Minor/Significance Unknown. SSRIs inhib. Use Caution/Monitor. Contraindicated. It's thought to help improve mood and pain by raising the level of chemicals called serotonin and norepinephrine in your brain. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Either increases effects of the other by sedation. Use Caution/Monitor. Minor (1)pleurisy root decreases effects of duloxetine by unspecified interaction mechanism. Monitor Closely (2)duloxetine will increase the level or effect of morphine by affecting hepatic enzyme CYP2D6 metabolism. duloxetine, indomethacin. Serious - Use Alternative (1)primidone will decrease the level or effect of duloxetine by affecting hepatic enzyme CYP1A2 metabolism. Mechanism: pharmacodynamic synergism. Duloxetine is a medication used to manage major depressive disorder (MDD), generalized anxiety disorder (GAD), fibromyalgia, diabetic peripheral neuropathy, and chronic musculoskeletal pain. Contraindicated. Use Caution/Monitor. Mechanism: unknown. Avoid leniolisib with CYP1A2 substrates that have a narrow therapeutic index. Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. duloxetine, sulfasalazine. Women's Health . Serious - Use Alternative (1)duloxetine and levomilnacipran both increase serotonin levels. Avoid or Use Alternate Drug. Monitor Closely (1)esomeprazole will decrease the level or effect of duloxetine by increasing gastric pH. This medicine is also used to treat erection problems in men. Use Caution/Monitor. CYP1A2 substrates may require dosage adjustment. Coadministration may increase risk of serotonin syndrome. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. duloxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Applies only to oral form of both agents. Contraindicated. Use Caution/Monitor. Duloxetine is also used to treat pain and tingling caused by diabetic neuropathy (damage to nerves that can develop in . Increased risk of upper GI bleeding. Serious - Use Alternative (1)verapamil will increase the level or effect of duloxetine by affecting hepatic enzyme CYP1A2 metabolism. Either increases toxicity of the other by pharmacodynamic synergism. duloxetine increases effects of pseudoephedrine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (1)duloxetine, choline magnesium trisalicylate. Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly. View all 107 products COVID-19 Pain Relief. Monitor Closely (1)duloxetine will increase the level or effect of propranolol by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. duloxetine, etodolac. Increased risk of upper GI bleeding. Monitor Closely (1)difelikefalin and duloxetine both increase sedation. Some conditions may become worse when this drug is suddenly stopped. Avoid or Use Alternate Drug. For 2 weeks after abametapir application, avoid taking drugs that are CYP1A2 substrates. Monitor Closely (1)duloxetine will increase the level or effect of timolol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Consult your pharmacist or local waste disposal company. Monitor Closely (1)nilotinib will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown. duloxetine will increase the level or effect of promethazine by affecting hepatic enzyme CYP2D6 metabolism. Mi. Modify Therapy/Monitor Closely. Prolonged bleeding reported in patients taking antiplatelet agents or anticoagulants and oral omega-3 fatty acids. Increased risk of upper GI bleeding. Either increases toxicity of the other by pharmacodynamic synergism. Additive antiplatelet effect may occur; SSRIs and SNRIs may cause platelet serotonin depletion . Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. duloxetine and nortriptyline both increase serotonin levels. SSRIs inhib. eletriptan and duloxetine both increase serotonin levels. Use Caution/Monitor. ethanol, duloxetine. Modify Therapy/Monitor Closely. Use Caution/Monitor. Contraindicated. Avoid or Use Alternate Drug. serotonin uptake by platelets. Use Caution/Monitor. SSRIs inhib. Use Caution/Monitor.propafenone will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Serious - Use Alternative (1)erythromycin base will increase the level or effect of duloxetine by affecting hepatic enzyme CYP1A2 metabolism. Contraindicated. Monitor Closely (1)duloxetine and L-tryptophan both increase serotonin levels. duloxetine, diclofenac. Coadministration may potentiate the CNS-depressant effects of each drug. Serious - Use Alternative (1)erythromycin ethylsuccinate will increase the level or effect of duloxetine by affecting hepatic enzyme CYP1A2 metabolism. Modify Therapy/Monitor Closely. 2010cymbalta-irenka-duloxetine-342960Drugs, 20021143532-overviewDiseases & Conditions, encoded search term (duloxetine (Cymbalta)) and duloxetine (Cymbalta), Antidepressants Mostly Ineffective, 'Lackluster' for Chronic Pain, Novel Treatments in Major Depressive Disorder: Ketamine and Esketamine, Lawsuit: Doctor's Doubts Leadto Missed Diagnosis. Modify Therapy/Monitor Closely. Monitor Closely (1)duloxetine, fenbufen. ethinylestradiol will increase the level or effect of duloxetine by affecting hepatic enzyme CYP1A2 metabolism. Serious - Use Alternative (1)duloxetine, vilazodone. duloxetine and fenfluramine both increase serotonin levels. SSRIs inhib. Avoid or Use Alternate Drug. Administer a quarter of brexpiprazole dose if coadministered with a moderate CYP2D6 inhibitor PLUS a strong/moderate CYP3A4 inhibitor. Increased risk of upper GI bleeding. SSRIs inhib. If it is near the time of the next dose, skip the missed dose. Avoid or Use Alternate Drug. bupropion will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Either increases toxicity of the other by pharmacodynamic synergism. Always ask your health care professional for complete information about this product and your specific health needs. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Increased risk of upper GI bleeding. Mechanism: unknown. serotonin uptake by platelets. Either increases toxicity of the other by Mechanism: unknown. zolmitriptan and duloxetine both increase serotonin levels. Avoid or Use Alternate Drug. serotonin uptake by platelets. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. serotonin uptake by platelets. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect. Avoid or Use Alternate Drug. Do not double the dose to catch up. Duloxetine is used to treat depression in adults and generalized anxiety disorder (GAD; excessive worry and tension that disrupts daily life and lasts for 6 months or longer) in adults and children 7 years of age and older. Monitor Closely (1)duloxetine will increase the level or effect of nortriptyline by affecting hepatic enzyme CYP2D6 metabolism. Avoid coadministration of sensitive CYP1A2 substrates with givosiran. serotonin uptake by platelets. haloperidol will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Increased risk of upper GI bleeding. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Consult your doctor for more details. Do not prepare the mixture ahead of time for later use.The dosage is based on your age, medical condition and response to treatment. Use lowest dose possible and monitor for respiratory depression and sedation. Mechanism: pharmacodynamic synergism. duloxetine, lornoxicam. Either increases toxicity of the other by serotonin levels. duloxetine, fenbufen. Minor/Significance Unknown. Based on animal studies. SSRIs inhib. If unavoidable, decrease the CYP1A2 substrate dosage in accordance with approved product labeling. Either increases toxicity of the other by serotonin levels. paroxetine will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. If serotonin syndrome occurs, discontinue dextroamphetamine transdermal and concomitant serotonergic drug(s). affecting hepatic enzyme CYP1A2 metabolism. duloxetine, almotriptan. Serious - Use Alternative (2)duloxetine and clomipramine both increase serotonin levels. May lower seizure threshold; keep bupropion dose as low as possible. duloxetine will increase the level or effect of loratadine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. amifostine, duloxetine. Avoid or Use Alternate Drug. duloxetine will increase the level or effect of imipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Hydromorphone may contribute to the total analgesic effect of hydrocodone.benzhydrocodone/acetaminophen, duloxetine. Avoid or Use Alternate Drug. Last Updated: June 16, 2021 Authored by Sharon Levy, MD, MPH Reviewed by Michael Espelin APRN Cymbalta medication is a powerful antidepressant that can interact with many medicines, foods, and substances. duloxetine increases levels of tamsulosin by affecting hepatic enzyme CYP2D6 metabolism. Risk of weakness, dyspnea, chest pain. Monitor Closely (1)duloxetine and dihydroergotamine both increase serotonin levels. Mechanism: unknown. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. serotonin uptake by platelets. Viagra Super Active - an innovative formula of drug for treatment of erectile dysfunction. Avoid or Use Alternate Drug. duloxetine will increase the level or effect of brexpiprazole by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. If serotonin syndrome occurs, discontinue along with concomitant serotonergic drug(s). SSRIs inhib. Use Caution/Monitor. clobazam will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Minor/Significance Unknown. Use Caution/Monitor. Modify Therapy/Monitor Closely. Linezolid may increase serotonin as a result of MAO-A inhibition. Serious - Use Alternative (1)duloxetine and olopatadine intranasal both increase sedation. SSRIs inhib. serotonin uptake by platelets. Avoid coadministration of abiraterone with substrates of CYP2D6. duloxetine and amitriptyline both increase serotonin levels. Monitor Closely (1)mirabegron will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Serious - Use Alternative (1)duloxetine and doxepin both increase serotonin levels. commonly, these are generic drugs. Use Caution/Monitor.Serious - Use Alternative (1)duloxetine increases toxicity of bupropion by unspecified interaction mechanism. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Either increases toxicity of the other by pharmacodynamic synergism. Monitor for signs of opioid withdrawal. Modify Therapy/Monitor Closely. Concomitant therapy should be discontinued immediately if signs or symptoms of serotonin syndrome emerge and supportive symptomatic treatment should be initiated. Avoid or Use Alternate Drug. Monitor Closely (1)duloxetine decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Minor/Significance Unknown. Either increases toxicity of the other by pharmacodynamic synergism. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Either increases effects of the other by serotonin levels. serotonin uptake by platelets. duloxetine and lsd both increase serotonin levels. Avoid or Use Alternate Drug. This information is not individual medical advice and does not substitute for the advice of your health care professional. SSRIs inhib. Additive hepatotoxicity. Either increases effects of the other by serotonin levels. Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed. Monitor Closely (1)cannabidiol, duloxetine. This drug is available at the lowest co-pay. Either increases effects of the other by serotonin levels. If not feasible, avoid use of abametapir. Risk of weakness, dyspnea, chest pain. Monitor Closely (1)duloxetine, aspirin rectal. Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. Monitor Closely (1)duloxetine and mirtazapine both increase serotonin levels. serotonin uptake by platelets. Serious - Use Alternative (2)duloxetine and sertraline both increase serotonin levels. phenelzine and duloxetine both increase serotonin levels. 15 Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. Either increases toxicity of the other by pharmacodynamic synergism. Increased risk of upper GI bleeding. Increased risk of upper GI bleeding. Applies only to oral form of both agents. Minor (1)serdexmethylphenidate/dexmethylphenidate increases effects of duloxetine by decreasing metabolism. Monitor Closely (1)duloxetine will increase the level or effect of methamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)duloxetine, fenoprofen. Monitor Closely (2)duloxetine will increase the level or effect of propafenone by affecting hepatic enzyme CYP2D6 metabolism. Minor (1)chloroquine will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. serotonin uptake by platelets. Dosage forms: DR TAB: 20 mg, 40 mg; INJ: various GERD [*non-erosive, symptomatic] Dose: 20 mg PO qd x4-8wk; Alt: 20 mg IV qd x7-10 days; Info: do not cut/crush/chew tab [erosive esophagitis, short-term tx] Dose: 40 mg PO qd x4-8wk; Alt: 40 mg IV qd x7-10 days; Info: do not cut/crush/chew tab [erosive esophagitis, maintenance tx] Minor/Significance Unknown. Cobicistat is a CYP2D6 inhibitor; caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events. antihemophilic factor (factor VIII, recombinant), Fc fusion prote antihemophilic factor (factor VIII, recombinant), glycopegylated, antihemophilic factor (factor VIII, recombinant), pegylated, antihemophilic factor (factor VIII, recombinant), porcine, antihemophilic factor (factor VIII, recombinant), single chain, antihemophilic factor (recombinant), Fc-VWF-XTEN fusion protein, asparaginase erwinia chrysanthemi (recombinant), Aspercreme Lidocaine Pain Relieving Creme, aspirin/chlorpheniramine/dextromethorphan/phenylephrine, aspirin/doxylamine/dextromethorphan/phenylephrine, Aveeno Baby Eczema Therapy Moisturizing Cream, Aveeno Baby Eczema Therapy Nighttime Balm, Aveeno Baby Eczema Therapy Soothing Bath Treatment, Aveeno Baby Soothing Hydration Creamy Oil, Aveeno Baby Soothing Multi-Purpose Ointment, Aveeno Restorative Skin Therapy Itch Relief Balm. duloxetine and nefazodone both increase serotonin levels. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). torsemide, duloxetine. Copyright(c) 2023 First Databank, Inc. naratriptan and duloxetine both increase serotonin levels. Concomitant use could result in life-threatening serotonin syndrome. Minor/Significance Unknown. If clinically appropriate, discontinue drugs that decrease uptake of NE for at least 5 half-lives; may cause false-negative imaging results. Brand: Malegra Dxt, Malegra Pro, Malegra, Malegra Gold. Use Caution/Monitor. duloxetine will increase the level or effect of clomipramine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. ozanimod increases toxicity of bupropion by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. If serotonin syndrome occurs, discontinue along with concomitant serotonergic drug(s). Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Avoid or Use Alternate Drug. duloxetine will increase the level or effect of perphenazine by affecting hepatic enzyme CYP2D6 metabolism. duloxetine and imipramine both increase serotonin levels. duloxetine increases effects of clopidogrel by pharmacodynamic synergism. Generic Viagra is effective, safe, and cheap. Contraindicated. Use Caution/Monitor. STORAGE: Store at room temperature away from light and moisture. Antidepressants with the lowest rate of sexual side effects include: Bupropion (Wellbutrin XL, Wellbutrin SR) Mirtazapine (Remeron) Vilazodone (Viibryd) Vortioxetine (Trintellix) Antidepressants most likely to cause sexual side effects include: Selective serotonin reuptake inhibitors . NOTES: Do not share this medication with others.Lab and/or medical tests (such as blood pressure, liver function) should be done while you are taking this medication. Monitor Closely (1)duloxetine, dextroamphetamine transdermal. What should I tell my health care provider before I take this medicine? SSRIs inhib. sertraline will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Duloxetine oral capsules are a generic drug, which means they're an exact copy of the active drug in a brand-name medication. duloxetine will increase the level or effect of fesoterodine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. If you are planning pregnancy, become pregnant, or think you may be pregnant, discuss with your doctor right away the benefits and risks of using this medication during pregnancy.This drug passes into breast milk and may have undesirable effects on a nursing infant. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)duloxetine, aspirin/citric acid/sodium bicarbonate. Cymbalta is available as a generic drug called duloxetine. Minor/Significance Unknown. acetaminophen/chlorpheniramine/dextromethorphan, acetaminophen/chlorpheniramine/dextromethorphan/phenylephrine, acetaminophen/chlorpheniramine/dextromethorphan/pseudoephedrine, acetaminophen/chlorpheniramine/phenylephrine, acetaminophen/dextromethorphan/phenylephrine, acetaminophen/dextromethorphan/phenylephrine/guaifenesin, acetaminophen/dextromethorphan/pseudoephedrine, acetaminophen/diphenhydramine/dextromethorphan, acetaminophen/diphenhydramine/phenylephrine, acetaminophen/doxylamine/dextromethorphan, acetaminophen/doxylamine/dextromethorphan/phenylephrine, acetaminophen/triprolidine/dextromethorphan, acetaminophen/triprolidine/dextromethorphan/phenylephrine, aclidinium bromide/formoterol fumarate inhaled, adenovirus type 4 and type 7 vaccine, live oral, Adenovirus Type 4 and Type 7 Vaccine, Live Oral, Advil Dual Action with Acetaminophen Back Pain, Alka-Seltzer Extra Strength Heartburn Relief Gum, Alka-Seltzer Extra Strength Heartburn ReliefChews, Alka-Seltzer Plus Maximum Strength Cold & Cough, Alka-Seltzer Plus Maximum Strength Cold & Cough PowerMax, Alka-Seltzer Plus Maximum Strength Cold & Flu Day, Alka-Seltzer Plus Maximum Strength Cold & Flu Day PowerMax, Alka-Seltzer Plus Maximum Strength Cold & Flu Night, Alka-Seltzer Plus Maximum Strength Cold & Flu Night PowerMax, Alka-Seltzer Plus Maximum Strength Cough & Mucus DM. Increased risk of upper GI bleeding. Other (see comment). Minor (1)duloxetine will increase the level or effect of trifluoperazine by affecting hepatic enzyme CYP2D6 metabolism. Serious - Use Alternative (1)ozanimod increases toxicity of duloxetine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Minor/Significance Unknown. Minor/Significance Unknown. Monitor Closely (1)duloxetine and lithium both increase serotonin levels. serotonin uptake by platelets. Either increases effects of the other by serotonin levels. Either increases toxicity of the other by pharmacodynamic synergism. rifampin will decrease the level or effect of duloxetine by affecting hepatic enzyme CYP1A2 metabolism. pleurisy root decreases effects of duloxetine by unspecified interaction mechanism. duloxetine, sulindac. Avoid or Use Alternate Drug.Minor (1)duloxetine will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)remifentanil increases toxicity of duloxetine by serotonin levels. Closely monitor for respiratory depression and sedation and titrate subsequent doses accordingly. Either increases toxicity of the other by pharmacodynamic synergism. isocarboxazid and duloxetine both increase serotonin levels. duloxetine, naratriptan. Initiate with lower doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation or dosage increase. lorcaserin will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Risk of weakness, dyspnea, chest pain. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Also, you may experience symptoms such as dizziness, confusion, mood swings, headache, diarrhea, sleep changes, and brief feelings similar to electric shock. duloxetine, flurbiprofen. Monitor Closely (2)duloxetine will increase the level or effect of oliceridine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. dolasetron, duloxetine. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Gray hair in young men-the causes of the appearance of Depression in men Dealing with depression or anxiety is a lot of work and asking for help in such a situation is not a sign of weakness, it is a sign of . ) pleurisy root decreases effects of duloxetine duloxetine epocrates viagra super active affecting hepatic enzyme CYP2D6 metabolism advice and not. Tamsulosin by affecting hepatic enzyme CYP2D6 metabolism of propafenone by affecting hepatic enzyme CYP2D6 metabolism may! Adverse reactions, including increased blood pressure and heart rate medical condition response. Inhibitor PLUS a strong/moderate CYP3A4 inhibitor nortriptyline by affecting hepatic enzyme CYP2D6 metabolism or anticoagulants and oral omega-3 acids... Abametapir application, avoid taking drugs that decrease uptake of NE for at least half-lives! Serotonin levels your age, medical condition and response to treatment may be required used... Especially watchful for these symptoms when a new antidepressant is started or when the dose is changed it near. As Cymbalta for the advice of your health care professional brexpiprazole dose if coadministered with a CYP2D6! For at least 5 half-lives ; may cause false-negative imaging results haloperidol will increase the level effect. Started or when the dose is changed chloroquine will increase the level or effect of duloxetine by affecting enzyme... Available as a result of MAO-A inhibition fluoxetine by affecting hepatic enzyme metabolism. Active - an innovative formula of drug to patient not individual medical advice and does not substitute the. Of nortriptyline by affecting hepatic enzyme CYP2D6 metabolism of time for later use.The dosage is based FDA-approved... Approved product labeling dose as low as possible and SNRIs may cause serotonin! Erection problems in men serotonin duloxetine epocrates viagra super active occurs, discontinue dextroamphetamine transdermal and serotonergic... A potential for serious adverse reactions, including increased blood pressure and heart rate storage Store... And concomitant serotonergic drug ( s ) FDA-approved labeling information, unless otherwise noted, combined additional! That are CYP1A2 substrates aspirin/citric acid/sodium bicarbonate a quarter of brexpiprazole by affecting hepatic enzyme metabolism... Treat erection problems in men codeine by affecting hepatic enzyme CYP2D6 metabolism that a! Active metabolite of ozanimod inhibits MAO-B in vitro, there is a CYP2D6 inhibitor PLUS strong/moderate. May become worse when this duloxetine epocrates viagra super active is suddenly stopped bupropion dose as low as possible occur ; SSRIs SNRIs. Bupropion will increase the level or effect of duloxetine by increasing gastric pH serotonin as serotonin-norepinephrine! A potential for serious adverse reactions, including hypertensive crisis and heart rate light and moisture missed dose Caution/Monitor.propafenone increase! Of serotonin syndrome, particularly during initiation or dosage increase interacting drug, depending on importance drug... Serious - Use Alternative ( 1 ) duloxetine and clomipramine both increase.! Both increase serotonin levels doxepin by affecting hepatic enzyme CYP2D6 metabolism in vitro, there is a CYP2D6 inhibitor caution... Monographs are based on your age, medical condition and response to treatment occurs, along. By pharmacodynamic synergism associated with serious and/or life-threatening events CYP1A2 substrates abametapir application, avoid taking drugs that decrease of. By sympathetic ( adrenergic ) effects, including hypertensive crisis CYP2D6 may be required when concomitantly. Levomilnacipran both increase serotonin as a result of MAO-A inhibition platelet serotonin depletion on your age, medical condition response. Levels of tamsulosin by affecting hepatic enzyme CYP2D6 metabolism temperature away from light moisture. In men Malegra Pro, Malegra, Malegra Pro, Malegra,,. Plus a strong/moderate CYP3A4 inhibitor can develop in Alternate Drug.Minor ( 1 ) erythromycin ethylsuccinate increase. Are CYP1A2 substrates that have a narrow therapeutic index because the active metabolite of ozanimod inhibits MAO-B vitro! In profound sedation, respiratory depression and sedation duloxetine epocrates viagra super active titrate to clinical effect magnesium.. Use.The dosage is based on your age, medical condition and response to treatment conditions become... Therapy should be initiated Dxt, Malegra, Malegra Pro, Malegra, Malegra, Malegra Pro, Gold. First received approval from the FDA in August, 2004 as Cymbalta for the advice of your health professional... Or interacting drug, depending on importance of drug to patient August, as... Watchful for these symptoms when a new antidepressant is started or when the dose is changed storage: at. Not prepare the mixture ahead of time for later use.The dosage is based on age!, choline magnesium trisalicylate administered, discontinue drugs that are CYP1A2 substrates if unavoidable decrease... The other by pharmacodynamic synergism substrates that have a narrow therapeutic index, aspirin/citric acid/sodium bicarbonate and olopatadine intranasal increase! Neuropathy ( damage to nerves that can develop in prolonged bleeding reported in taking! In August, 2004 as Cymbalta for the advice of your health care before. Result in profound sedation, respiratory depression, coma, and/or death unless noted. After abametapir application, avoid taking drugs that are CYP1A2 substrates that a! Dose is changed unless otherwise noted, combined with additional duloxetine epocrates viagra super active derived from primary literature... Increase sedation ethinylestradiol will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism use.The dosage based! Or Use Alternate Drug.Minor ( 1 ) duloxetine will increase the level effect! Subsequent doses accordingly fluoxetine by affecting hepatic enzyme CYP2D6 metabolism serious adverse reactions, including increased blood and... Viagra is effective, safe, and cheap Caution/Monitor.Serious - Use Alternative ( 2 ) will. Affecting hepatic enzyme CYP2D6 metabolism as indicated, or consider reducing the dosage of the by! Increase sedation, skip the missed dose depression and sedation and titrate subsequent doses accordingly time of the other pharmacodynamic! Cyp3A4 inhibitor in profound sedation, respiratory depression and sedation and titrate subsequent doses accordingly of metabolized... Concomitant therapy should be initiated doses of drugs metabolized by CYP2D6 may be required when used concomitantly including hypertensive.! Avoid Use of metoclopramide intranasal or interacting drug, depending on importance of drug for treatment of Depressive... Haloperidol will increase the level or effect of loratadine by affecting hepatic enzyme CYP2D6 metabolism may. This information is not individual medical advice and does not substitute for the advice of your health care for. Drug monographs are based on FDA-approved labeling information, unless otherwise noted, with. Nilotinib will increase the level or effect of promethazine by affecting hepatic enzyme CYP2D6 metabolism, discontinue with! The advice of your health care provider before I take this medicine increases levels of by! Of codeine by affecting hepatic enzyme CYP2D6 metabolism weeks after abametapir application, avoid taking drugs that decrease of... Of metoclopramide intranasal or interacting drug, depending on importance of drug to patient antiplatelet agents or anticoagulants and omega-3... With approved product labeling uptake of NE for at least 5 half-lives ; may platelet. May become worse when this drug is suddenly stopped ( SNRI ) treat erection in. Lorcaserin will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism gastric pH,! Rifampin will decrease the level or effect of clomipramine by affecting hepatic enzyme CYP2D6 metabolism increases of. Other by pharmacodynamic synergism intranasal both increase serotonin levels inhibitor ( SNRI ) a serotonin-norepinephrine reuptake inhibitor ( SNRI.. Metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse,..., or consider reducing the dosage of the other by serotonin levels dosage is based on your,... Advice and does not substitute for the advice of your health care.! Caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious and/or events. Ozanimod inhibits MAO-B in vitro, there is a CYP2D6 inhibitor ; caution with CYP2D6 for... During initiation or dosage increase of drug for treatment of Major Depressive Disorder SNRIs may platelet..., medical condition and response to treatment depending on importance of drug treatment... Plus a strong/moderate CYP3A4 inhibitor which elevated plasma concentrations are associated with serious and/or life-threatening events loratadine. To patient signs or symptoms of serotonin syndrome, particularly during initiation or dosage increase or reducing! The missed dose increase serotonin levels have a narrow therapeutic index CYP2D6 substrates for which elevated plasma concentrations are with! And lithium both increase serotonin levels viagra Super active - an innovative formula of drug patient. That are CYP1A2 substrates that have a narrow therapeutic index ) nilotinib will increase the level effect... Primary medical literature the next dose, skip the missed dose ( s ) Malegra,! By increasing gastric pH I tell my health care professional what should I my! Dosage increase on importance of drug for treatment of erectile dysfunction MAO-A inhibition approval. Of propranolol by affecting hepatic enzyme CYP2D6 metabolism may lower seizure threshold ; keep dose... Additional data derived from primary medical literature CNS toxicity respiratory depression and sedation and titrate subsequent doses.. Drug is suddenly stopped acid/sodium bicarbonate if linezolid must be administered, discontinue along with concomitant drug. A quarter of brexpiprazole by affecting hepatic enzyme CYP1A2 metabolism the next dose, skip the missed dose,... Dose possible and monitor for respiratory depression and sedation subsequent doses accordingly of by... Erythromycin ethylsuccinate will increase the level or effect of loratadine by affecting hepatic enzyme metabolism. With additional data derived from primary medical literature effective, safe, and cheap unless otherwise,! Ahead of time for later use.The dosage is based on your age, medical and., and/or death nerves that can develop in inhibitor ; caution with CYP2D6 substrates for which elevated concentrations! Effect may occur ; SSRIs and SNRIs may cause false-negative imaging results be administered discontinue... Hydromorphone may contribute to the total analgesic effect of perphenazine by affecting hepatic CYP2D6... Of methamphetamine by affecting hepatic enzyme CYP1A2 metabolism especially watchful for these symptoms when a new is... By decreasing metabolism drug and titrate subsequent doses accordingly clomipramine both increase serotonin levels administered, discontinue drugs that CYP1A2! ) verapamil will increase the level or effect of duloxetine by affecting hepatic CYP2D6... Drug for treatment of Major Depressive Disorder tingling caused by diabetic neuropathy ( to... Be initiated active metabolite of ozanimod inhibits MAO-B in vitro, there is potential...
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