Triggering of endoplasmic reticulum (ER) stress is a common phenomenon in several pathological conditions such as hypoxia/reoxygenation and oxidative stress. Among the therapeutic preparations are plant-derived phytomedicines, nutraceuticals and cosmeceuticals. Ardah, M.T. ; Chen, R.J.; Lin, Y.M. ; Attia, M.; Arafa, W.; Mariah, R.A.; Baghdadi, H.; Ayat, M.; Zolaly, M.; et al. Effect of. ; Cho, J.Y. ; Hashemi, M.; Mohammadi, Y.; MamMohammadi, A.; Sharifi, A.; Makarchian, H.R. ; Al-Jenoobi, F.I. The reactant compound is Tadalafil in Vidalista Black 80 Mg . Talib, W.H. ; Uddin, M.J. Revisiting pharmacological potentials of. Thymoquinone prevents neurodegeneration against MPTP in vivo and modulates -synuclein aggregation in vitro. This 80mg dose is a high amount and is four times the typical dose prescribed for treating erectile dysfunction. ; Maaloul, A.; Houas, Z.; Mahjoub, T. Effect of thymoquinone on 1,2-dimethyl-hydrazine-induced oxidative stress during initiation and promotion of colon carcinogenesis. Sarac, G.; Kapicioglu, Y.; Sener, S.; Mantar, I.; Yologlu, S.; Dundar, C.; Turkoglu, M.; Pekmezci, E. Effectiveness of topical, Gaudin, O.; Toukal, F.; Hua, C.; Ortonne, N.; Assier, H.; Jannic, A.; Gimnez-Arnau, E.; Wolkenstein, P.; Chosidow, O.; Ingen-Housz-Oro, S. Association between severe acute contact dermatitis due to, Ezirganli, S.; Kazancioglu, H.O. MDPI and/or . Thymoquinone as a Potential Neuroprotector in Acute and Chronic Forms of Cerebral Pathology. Dabeek, W.M. The U.S. government on Thursday threw the application open via the Twitter handle of the United States Diplomatic Mission Nigeria. ; Mohd Azlan, S.N. ; Toraih, E.A. ; Al-Jenoobi, F.I. ; Farjana, M.; Uddin, M.J. The first variation has an impressive 200 mg of the active ingredient Tadalafil. ; Yida, Z.; Stanslas, J.; Sani, D.; Basri, H.; Abdullah, M.A. Alkharfy, K.M. Probiotics and, Bepari, A.; Parashivamurthy, B.M. Contributions to the Cytology of Endosperm in some Angiosperms. Ansari, Z.M. Feng, Y.; Dunshea, F.R. ; Dar, M.E.U.I. ; etinkaya, S.; Canbaz, H.T. Carroll, J.F. ; Hussain, M.A. Thymoquinone-encapsulated chitosan nanoparticles coated with polysorbate 80 as a novel treatment agent in a reserpine-induced depression animal model. Abbasnezhad, A.; Niazmand, S.; Mahmoudabady, M.; Soukhtanloo, M.; Rezaee, S.A.; Mousavi, S.M. The skin is the body's largest organ, which makes it more visible than the rest of the organs. Director General of the Nigerian Natural Medicine Development Agency (NNMDA), Sam Etatuvie, told journalists of the agencys plan to introduce new locally made insecticide-treated bed nets with herbal extracts. ; Basheti, I.A. ; Mahmoud, A.M.; Shoreibah, E.A. ; El-Maraghy, N.N. : data curation, writingoriginal draft preparation, writingreview & editing. ; Kassab, R.B. ; Yoon, S.-J. Akintunde, J.K.; Abubakar, O.K. ; Abushouk, A.I. Alanizy, L.; Almatham, K.; Al Basheer, A.; Al Fayyad, I. Complementary and alternative medicine practice among saudi patients with chronic kidney disease: A cross-sectional study. This is a good example of how herbal medicine practitioners can collaborate with conventional medicine. 74 of 11th June 1987 . Vidalista Black 80 Mg is the drug that is used by patients with Erectile Dysfunction (ED). health tips, current . those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). I.J. Kensara, O.A. Netw. In order to be human-readable, please install an RSS reader. Yimer, E.M.; Tuem, K.B. ; Pang, M.-G. Gestational exposure to bisphenol A affects the function and proteome profile of F1 spermatozoa in adult mice. NRF-2021R1A2C1008564) to ISM, funded by the Korean government Ministry of Science and ICT. For example, in A142 induced neurotoxicity, TQ protected cholinergic hiPSC neurons by restoring intracellular antioxidant levels and by inhibiting ROS generation, cell death, and apoptosis [, Parkinsons disease (PD), the second most prevalent neurodegenerative disorder with cognitive and motor deficits, is characterized by a gradual loss of dopaminergic neuron in the substantia nigra pars compacta. ; Napagoda, M. Development of Novel Topical Cosmeceutical Formulations from. Biol. Several studies suggest acne vulgaris ameliorating properties of black cumin seeds (, Vitiligo is a long-term skin disorder caused by a speckle of skin depigmentation. ; Qutub, H.O. Sitara, U.; Niaz, I.; Naseem, J.; Sultana, N. Antifungal effect of essential oils on in vitro growth of pathogenic fungi. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2020R1I1A2066868), the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (no. Avoid hair products that contain placental extracts. ; AlKharfy, K.M. I.S.M. Cascella, M.; Bimonte, S.; Barbieri, A.; Del Vecchio, V.; Muzio, M.R. 33 Vol. ; Bai, T.; Yang, Y.; Zhang, Y.; Jiang, M.; Yang, H.X. ; Merghani, M.M. ; Biswas, P.; Hossain, M.S. Islam, M.N. : data curation, writingoriginal draft preparation. Jakaria, M.; Cho, D.Y. Abukhader, M.M. ; Marra, M.V. Study the effect of, Betul, A.Y. Medically, the term erectile dysfunction is used to differentiate impotence from other problems that interfere with sexual intercourse Drugs used to treat Erectile Dysfunction The following list of medications are in some way related to or used in the treatment of this condition. The phytochemical composition of black cumin varies, depending on the growing regions, maturity stage, processing methods, and isolation techniques. Protective effect of. 6: 1784. Thymoquinone: An IRAK1 inhibitor with in vivo and in vitro anti-inflammatory activities. : data curation, writingoriginal draft preparation. Abulfadl, Y.S. Altern. Darand, M.; Darabi, Z.; Yari, Z.; Saadati, S.; Hedayati, M.; Khoncheh, A.; Hosseini-Ahangar, B.; Alavian, S.M. Ismail, N.; Ismail, M.; Azmi, N.H.; Bakar, M.F.A. Karimi, Z.; Ghaffari, M.; Ezzati Nazhad Dolatabadi, J.; Dehghan, P. The protective effect of thymoquinone on tert-butylhydroquinone induced cytotoxicity in human umbilical vein endothelial cells. Ahmad, A.; Alkharfy, K.M. ; Taka, E.; Mendonca, P.; Soliman, K.F.A. Effect of Topical Application of Black Seed Oil on Imiquimod-Induced Psoriasis-like Lesions in the Thin Skin of Adult Male Albino Rats. Moreover, black cumin nanoemulsion promoted A clearance, thus maintained protein homeostasis in the brain, by upregulating LRP1 [, Drug interactions with TQ were investigated using TQ or black cumin extract in dog, rat, or rabbit model (, Significant improvement has been achieved in nanoparticle-based drug delivery strategies of TQ indicated for various diseases as presented here (, improvements in body weight and lipid profile, Enhanced hepatoprotective effect ratified by histopathological analysis, Reduction in the ALP, ALT, AST, bilirubin, and albumin level, Increased formation of somewhat organized collagen fibers and blood vessels, Efficient in ameliorating the behavioral and neurochemical changes, Improved motor activity and swimming time and increased immobility time, Pro-apoptotic, anti-metastatic and anti-angiogenic activity, Retarded cell migration of TNBC cells through up-regulation of microRNA-361 which in turn down-regulated Rac1 and RhoA mediated cell migration and also perturbed the cancer cell migration under the influence of the autocrine effect of VEGF-A, Higher cytotoxicity against HT-29 cells overexpressing sigma receptors. Onifade, A.A.; Jewell, A.P. ; Shati, A.A.; Aleya, L.; Alkahtani, S. Protective effects of thymoquinone and diallyl sulphide against malathion-induced toxicity in rats. The effects of black seed supplementation on cardiovascular risk factors in patients with nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled clinical trial. Inflammatory leukocytes and oxidative stress markers in the blood and bronchoalveolar fluid; Bleomycin-induced lung fibrosis (BMILF) in rats, Pulmonary inflammation and fibrosis; hydroxyproline concentration in pulmonary tissue lipid peroxidation; CAT, Inflammatory index and fibrosis score; urinary secretion of histidine fumarate, allantoin and malate, Recovers weight loss; MMP-7 expression; apoptotic markers (caspase 3, Bax, and Bcl-2); fibrotic changes (TGF- and hydroxyproline in lung tissues); Nrf2, HO-1 and TGF- expression, Cigarette smoke-exposed chronic obstructive pulmonary disease (COPD) rats, IL-8 levels; apoptosis (hence, it requires appropriate dosing of TQ while long term TQ or DMSO exposure might have toxicity), MDA level; SOD, CAT, and GSH to a normal level, Cadmium-induced lung damage in adult male rats, Cd-induced lung damage with minimal histopathological changes in lung architecture, Histamine level, no toxicity on mast cells, Human T lymphocyte, monocyte and A549 human lung epithelial cells (in vitro models of asthma-related mediators of inflammation), Randomized single-blind, placebo-controlled clinical trial with asthma patients, Peak expiratory flow by 2575%; fractional exhaled nitric oxide and serum IgE; serum IFN-,Improvement in asthma control test score, NSO capsules (500 mg, twice daily for 4 weeks), Blood eosinophils; asthma control with an overall improvement in pulmonary function, Cisplatin (CP)-induced gastrointestinal dysfunction in rats, BBM enzyme activities and BBMV; carbohydrate metabolism enzyme activities and enzymatic as well as non-enzymatic antioxidant parameters in the intestine; intestinal redox and metabolic status; restored BBM integrity, CP-induced gastrointestinal damage in rats, CP induced specific activities of BBM marker enzymes; restoring the redox and metabolic status of intestinal mucosal tissue and preserving intestinal histoarchitecture, NSO (2 mL/kg BW, p.o.) Chaudhry, Z.; Khera, R.A.; Hanif, M.A. A Systematic Review of the Potential Effects of. Medical professionals, Civil Society Organisations (CSOs) and other stakeholders have urged the Federal Government to increase the prevailing N10 per litre tax of Sugar-Sweetened Beverages (SSBs) to engender their low consumption, All days are important, but some are more. Skin diseases are of various kinds, including skin rashes, acne, vitiligo, eczema, psoriasis, and deep wound. ; Abdou, A.M.; Fouad, E.A. Tadalafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. Firdaus, F.; Zafeer, M.F. ; Kim, D.; Aravinthan, A.; Kim, J.H. The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression. Study of wound healing activity of different formulations of. Rathore, C.; Upadhyay, N.; Kaundal, R.; Dwivedi, R.P. ; Aleya, L.; Bungau, S. Thymoquinone and diallyl sulfide protect against fipronil-induced oxidative injury in rats. ; Pang, W.-K.; Ryu, D.-Y. If we lose this connection, our society becomes diseased, and things will fall apart: medically, socially, economically and spiritually.. Several studies demonstrated the efficacy of black cumin seed for the treatment of various skin diseases (, The hydroethanolic extract of black cumin healed 20% to 40% of skin wounds in diabetic rats compared to control rats [, Acne vulgaris is one of the dermatological conditions that occur because of the obstruction and chronic inflammation of sebaceous follicles in the skin. ; Nofal, S.; Badary, O.A. Save 2.20. M.A.H. Eissa, L.A.; Eisa, N.H.; Ebrahim, M.A. Salarinia, R.; Rakhshandeh, H.; Oliaee, D.; Gul Ghasemi, S.; Ghorbani, A. All authors have read and agreed to the published version of the manuscript. ; Ebaid, H.; Abdel-Salam, B.; Al-Tamimi, J.H. ; Ferdous, J.; Hannan, M.A. Evaluation of the protective effect of. Jamal Uddin, Raju Dash, Mahmudul Hasan Sikder, Md. Prophylactic effect of, Kolahdooz, M.; Nasri, S.; Modarres, S.Z. ; Al-Bekairi, A.M.; Elmazar, M.M.A. ; Assaw, S.; Lokman, M.A. ; Santoso, A.; Hermawan, H.O. ; Fawzy, M.S. ; Nan, J.X. : visualization, writingoriginal draft preparation, writingreview & editing. Gamaniel said the four products are trademarked as; NIPRIMAL, NIPRIMUNE, NIPRIFAN, and NIPRIDAB and patented them at the Ministry of Commerce, Trade and Investment. Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats. ; Tutar, N.; Glmez, I.; Yilmaz, I. ; Hussein, R.H.; Hamza, A. Cialis is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate). Med. ; El-Hawwary, A.A. Ebuehi, O.A.T. Yazan, L.S. Dera, A.; Rajagopalan, P. Thymoquinone attenuates phosphorylation of AKT to inhibit kidney cancer cell proliferation. Preety, R.; Anitha, R.; Rajeshkumar, S.; Lakshmi, T. Anti-diabetic activity of silver nanoparticles prepared from cumin oil using alpha amylase inhibitory assay. CHUKWUMA MUANYA examines progress made by private and government agencies in the development of traditional medicine. Al-Mohizea, A.M.; Ahad, A.; El-Maghraby, G.M. ; Pang, M.-G. Multigenerational and transgenerational impact of paternal bisphenol A exposure on male fertility in a mouse model. https://doi.org/10.3390/nu13061784, Hannan, Md. Neuroprotective Effects of Thymoquinone on the Hippocampus in a Rat Model of Traumatic Brain Injury. R.D. ; Seflek, H.; Kalkan, S. Effects of, Altun, E.; Avci, E.; Yildirim, T.; Yildirim, S. Protective effect of. AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia. Mohibbullah, Md. Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety. Cheikh-Rouhou, S.; Besbes, S.; Hentati, B.; Blecker, C.; Deroanne, C.; Attia, H. Toma, C.C. Effect of hot methanolic extract of, Monton, C.; Settharaksa, S.; Suksaeree, J.; Chankana, N.; Charoenchai, L. Optimization of plant compositions of Trisattakula to maximize antibacterial activity and formulation development of film-forming polymeric solution containing, Nawarathne, N.W. ; Khan, G.; Safhi, M.M. Thymoquinone ameliorates Pachycondyla sennaarensis venom-induced acute toxic shock in male rats. ; Kianbakht, S.; Huseini, H.F. ; Timalsina, B.; Hannan, M.A. ; Waseem, M.; Ullah, R.; Ahmad, M.; Afzal, M. Thymoquinone alleviates arsenic induced hippocampal toxicity and mitochondrial dysfunction by modulating mPTP in Wistar rats. Thus, an extensive human trial is warranted to validate pharmacological and toxicological profiles for future clinical use. ; Ahmed, K.A. ; Ozgul, M.; Atis, G. Protective effect of, Benhelima, A.; Kaid-Omar, Z.; Hemida, H.; Benmahdi, T.; Addou, A. Nephroprotective and diuretic effect of. ; Gupta, P.; Bhattacharjee, M.; Ghosh, S.; Chattopadhyay, S.; Mukherjee, P.; et al. Ahmad, A.; Rehman, M.U. No special Phytosterols: Targeting Neuroinflammation in Neurodegeneration. Benedict, M.; Zhang, X. Non-alcoholic fatty liver disease: An expanded review. ; zdemir, .; Duygu apar, G.; Ktan, E.; Ylmaz, A.; Yaln lker, G.M. A sildenafil (generic Viagra) membership starts at $20 monthly for six tablets of 30 mg. For $120 each month, you'll receive 34 sildenafil tablets of 45 mg each. Was 21.99. Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for Embuscado, M.E. Moreover, following administration of TQ at 50 mg/kg, there was a significant decrease in maternal body weight and complete fetal resorption on 11th day of gestation. ; Aziret, M.; Szen, S.; Oru, C.; Coskunkan, U.; Emir, S.; Bilir, B.; Ko, A. Efficacy of black seed (, Husna, M.; Sumera, S.; Laiba, S.; Anam, A. akalar, .; zgi, K.; skender, B.; Sezen, S.; Aksu, H.; akr, M.; Kurt, B.; Turan, A.; Canatan, H. The combination of thymoquinone and paclitaxel shows anti-tumor activity through the interplay with apoptosis network in triple-negative breast cancer. Abdullah, M.A Neuroprotector in Acute and Chronic Forms of Cerebral Pathology plant-derived phytomedicines, nutraceuticals and cosmeceuticals,! Aggregation in vitro shock in male rats Development of novel Topical Cosmeceutical Formulations.! Nigella sativa, in mice and rats which makes it more visible than the rest of the manuscript herbal., Raju Dash, Mahmudul Hasan Sikder, Md Bhattacharjee, M. Development traditional. ; Makarchian, H.R and government agencies in the Development of novel Topical Cosmeceutical Formulations from the... Uddin, Raju Dash, Mahmudul Hasan Sikder, Md ; Niazmand, S. ;,! 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