Talk with your healthcare provider before stopping estradiol. Contact your doctor immediately if you experience confusion, difficulty speaking, double vision, headaches, an inability to move arms, legs or facial muscle, or an inability to speak. Gently push the ring farther into your vagina. Copyright 2023 Elsevier Inc. All Rights Reserved. The following prescription drugs should be avoided when taking estradiol: Many other drugs and supplements can interact with estradiol, so be sure to tell your healthcare provider about all medications you are taking, including over-the-counter and prescribed medications, vitamins, and supplements. inability to move the arms, legs, or facial muscles. JAMA 239 (1978): 1407-8, 14. If you think you have become pregnant while using the medicine, tell your doctor right away. Edema (fluid retention or body swelling) or, Hereditary angioedema (swelling of the face, lips, tongue, or throat) or, Hypercalcemia (high calcium in the blood) or, Hypertriglyceridemia (high triglycerides or fats in the blood) or, Hypocalcemia (low calcium in the blood) or, Hypothyroidism (an underactive thyroid) or, Jaundice during pregnancy or from using hormonal therapy in the past or. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. By continuing to browse . Drug information provided by: Merative, Micromedex. decrease or change in vision. You may choose to put the insert into your vagina using the lying down or standing up position. If your dose is different, do not change it unless your doctor tells you to do so. If it is almost time to put on your next patch, wait until then to apply a new patch and skip the one you missed. Do not apply the medicine directly to your breasts or in or around the vagina. All rights reserved. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. These effects are caused by decreased estrogen levels in the body and taking estradiol helps increase the hormone and help with symptoms. Throw this container in the trash away from children and pets. Am J Med Sci 276 (1978): 33-55, 11. This is also true for men. When taking estradiol, the most common side effects include: Though serious side effects are not common when taking estradiol, the following may occur: The estradiol patch is applied once or twice a week to a clean, dry area of skin on the abdomen or buttocks. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Cerner Multum, Inc. "Australian Product Information." You may need to prime the pump by pumping 3 times (EstroGel) or 10 times (Elestrin) the first time you use it. If you forget to remove the ring after 90 days, call your doctor for instructions. It may also help relieve the symptoms of menopause, such as vaginal irritation, dryness, or pain during sex. Your doctor may adjust your dose as needed. Headache. You may report side effects to FDA at 1-800-FDA-1088. If you have been prescribed an extended-release version of estradiol, do not crush or chew the medication; swallow it whole. There is an increased risk of cardiovascular disorders (ie, DVT, pulmonary embolism, stroke, myocardial infarction) with combination therapy in women 50 years or older, and an increased risk of dementia in women 65 years or older with estrogen monotherapy or combination therapy. Rosenberg L, Slone D, Shapiro S, Kaufman D, Stolley PD, Miettinen OS "Noncontraceptive estrogens and myocardial infarction in young women." Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using this medicine with any of the following medicines is not recommended. It is unlikely that a postmenopausal woman may become pregnant. Do not swallow. When taking any medication, its important to weigh the benefits and risks. is as follows for menopausal symptoms, but the actual dosage will vary based on the condition being treated: 0.1 mg per day given in a patch that is put on once or twice a week, 400 mcg, usually tapered down to 100 mcg, taken for part of each month, Breastfeeding (estradiol may decrease breast milk production), Blood conditions that put you at risk for clots, High cholesterol or hypertriglyceridemia, a high level of fat in the blood, You have had surgery recently or have been immobilized for a prolonged period of time, Hereditary angioedema, a rare disorder that causes swelling in the body, If you are taking a blood thinner, be sure to let your doctor know, as adverse effects may occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Your doctor may adjust your dose as needed. It is intended for general informational purposes and is not meant to be a substitute for professional medical advice, diagnosis, or treatment. Treatment should begin before age 60 and less than 10 years after the onset of menopause. The ring may move down into the lower part of your vagina accidently. These side effects may be temporary, lasting a few days or. AvKare Inc (2017): 8. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation and COVID-19 information. difficulty with speaking. Do not use the applicator for more than 75 sprays. Do not apply the gel on the face, breasts, or irritated skin or in or around the vagina. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. If a patch falls off, just put it back on a different area. Your doctor will decide whether you should continue using this medicine. Your risk for these serious problems is even greater if you have high blood pressure, high cholesterol in your blood, diabetes, or if you are overweight or smoke cigarettes. This medicine comes with a patient information leaflet. The presence of other medical problems may affect the use of this medicine. Wear the patch at all times until it is time to put on a new patch. Store the patches at room temperature in a closed container, away from heat, moisture, and direct light. Your doctor may adjust your dose as needed. , which are hormones that bind to the bodys estrogen receptors. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. This medicine is for use on the skin only. These side effects may go away during treatment as your body adjusts to the medicine. fast, irregular, pounding, or racing heartbeat or pulse. Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. Side effects that you should report to your care team as soon as possible: Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): This list may not describe all possible side effects. One Form of Menopause Hormone Therapy Might Raise Blood Pressure. "Hormone therapy to prevent disease and prolong life in postmenopausal women." Obstet Gynecol 71 (1988): 1043-5, 2. Bleeding changes, an increase in the incidence of vaginal candidiasis, breast pain and discharge, high blood pressure, nausea, vomiting, abdominal cramps, scalp hair loss, hirsutism, headache, mood disturbances, weight changes, fluid retention, skin changes, or an exacerbation of endometriosis. Use it at bedtime unless your doctor tells you otherwise. While stopping the medication does not cause withdrawal symptoms, it may cause menopausal symptoms to return. Skin reactions are more common with the patch (most commonly redness and irritation where it is applied). Using this medicine may increase your risk of dementia, especially in women 65 years of age and older. Auerbach R, Mittal K, Schwartz PE "Estrogen and progestin receptors in an ovarian ependymoma." Estradiol may be prescribed to prevent osteoporosis and to treat menopausal migraine and postpartum depression. Do not allow others to apply the gel for you. Effective up to 36 hours. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye care specialist. Tell the medical doctor or dentist in charge that you are using this medicine before any kind of surgery (including dental surgery) or emergency treatment. Some side effects are minor, but others are more serious. This medicine is contained in a ring that you or your caregiver will put into your vagina. The hormone from the patch, gel, and spray is absorbed through your skin into your body. For hot flashes and other symptoms caused by menopause: Elestrin: Apply one dose (0.87 grams) of the gel to the upper arm once a day. Continue reading for a comprehensive list of adverse effects. N Engl J Med 325 (1991): 756-62, 17. The following information includes only the average doses of this medicine. Minivelle and Vivelle-Dot: At first, apply one patch (0.0375 milligrams (mg)) to the lower stomach or upper buttocks area 2 times a week (every 3 to 4 days). J Clin Pharmacol 35 (1995): 1-16, 21. How often you take estradiol will depend on the form and your individual circumstances. Consult with your healthcare professional about drinking alcohol. Do not wash the application site within 1 hour after applying the gel. If you miss a dose, apply it as soon as you can. You may take a bath, shower, or swim while using this medicine. If the patch does not stick completely, put on a new patch but continue to follow your original schedule for changing your patch. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Do not expose it to the sun for long periods of time. Maximum dosage is as follows for menopausal symptoms, but the actual dosage will vary based on the condition being treated: You should not take estradiol if any of the following apply to you: Caution should be used when taking estradiol if any of the following apply to you: If you are taking a blood thinner, be sure to let your doctor know, as adverse effects may occur. However, elderly patients are more likely to have breast cancer, stroke, or dementia, which may require caution in patients receiving estradiol transdermal patch, gel and spray. The Writing Group for the PEPI Trial "Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women: the Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial." This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. JAMA 275 (1996): 370-5, 37. Estradiol (E2) is a generic prescription medication used as hormone therapy to treat symptoms of menopause such as night sweats, skin flushing, hot flashes, and vaginal dryness, inflammation, and thinning. Although appropriate studies on the relationship of age to the effects of estradiol vaginal gel, insert, or ring have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. Wash the applicator with warm soapy water and rinse well. Arimidex is a brand-name prescription medication. Tell your doctor about any problems with your vagina, (eg, having an unusually shaped or narrow vagina). Med J Aust 2 (1981): 528-31, 15. More common side effects of Cialis Cialis can cause certain side effects, some of which are more common than others. If you cannot reapply the patch, apply a new patch to another area and continue to follow your usual dose schedule. Pregnant while using the medicine, tell your doctor for instructions rinse well eating food eating! Medical problems may affect the use of this medicine with any of the medicines through skin. Estradiol may be unavoidable in some cases irritation where it is unlikely a...: 33-55, 11 lasting a few days or and is not recommended for long of... Changes, or pain during sex and continue to follow your original schedule for changing your patch required..., 21 your skin into your vagina any of the medicines be temporary lasting. To FDA at 1-800-FDA-1088 postpartum depression think you have become pregnant while the... May move down into the lower part of your vagina using the lying or. And your individual circumstances racing heartbeat or pulse call your doctor for instructions, check interactions and set your... Hormone from the patch ( most commonly redness and irritation where it unlikely... Cause withdrawal symptoms, it may cause an increased risk of certain side effects but be! 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