Levofloxacin 500 MG Tablet can cause diarrhoea. Iquix Levofloxacin Solution (Vistakon Pharmaceuticals LLC). Inhalational (postexposure prophylaxis) (AAP [Bradley 2014]): Reserve levofloxacin use for penicillin-resistant strains or prior to susceptibility testing. https://dailymed.nlm.nih.gov/dailymed/. This information is not country-specific. Longer treatment duration (eg, >14 days) may increase risk (Lee 2018a). Patients with additional risk factors for QTc prolongation may be at even higher risk. Accessed 02/07/2019. This is only a brief summary of general information about this medicine. DailyMed. Ensure adequate fluid intake. A typical levofloxacin dosage is 250, 500, or 750 mg every 24 hours for five to 10 days. Confirmation of positive opioid screens by more specific methods should be considered. Patients with additional risk factors for QTc prolongation may be at even higher risk. Treatment duration: 7 to 10 days for naturally-acquired infection, and up to 60 days for biological weapon-related event. Because fluoroquinolones have been associated with serious adverse reactions, reserve levofloxacin for use in patients who have no alternative treatment options for the following indications: uncomplicated urinary tract infection, acute bacterial exacerbation of chronic bronchitis, and acute bacterial sinusitis. Avoid combination, Amphetamines: May enhance the cardiotoxic effect of Quinolones. Uniquin (Levofloxacin) dosage. 500 milligrams (mg) once a day. Infants 6 months and Children <5 years: Oral, IV: 8 to 10 mg/kg/dose every 12 hours; maximum daily dose: 750 mg/day, Children 5 years and Adolescents 16 years: Oral, IV: 8 to 10 mg/kg/dose once every 24 hours; maximum daily dose: 750 mg/day. Systemic anthrax (excluding meningitis); treatment (AAP [Bradley 2014]): Note: A fluoroquinolone is appropriate for all strains regardless of penicillin susceptibility or if susceptibility unknown; ciprofloxacin is preferred. Drug information provided by: Merative, Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Accessed 02/07/2019. Elderly: Adverse effects (eg, hepatotoxicity, tendon rupture, QT changes, aortic dissection) may be increased in the elderly. Duration of therapy to complete treatment course is variable; some patients may require up to 60 days additional prophylaxis from onset of illness. Levofloxacin also comes as. Patients with additional risk factors for QTc prolongation may be at even higher risk. Accessed 24/09/2014. Monitor therapy, Probenecid: May decrease the excretion of Quinolones. Management: Vaccination with live attenuated typhoid vaccine (Ty21a) should be avoided in patients being treated with systemic antibacterial agents. Never take more than the prescribed dose. Accessed 24/09/2014. Adults: The typical dose is 250 mg, 500 mg, or 750 mg by mouth once every 24 hours. Typical pathogens (eg, H. influenzae, S. pneumoniae): Note: Oral administration is generally reserved for mild infections or step-down therapy. DailyMed. Children and Adolescents: Oral, IV: 10 to 20 mg/kg/day divided every 12 to 24 hours for 10 to 14 days; maximum daily dose: 500 mg/day. 8. Levofloxacin (brand: Levaquin) is the generic name of the third generation fluoroquinolone antibiotics used for the management of various bacterial infections- especially those found in the urinary and lower respiratory tract infections. Viagra relaxes muscles found in the walls of blood vessels and increases blood flow to particular areas of the body. Patients with additional risk factors for QTc prolongation may be at even higher risk. For dosing of 500 mg 12 hourly: Initially, 500 mg followed by 125 mg 24 hourly. Exceptions: Calcium Chloride. It cures the infection by killing or stopping the growth of bacteria. Information specific to levofloxacin use during pregnancy is limited (Padberg 2014). Levofloxacin Solution/Drops (Micro Labs Limited). Monitor therapy, QT-prolonging Antipsychotics (Moderate Risk): QT-prolonging Quinolone Antibiotics (Moderate Risk) may enhance the QTc-prolonging effect of QT-prolonging Antipsychotics (Moderate Risk). Levofloxacin 500 MG Tablet is effective against a large number of bacteria. Monitor therapy, Verteporfin: Photosensitizing Agents may enhance the photosensitizing effect of Verteporfin. Cases have been reported within hours or days of initiation, and up to several months after discontinuation of therapy. Community acquired pneumonia: 500 mg once daily for 7-14 days or 750 mg once daily for 5 days. Management: Administer oral quinolones at least 2 hours before or 6 hours after sevelamer. <50 kg: IV: 10 mg/kg/dose every 12 hours; maximum dose: 250 mg/dose. Interaction with alcohol is unknown. Specifically, polyvalent cations in multivitamin products may decrease the absorption of orally administered quinolone antibiotics. Consider therapy modification, Magnesium Salts: May decrease the serum concentration of Quinolones. Oral step-down therapy: Use in combination with a protein synthesis inhibitor (eg, clindamycin). Used in the systemic treatment of infections. Accessed 02/07/2019. . Consider therapy modification, QT-prolonging Miscellaneous Agents (Moderate Risk): May enhance the QTc-prolonging effect of QT-prolonging Quinolone Antibiotics (Moderate Risk). Patient with history of prolonged QT interval, uncorrected electrolyte disorders (e.g. Rheumatoid arthritis: Use with caution in patients with rheumatoid arthritis; may increase risk of tendon rupture. Strenuous physical activity, renal failure, and previous tendon disorders may be independent risk factor for tendon rupture. Thus it cures the infection by killing or stopping the growth of bacteria. G6PD deficiency: Hemolytic reactions may (rarely) occur with quinolone use in patients with latent or actual G6PD deficiency. Altered cardiac conduction: Fluoroquinolones may prolong QTc interval; avoid use in patients with a history of QTc prolongation, uncorrected hypokalemia, hypomagnesemia, or concurrent administration of other medications known to prolong the QT interval (including Class Ia and Class III antiarrhythmics, cisapride, erythromycin, antipsychotics, and tricyclic antidepressants). Chronic obstructive pulmonary disease, acute exacerbation: Oral, IV: 500 mg once daily (Amsden 2003) for 5 to 7 days (Bartlett 2019; GOLD 2018); use 750 mg once daily if Pseudomonas aeruginosa is suspected (Martinez 2005; Nicolau 2012). Consider therapy modification, Lactobacillus and Estriol: Antibiotics may diminish the therapeutic effect of Lactobacillus and Estriol. Consider therapy modification, BCG (Intravesical): Antibiotics may diminish the therapeutic effect of BCG (Intravesical). Accessed 02/07/2019. Tuberculosis, multidrug-resistant: Limited data available: Note: Use in combination with at least 2 to 3 additional anti-TB agents (overall multidrug regimen dependent upon susceptibility profile/patterns) (Seddon 2012): Infants and Children <5 years: Oral: 7.5 to 10 mg/kg/dose every 12 hours; maximum daily dose: 750 mg/day, Children 5 years and Adolescents: Oral: 7.5 to 10 mg/kg/dose every 24 hours; maximum daily dose: 750 mg/day, Urethritis, nongonococcal: Adolescents: Oral: 500 mg every 24 hours for 7 days (CDC [Workowski 2015]). If a drug's FDA approval could be overturned by any judge, anywhere, anytime the pharmaceutical industry would be . mice, rats, monkeys) observed symptoms included ataxia, ptosis, decreased motor activity, dyspnea, tremors, and convulsions. Maintain adequate hydration of patient to prevent crystalluria or cylindruria. Recommendations for optimal dose separation vary by specific quinolone. Some experts instead categorize UTI as either acute simple cystitis (mild infection limited to the bladder with no signs/symptoms of upper tract or systemic infection in a nonpregnant adult) or complicated UTI (pyelonephritis or cystitis symptoms with other signs/symptoms of systemic infection) (Hooton 2019a; Hooton 2019b). Monitor therapy, Vitamin K Antagonists (eg, warfarin): Quinolones may enhance the anticoagulant effect of Vitamin K Antagonists. Acute pyelonephritis or other complicated urinary tract infection: Note: If the prevalence of fluoroquinolone resistance is >10%, an initial dose of a long-acting parenteral antimicrobial, such as ceftriaxone, ertapenem, or a consolidated 24-hour dose of an aminoglycoside is recommended for outpatients (Hooton 2019b; IDSA [Gupta 2011]). Mild to moderate infection: Oral: 500 mg every 24 hours (750 mg every 24 hours if P. aeruginosa is suspected) (IDSA [Lipsky 2012]; Weintrob 2019). Lexicomp Online. Drug-resistant tuberculosis: Oral, IV: 750 mg to 1 g every 24 hours given in combination with additional appropriate antituberculosis agents. European Medicines Agency [online]. When used as empiric therapy, use in combination with other appropriate agents (IDSA/ATS [Kalil 2016]). Based on the American Thoracic Society, CDC, and IDSA guidelines for the treatment of tuberculosis, levofloxacin is an effective and recommended alternative agent for treatment of drug-resistant tuberculosis caused by sensitive organisms or when first-line agents are intolerable. Levofloxacin 500 MG Tablet may cause dizziness or sleepiness and alter your eyesight. Monitor therapy, QT-prolonging Antidepressants (Moderate Risk): QT-prolonging Quinolone Antibiotics (Moderate Risk) may enhance the QTc-prolonging effect of QT-prolonging Antidepressants (Moderate Risk). Dosage. Levofloxacin Injection (Akorn, Inc.). Monitor therapy, Multivitamins/Minerals (with ADEK, Folate, Iron): May decrease the serum concentration of Quinolones. Avoid combination, Nonsteroidal Anti-Inflammatory Agents: May enhance the neuroexcitatory and/or seizure-potentiating effect of Quinolones. Begin therapy as soon as possible after exposure. As the S(-) enantiomer of the fluoroquinolone, ofloxacin, levofloxacin, inhibits DNA-gyrase in susceptible organisms thereby inhibits relaxation of supercoiled DNA and promotes breakage of DNA strands. Levofloxacin 500 MG Tablet is effective against a large number of bacteria. Note: Anthrax vaccine should also be administered to exposed individuals (CDC [Hendricks 2014]). Dosage Warnings Take as directed Important considerations Alternatives Highlights for levofloxacin Levofloxacin oral tablet is available as a generic drug only. Courts Allowed to Ban Mife Today, Viagra Tomorrow? Disclaimer: This information is independently developed by MIMS based on Levofloxacin from various references and is provided for your reference only. Martindale: The Complete Drug Reference [online]. Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Patients with additional risk factors for QTc prolongation may be at even higher risk. Benzyl alcohol and derivatives: Some dosage forms may contain benzyl alcohol; large amounts of benzyl alcohol (99 mg/kg/day) have been associated with a potentially fatal toxicity ("gasping syndrome") in neonates; the "gasping syndrome" consists of metabolic acidosis, respiratory distress, gasping respirations, CNS dysfunction (including convulsions, intracranial hemorrhage), hypotension, and cardiovascular collapse (AAP ["Inactive" 1997]; CDC 1982); some data suggests that benzoate displaces bilirubin from protein binding sites (Ahlfors 2001); avoid or use dosage forms containing benzyl alcohol with caution in neonates. Specifically, minerals in the multivitamin/mineral product may impair absorption of quinolone antibiotics. 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