The PRISMA reporting guideline was applied. All data generated or analyzed during this study are included in this published article. Collins shares a few tips for avoiding the junk and garbage of supplements and vitamins: "Don't go to Walmart (or whatever big box store) and buy whichever bottle is 50% off. But ginger is both delicious and highly nutritious. Shanmugam K.R. 2023 Mar 1;12(5):1037. doi: 10.3390/foods12051037. The present study was the first human research investigating the effects of ginger on glycemic status and stress oxidative in type 2 diabetic patients whose information regarding potential confounding variables, including dietary intake and physical activity level were available. An official website of the United States government. Lebda M.A. Ginger may be useful in both type 1 and type 2 diabetes. Li FF, Jiang LL, Yan RN, et al. FOIA government site. Un programa que dej de tener gracia cuando se. Jafri SA. Bookshelf Medicine (Baltimore) 2016;95:e4018. 2022 Jul 19;2022:2755332. doi: 10.1155/2022/2755332. When youre eating ginger, youre eating the root (called the rhizome), which resembles a smaller sweet potato or even a gnarled tree. Sample size was determined based on data from previous study (14) by considering type I error level =0.05 with test power of 80%. Eight randomized trials consisting of a total number of 454 participants with T2DM were included in this analysis. Harliansyah AH, Noor Azian M, Wan Zurinah WN, Yasmin Anum MY. Esteghamati A, Gouya MM, Abbasi M, Delavari A, Alikhani S, Alaedini F. Prevalence of diabetes and impaired fasting glucose in the adult population of Iran. Essent. Reduction of lipid peroxidation by ginger has been attributed to it's antioxidant activity, because ginger have many phenolic compounds, which have inhibitory effects on lipid peroxidation and preserve the antioxidant compounds (33). Khadem Ansari MH, Karimipour M, Salami S, Shirpoor A. et al. Avoiding the Scams. The first images of the 'middle aged' Love Island programme hosted by Davina McCall have been released ahead of the show's launch. However, a significantly improved HbA1c from baseline to follow-up was observed in those participants with ginger consumption (WMD: 0.46, 95% CI: [0.09-0.84]; P = .02) whereas in the control group, no significant difference in HbA1c was observed (WMD: -0.23, 95% CI: [-0.60-0.14]; P = .22). The report of daily dietary intake was collected by a 24-hour diet recall questionnaire once at the beginning and at the end of the study. The antioxidant potency of ginger has been attributed to gingerols that prevent reactive oxygen species (ROS) production (5). Thus, at treated cells with gingerol, insulin responsive glucose uptake has increased and improved diabetes (30). A randomized clinical trial study: anti-oxidant, anti-hyperglycemic and anti-hyperlipidemic effects of olibanum gum in type 2 diabetic patients. Fasting blood glucose in patients with type 2 diabetes mellitus assigned to the control group. Abdulrazaq NB. Fish Oil. Regarding negligible side effects of ginger, it may be a good remedy for diabetic patients to diminish the risk of some secondary chronic complications. Batch CBD Full-Spectrum Gummies. The site is secure. HbA1c in patients with type 2 diabetes mellitus assigned to the control group. Elm & Rye Vitamin D3. [32] Additionally, ginger has shown to protect the liver, kidney, and neural system complications in patients with T2DM. Ginger supplementation significantly reduced the levels of fasting blood sugar, hemoglobin A1c, apolipoprotein B, apolipoprotein B/apolipoprotein A-I and malondialdehyde in ginger group in comparison to baseline, as well as control group, while it increased the level of apolipoprotein A-I (p<0.05). Garlic Cassia cinnamon Ginkgo biloba Grape seed extract Dong quai Feverfew Bromelain Aloe Evening primrose Melatonin Takeaway Natural blood thinners are substances that reduce the blood's ability. See this image and copyright information in PMC. Effect of ginger extract consumption on levels of blood glucose, lipid profile and kidney functions in Alloxan induced-diabetic rats. Blood samples (10 mL) were taken in a 10-12 hours fasting state at the beginning and after 12 weeks of intervention. These CBD candies offer a simple and flexible . Task Force Team for Diabetes Fact Sheet of the Korean Diabetes Association. Garden of Life mykind Organics Extra Strength Turmeric. and transmitted securely. Can diabetes cause erectile dysfunction? Supplementing with vitamin D may also increase the effectiveness of ED drugs in men with low vitamin D levels. 2022 May;65:102802. doi: 10.1016/j.ctim.2022.102802. National Library of Medicine There was also no major mention about the consumption of western medicine which might have influenced the final outcomes. Major Moderate Minor Unknown Aleve (naproxen) Aspirin Low Strength (aspirin) Benadryl (diphenhydramine) Claritin (loratadine) Coenzyme Q10 (ubiquinone) CoQ10 (ubiquinone) Cymbalta (duloxetine) Fish Oil (omega-3 polyunsaturated fatty acids) Flonase (fluticasone nasal) Ginkgo Biloba (ginkgo) Are alternative supplements effective treatment for diabetes mellitus? One was contaminated with lead. That means, diabetes can lead to damage in your body that may make it more likely for you to have erectile dysfunction. Choose natural, organic ginger root over processed ginger products. Be sure to talk with your doctor before adding this to your treatment regimen. The authors thank Iran association of diabetes for helping in recruiting patients. We avoid using tertiary references. Ebrahimzadeh A, Ebrahimzadeh A, Mirghazanfari SM, Hazrati E, Hadi S, Milajerdi A. Complement Ther Med. Common side effects of ginger may include: heartburn, diarrhea, stomach discomfort; heavier menstrual periods; and. When you take over-the-counter pain medication, it helps in an instant. In this article, learn about seven herbs and supplements that may benefit people with type 2 diabetes. Epub 2019 Dec 4. Also see the evidence regarding ginger for nausea, heartburn, osteoarthritis, diabetes and migraine. The effect peak was observed after 4 hours and 24-53% reduction of blood glucose with consumption of doses of 100-800 mg/Kg (19). According to the National Center for Complementary and Alternative Medicine, other potential side effects of ginger include: Ginger is easy to add to your diet, in no small part because a little goes a long way. Potential Health Benefits of Ginger for Type 2 Diabetes. Keep these things in mind when adding ginger to your diet: Ginger isnt a replacement for your regular treatment. Ginger has been reported to have a lowering effect on lipid peroxidation, thus MDA level, by influencing the enzymatic blood level of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX). Impact of Thermal Processing on the Composition of Secondary Metabolites of Ginger Rhizome-A Review. Shanmugam K R, Ramakrishana Ch, Mallikarjuna K, Sathyavelu Reddy K. The impact of ginger on kidney carbohydrate metabolic profiles in STZ induced diabetic rats. The effect of ginger supplementation on metabolic profiles in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. The differences in the levels of blood biochemical variables were compared, before and after the intervention, in each group. The site is secure. eCollection 2022. Fang-yan Huang, Ting Deng, Lian-xin Meng, and Xin-ling Ma were responsible for the conception and design, acquisition of data, analysis and interpretation of data, drafting the initial manuscript and revising it critically for important intellectual content. et al. Ginger can also have blood-thinning effects, which can increase your risk of excessive bleeding. Chemotherapy. (2011) showed that oral administration of ginger extract with daily dose of 500 mg/Kg for 6 weeks in Alloxan-diabetic rats caused decreased in blood glucose level at 21 and 42 days (24). Theres no magic amount of ginger that makes a difference for inflammatory-related conditions and pain relief. However, dietary ginger significantly improved HbA1c from baseline to follow-up showing that this natural medicine might have an impact on glucose control over a longer period of time in patients with T2DM. Medicine (Baltimore) 2016;95:e5229. According to a study, black ginger is known as natural viagra because it contains a large number of PDE5 inhibitors, which act like viagra, but without negative side effects. et al. Over the years, ginger has been shown to help reduce blood sugar levels and help regulate insulin response in people with diabetes. [813] Spices have long been known for their anti-inflammatory, antioxidant, and antidiabetic properties. Ojewole JAO. The effects of ginger on fasting blood sugar, hemoglobin A1c, and lipid profiles in patients with type 2 diabetes, Effects of cinnamon, cardamom, saffron, and ginger consumption on markers of glycemic control, lipid profile, oxidative stress, and inflammation in type 2 diabetes patients, The effects of ginger on fasting blood sugar, hemoglobin a1c, apolipoprotein B, apolipoprotein a-I and malondialdehyde in type 2 diabetic patients. (2011) indicated that addition of ginger (1%) to a normal diet prevented the formation of free radicals and maintained the integrity of rat erythrocytes. The study was approved by the Ethics Committee of Public Health School of Tehran University of Medical Sciences (No. (2012) found that polar portion of ginger extract containing mainly gingerols, particularly (S)-[6]- and (S)-[8]- gingerol, promoted glucose uptake significantly in cultured rat skeletal muscle cells. The capsules were placed in the identical bottles by a third person not directly involved in this study. The mean and standard deviation (Mean SD) of blood biochemical variables at the beginning and the end of the study. Some contained less ginger than listed or very poor quality ginger based on the gingerols and shogaols that we found. It affects the way people produce or respond to insulin, which in turn affects the way your body processes sugar. sharing sensitive information, make sure youre on a federal This site needs JavaScript to work properly. Let it evolve from treatment to treat. Black ginger can increase sperm density and promote health through its Adaptogenic activity, lowering triglycerides and preventing diabetes. Abbreviations: FBS = fasting blood sugar, HbA1c = glycosylated hemoglobin, T2DM = type 2 diabetes mellitus. Ginger (Zingiber officinale), is a nontoxic spice with negligible side effects, and is considered safe by the food and drug administration. Two hundred and fifteen participants with T2DM were assessed. However, oral antidiabetic medications might sometimes be associated with unwanted side effects leading to drug discontinuation. High-dose supplements can actually cause nausea andgastric reflux, ONeill warns. 2402), and registered in Iranian center of clinical trial registration with the ID number of IRCT 201109082709N19. You should continue to follow your doctors recommendations. Many people are aware of its . Kidney damage is a common diabetes complication, but you can slow or reduce your risk of kidney damage. Together you can determine the best dosage for you, as well as discuss any potential side effects. Moradabadi L, Montasser Kouhsari Sh, Fehresti Sani M. Hypoglycemic Effects of Three Medicinal Plants in Experimental Diabetes: Inhibition of Rat Intestinal -glucosidase and Enhanced Pancreatic Insulin and Cardiac Glut-4 mRNAs Expression. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Ginger is POSSIBLY SAFE when it is applied to the skin appropriately, short-term. The results showed no significant difference in FBS with WMD: 1.38, 95% CI: [0.533.30]; P=.16 as shown in Figure Figure22. 8600 Rockville Pike It has a long history of use as herbal medicine to treat a variety of diseases including nausea and vomiting, constipation, indigestion (dyspepsia), pain, and cold induced syndromes. Unable to load your collection due to an error, Unable to load your delegates due to an error. Regarding a possible loss to follow-up, a safety margin of 25% was determined, and therefore 25 patients were allocated in each group. Ginger shots are made from concentrated amounts of ginger and are popular in the health community. See additional information. (2014). Would you like email updates of new search results? Ginger may be helpful because it helps increase the way food moves through your GI tract, called gastric motility, and block serotonin receptors in our gut lining, she adds. [20] Search databases resulted in a total number of 205 publications. The sample size was computed as 20 per group. The statistic effect models which were used during the analysis included a fixed effect model (I2<50%) or a random effect model (I2>50%). Spices arent just a way to add zest and flavor to your favorite dishes. Having low levels of magnesium has been associated with heart disease, diabetes, and osteoporosis . Diakos A, Silva ML, Brito J, Moncada M, de Mesquita MF, Bernardo MA. There are alsoginger shotsthat might be beneficial.. Ginger is also an efficient aid in preventing and reducing nausea. This meta-analysis is based on previously conducted studies and does not contain any studies with human participants or animals performed by any of the authors. Akhani et al. Elshater A-EA, Muhammad MA Salman, Mahrous MA Moussa. The present study was conducted to investigate the effects of ginger on fasting blood sugar (FBS), Hemoglobin A1c (HbA1c), apolipoprotein B (Apo B), apolipoprotein A-I (Apo A-I), Apo B/Apo AI, and malondialdehyde (MDA) in type 2 diabetic patients. The results showed no significant difference in FBS (WMD: 1.38, 95% CI: [-0.53-3.30]; P = .16). Type 2 diabetes accounts for >90% of diabetes and is resulting in impaired function in carbohydrate, lipid and protein metabolism. Conceptualization: Fang-yan Huang, Ting Deng, Lian-xin Meng, Xin-ling Ma. Unauthorized use of these marks is strictly prohibited. Fuhrman B, Rosenblat M, Hayek T, Coleman R, Aviram M. Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein-E deficient mice. You should also consult your doctor if youre taking any blood pressure medications. Rys P, Wojciechowski P, Siejka S, Maecki P, Hak L, Malecki MT. 2020 Feb;34(2):282-294. doi: 10.1002/ptr.6535. Eight randomized trials consisting of a total number of 454 participants with T2DM were included in this analysis. 2022;22(3):550-563. doi: 10.2174/1389557521666210929143112. (2005) indicated that the treatment of human normal liver cells and liver cancer cells with 500 g/mL of ginger extract, in-vitro, didnt change the content of malondialdehyde (MDA); our findings are inconsistent with these findings. 2016 ; 95: e5229 the years, ginger has been shown to protect the liver,,! Of the study was approved by the Ethics Committee of Public Health School of Tehran University of Medical (! About seven herbs and supplements that may benefit people with type 2.!, insulin responsive glucose uptake has increased and improved diabetes ( 30 ) There are shotsthat... In the levels of blood biochemical variables at the beginning and after the intervention, in each.... 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