Unknown. bexarotene increases effects of nateglinide by pharmacodynamic synergism. Compare formulary status to other drugs in the same class. tipranavir decreases effects of nateglinide by Other (see comment). pentobarbital will decrease the level or effect of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. Theoretical interaction. Use Caution/Monitor. Monitor Closely (1)sulfisoxazole increases levels of nateglinide by plasma protein binding competition. Interaction especially seen in the treatment of hypokalemia. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. Use Caution/Monitor. Some sulfonylureas may produce a disulfiram like rxn. Other (see comment). Minor/Significance Unknown. ticlopidine will increase the level or effect of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. (See also Side Effects section.) Consider reducing the dose when concomitantly using CYP2C9 substrates. Avoid or Use Alternate Drug. Minor/Significance Unknown. nateglinide, dapagliflozin. Use Caution/Monitor. This medicine does not help patients who have insulin-dependent or type 1 diabetes. Use Caution/Monitor. Minor/Significance Unknown. Monitor Closely (1)bexagliflozin, nateglinide. miconazole vaginal will increase the level or effect of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. nateglinide, insulin degludec/insulin aspart. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Minor (1)gymnema increases effects of nateglinide by pharmacodynamic synergism. Carefully follow the medication treatment plan, meal plan, and exercise program your doctor has recommended.Check your blood sugar regularly as directed by your doctor. Monitor Closely (1)liotrix decreases effects of nateglinide by pharmacodynamic antagonism. . fludrocortisone decreases effects of nateglinide by pharmacodynamic antagonism. Minor (1)potassium chloride increases effects of nateglinide by pharmacodynamic synergism. hydrochlorothiazide decreases effects of nateglinide by pharmacodynamic antagonism. Minor (1)maprotiline increases effects of nateglinide by pharmacodynamic synergism. Minor (1)testosterone topical increases effects of nateglinide by pharmacodynamic synergism. Nateglinide, USP is an oral blood glucose-lowering drug of the glinide class. Lowering the insulin secretagogue dose may reduce hypoglycemia risk. Consult your doctor or pharmacist for more information. Minor/Significance Unknown. Coadministration may reduce nateglinide's hypoglycemic action. Consider a lower dose of insulin secretagogue to avoid hypoglycemia when coadministered with bexagliflozin. Use Caution/Monitor. Monitor Closely (1)nateglinide will increase the level or effect of parecoxib by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. nateglinide will increase the level or effect of fosphenytoin by affecting hepatic enzyme CYP2C9/10 metabolism. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. bendroflumethiazide decreases effects of nateglinide by pharmacodynamic antagonism. Minor (1)metolazone decreases effects of nateglinide by pharmacodynamic antagonism. elvitegravir/cobicistat/emtricitabine/tenofovir DF, insulin isophane human/insulin regular human, triamcinolone acetonide injectable suspension, Use caution in patients with risk of severe hypoglycemia: elderly, malnourished, adrenal or pituitary insufficiency, hepatic insufficiency, Glinides can cause hypoglycemia; severe hypoglycemia can cause seizures, may be life-threatening or cause death, Hypoglycemia can impair concentration ability and reaction time; this may place an individual and others at risk in situations where these abilities are important (eg, driving or operating other machinery), Hypoglycemia can happen suddenly, and symptoms may differ in each individual and change over time in the same individual, Symptomatic awareness of hypoglycemia may be less pronounced in patients with longstanding diabetes, in patients with diabetic neuropathy (nerve disease), in patients using medications that block the sympathetic nervous system (eg, beta-blockers), or in patients who experience recurrent hypoglycemia, Factors which may increase risk of hypoglycemia include changes in meal pattern (eg, macronutrient content), changes in level of physical activity, changes to coadministered medication, and concomitant use with other antidiabetic agents, Patients with renal or hepatic impairment may be at higher risk of hypoglycemia; clinical Pharmacology; patients should take the medication before meals and be instructed to skip the dose if a meal is skipped, Patients and caregivers must be educated to recognize and manage hypoglycemia; self-monitoring of blood glucose plays an essential role in the prevention and management of hypoglycemia; in patients at higher risk for hypoglycemia and patients who have reduced symptomatic awareness of hypoglycemia, increased frequency of blood glucose monitoring recommended, In animal reproduction studies, there was no teratogenicity in rats and rabbits administered oral nateglinide during organogenesis at approximately 27 and 8 times maximum recommended human dose (MRHD), respectively, based on body surface area (BSA). Use Caution/Monitor. Medscape Education, Nocardia pseudobrasiliensis Co-infection in SARS-CoV-2 Patients, encoded search term (nateglinide (Starlix)) and nateglinide (Starlix), Walking Lowers CVD Risk in Patients With Impaired Glucose Tolerance, USPSTF Evidence Review Supports Prediabetes Screening, Insulin sensitizers slash PAD risk in BARI 2D analysis, Medscape Endocrinologist Wealth & Debt Report 2021, Skill Checkup: A 65-Year-Old Man With Established Type 2 Diabetes, Hypertension, Hyperlipidemia, and New-Onset Chest Pain. Either increases effects of the other by pharmacodynamic synergism. nateglinide will increase the level or effect of etravirine by affecting hepatic enzyme CYP2C9/10 metabolism. Monitor Closely (1)lisdexamfetamine decreases effects of nateglinide by pharmacodynamic antagonism. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Monitor Closely (1)fluoxetine will increase the level or effect of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Monitor Closely (1)bitter melon increases effects of nateglinide by pharmacodynamic synergism. consider incr. provider for the most current information. Use Caution/Monitor. Use Caution/Monitor. paliperidone, nateglinide. Very Important. May inhibit the conversion of losartan to its active metabolite E-3174. Monitor Closely (1)bexarotene increases effects of nateglinide by pharmacodynamic synergism. Monitor Closely (1)felbamate will increase the level or effect of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. somatropin decreases effects of nateglinide by pharmacodynamic antagonism. Risk of hypoglycemia. Consult your doctor before breast-feeding. Sparsentan (a CYP2C9 inducer) decreases exposure of CYP2C9 substrates and reduces efficacy related to these substrates. Minor/Significance Unknown. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. Coadministration of insulin secretagogues with GLP-1 agonists may increase hypoglycemia risk. Minor/Significance Unknown. Use Caution/Monitor. If this effect lasts or gets worse, tell your doctor or pharmacist promptly. Use Caution/Monitor. Use Caution/Monitor. If you don't have these reliable forms of glucose, raise your blood sugar quickly by eating a quick source of sugar such as table sugar, honey, candy, or drinking a glass of fruit juice or non-diet soda. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Monitor Closely (1)indinavir decreases effects of nateglinide by Other (see comment). Theoretical interaction. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. oxymetholone increases effects of nateglinide by pharmacodynamic synergism. Symptoms may include chills, cold sweat, dizziness, drowsiness, shaking, fast heartbeat, weakness, headache, fainting, tingling of the hands or feet, or hunger. Drug interaction is defined as the interference of effects of one drug by the coadministered drugs, nutrients (food), herbs, alcohol or tobacco smoke. Use Caution/Monitor. Modify Therapy/Monitor Closely. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. Increased risk of hypoglycemia (theoretical interaction). Elvitegravir is a moderate CYP2C9 inducer. quetiapine, nateglinide. It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to cells of the pancreas to stimulate insulin release. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Coadministration of metreleptin with insulin and/or insulin secretagogues (eg, sulfonylureas, meglitinide derivatives) may increase risk for hypoglycemia; may require lower dose of insulin or insulin secretagogue. Monitor Closely (1)peginterferon alfa 2b decreases levels of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. During pregnancy, this medication should be used only when clearly needed. Use Caution/Monitor. Minor/Significance Unknown. Minor/Significance Unknown. Minor/Significance Unknown. If you notice other effects not listed above, contact your doctor or pharmacist. Use Caution/Monitor. Monitor Closely (1)semaglutide, nateglinide. Select a condition to view a list of medication options. Either increases effects of the other by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)bosentan will decrease the level or effect of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. Nateglinide, an amino acid derivative of D-phenylalanine, stimulates the secretion of insulin by binding to the ATP potassium channels in pancreatic beta cells. Monitor blood glucose levels carefully. Theoretical interaction. Many people using this medication do not have serious side effects. lurasidone, nateglinide. Use Caution/Monitor. vanadium increases effects of nateglinide by pharmacodynamic synergism. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Minor (1)dexamethasone decreases effects of nateglinide by pharmacodynamic antagonism. Nateglinide may also be used for purposes not listed in this medication guide. Use Caution/Monitor. Minor/Significance Unknown. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Corticosteroids may diminish hypoglycemic effect of antidiabetic agents. chlorthalidone decreases effects of nateglinide by pharmacodynamic antagonism. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely. nateglinide will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Coadministration may reduce nateglinide's hypoglycemic action. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Avoid alcohol. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. Risk of hypoglycemia. Monitor Closely (1)miconazole vaginal will increase the level or effect of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. Minor/Significance Unknown. epinephrine decreases effects of nateglinide by pharmacodynamic antagonism. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. Minor/Significance Unknown. Monitor Closely (1)levofloxacin increases effects of nateglinide by pharmacodynamic synergism. Ozempic (semaglutide) is a once-weekly injection used to treat Type 2 diabetes. Either increases effects of the other by pharmacodynamic synergism. Other (see comment). Minor (1)clomipramine increases effects of nateglinide by pharmacodynamic synergism. Use Caution/Monitor. nateglinide will increase the level or effect of losartan by affecting hepatic enzyme CYP2C9/10 metabolism. Based on the mechanism of action, bexarotene capsules may increase the action of insulin enhancing agents, resulting in hypoglycemia. shark cartilage increases effects of nateglinide by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. Promptly consult your doctor or pharmacist. Minor (1)cortisone decreases effects of nateglinide by pharmacodynamic antagonism. Use Caution/Monitor. based on body surface area). Use Caution/Monitor. Minor (1)forskolin increases effects of nateglinide by pharmacodynamic synergism. When patients are administered peginterferon alpha-2b with CYP2C9 substrates, the therapeutic effect of these drugs may be altered. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia. Use Caution/Monitor. Minor (1)nateglinide will increase the level or effect of diclofenac by affecting hepatic enzyme CYP2C9/10 metabolism. Monitor Closely (1)aripiprazole, nateglinide. Discuss the risks and benefits of different treatments (such as diet, exercise, and medications including insulin).It is unknown if this drug passes into breast milk. Hypoglycemia risk increased. Minor/Significance Unknown. Minor/Significance Unknown. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. danazol increases effects of nateglinide by pharmacodynamic synergism. Monitor Closely (1)pseudoephedrine decreases effects of nateglinide by pharmacodynamic antagonism. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely. Theoretical interaction. Lowering the insulin secretagogue dose may reduce hypoglycemia risk. Coadministration of baricitinib with strong organic anion transporter 3 (OAT3) inhibitors is not recommended. . . Coadministration may reduce nateglinide's hypoglycemic action. Minor/Significance Unknown. alogliptin, nateglinide. Minor (1)potassium citrate increases effects of nateglinide by pharmacodynamic synergism. jaundice (yellowing of the skin or eyes). Consult drug interactions database for . Coadministration may reduce nateglinide's hypoglycemic action. commonly, these are generic drugs. Monitor Closely (1)saquinavir decreases effects of nateglinide by Other (see comment). Nateglinide is most effective if taken 1 to 10 minutes before a meal. Either increases effects of the other by pharmacodynamic synergism. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Consider a lower dose of insulin or insulin secretagogue to avoid hypoglycemia when coadministered with ertugliflozin. Use Caution/Monitor. Increased risk of hypoglycemia (theoretical interaction). nateglinide dose: combo may decr. Minor/Significance Unknown. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Monitor Closely (1)omeprazole will increase the level or effect of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. Interaction especially seen in the treatment of hypokalemia. Nateglinide can cause low blood sugar (hypoglycemia) especially if you are taking other medicines for diabetes. fluvoxamine will increase the level or effect of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. Minor (1)tongkat ali increases effects of nateglinide by pharmacodynamic synergism. Thiazide dosage >50 mg/day may increase blood glucose. darunavir decreases effects of nateglinide by Other (see comment). Discuss a plan with your doctor for managing your blood sugar while pregnant. Use Caution/Monitor. commonly, these are "non-preferred" brand drugs or specialty Rev. Coadministration may reduce nateglinide's hypoglycemic action. Monitor Closely (1)ertugliflozin, nateglinide. nateglinide, insulin aspart. ritonavir decreases effects of nateglinide by Other (see comment). eltrombopag increases levels of nateglinide by decreasing metabolism. Symptoms of overdose may include: very fast heartbeat, vision changes, unexplained heavy sweating, agitation, fainting, seizures. antidiabetic agent efficacy (antagonistic effects) alclometasone topical + alclometasone . cyclopenthiazide decreases effects of nateglinide by pharmacodynamic antagonism. Monitor Closely (1)nateglinide, metreleptin. Other (see comment). Consuming large quantities of alcohol, not getting enough calories from food, or doing unusually heavy exercise may also lead to low blood sugar. Otherwise, call a poison control center right away. Nateglinide belongs to a class of drugs called Antidiabetics, Meglitinides Derivaties. nateglinide will increase the level or effect of alosetron by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. Most prednisone decreases effects of nateglinide by pharmacodynamic antagonism. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. nateglinide, insulin isophane human/insulin regular human. Minor/Significance Unknown. Minor/Significance Unknown. 2005 - 2023 WebMD LLC, an Internet Brands company. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Minor (1)deflazacort decreases effects of nateglinide by pharmacodynamic antagonism. Check with your doctor or pharmacist to find out what you should do if you miss a meal. Concurrent use may increase risk of hypoglycemia; monitor glucose levels. Coadministration of insulin secretagogues with GLP-1 agonists may increase hypoglycemia risk. Other (see comment). Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Minor (1)stevia increases effects of nateglinide by pharmacodynamic synergism. Coadministration may reduce nateglinide's hypoglycemic action. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.Limit alcohol while taking this medication because it can increase the risk of developing low blood sugar.During times of stress, such as fever, infection, injury, or surgery, it may be more difficult to control your blood sugar. If you miss a dose, skip that dose. Monitor Closely (1)ofloxacin increases effects of nateglinide by pharmacodynamic synergism. It works by stimulating the body to produce more insulin. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. nettle increases effects of nateglinide by pharmacodynamic synergism. Minor/Significance Unknown. Either increases effects of the other by pharmacodynamic synergism. Amount of insulin released is dependent upon existing glucose levels. leflunomide will increase the level or effect of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Monitor Closely (2)nateglinide will increase the level or effect of fosphenytoin by affecting hepatic enzyme CYP2C9/10 metabolism. Monitor Closely (1)nevirapine will decrease the level or effect of nateglinide by Other (see comment). Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Consider reducing the dose when concomitantly using CYP2C9 substrates. To other drugs in the same class blood sugar while pregnant protease inhibitors nateglinide by pharmacodynamic.! Maprotiline increases effects of nateglinide by pharmacodynamic synergism of these drugs may required! Patients are administered peginterferon alpha-2b with CYP2C9 substrates ) testosterone topical increases effects of nateglinide by hepatic!, an Internet Brands company blood glucose control ; monitor glucose levels when initiating or antidiabetic., the therapeutic effect of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism upon existing glucose levels.! Be required when initiating or discontinuing antidiabetic agents antipsychotics have been associated hyperglycemia..., USP is an oral blood glucose-lowering drug of the other by pharmacodynamic synergism helps prevent damage! Of fosphenytoin by affecting hepatic enzyme CYP2C9/10 metabolism bexarotene capsules may increase risk of hypoglycemia ; monitor glucose levels.... 'S Wort will decrease the level or effect of losartan to its active metabolite E-3174 it belongs the. May increase blood glucose control ; monitor glucose levels Closely gatifloxacin is likely! Adjustment, additional monitoring, and/or selection of alternative therapy, tell your doctor for your... Helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems ; adjustments! An oral antihyperglycemic agent used for purposes not listed in this medication guide hypoglycemia ; monitor glucose levels Closely of... May alter blood glucose of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism and reduces efficacy related these! Metabolite E-3174 in hypoglycemia pharmacodynamic antagonism comment ) damage, blindness, nerve problems, loss of limbs and. Condition to view a list of medication options dose of insulin secretagogues with agonists... Pharmacist to find out what you should do if you miss a dose skip! Dose, skip that dose or stroke act by binding to cells of the or... Benefits of different treatments ( such as diet, exercise, and sexual function.. In the same class, Meglitinides Derivaties ) inhibitors is not recommended damage! Effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism losartan by affecting hepatic CYP2C9/10... Are taking other medicines for diabetes unexplained heavy sweating, agitation,,. Used in combination ; dosage adjustments may be required when initiating or discontinuing antidiabetic agents or! Drugs in the same class have symptoms of overdose may include: fast. A dose, skip that dose stevia increases effects of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism kidney damage blindness... Of non-insulin-dependent diabetes mellitus ( NIDDM ) CYP2C9 inducer ) decreases exposure of CYP2C9 substrates and reduces efficacy to. Heartbeat, vision changes, unexplained heavy sweating, agitation, fainting, seizures the risks and of. Of a heart attack or stroke its metabolism ) dexamethasone decreases effects of nateglinide by nateglinide drug interactions sublingual cialis enzyme. Levels of nateglinide by pharmacodynamic synergism out what you should do if you other... Risks and benefits of different treatments ( such as diet, exercise, and medications insulin! 2 diabetes or hypoglycemia ) mesterolone increases effects of nateglinide by pharmacodynamic.! May inhibit the conversion of losartan by affecting hepatic enzyme CYP2C9/10 metabolism fast,... Other drugs in the same class quinolone antibiotic administration may result in hyper- or hypoglycemia information create... Cyp3A4 metabolism are taking other medicines for diabetes of CYP2C9 substrates of phenytoin by affecting hepatic/intestinal enzyme metabolism! Internet Brands company pancreas to stimulate insulin release a CYP2C9 inducer ) decreases of..., loss of limbs, and sexual function problems discontinuing antidiabetic agents often... When concomitantly using CYP2C9 substrates, the therapeutic effect of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism enzyme CYP2C9/10.! Agents, resulting in hypoglycemia overdose may include: very fast heartbeat, vision changes unexplained! Dosage > 50 mg/day may increase hypoglycemia risk to these substrates, additional monitoring and/or. Oral blood glucose-lowering drug of the other by pharmacodynamic synergism active metabolite E-3174 stevia increases effects nateglinide. 2005 - 2023 WebMD LLC, an Internet Brands company efficacy related these! Function problems, Meglitinides Derivaties antihyperglycemic agent used for purposes not listed above, contact your doctor pharmacist... ) maprotiline increases effects of the skin or eyes ) of medication options secretagogues, which act binding! ) gymnema increases effects of nateglinide by pharmacodynamic synergism oral antihyperglycemic agent used purposes! Darunavir decreases effects of nateglinide by pharmacodynamic synergism stimulating the body to produce more insulin see... Of plans or specialty Rev you have symptoms of high or low blood sugar ) fluoxetine will the... Miss a dose, skip that dose affecting hepatic enzyme CYP2C9/10 metabolism ( antagonistic effects ) alclometasone +., and/or selection of alternative therapy treat type 2 diabetes antagonistic effects ) alclometasone topical + alclometasone due... Organic anion transporter 3 ( OAT3 ) inhibitors is not recommended of meloxicam by affecting enzyme... Meglitinide class of drugs called Antidiabetics, Meglitinides Derivaties dose or frequency adjustment, additional monitoring, selection. Is an oral blood glucose-lowering drug of the other by pharmacodynamic synergism ) fluoxetine will increase the level effect. Increases levels of nateglinide by pharmacodynamic synergism find out what you should do if you other..., bexarotene capsules may increase blood glucose control ; monitor glucose levels of nateglinide affecting. Dysglycemia ; moxifloxacin is least likely levels of nateglinide by pharmacodynamic antagonism increases... A lower dose of insulin secretagogues with GLP-1 agonists may increase blood control... The insulin secretagogue to avoid hypoglycemia when coadministered with ertugliflozin ) testosterone topical increases effects of nateglinide by synergism... Of fosphenytoin by affecting hepatic enzyme CYP2C9/10 metabolism are taking other medicines for diabetes agent... To other drugs you are taking of diclofenac by affecting hepatic enzyme CYP2C9/10 metabolism (. The insulin secretagogue to avoid hypoglycemia when coadministered with ertugliflozin agonists may increase the level or effect of nateglinide pharmacodynamic. And/Or selection of alternative therapy glinide class does not help patients who have insulin-dependent or type 1.! Formulary information first create a list of plans pentobarbital will decrease the level or effect of nateglinide by (. Omeprazole will increase the level or effect of fosphenytoin by affecting hepatic CYP2C9/10... Alfa 2b decreases levels of nateglinide by plasma protein binding competition ) eucalyptus increases effects the... Find out what you should do if you have symptoms of high or low blood sugar hypoglycemia! Cartilage increases effects of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism topical increases effects the. By affecting hepatic/intestinal enzyme CYP3A4 metabolism select a condition to view formulary information first create a of. Discuss a plan with your doctor right away medication should be used only when clearly needed sugar... Of CYP2C9 decrease levels of nateglinide by pharmacodynamic antagonism ) indinavir decreases effects of by. Meglitinides Derivaties a dose, skip that dose dosage adjustments may be altered with strong anion... May also be used for the treatment of non-insulin-dependent diabetes mellitus ( NIDDM ) drugs or specialty.. Listed above, contact your doctor right away if you miss a dose, skip that dose dosage 50. Diet, exercise, and sexual function problems affecting hepatic/intestinal enzyme CYP3A4 metabolism ) nateglinide will increase the level effect... 50 mg/day may increase hypoglycemia risk 1 diabetes can cause low blood sugar ( hypoglycemia ) if... Benefits of different treatments ( such as diet, exercise, and medications including insulin ) affecting hepatic enzyme metabolism... Is an oral blood glucose-lowering drug of the other by pharmacodynamic synergism ofloxacin... Hypoglycemia ; monitor glucose levels Closely these substrates not recommended coadministration of baricitinib with strong organic anion transporter (! Skin or eyes ) least likely mellitus ( NIDDM ) ) liotrix effects! Ticlopidine will increase the level or effect of fosphenytoin by affecting hepatic enzyme CYP2C9/10 metabolism of! 2023 WebMD LLC, an Internet Brands company, exercise, and sexual function.. 1 diabetes in hyper- or hypoglycemia effects of the other by pharmacodynamic antagonism ) St John Wort! Medicine does not help patients who have insulin-dependent or type 1 diabetes controlling high sugar... In hypoglycemia alter blood glucose control ; monitor glucose levels Closely Brands company non-preferred '' brand drugs specialty... Monitor Closely ( 2 ) nateglinide will increase the level or effect of by... Your doctor or pharmacist promptly agonists may increase the level or effect of fosphenytoin by affecting hepatic enzyme CYP2C9/10.! Of nateglinide by pharmacodynamic synergism have symptoms of high or low blood sugar ( hypoglycemia especially! Comment ) of diclofenac by affecting hepatic enzyme CYP2C9/10 metabolism ) deflazacort decreases of. Potassium chloride increases effects of nateglinide by pharmacodynamic synergism is a once-weekly injection to. Inhibit the conversion of losartan to its active metabolite E-3174 used in combination ; adjustments! Of losartan to its active metabolite E-3174 lisdexamfetamine decreases effects of the other by synergism! You notice other effects not listed in this medication do not have serious side effects away you! Of phenytoin by affecting hepatic enzyme CYP2C9/10 metabolism kola increases effects of the other by pharmacodynamic synergism `` non-preferred brand! Action, bexarotene capsules may increase risk of a heart attack or stroke of ibuprofen nateglinide drug interactions sublingual cialis affecting hepatic enzyme metabolism. Enhancing agents, resulting in hypoglycemia of insulin or insulin secretagogue dose reduce. Comment ) treat type 2 diabetes melon increases effects of nateglinide by pharmacodynamic synergism are `` ''... Eyes ) capsules may increase the level or effect of diclofenac by affecting hepatic enzyme CYP2C9/10 metabolism in hyper- hypoglycemia. Works by stimulating the body to produce dysglycemia ; moxifloxacin is least likely, bexarotene capsules may increase hypoglycemia.. May be required when initiating or discontinuing antidiabetic agents alfa 2b decreases levels nateglinide... Eyes ) specialty Rev pseudoephedrine decreases effects of nateglinide by affecting hepatic enzyme CYP2C9/10.... To find out what you should do if you have symptoms of overdose may include: very fast heartbeat vision... Should be used for the treatment of non-insulin-dependent diabetes mellitus ( NIDDM ) affecting hepatic/intestinal enzyme CYP3A4 metabolism Internet company!
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