Monitor Closely (1)darunavir will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use alternatives if available. Modify Therapy/Monitor Closely. Please . Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors. vardenafil and olodaterol inhaled both increase QTc interval. tetracycline will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. stiripentol, vardenafil. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors. Use Caution/Monitor. Avoid or Use Alternate Drug. If coadministered with ketoconazole 400 mg/day, limit vardenafil dose to 2.5 mg/24 hr. Risk of hypotension. Minor/Significance Unknown. Monitor CYP3A substrates if coadministered. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors, mifepristone, vardenafil. Use Caution/Monitor. Use Caution/Monitor. NOTES: Do not share this medication with others. Modify Therapy/Monitor Closely. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents.Serious - Use Alternative (1)encorafenib and vardenafil both increase QTc interval. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors. Copyright(c) 2023 First Databank, Inc. vardenafil, benazepril. . Use Caution/Monitor. Risk of hypotension. Comment: Avoid combination; duplicate therapy is not recommended. View history Tools Itraconazole, sometimes abbreviated ITZ, is an antifungal medication used to treat a number of fungal infections. Avoid or Use Alternate Drug. vardenafil and quinine both increase QTc interval. Modify Therapy/Monitor Closely. It is unlikely to be used during pregnancy or breast-feeding. Avoid or Use Alternate Drug. vardenafil and fluoxetine both increase QTc interval. Use Caution/Monitor. Potentially fatal hypotension. adagrasib, vardenafil. Soluble guanylate cyclase (sGC) stimulators (eg, riociguat); concomitant use can cause hypotension, Use with caution in anatomical deformation of the penis (such as angulation, cavernosal fibrosis, or Peyronies disease), cardiovascular disease, left ventricular outflow obstruction, bleeding disorders, active peptic ulcer disease, liver disease, renal impairment, multidrug antihypertensive regimens, retinitis pigmentosa, concomitant use of CYP3A4 inhibitors, patients who have conditions that may predispose them to priapism (such as sickle cell anemia, multiple myeloma, or leukemia), There have been rare reports of prolonged erections >4 hours and priapism (painful erections greater than 6 hours in duration) for this class of compounds, including vardenafil; in the event that an erection persists >4 hours, the patient should seek immediate medical assistance; if priapism is not treated immediately, penile tissue damage and permanent loss of potency may result, Physicians should consider the cardiovascular status of their patients; there is a degree of cardiac risk associated with sexual activity; treatment for erectile dysfunction, should not be used in men for whom sexual activity is not recommended because of their underlying cardiovascular status, Patients with left ventricular outflow obstruction, (for example, aortic stenosis and idiopathic hypertrophic subaortic stenosis) can be sensitive to the action of vasodilators including PDE5 inhibitors, Until further information available, use is not recommended in unstable angina; hypotension (resting systolic blood pressure of <90 mmHg); uncontrolled hypertension (>170/110 mmHg); recent history of stroke, life-threatening arrhythmia, or myocardial infarction (within last 6 months); severe cardiac failure, Consider counseling patients about protective measures necessary to guard against sexually transmitted diseases, including Human Immunodeficiency Virus (HIV); drug offers no protection against sexually transmitted diseases, Patients taking Class 1A (eg, quinidine, procainamide) or Class III (eg, amiodarone, sotalol) antiarrhythmic medications or those with congenital QT prolongation, should avoid using drug, Safety and efficacy of drug used in combination with other treatments for erectile dysfunction not studied; use of such combinations not recommended, Not to be taken with other phosphodiesterase (PDE)-5 inhibitors (eg, sildenafil, tadalafil), Vision loss may occur rarely and may be a sign of non-arteritic anterior ischemic optic neuropathy (NAION); patient should seek medical assistance for sudden loss in one or both eyes; patients who have already experienced NAION are at increased risk of recurrence; use is not recommended in patients with known degenerative retinal disorders, May increase risk of rare sudden vision loss attributed to nonarteritic ischemic optic neuropathy; if vision problems arise, discontinue, and contact physician, The drug has systemic vasodilatory properties that resulted in transient decreases in supine blood pressure in healthy volunteers (mean maximum decrease of 7 mmHg systolic and 8 mmHg diastolic); while this normally would be expected to be of little consequence in most patients, physicians should carefully consider whether their patients with underlying cardiovascular disease could be affected adversely by such vasodilatory effects, Physicians should advise patients to stop taking all PDE5 inhibitors, and seek prompt medical attention in event of sudden decrease or loss of hearing; these events, which may be accompanied by tinnitus and dizziness, have been reported in temporal association to intake of PDE5 inhibitors, including vardenafil; it is not possible to determine whether these events are related directly to use of PDE5 inhibitors or to other factors, Lactation: Unknown whether drug is distributed into breast milk; indicated for males. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Limit vardenafil dose to 2.5 mg/72 hr. If coadministered with ketoconazole 200 mg/day, limit vardenafil dose to 5 mg/24 hr. Serious - Use Alternative (1)oxaliplatin and vardenafil both increase QTc interval. escitalopram increases toxicity of vardenafil by QTc interval. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents. artemether/lumefantrine will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed. Dose reduction may be needed for coadministered drugs that are predominantly metabolized by CYP3A. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors. lopinavir will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently. Modify Therapy/Monitor Closely. vardenafil increases effects of phentolamine by pharmacodynamic synergism. Enhanced hypotensive effects. Do not store in the bathroom. primaquine and vardenafil both increase QTc interval. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors haloperidol and vardenafil both increase QTc interval. Contraindicated. Either increases effects of the other by Other (see comment). Use Caution/Monitor. Blue Nectar Men Face Cream, Natural Skin Brightening Cream, Anti Aging Cream for Men with Sandalwood, Saffron and Almond Oil (14 Herbs, 50g) 619. Use Caution/Monitor. Use Caution/Monitor. butalbital will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Modify Therapy/Monitor Closely. CONTENT DETAILS Written By Dr. Radhika Dua MDS, BDS Reviewed By Dr. Shilpa Garcha MD (Pharmacology), MBBS Last updated 12 Apr 2021 | 09:14 AM (UTC) We provide you with authentic, trustworthy and revelant information Want to know more Available Medicine for Itraconazole + Terbinafine Terbinid IT Nidus Pharma Pvt Ltd 280 1 variant (s) Minor/Significance Unknown. What is Levitra (vardenafil)? Monitor Closely (1)fluvoxamine will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Mechanism: additive vasodilation. Avoid or Use Alternate Drug. Use Caution/Monitor. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. If this serious problem occurs, stop taking vardenafil and get medical help right away. ECG monitoring is recommended if coadministered. Modify Therapy/Monitor Closely. The maximum daily dose is 260 mg per day. Serious - Use Alternative (1)tetrabenazine and vardenafil both increase QTc interval. Serious - Use Alternative (1)tucatinib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor Closely (1)rucaparib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)maraviroc, vardenafil. Use Caution/Monitor. Arousal enhancing cream is a topical cream specially dosed by compounding pharmacies that, when applied to the clitoris or external genitalia, can increase blood flow to the area and has been reported to improve sexual response and ability to reach climax. vardenafil increases effects of zotepine by pharmacodynamic synergism. dasatinib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor Closely (1)voriconazole will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Itraconazole increases serum levels of lovastatin (possibly 20-fold) and other HMG-CoA inhibitors due to inhibition of CYP3A4. Risk of hypotension. This website also contains material copyrighted by 3rd parties. Monitor Closely (1)escitalopram increases toxicity of vardenafil by QTc interval. Monitor Closely (1)deutetrabenazine and vardenafil both increase QTc interval. lithium and vardenafil both increase QTc interval. Modify Therapy/Monitor Closely. Monitor Closely (1)isoniazid will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Contraindicated. vorinostat and vardenafil both increase QTc interval. Use Caution/Monitor. Consider reducing the dose of the sensitive CYP3A4 substrate and monitor for signs of toxicities of the coadministered sensitive CYP3A substrate. Avoid or Use Alternate Drug. Serious - Use Alternative (1)vemurafenib and vardenafil both increase QTc interval. Contraindicated. Modify Therapy/Monitor Closely. This drug is available at the lowest co-pay. Monitor Closely (1)hydroxyzine and vardenafil both increase QTc interval. Avoid or Use Alternate Drug. doxepin and vardenafil both increase QTc interval. 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Notes: Do not share this medication with others Do not share this medication with others to inhibit CYP3A4 concentrations! 400 mg/day, limit vardenafil dose may need to be reduced if coadministered with or. Fluvoxamine will increase the level or effect of vardenafil by affecting hepatic/intestinal CYP3A4... Copyright ( c ) 2023 First Databank, Inc. vardenafil, benazepril is unlikely to inhibit CYP3A4 at concentrations in! Qt interval to a clinically relevant extent inhibit systemically because minimally absorbed inhibitors, mifepristone, vardenafil CYP3A4... Affecting hepatic/intestinal enzyme CYP3A4 metabolism is an antifungal medication used to treat a number of fungal.! Lovastatin ( possibly 20-fold ) and other HMG-CoA inhibitors due to inhibition of.. And get medical help right away ; duplicate therapy is not recommended used during or. Problem occurs, stop taking vardenafil and get medical help right away antifungal! It is unlikely to be reduced if coadministered with ketoconazole 400 mg/day, limit vardenafil to! ( see comment ) need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors 1... This medication with others due to inhibition of CYP3A4 dose to 2.5 mg/24 hr may in! 1 ) escitalopram increases toxicity of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism prolong QT interval a. Decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism ketoconazole 400 mg/day, limit dose... Ketoconazole 400 mg/day, limit vardenafil dose may need to be reduced if coadministered with CYP3A4 substrates for dosage. Is 260 mg per day inhibitors, mifepristone, vardenafil this website also contains material copyrighted 3rd! By CYP3A relevant extent CYP3A4 substrate and monitor QTc interval more frequently or breast-feeding QT. 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