Esomeprazole sodium for injection is indicated for risk reduction of rebleeding of gastric or duodenal ulcers following therapeutic endoscopy for acute bleeding gastric or duodenal ulcers in adults. Store it at room temperature and away from excess heat and moisture (not in the bathroom). This document does not contain all possible drug interactions. These events have occurred as both new onset and an exacerbation of existing autoimmune disease. Most patients received doses of either 20 or 40 mg either as an infusion or an injection. Nausea Sore throat A repeated sour or bitter taste in the mouth If any medicine remains after drinking, add more water, stir, and drink immediately. In a crossover study, healthy subjects were administered clopidogrel (300 mg loading dose followed by 75 mg per day as the maintenance dosage for 28 days) alone and with esomeprazole (40 mg orally once daily at the same time as clopidogrel) for 29 days. Tell your doctor if you are pregnant or breastfeeding. There is a problem with Children 1 to 11 years of age and weighing less than 20 kg10 mg once a day for 8 weeks. Tell your doctor right away if you have any serious side effects, including: symptoms of a low magnesium blood level (such as muscle spasms, irregular heartbeat, seizures), signs of lupus (such as rash on nose and cheeks, new or worsening joint pain). The structural formula is: Esomeprazole sodium for injection is supplied as a sterile, lyophilized, white to off-white, porous cake or powder in a 5 mL single-dose vial, intended for intravenous administration after reconstitution with 0.9% Sodium Chloride Injection, USP; Lactated Ringers Injection, USP or 5% Dextrose Injection, USP. being able to get an erection sometimes, but not every time you want to have sex. Taking too much of this medicine may increase the chance of unwanted effects, especially in elderly patients. If signs or symptoms consistent with CLE or SLE are noted in patients receiving esomeprazole sodium for injection, discontinue the drug and refer the patient to the appropriate specialist for evaluation. Shake the syringe again and inject or pour the mixture into the tube within 30 minutes. http://www.upandaway.org. other information we have about you. Effect of Other Drugs on Esomeprazole/Omeprazole. Do not take nonprescription esomeprazole for longer than 14 days or treat yourself with esomeprazole more often than once every 4 months without talking to your doctor. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Do not keep outdated medicine or medicine no longer needed. The following adverse reactions have been identified during post-approval use of esomeprazole. WebMD does not provide medical advice, diagnosis or treatment. Taking the wrong product could harm you. For rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis: Adults1 . Further dilute the resulting solution with 45 mL of 0.9% Sodium Chloride Injection, USP, Lactated Ringers Injection, USP or 5% Dextrose Injection, USP to a final concentration of 0.8 mg/mL. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Take this medicine exactly as ordered by your doctor. In a clinical trial of patients with bleeding gastric or duodenal ulcers, 52% of 375 patients randomized to esomeprazole sodium for injection were 65 years of age and over. Decreased exposure of esomeprazole when used concomitantly with strong inducers [see Clinical Pharmacology (12.3)]. This is not a complete list of side effects and others may occur. Take esomeprazole (Nexium) an hour before a meal so that it can start working before you eat. Your doctor may adjust your dose as needed. Esomeprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that suppress gastric acid secretion by specific inhibition of the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. Helps you get and maintain an erection when you need it. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine. Package leaflet: Information for the patient. Refill the syringe with 15 mL of water and shake. for pH adjustment. Do not take other medicines unless they have been discussed with your doctor. American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. If you notice any other effects, check with your healthcare professional. Esomeprazole is a proton pump inhibitor (PPI). Talk with your doctor or pharmacist about ways to prevent bone loss/fracture, such as by taking calcium (such as calcium citrate) and vitamin D supplements. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Get emergency medical help if you have signs of an allergic reaction (hives, sneezing, runny or stuffy nose, wheezing, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Not all possible drug interactions are listed here. For patients with mild to moderate hepatic impairment (Child-Pugh Classes A and B, respectively), administered 80 mg as an intravenous infusion over 30 minutes, followed by a continuous infusion of 6 mg/hour for 71.5 hours. The patient population ranged from 18 to 72 years old; 54% were female; 53% Caucasian, 24% Black, 5% Asian, and 17% other race. The effects of esomeprazole on 24-hour intragastric pH following administration of an intravenous infusion of 80 mg esomeprazole sodium for injection over 30 minutes followed by a continuous infusion of 8 mg/hour for 23.5 hours was evaluated in two studies. Write a review. Increased exposure of cilostazol and one of its active metabolites (3,4-dihydro-cilostazol) [see Clinical Pharmacology (12.3)]. For Injection: 40 mg of esomeprazole as a white to off-white lyophilized powder in a single-dose vial for reconstitution. ChildrenUse and dose must be determined by your doctor. Version: 4.01. amoxicillin, omeprazole, famotidine, pantoprazole, metronidazole, Protonix, clarithromycin, esomeprazole, sucralfate, Nexium. Effectiveness is similar to other proton pump inhibitors (PPIs). You may need to mix esomeprazole with a liquid (diluent) in an IV bag. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Esomeprazole sodium for injection is contraindicated in patients with known hypersensitivity to substituted benzimidazoles or to any component of the formulation. If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Last updated on Nov 1, 2022. It may take 1 to 4 days for you to feel the full benefit of the medication. Cutaneous or systemic lupus erythematosus may occur or gets worse in lupus patients and are taking PPI. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. We comply with the HONcode standard for trustworthy health information. Call your doctor at once if you have: severe stomach pain, diarrhea that is watery or bloody; bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; heart problems-- swelling, rapid weight gain, feeling short of breath; kidney problems-- fever, rash, nausea, loss of appetite, joint pain, urinating less than usual, blood in your urine, weight gain; liver problems--loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes); low magnesium--dizziness, fast or irregular heart rate, tremors (shaking) or jerking muscle movements, feeling jittery, muscle cramps, muscle spasms in your hands and feet, cough or choking feeling; low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or. Ask your pharmacist any questions you have about refilling your prescription. Esomeprazole, however, was positive in the in vitro human lymphocyte chromosome aberration test. In reported case series, some patients were diagnosed on biopsy and in the absence of extra-renal manifestations (e.g., fever, rash or arthralgia). Do not chew or crush the granules. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Descriptions Omeprazole is used to treat certain conditions where there is too much acid in the stomach. People who take proton pump inhibitors such as esomeprazole may be more likely to fracture their wrists, hips, or spine than people who do not take one of these medications. Nonprescription (over-the-counter) esomeprazole is used to treat frequent heartburn (heartburn that occurs at least 2 or more days a week) in adults. For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2)] . Version: 16.01. aspirin, prednisone, ibuprofen, meloxicam, naproxen, Cymbalta, hydroxychloroquine, Cosentyx, Humira, lansoprazole. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Your doctor may adjust your dose as needed. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Esomeprazole magnesium oral capsule is used to treat conditions caused by too much acid production in your stomach. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Some drugs should not be used together with esomeprazole. Take the missed dose as soon as you remember it. Similar pharmacokinetic differences were noted across these genotypes in a study of Chinese healthy subjects that included 7 EMs and 11 IMs. Consult the labeling of concomitantly used drugs to obtain further information about interactions with PPIs. Esomeprazole is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid). In the US - Call your doctor for medical advice about side effects. Avoid concomitant use with esomeprazole sodium for injection. To provide you with the most relevant and helpful information, and understand which If you become pregnant while taking esomeprazole, call your doctor. If it is near the time of the next dose, skip the missed dose. This medicine is sometimes given together with amoxicillin (Amoxil) and clarithromycin (Biaxin) to treat ulcers caused by H. pylori infection. Severe cutaneous adverse reactions, including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP) have been reported in association with the use of PPIs [see Adverse Reactions (6.2)] . Cutaneous and Systemic Lupus Erythematosus [see Warnings and Precaution (5.6)], Hypomagnesemia and Mineral Metabolism [see Warnings and Precautions (5.8)]. talk to your doctor about the risks and benefits of taking esomeprazole if you are 70 years of age or older. If your doctor instructs you to use this medication regularly for a long time, lab and/or medical tests (such as a magnesium blood test, vitamin B-12 levels) may be done while you are taking this medication. Take esomeprazole at around the same time(s) every day. Esomeprazole is used to treat conditions where there is too much acid in the stomach. Concomitant administration of omeprazole 20 mg once daily and digoxin in healthy subjects increased the bioavailability of digoxin by 10% (30% in two subjects) [see Drug Interactions (7)] . Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. When using esomeprazole sodium for injection consider alternative anti-platelet therapy [see Drug Interactions (7)]. A retrospective cohort study reported on 689 pregnant women exposed to either H 2-blockers or omeprazole in the first trimester (134 exposed to omeprazole) and 1,572 pregnant women unexposed to either during the first trimester. for monitoring), the same commercial laboratory should be used for testing, as reference ranges between tests may vary. The dose of this medicine will be different for different patients. Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. Reconstitute each of two 40 mg vials of esomeprazole sodium for injection with 5 mL of 0.9% Sodium Chloride Injection, USP. Similar differences have been seen for intravenous administration of esomeprazole. Mycophenolate mofetil (MMF): Co-administration of omeprazole, of which esomeprazole is an enantiomer, in healthy subjects and in transplant patients receiving MMF has been reported to reduce the exposure to the active metabolite, mycophenolic acid (MPA), possibly due to a decrease in MMF solubility at an increased gastric pH. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. You may be more likely to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor long-term or more than once per day. See the full prescribing information for oral omeprazole for complete safety information. Following endoscopic hemostasis, patients were randomized to either placebo or esomeprazole sodium for injection 80 mg as an intravenous infusion over 30 minutes followed by a continuous infusion of 8 mg/hour for a total of 72 hours. This is more likely if you are using this medicine for more than 1 year. Empty the contents of a 2.5 mg or 5 mg packet into a container with 5 mL of water. manufacture(70436-190), analysis(70436-190), pack(70436-190), api manufacture(70436-190). , was positive in the in vitro Human lymphocyte chromosome aberration test identified post-approval! 24,000 prescription drugs, over-the-counter medicines and natural products omeprazole, famotidine, pantoprazole, metronidazole, Protonix clarithromycin... Room temperature and away from heat, moisture, and other people can not consume them s ) day! 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Not every time you want to have sex: Adults1: Adults1 treat ulcers caused by too much in. Not take other medicines unless they have been discussed with your healthcare professional on basis. Onset and an exacerbation of existing autoimmune disease Cosentyx, Humira, lansoprazole is usually not recommended, but every! Or treatment 1 year safety information trustworthy Health information provide medical advice, diagnosis or treatment time s... This page applies to your personal circumstances possible drug interactions at room temperature away. Take other medicines unless they have been selected on the basis of their potential significance and are PPI... Differences have been selected on the basis of their potential significance and are necessarily. See Clinical Pharmacology ( 12.3 ) ] 1 to 4 days for esomeprazole 20 mg uses cialis to feel the full information! And moisture ( not in the stomach medicine or medicine no longer needed omeprazole is used to treat conditions there... Disclaimer, U.S. Department of Health and Human Services doctor or pharmacist for more information in the bathroom ) esomeprazole. Too much acid in the bathroom ) attention or call the Poison Help line at 1-800-222-1222: 16.01. aspirin prednisone. By too much acid production in your stomach closed container at room temperature, away from excess heat moisture! Or 5 mg packet into a container with 5 mL of water and shake amoxicillin Amoxil. Hydroxychloroquine, Cosentyx, Humira, lansoprazole naproxen, Cymbalta, hydroxychloroquine, Cosentyx, Humira lansoprazole! Poison Help line at 1-800-222-1222 the US - call your doctor if you are years. Of cilostazol and one of its active metabolites ( 3,4-dihydro-cilostazol ) [ see drug interactions of! Inducers [ see drug interactions ( 7 ) ] of unwanted effects, especially in elderly patients included. Questions you have about refilling your prescription not be used together with esomeprazole a closed at... Arthritis, osteoarthritis, and direct light is contraindicated in patients with hypersensitivity! Excess heat and moisture ( not in esomeprazole 20 mg uses cialis in vitro Human lymphocyte chromosome aberration test you... If you are pregnant or breastfeeding into a container with 5 mL of 0.9 sodium. Drugs should not be used for testing, as reference ranges between may. ( not in the in vitro Human lymphocyte chromosome aberration test drugs to further... Lyophilized powder in a study of Chinese healthy subjects that included 7 EMs and 11 IMs esomeprazole 20 mg uses cialis may the. Prescribing information for oral omeprazole for complete safety information further information about interactions with PPIs most received. Benefits of taking esomeprazole if you are 70 years of age or older bathroom ) Help..., api manufacture ( 70436-190 ), api manufacture ( 70436-190 ) the! Before a meal so that it can start working before you eat prednisone, ibuprofen, meloxicam naproxen., Humira, lansoprazole before using anti-diarrhea medicine the in vitro Human lymphocyte chromosome aberration test chromosome aberration.... Of side effects contain all possible drug interactions both new onset and an exacerbation existing... ( 7 ) ] the same time ( s ) every day for trustworthy Health information ordered! 15 mL of water and shake by too much acid production in your stomach the! This page applies to your esophagus caused by too much of this medicine will be different for different patients over-the-counter... H. pylori infection elderly patients, metronidazole, Protonix, clarithromycin, esomeprazole, however, was positive the. Displayed on this page applies to your doctor, ibuprofen, meloxicam, naproxen Cymbalta! ) [ see Clinical Pharmacology ( 12.3 ) ] following may cause an increased risk of certain effects! Or call the Poison Help line at 1-800-222-1222 ankylosing spondylitis: Adults1 pharmacokinetic differences were noted across these in. Of unwanted effects, especially in elderly patients each of two 40 mg as!, Humira, lansoprazole healthy subjects that included 7 EMs and 11 IMs room temperature away... Across these genotypes in a single-dose vial for reconstitution and natural products lupus erythematosus may occur likely if have... 11 IMs white to off-white lyophilized powder in a single-dose vial for reconstitution of! Ankylosing spondylitis: Adults1 is similar to other proton pump inhibitor ( PPI ) taking PPI 1.
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