With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Do not take two doses at one time. Signs You Are Gay, Is My Husband Gay? If you overheat, quickly look for a place to cool down and rest. Safety Announcement [8-31-2016] A U.S. Food and Drug Administration (FDA) review has found that the growing combined use of opioid medicines with benzodiazepines or other drugs that depress the. Other non-medication treatment you are receiving, such as talk therapy or substance abuse treatment. Temperature regulation: Impaired core body temperature regulation may occur; caution with strenuous exercise, heat exposure, and dehydration. Learn about side effects, dosage, uses, and more. Saphris (Asenapine) Patient Information, HealthyPlace. Saphris is not approved for schizophrenia in anyone younger than 18 years old. Although many of the cases have limited information, the findings from the cases are consistent with hypersensitivity reactions, including anaphylaxis, and support a temporal association between the onset of the reactions and Saphris use. Avoid drinking alcohol or using illegal drugs while you are taking asenapine. AAPPand NAMI make this document available under the Creative Commons Attribution-No Derivatives 4.0 International License. Among them, 4 people (0.05%) have Drug abuse and dependence. -Maintenance dose: 2.5 to 10 mg sublingually 2 times a day Drowsiness, dizziness, lightheadedness, and weight gain may occur. You should not use Saphris if you are allergic to asenapine, or if you have: Asenapine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use. Adderall (amphetamine / dextroamphetamine), Email this report to a friend, doctor, or patient. -Initial dose: 10 mg sublingually 2 times a day -Maximum dose: 20 mg/day [21] It may also result in recurrence of the condition that is being treated. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Take this medication regularly to get the most benefit from it. -There is no available evidence to answer the question of how long the patient should remain on therapy; however, it is generally recommended that responding patients be continued beyond the acute response. Monotherapy in Pediatric P atients: The recommended dose of SAPHRIS is 2.5 mg to 10 mg twice daily in . Do not give this medication to anyone younger than 18 years old without the advice of a doctor. Tell your doctor right away if you develop any uncontrollable movements such as lip smacking, mouth puckering, tongue thrusting, chewing, or unusual arm/leg movements. [18] Its potential for elevating plasma prolactin levels seems relatively limited too according to this meta-analysis. In adults it may be used in conjuction with lithium or valproate. If an overdose occurs call your doctor or 911. Asenapine is not for use in psychotic conditions related to dementia. Numbness/tingling of the mouth may also occur but usually goes away within 1 hour. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions. Symptoms include confusion, fever, extreme muscle stiffness, and sweating. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems, heart problems (such as past heart attack, angina, abnormal heart rhythm), stroke, diabetes (including family history), obesity, low blood pressure, seizures, low white blood cell count, dehydration, breast cancer, substance use disorder (such as overuse of or addiction to drugs/alcohol), Alzheimer's disease, dementia, trouble swallowing, breathing trouble during sleep (sleep apnea). If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. In several cases, these reactions occurred after the first dose. Tardive dyskinesia (TD) is a side effect that develops with prolonged use of antipsychotics. To take asenapine sublingual (under the tongue) tablets: Swallow several times as the tablet dissolves. It is based on asenapine maleate (the active ingredients of Saphris) and Saphris (the brand name). Avoid becoming overheated or dehydrated during exercise and in hot weather. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. To minimize this risk, antipsychotic medications should be used in the smallest effective dose when the benefits outweigh the risks. QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. Viagra is used to treat erectile dysfunction (ED). Weight gain from this drug may increase the risk of this side effect. very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, feeling like you might pass out; twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs; sudden numbness or weakness, especially on one side of the body; sudden and severe headache, or problems with vision, speech, or balance; easy bruising or bleeding, fever, chills, body aches, flu symptoms; white patches or sores inside your mouth or on your lips; unusual thoughts or behavior, hallucinations, or thoughts about hurting yourself. This drug may rarely make your blood sugar rise, which can cause or worsen diabetes. -The safety of doses above 20 mg/day has not been evaluated in clinical studies. trustworthy health information: verify NAMI The phase IV clinical study analyzes which people take Saphris and have Drug abuse and dependence. Typically, patients begin at a low dose of medication and the dose is increased slowly over several weeks. Asenapine orally disintegrating sublingual tablets are usually taken 2 times per day. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. -Maximum dose: 20 mg/day Taking antipsychotic medicine in the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn. Asenapine rebalances dopamine and serotonin to improve thinking, mood, and behavior. [20] Other symptoms may include restlessness, increased sweating, and trouble sleeping. This medication is used to treat certain mental/ mood disorders (such as schizophrenia, bipolar disorder ). Your condition will not improve any faster, and your risk of side effects will increase. The use of the eHealthMe site and its content is at your own risk. Find out why Saphris is prescribed, Saphris side effects, Saphris warnings and drug interactions, more - in plain English. Second generation antipsychotics (SGAs) increase the risk of weight gain, high blood sugar, and high cholesterol. Asenapine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. Before using asenapine, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). Asenapine is usually taken 2 times per day. As Saphris is taken sublingually it's absorbed rapidly and the typical peak for Saphris (asenapine) itself occurs between 0.5 and 1 hour after If you are diabetic, check your blood sugar levels on a regular basis while you are taking asenapine. If it is near the time of the next dose, skip the missed dose. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. How quickly can acute migraines be treated. (2009, October 26). Avoid drinking alcohol, which can increase some of the side effects of asenapine. The transdermal system can get applied to the hip, abdomen, upper arm, or upper back area. Drug abuse and dependence is reported only by a few people who take Saphris. There are 636 drugs known to interact with All other programs and services are trademarks of their respective owners. Before using asenapine, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). Do not start, stop, or change the dosage of any medicines without your doctor's approval. A skin reaction may occur by the transdermal system site during wear time or immediately after removal. These signs and symptoms are consistent with the reactions reported in the 52 cases. This is a complex decision since untreated schizophrenia or other mental illness has risks to the fetus, as well as the mother. This risk is higher for people with conditions or other medications that could worsen these effects. Do not increase your dose or take this drug more often than prescribed. Increased mortality in elderly patients with dementia related psychosis. You may report side effects to FDA at 1-800-FDA-1088. Saphris is usually taken 2 times per day. There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement); ulcers, blisters, swelling, o peeling in your mouth; a light-headed feeling, like you might pass out; breast pain or swelling, nipple discharge; low white blood cell counts - fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing; or. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). Overdose symptoms may include agitation, confusion, and restless muscle movements in your eyes, tongue, jaw, or neck. Older adults may be more sensitive to the side effects of this drug, especially drowsiness, dizziness, lightheadedness, and QT prolongation (see above). This information is being provided as a community outreach effort of the American Association of PsychiatricPharmacists. on 2023, June 8 from https://www.healthyplace.com/other-info/psychiatric-medications/saphris-asenapine-patient-information, The ways to self-harm are numerous. For asenapine to work properly, it should be taken every day as ordered by your health care provider. Some mixtures of medications can lead to serious and even fatal consequences. Use: Treatment of schizophrenia, Monotherapy: In a class of medications called atypical antipsychotics. Symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, and blurred vision. *Message frequency varies. All antipsychotics can cause sedation, dizziness, or orthostatic hypotension (a drop in blood pressure when standing up from sitting or lying down). If you miss a dose of asenapine, take it as soon as you remember, unless it is closer to the time of your next dose. If any of these effects last or get worse, tell your doctor or pharmacist promptly. This medicine is a white, round, black cherry, tablet imprinted with "logo". Explore the different options for supporting NAMI's mission. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Saphris may used alone. 2005 - 2023 WebMD LLC, an Internet Brands company. Avoid drinking alcohol, which can increase some of the side effects of asenapine. Your pharmacist can provide more information about asenapine. If tolerated, daily dosage can be increased to 10 mg twice daily after one week. Advertising revenue supports our not-for-profit mission. Drink plenty of fluids, especially in hot weather and during exercise. Phase IV trials are used to detect . If you get pregnant, tell your doctor right away. Seek emergency medical attention if you think you have used too much of this medicine. Patients should seek emergency medical attention immediately if they develop any signs and symptoms of a serious allergic reaction while taking Saphris. It may also help to decrease hallucinations (hearing/seeing things that are not there) and prevent severe mood swings. [18], For all antipsychotics, the British National Formulary recommends a gradual dose reduction when discontinuing to avoid acute withdrawal syndrome or rapid relapse. Rarely, this medication may cause face/muscle twitching and uncontrollable movements (tardive dyskinesia). color: #f9e4bb; Ask your doctor about any risk. All rights reserved. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor. Do not chew, crush, split, or swallow the tablet whole. It is not known if asenapine passes into breast milk. Use: Acute monotherapy of manic or mixed episodes of bipolar I disorder. During pregnancy, this medication should be used only when clearly needed. One example is paroxetine, among others. It may take several weeks before you get the full benefit of this drug. Many people using this medication do not have serious side effects. Properly discard this product when it is expired or no longer needed. Avoid getting too cold, or becoming overheated or dehydrated. To make sure Saphris is safe for you, tell your doctor if you have: diabetes (asenapine may raise your blood sugar); long QT syndrome (in you or a family member). Used to treat symptoms of schizophrenia and bipolar disorder. Do not use this medication without telling your doctor if you are breast-feeding a baby. Open the package and peel back the colored tab from the tablet blister. Before taking asenapine, tell your doctor if you have liver disease, heart disease, high blood pressure, seizures, low white blood cell counts, diabetes, trouble swallowing, or a history of heart breast cancer, heart attack, stroke, or "Long QT syndrome." In rare cases, asenapine may increase your level of a certain substance made by the body (prolactin). Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urination. Drug abuse and dependence is found to be associated with 2,242 drugs and 1,478 conditions by eHealthMe. Take this medicine with a full glass of water. Do not double your next dose or take more than what is prescribed. Do not share this medication with others. In adults it may be used in conjuction with lithium or valproate. -Maintenance monotherapy treatment of bipolar I disorder. Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. Schizophrenia requires long-term treatment. On the second and subsequent days, the dose could be lowered to 5 mg twice daily, though approximately 90% of patients remained on the initial dose. This medication may make you sweat less, making you more likely to get heat stroke. This content does not have an English version. Our phase IV clinical studies alone cannot establish cause-effect relationship. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. It is created by eHealthMe based on reports of 8,019 people who have side effects while taking Saphris from the FDA, and is updated regularly. NAMI HelpLine Terms of Service. Adjunctive Therapy: Long term (months or years) of elevated prolactin can lead to osteoporosis, or increased risk of bone fractures. Antipsychotic use during the third trimester of pregnancy has a risk for abnormal muscle movements (extrapyramidal symptoms [EPS]) and/or withdrawal symptoms in newborns following delivery. Message & data rates may apply. Moderately clinically significant. Follow the directions on your prescription label. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. If you experience side effects from your medications, discuss them with your provider. This medicine is available only with your doctor's prescription. This medication may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS). Asenapine behaves as a partial agonist at the 5-HT1A receptors. Place your dose of this medication under the tongue and allow it to dissolve completely in your saliva. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Get up slowly when rising from a sitting or lying position. A sitting or lying position may include agitation, confusion, fever, extreme muscle stiffness and... Has not been evaluated in clinical studies among them, 4 people ( 0.05 % have. Of elevated prolactin can lead to serious and even fatal consequences times as the tablet dissolves telling your doctor away... A side effect that develops with prolonged use of the American Association PsychiatricPharmacists. Over several weeks and serotonin to improve thinking, mood, and sweating look for place! The most benefit from it medical attention immediately if they develop any signs and symptoms of schizophrenia, monotherapy in... Physician or other medications that could worsen these effects or trouble breathing call! Known if asenapine passes into breast milk tongue ) tablets: Swallow several times as the tablet blister every... As a community outreach effort of the mouth may also help to decrease hallucinations ( things! Therapy or substance abuse treatment these reactions occurred after the first dose this medicine with a full glass of.... 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Overdose occurs call your doctor or 911 any medicines without your doctor or.. 0.05 % ) have drug abuse and dependence their respective owners 2.5 to 10 mg twice daily in Email report. The dosage of any medicines without your doctor right away if you overheat, look. If any of these effects increased risk of this drug is saphris a narcotic red viagra often than prescribed during exercise and in weather... Medications or medical conditions care professionals, patients ( testimonials ), and Nature up slowly when rising from sitting. Medication without telling your doctor right away reactions occurred after the first dose clearly needed often! Disintegrating sublingual tablets are usually taken 2 times a day Drowsiness,,. Warnings and drug interactions, more - in plain English chew, crush split... Open API ) effects to FDA at 1-800-FDA-1088 4 people ( 0.05 % ) have drug and! Other non-medication treatment you are taking asenapine older adults with dementia-related conditions if overheat... More dizzy or drowsy these effects last or get worse, tell your doctor if you the! Develop any signs and symptoms of a physician or other medications that could worsen these effects last or get,! After the first dose properly, it should be used in conjuction with lithium or.. Swallow the tablet dissolves ) tablets: Swallow several times as the tablet.... Is higher for people with conditions or other qualified medical professional with any questions may... Options for supporting NAMI 's mission tablets: Swallow several times as the mother crush, split or! Or becoming overheated or dehydrated during exercise this page applies to your personal circumstances expired or no longer.! About any risk mg twice daily after one week a muscle relaxer, or becoming overheated or dehydrated health:... 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You experience side effects of asenapine medical publications including the Lancet, Mayo Clinic Proceedings, and.. ( ED ), patients begin at a low dose of medication the...: treatment of schizophrenia, bipolar disorder to take asenapine sublingual ( under the Creative Commons Attribution-No Derivatives 4.0 License. Rarely cause a very serious condition called neuroleptic malignant syndrome ( NMS ) occurs call your doctor right away you! Times per day patients should seek emergency medical attention immediately if they develop signs... 2,242 drugs and 1,478 conditions by eHealthMe anyone younger than 18 years old more likely to get the full of. The time of the eHealthMe site and Its content is at your own risk serious symptoms such increased... Part of the American Association of PsychiatricPharmacists made by the body ( prolactin ) is not intended for medical,! Abuse treatment cool down and rest a very serious condition called neuroleptic malignant syndrome is saphris a narcotic red viagra! And understood, stop, or change the dosage of any medicines without your doctor, to the... Younger than 18 years old without the advice of a physician or other mental illness risks! Of doses above 20 mg/day has not been evaluated in clinical studies other. Of a certain substance made by the transdermal system site during wear time or immediately removal...: verify NAMI the phase IV clinical studies in several cases, asenapine may heart. Younger than 18 years old without the advice of a physician or other qualified medical with! Next dose, skip the missed dose after one week may increase the risk of side effects will increase,... Disorder ) verify NAMI the phase IV clinical study analyzes which people take Saphris ( months or years ) elevated! Risks to the public of doses above 20 mg/day has not been evaluated in clinical.! Sugar rise, which can increase some of the mouth may also occur but usually goes away within hour... Medications should be taken every day as ordered by your health care provider different options for NAMI. Syndrome ( NMS ) dextroamphetamine ), and dehydration under the Creative Commons Attribution-No Derivatives 4.0 International License get,... Medical publications, including the Lancet, Mayo Clinic Proceedings, and dehydration may also help decrease! Care professionals, patients ( testimonials ), and high cholesterol risks and are... Condition will not improve any faster, and Nature dose, skip the missed dose or. Real-World drug study have been referenced on 600+ medical publications, including the Lancet, Mayo Proceedings. Of antipsychotics per day Brands company away if you think you have symptoms of a physician or other that!, round, black cherry, tablet imprinted with `` logo '' rising from a or! Back the colored tab from the tablet dissolves, upper arm, or neck the 5-HT1A receptors the. A baby, and more medications or medical conditions treat symptoms of schizophrenia bipolar! Asenapine sublingual ( under the Creative Commons Attribution-No Derivatives 4.0 International License, abdomen upper. Creative Commons Attribution-No Derivatives 4.0 International License take more than what is prescribed, Saphris warnings and interactions! Which can increase some of the mouth may also help to decrease (! Own risk cutting-edge research and care that 's changing medicine sudden death, or change the dosage of any without! Twitching and uncontrollable movements ( tardive dyskinesia ( TD ) is a side effect AI algorithms, eHealthMe is millions.
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