The time from the onset of therapy to the first sign of peripheral neuropathy averaged 4 months (range: 10 days to 6 months) in 10 patients with only peripheral neuropathy. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Infection 33 (2005): 151-4, 11. Limit alcoholic beverages. Solution Before Using In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Akins RL, Haase MR, Levy EN "Pharmacokinetics of daptomycin in a critically ill adolescent with vancomycin-resistant enterococcal endocarditis." Several cases of peripheral and/or optic neuropathy have been reported, mainly when the duration of therapy was longer than 28 days. Call your pharmacist if the medicine has particles in it. A 60-year-old man with spondylodiscitis developed a fatal case of C difficile colitis after a long-term course of this drug. Longer-term use of these drugs has been limited by concern for adverse effects. Linezolid comes as a tablet and oral suspension (liquid) to take by mouth. All rights reserved. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs. The patient had cardiopulmonary arrest, then anoxic brain injury, hypertension, tachycardia, and diarrhea, and died in 2 weeks; a similar incident occurred 6 weeks earlier when this drug and sertraline were used. Many people using this medication do not have serious side effects. Last updated on Apr 4, 2023. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. The intravenous infusion should be administered over a period of 30 to 120 minutes.14 Several incompatibilities have been reported: amphotericin B (Fungizone), ceftriaxone (Rocephin), chlorpromazine (Thorazine), diazepam (Valium), erythromycin, phenytoin (Dilantin), and trimethoprim-sulfamethoxazole (Bactrim).17 Because compatibility information changes, it is recommended that a pharmacist be consulted when there is doubt. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. It can increase the levels of certain natural substances in the body (such as dopamine, norepinephrine, serotonin) which can increase the chance of certain side effects and food and drug interactions. Tell your doctor right away if you have symptoms of low blood sugar such as sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. Keep all medications away from children and pets. Avoid foods that have a high level of tyramine, such as: pickled or fermented meats, smoked or air-dried meats; any meat, cheese, or other protein-based food that has been improperly stored. Pharmacotherapy 26 (2006): 694-8, 52. Do not shake the bottle. If you notice other effects not listed above, contact your doctor or pharmacist. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Senneville E, Legout L, Valette M, et al. Orrick JJ, Johns T, Janelle J, Ramphal R "Thrombocytopenia secondary to linezolid administration: what is the risk?" Quinupristin/dalfopristin (Synercid) was recently approved by the FDA for the treatment of patients with vancomycin-resistant Enterococcus faecium, methicillin-susceptible and methicillin-resistant infections. It works by stopping the growth of bacteria.This antibiotic treats only bacterial infections. Do not share this medication with others. Common side effects of linezolid may include: This is not a complete list of side effects and others may occur. pyogenes bacteria, diabetic with foot infection due to a specific bacteria, vancomycin-resistant Enterococcus faecium in the blood, hospital-acquired pneumonia from Staphylococcus bacteria, hospital-acquired pneumonia due to Streptococcus pneumoniae, infection of the brain or spinal cord caused by anthrax, infection of the blood caused by the bacteria anthrax, pulmonary multi-drug resistant tuberculosis. irritation, burning, or itching of the vagina, hives,rash, itching, difficulty breathing or swallowing, swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs, hoarseness, repeated nausea and vomiting; fast breathing; confusion; feeling tired, pain, numbness, or weakness in hands, feet, or other parts of the body, severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment), changes in color vision, blurred vision, or other changes in vision, confusion, drowsiness, weakness, difficulty breathing. Talk to your doctor or pharmacist for more details. The enterococcus species is recognized as a major nosocomial pathogen. severe stomach pain, diarrhea that is watery or bloody; a seizure; sweating, feeling anxious or shaky (may be signs of low blood sugar); lactic acidosis --unusual muscle pain, trouble breathing . pyogenes bacteria, diabetic with foot infection due to a specific bacteria, vancomycin-resistant Enterococcus faecium in the blood, hospital-acquired pneumonia from Staphylococcus bacteria, hospital-acquired pneumonia due to Streptococcus pneumoniae, infection of the brain or spinal cord caused by anthrax, infection of the blood caused by the bacteria anthrax, pulmonary multi-drug resistant tuberculosis, diarrhea from an infection with Clostridium difficile bacteria, a disorder with excess antidiuretic hormone called syndrome of inappropriate antidiuretic hormone, increased blood acidity due to high levels of lactic acid, a type of blood disorder with a decrease in all types of blood cells called pancytopenia, serotonin syndrome, a type of disorder with high serotonin levels, a painful condition that affects the nerves in the legs and arms called peripheral neuropathy, optic neuropathy, a disease of the optic nerve, allergic reaction causing inflammation of blood vessels, a blockage of the bile duct that resulting in high bilirubin levels, a skin disorder with blistering and peeling skin called toxic epidermal necrolysis, a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome, a significant type of allergic reaction called anaphylaxis, a type of allergic reaction called angioedema. In a study of patients with linezolid-associated thrombocytopenia, the use of vitamin B6 helped reverse the incidence of thrombocytopenia. Clin Infect Dis 37 (2003): 741-2, 44. Linezolid tablets or liquid can be taken with or without food. The first of the oxazolidinones, linezolid, is available as an intravenous or oral agent. If you become pregnant while taking linezolid, call your doctor. What are the side effects of Linezolid (Zyvox)? Mayo Clinic on Incontinence - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, numbness or tingling in the hands, feet, or lips, sores, ulcers, or white spots on the lips or in the mouth, vomiting of blood or material that looks like coffee grounds, blistering, peeling, or loosening of the skin, burning, numbness, tingling, or painful sensations, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, weakness in the arms, hands, legs, or feet, Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site, itching of the vagina or outside genitals, thick, white curd-like vaginal discharge without odor or with mild odor. More frequently reported side effects include: anemia, decreased hemoglobin, and thrombocytopenia. Canada residents can call a provincial poison control center. Grau S, Morales-Molina JA, Mateu-de Antonio J, Marin-Casino M, Alvarez-Lerma F "Linezolid: low pre-treatment platelet values could increase the risk of thrombocytopenia." All Rights Reserved. It has been approved for certain gram-positive infections including certain drug-resistant enterococcus, staphylococcus, and pneumococcus strains. Last updated on May 14, 2023. If you have diabetes, linezolid may lower your blood sugar. COMMON side effects If experienced, these tend to have a Severe expression i anemia headache vomiting diarrhea If experienced, these tend to have a Less Severe expression i nausea INFREQUENT. Do not use two doses at one time. 9 The absorption of orally administered linezolid is not . Arellano FM "Linezolid and reversible myelosuppression." Absorption. 2005 - 2023 WebMD LLC, an Internet Brands company. Medically reviewed by Drugs.com. Linezolid is used to treat infections, including pneumonia, and infections of the skin . Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take the missed dose as soon as you remember it. Adverse effects reported in clinical trials in more than 2 percent of patients include the following: rash, headache, diarrhea, nausea, vomiting, insomnia, constipation, and fever.15 The incidence was similar to the comparator groups: ceftriaxone, clarithromycin (Biaxin), dicloxacillin (Pathocil), oxacillin (Bactocill), and vancomycin. However, you should not flush this medication down the toilet. Infection 33 (2005): 155-7, 30. Senneville E, Legout L, Valette M, et al. All rights reserved. The introduction of penicillin in 1944 was soon followed by reports of resistance to Staphylococcus aureus. Med Lett Drugs Ther 51 (2009): 36; quiz 37, 58. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. . Espaol. Ann Pharmacother 41 (2007): 1694-9, 24. Clin Infect Dis 37 (2003): 1609-16, 45. Tedizolid is a newer drug in the same class with comparable spectrum of activity but with limited US Food and Drug Administration-approved indications. Also tell your doctor if you are taking fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), or have stopped taking it within the past 5 weeks. tell your doctor if you are taking the following medications or have stopped taking them within the past two weeks: isocarboxazid (Marplan) phenelzine (Nardil). Many other medications may also interact with linezolid, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Do not take more or less of it or take it more often than prescribed by your doctor. Methicillin-Resistant Staphylococcus Aureus Infection. Rare, but severe side effects include serotonin syndrome, thrombocytopenia, optic and peripheral neuropathy, pancreatitis and lactic acidosis. Some products that may interact with this drug include: diet pills/appetite suppressants (such as diethylpropion), drugs for attention deficit disorder (such as atomoxetine, methylphenidate), apraclonidine, bupropion, buspirone, carbamazepine, cyclobenzaprine, deutetrabenazine, a certain combination product (dextromethorphan/quinidine), levodopa, maprotiline, methyldopa, metoclopramide, certain opioid pain relievers (such as fentanyl, meperidine, methadone, tapentadol), certain drugs for Parkinson's disease (such as entacapone, tolcapone), certain supplements (such as tryptophan, tyramine), tetrabenazine, tricyclic antidepressants (such as amitriptyline, doxepin), valbenazine. Keep using linezolid even if your symptoms quickly improve. This study concluded vitamin B6 was not beneficial in the prevention of leukopenia or thrombocytopenia, but found a possible trend towards the prevention of anemia. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). tell your doctor if you have a chronic (long-lasting) infection, or if you have or have ever had carcinoid syndrome (a condition in which a tumor secretes serotonin). You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Do not freeze. Skipping doses could make your infection resistant to medication. You will need frequent medical tests. This drug may rarely cause an attack of extremely high blood pressure (hypertensive crisis), which may be fatal. Three patients died. Linezolid is a synthetic antibiotic belonging to a new class of antimicrobials called the oxazolidinones. Clin Infect Dis 35 (2002): 347-8, 41. Continue reading for a comprehensive list of adverse effects. The lactate levels normalized in the 5 surviving patients after stopping this drug, but 1 of the patients had sequelae of blindness and disorientation. Although not all of these side effects may occur, if they do occur they may need medical attention. Results from a compassionate use trial involving treatment of patients with bacteremia for resistant, gram-positive infections reveal that linezolid was well tolerated.20 By the fifth day of the study, 75 percent of the bacteremia had resolved. Serotonin syndrome, thrombocytopenia, the use of vitamin B6 helped reverse the incidence of thrombocytopenia start or the... Consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances antibiotic belonging a... 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