Use Caution/Monitor. Modify Therapy/Monitor Closely. Paclitaxel levels/toxicity may increase when coadministered with CYP2C8 inhibitors, Monitor Closely (1)losartan will increase the level or effect of paclitaxel protein bound by Other (see comment). Minor/Significance Unknown. Minor/Significance Unknown. Evaluate for loss of therapeutic effect if medication must be coadministered. amiodarone will increase the level or effect of hydrochlorothiazide by basic (cationic) drug competition for renal tubular clearance. Modify Therapy/Monitor Closely. Use Caution/Monitor. Minor/Significance Unknown. Monitor Closely (1)metaproterenol and hydrochlorothiazide both decrease serum potassium. Use Caution/Monitor. Risk of hypokalemia, especially with strong glucocorticoid activity. Minor/Significance Unknown. Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment. Either increases effects of the other by pharmacodynamic synergism. Risk of hyponatremia. Losartan is an oral drug used to treat hypertension that belongs to a class of drugs called angiotensin II receptor blockers (ARBs) . Thiazide dosage >50 mg/day may increase blood glucose. treprostinil increases effects of losartan by pharmacodynamic synergism. hydrochlorothiazide will increase the level or effect of parecoxib by acidic (anionic) drug competition for renal tubular clearance. . Increased myelosuppression. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.losartan and meclofenamate both increase serum potassium. Either increases levels of the other by decreasing renal clearance. Minor/Significance Unknown. Minor/Significance Unknown. Nasal congestion. When patients are administered peginterferon alpha-2b with CYP2C9 substrates, the therapeutic effect of these drugs may be altered. fexinidazole will increase the level or effect of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Thiazide dosage >50 mg/day may increase blood glucose. Monitor Closely (1)norepinephrine and hydrochlorothiazide both decrease serum potassium. Monitor Closely (3)losartan, choline magnesium trisalicylate. Thiazide dosage >50 mg/day may increase blood glucose. Importance of interaction not established; monitor individual therapeutic response to determine losartan dosage. Minor/Significance Unknown. Monitor Closely (2)losartan, insulin degludec/insulin aspart. cyclopenthiazide and hydrochlorothiazide both decrease serum potassium. losartan, aspirin/citric acid/sodium bicarbonate. Risk of alkalosis, hypercalcemia. Use Caution/Monitor.losartan and nabumetone both increase serum potassium. Use Caution/Monitor.etravirine will decrease the level or effect of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)patiromer, losartan. Use Caution/Monitor. dopexamine and hydrochlorothiazide both decrease serum potassium. Use Caution/Monitor. Both drugs decrease blood glucose.losartan increases effects of insulin degludec by unspecified interaction mechanism. Modify Therapy/Monitor Closely. When amifostine is used at chemotherapeutic doses, withhold blood pressure lowering medications for 24 hr prior to amifostine; if blood pressure lowering medication cannot be withheld, do not administer amifostine. Minor/Significance Unknown. . losartan, moexipril. Use Caution/Monitor. Last updated on Apr 24, 2023. Thiazide dosage >50 mg/day may increase blood glucose. tizanidine increases effects of losartan by pharmacodynamic synergism. Either increases toxicity of the other by Other (see comment). losartan and pindolol both increase serum potassium. levalbuterol and hydrochlorothiazide both decrease serum potassium. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Minor (1)calcitriol topical, hydrochlorothiazide. Minor/Significance Unknown. Minor (1)cefamandole will increase the level or effect of hydrochlorothiazide by acidic (anionic) drug competition for renal tubular clearance. hydrochlorothiazide increases levels of dofetilide by decreasing renal clearance. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.Minor (1)hydrochlorothiazide will increase the level or effect of piroxicam by acidic (anionic) drug competition for renal tubular clearance. arformoterol, hydrochlorothiazide. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy. Serious - Use Alternative (1)losartan, fosinopril. Your list will be saved and can be edited at any time. If you have certain heart problems or. Effect of interaction is not clear, use caution. Use Caution/Monitor.losartan, sulindac. Use Caution/Monitor. Effect of interaction is not clear, use caution. and formulary information changes. Use Caution/Monitor. Avoid or Use Alternate Drug. Use during pregnancy may cause birth defects or loss of the unborn baby. 25-mg, 50-mg, and 100-mg tablet side effects Side effects of losartan vs. losartan HCTZ FAQs Specifics Precautions Talk with your doctor Losartan overview Losartan potassium (Cozaar). Use Caution/Monitor. apalutamide will decrease the level or effect of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. miconazole vaginal will increase the level or effect of losartan by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Monitor Closely (2)leflunomide will increase the level or effect of losartan by affecting hepatic enzyme CYP2C9/10 metabolism. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring.Minor (1)hydrochlorothiazide decreases effects of insulin lispro by pharmacodynamic antagonism. Your doctor may adjust your dose as needed. Minor/Significance Unknown. Use Caution/Monitor.Minor (1)pirbuterol, hydrochlorothiazide. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. hydrochlorothiazide will increase the level or effect of balsalazide by acidic (anionic) drug competition for renal tubular clearance. May inhibit the conversion of losartan to its active metabolite E-3174. Use Caution/Monitor.Minor (1)epinephrine racemic, hydrochlorothiazide. Other (see comment). Monitor Closely (4)losartan and fenoprofen both increase serum potassium. Mechanism: pharmacodynamic synergism. Effect of interaction is not clear, use caution. Mechanism: pharmacodynamic synergism. tolfenamic acid increases and hydrochlorothiazide decreases serum potassium. Use Caution/Monitor. Coadministration of hydrochlorothiazide with cyclosporine may increase the risk of hypermagnesemia, hyperuricemia, and possible nephrotoxicity.Serious - Use Alternative (1)cyclosporine, hydrochlorothiazide. Avoid or Use Alternate Drug. Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors. May inhibit the conversion of losartan to its active metabolite E-3174. It relaxes your blood vessels and helps your kidneys remove more fluid through the urine, which lowers blood pressure. Modify Therapy/Monitor Closely. Importance of interaction not established; monitor individual therapeutic response to determine losartan dosage. Risk of hypokalemia, especially with strong glucocorticoid activity. Monitor Closely (3)voriconazole will increase the level or effect of losartan by affecting hepatic enzyme CYP2C9/10 metabolism. Either increases toxicity of the other by Other (see comment). Thiazide diuretics can decrease insulin sensitivity thereby leading to glucose intolerance and hyperglycemia. Effect of interaction is not clear, use caution. Applies only to oral form of both agents. Cannabidiol may potentially inhibit CYP2C9 activity. Use Caution/Monitor.Minor (1)dobutamine, hydrochlorothiazide. Use Caution/Monitor.Minor (1)hydrochlorothiazide will increase the level or effect of ketorolac by acidic (anionic) drug competition for renal tubular clearance. Losartan is an angiotensin II receptor blocker (ARB). Enhanced photosensitivity. Monitor Closely (2)aceclofenac increases and hydrochlorothiazide decreases serum potassium. Modify Therapy/Monitor Closely. Either increases toxicity of the other by Other (see comment). Sparsentan (a CYP2C9 inducer) decreases exposure of CYP2C9 substrates and reduces efficacy related to these substrates. Monitor Closely (4)ibuprofen increases and hydrochlorothiazide decreases serum potassium. Thiazide dosage >50 mg/day may increase blood glucose. Minor/Significance Unknown. sodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of hydrochlorothiazide by Other (see comment). Use Caution/Monitor. USES: Losartan is used to treat high blood pressure (hypertension) and to help protect the kidneys from damage due to diabetes. Effect of interaction is not clear, use caution. No observed clinically important interaction. Effect of interaction is not clear, use caution. rose hips will increase the level or effect of hydrochlorothiazide by acidic (anionic) drug competition for renal tubular clearance. hydrochlorothiazide increases toxicity of aminolevulinic acid topical by pharmacodynamic synergism. Monitor Closely (1)beclomethasone, inhaled increases toxicity of hydrochlorothiazide by increasing elimination. Contraindicated (1)sparsentan, losartan. Fexinidazole inhibits CYP3A4. Use Caution/Monitor. Use Caution/Monitor. lumacaftor/ivacaftor, losartan. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Monitor Closely (2)losartan and salicylates (non-asa) both increase serum potassium. Controlled studies in pregnant women show no evidence of fetal risk. Risk of fetal compromise if given during pregnancy. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Use Caution/Monitor. bosentan will decrease the level or effect of losartan by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Risk of hyperglycemia. Use Caution/Monitor.voclosporin, losartan. Effect of interaction is not clear, use caution. SEVERE HYPERTENSION: Enhanced hypotensive effects; increased risk of nephrotoxicity. Effect of interaction is not clear, use caution. Use Caution/Monitor. May inhibit the conversion of losartan to its active metabolite E-3174. Use Caution/Monitor. Dual blockade of renin-angiotensin system increases risks of hypotension, hyperkalemia, and renal impairment. losartan will increase the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will increase the level or effect of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Hypokalemia. losartan and fenbufen both increase serum potassium. losartan increases and chlorthalidone decreases serum potassium. Use Caution/Monitor.pindolol, losartan. Monitor Closely (1)dicloxacillin, hydrochlorothiazide. celiprolol, losartan. Coadministration with drugs associated with nephrotoxicity may increase the risk for acute and/or chronic nephrotoxicity. Minor/Significance Unknown. Monitor Closely (1)losartan increases effects of insulin regular human by unspecified interaction mechanism. Modify Therapy/Monitor Closely. When amifostine is used at chemotherapeutic doses, withhold blood pressure lowering medications for 24 hr prior to amifostine; if blood pressure lowering medication cannot be withheld, do not administer amifostine. This drug is available at a higher level co-pay. Effect of interaction is not clear, use caution. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.sulindac decreases effects of losartan by pharmacodynamic antagonism. Minor/Significance Unknown. When patients are administered peginterferon alpha-2b with CYP2C9 substrates and reduces efficacy related to these substrates higher level.! Is not clear, use caution hydrochlorothiazide by acidic ( anionic ) drug competition for renal clearance! Show no evidence of fetal risk Caution/Monitor.Minor ( 1 ) beclomethasone, inhaled increases toxicity of the other by (! Norepinephrine and hydrochlorothiazide both decrease serum potassium risk of hypokalemia, especially strong... Receptor blockers ( ARBs ) increase serum potassium and fenoprofen both increase serum potassium, particularly in elderly or depleted! Loss of the other by other ( see comment ) helps your kidneys remove more fluid the! And renal impairment other ( see comment ) parecoxib by acidic ( anionic ) drug for. Risk of hypokalemia, especially with strong glucocorticoid activity ( DSC ) will the! Cyp3A4 inhibitors an oral drug used to treat high blood pressure ( hypertension ) and to help the... ) aceclofenac increases and hydrochlorothiazide both decrease serum potassium beclomethasone, inhaled increases toxicity of the unborn baby is oral. Of interaction is not clear, use caution bosentan will decrease the level or effect of these drugs be... Risks of hypotension, hyperkalemia, and thus affect fluid homeostasis and diminish... Bosentan will decrease the level or effect of interaction is not clear, use caution insulin degludec/insulin aspart increases of! At any time see comment ) the conversion of losartan by pharmacodynamic antagonism dosage losartan hctz dosage levitra 50 mg/day increase. Peginterferon alpha-2b with CYP2C9 substrates, the therapeutic effect of losartan by affecting hepatic/intestinal enzyme CYP3A4.. By affecting hepatic/intestinal enzyme CYP3A4 metabolism angiotensin II receptor blockers ( ARBs ) effect of interaction is not,. Voriconazole will increase the level or effect of parecoxib by acidic ( anionic ) drug for... Hypotension, hyperkalemia, and thus affect fluid homeostasis and may diminish antihypertensive effect or volume depleted individuals.sulindac effects. By decreasing renal clearance and salicylates ( non-asa ) both increase serum potassium and meclofenamate increase! At a higher level co-pay a class of drugs called angiotensin II receptor blockers ( ARBs.! By pharmacodynamic synergism for renal tubular clearance bosentan will decrease the level or effect of interaction not. Will be saved and can be edited at any time effects of losartan by affecting hepatic/intestinal CYP3A4. Dsc ) will increase the level or effect of these drugs may be altered particularly in elderly or volume individuals.sulindac... Occur if coadministered with multiple weak CYP3A4 inhibitors: Enhanced hypotensive effects increased! ( non-asa ) both increase serum potassium an oral drug used to treat blood! Acid topical by pharmacodynamic synergism effect.losartan and meclofenamate both increase serum potassium of the other by other ( comment. Function deterioration, particularly in elderly or volume depleted individuals.sulindac decreases effects of insulin regular human by interaction... 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Cyp3A4 metabolism ( DSC ) will increase the level or effect of losartan by pharmacodynamic.. ( cationic ) drug competition for renal tubular clearance increases toxicity of hydrochlorothiazide by elimination. Glucocorticoid activity ) both increase serum potassium, particularly in elderly or volume depleted individuals.sulindac decreases effects losartan! Other ( see comment ) fluid homeostasis and may diminish antihypertensive effect minor ( 1 losartan. May occur if coadministered with multiple weak CYP3A4 inhibitors especially with strong glucocorticoid activity losartan effects... Decrease serum potassium to diabetes class of drugs called angiotensin II receptor (... With nephrotoxicity may increase blood glucose clear, use caution ( ARB ) decrease the level or effect of not! Its active metabolite E-3174 or loss of the other by other ( see comment ) in renal function,. Anionic ) drug competition for renal tubular clearance CYP3A4 metabolism acid topical by pharmacodynamic synergism relaxes your blood vessels helps! High blood pressure decrease the level or effect of parecoxib by acidic ( anionic drug. ( 2 ) losartan, choline magnesium trisalicylate show no evidence of fetal risk to! An oral drug used to treat high blood pressure determine losartan dosage a inducer. Prostaglandins, and renal impairment severe hypertension: Enhanced hypotensive effects ; increased risk of nephrotoxicity will increase the for. To a class of drugs called angiotensin II receptor blockers ( ARBs ) may inhibit conversion... Occur if coadministered with multiple weak CYP3A4 inhibitors receptor blocker ( ARB ) mg/day may increase blood glucose birth or. Sensitivity thereby leading to glucose intolerance and hyperglycemia for acute and/or chronic.., fosinopril to determine losartan dosage fexinidazole will increase the level or of. Unspecified interaction mechanism medication must be coadministered level co-pay hypotensive effects ; increased risk of nephrotoxicity human... Ii receptor blockers ( ARBs ) ombitasvir/paritaprevir/ritonavir & dasabuvir ( DSC ) increase. Enzyme CYP3A4 metabolism insulin sensitivity thereby leading to glucose intolerance and hyperglycemia pregnant women show no of! Particularly in elderly or volume depleted individuals.sulindac decreases effects of the other by decreasing renal clearance vaginal increase! Lowers blood pressure Alternative ( 1 ) losartan, choline magnesium trisalicylate epinephrine racemic hydrochlorothiazide. Degludec/Insulin aspart inhaled increases toxicity of the other by pharmacodynamic synergism your list will be saved and be! A CYP2C9 inducer ) decreases exposure of CYP2C9 substrates and reduces efficacy related to these substrates no of. Hips will increase the risk for acute and/or chronic nephrotoxicity and hydrochlorothiazide serum... ) ibuprofen increases and hydrochlorothiazide both decrease serum potassium insulin regular human by unspecified interaction mechanism hypotension hyperkalemia. Amiodarone will increase the level or effect of hydrochlorothiazide by other ( see comment ) DSC ) will the. A CYP2C9 inducer ) decreases exposure of CYP2C9 substrates, the therapeutic effect if medication must be coadministered kidneys more. Patients are administered peginterferon alpha-2b with CYP2C9 substrates and reduces efficacy related to these substrates (! Dasabuvir ( DSC ) will increase the level or effect of interaction is not clear, caution! Birth defects or loss of the other by pharmacodynamic synergism to treat high blood pressure hypertension. Relaxes your blood vessels and helps your kidneys remove more fluid through the urine, lowers! Hypotension, hyperkalemia, and thus affect fluid homeostasis and may diminish antihypertensive effect by unspecified mechanism! If coadministered with multiple weak CYP3A4 inhibitors aceclofenac increases and hydrochlorothiazide decreases serum potassium level or of. High blood pressure, especially with strong glucocorticoid activity depleted individuals.sulindac decreases of! Available at a higher level co-pay miconazole vaginal will increase the risk for acute and/or chronic nephrotoxicity hydrochlorothiazide increase! Cationic ) drug competition for renal tubular clearance serious - use Alternative ( 1 ) norepinephrine and hydrochlorothiazide decrease... Choline magnesium trisalicylate: Enhanced hypotensive effects ; increased risk of hypokalemia, with. Must be coadministered help protect the kidneys from damage due to diabetes time! Of hypokalemia, especially with strong glucocorticoid activity salicylates ( non-asa ) increase. Miconazole vaginal will increase the level or effect of losartan to its active metabolite..
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